LOCUS       NM_005830               1486 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein S31 (MRPS31), mRNA.
ACCESSION   NM_005830
VERSION     NM_005830.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1486)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1486)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   3  (bases 1 to 1486)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   4  (bases 1 to 1486)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 1486)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 1486)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1486)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
REFERENCE   8  (bases 1 to 1486)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   9  (bases 1 to 1486)
  AUTHORS   Tchernev,V.T., Mansfield,T.A., Giot,L., Kumar,A.M., Nandabalan,K.,
            Li,Y., Mishra,V.S., Detter,J.C., Rothberg,J.M., Wallace,M.R.,
            Southwick,F.S. and Kingsmore,S.F.
  TITLE     The Chediak-Higashi protein interacts with SNARE complex and signal
            transduction proteins
  JOURNAL   Mol Med 8 (1), 56-64 (2002)
   PUBMED   11984006
REFERENCE   10 (bases 1 to 1486)
  AUTHORS   Cavdar Koc,E., Burkhart,W., Blackburn,K., Moseley,A. and
            Spremulli,L.L.
  TITLE     The small subunit of the mammalian mitochondrial ribosome.
            Identification of the full complement of ribosomal proteins present
  JOURNAL   J Biol Chem 276 (22), 19363-19374 (2001)
   PUBMED   11279123
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AV712217.1, BC010159.1,
            BC022045.1, AI343737.1 and AL355132.19.
            
            On May 17, 2019 this sequence version replaced NM_005830.3.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. The 28S subunit of the mammalian mitoribosome may play a
            crucial and characteristic role in translation initiation. This
            gene encodes a 28S subunit protein that has also been associated
            with type 1 diabetes; however, its relationship to the etiology of
            this disease remains to be clarified. Pseudogenes corresponding to
            this gene have been found on chromosomes 3 and 13. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022045.1, AK315248.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000323563.8/
                                                  ENSP00000315397.6
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-33                AV712217.1         22-54
            34-776              BC010159.1         1-743
            777-1310            BC022045.1         766-1299
            1311-1318           AI343737.1         6-13                c
            1319-1486           AL355132.19        123804-123971       c
FEATURES             Location/Qualifiers
     source          1..1486
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.11"
     gene            1..1486
                     /gene="MRPS31"
                     /gene_synonym="IMOGN38; MRP-S31; mS31; S31mt"
                     /note="mitochondrial ribosomal protein S31"
                     /db_xref="GeneID:10240"
                     /db_xref="HGNC:HGNC:16632"
                     /db_xref="MIM:611992"
     exon            1..206
                     /gene="MRPS31"
                     /gene_synonym="IMOGN38; MRP-S31; mS31; S31mt"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1242
                     /gene="MRPS31"
                     /gene_synonym="IMOGN38; MRP-S31; mS31; S31mt"
                     /note="imogen 38; 28S ribosomal protein S31,
                     mitochondrial; mitochondrial small ribosomal subunit
                     protein mS31"
                     /codon_start=1
                     /product="small ribosomal subunit protein mS31"
                     /protein_id="NP_005821.2"
                     /db_xref="CCDS:CCDS9372.1"
                     /db_xref="GeneID:10240"
                     /db_xref="HGNC:HGNC:16632"
                     /db_xref="MIM:611992"
                     /translation="MFPRVSTFLPLRPLSRHPLSSGSPETSAAAIMLLTVRHGTVRYR
                     SSALLARTKNNIQRYFGTNSVICSKKDKQSVRTEETSKETSESQDSEKENTKKDLLGI
                     IKGMKVELSTVNVRTTKPPKRRPLKSLEATLGRLRRATEYAPKKRIEPLSPELVAAAS
                     AVADSLPFDKQTTKSELLSQLQQHEEESRAQRDAKRPKISFSNIISDMKVARSATARV
                     RSRPELRIQFDEGYDNYPGQEKTDDLKKRKNIFTGKRLNIFDMMAVTKEAPETDTSPS
                     LWDVEFAKQLATVNEQPLQNGFEELIQWTKEGKLWEFPINNEAGFDDDGSEFHEHIFL
                     EKHLESFPKQGPIRHFMELVTCGLSKNPYLSVKQKVEHIEWFRNYFNEKKDILKESNI
                     QFN"
     exon            207..494
                     /gene="MRPS31"
                     /gene_synonym="IMOGN38; MRP-S31; mS31; S31mt"
                     /inference="alignment:Splign:2.1.0"
     exon            495..653
                     /gene="MRPS31"
                     /gene_synonym="IMOGN38; MRP-S31; mS31; S31mt"
                     /inference="alignment:Splign:2.1.0"
     exon            654..794
                     /gene="MRPS31"
                     /gene_synonym="IMOGN38; MRP-S31; mS31; S31mt"
                     /inference="alignment:Splign:2.1.0"
     exon            795..868
                     /gene="MRPS31"
                     /gene_synonym="IMOGN38; MRP-S31; mS31; S31mt"
                     /inference="alignment:Splign:2.1.0"
     exon            869..1012
                     /gene="MRPS31"
                     /gene_synonym="IMOGN38; MRP-S31; mS31; S31mt"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1486
                     /gene="MRPS31"
                     /gene_synonym="IMOGN38; MRP-S31; mS31; S31mt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1292..1297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS31"
                     /gene_synonym="IMOGN38; MRP-S31; mS31; S31mt"
                     /note="hexamer: AATAAA"
     polyA_site      1311
                     /gene="MRPS31"
                     /gene_synonym="IMOGN38; MRP-S31; mS31; S31mt"
                     /note="major polyA site"
     regulatory      1461..1466
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS31"
                     /gene_synonym="IMOGN38; MRP-S31; mS31; S31mt"
                     /note="hexamer: AATACA"
     polyA_site      1486
                     /gene="MRPS31"
                     /gene_synonym="IMOGN38; MRP-S31; mS31; S31mt"
ORIGIN      
        1 ggcagcggga cgcaccattt cagttgtgtt cttggttcat ttcgtgtctc ggcgatgttt
       61 cctagagtct cgacgttcct acctcttcgc cccctttccc gccacccttt gtcctctgga
      121 agcccggaga catcagcggc tgcgattatg ctactcactg ttcggcacgg aacagtcagg
      181 taccgcagtt cagcgctgtt ggcccggaca aaaaataaca tccaaagata ttttggcact
      241 aacagtgtga tctgtagcaa gaaagataag cagtctgttc gaactgagga gacttccaag
      301 gagacttcag agagccaaga cagtgaaaag gaaaatacga aaaaagactt gttaggcatt
      361 attaagggca tgaaagttga attaagcaca gtaaatgtac gaacaacaaa gccccccaaa
      421 agaagaccac ttaaaagttt ggaagctaca cttggcaggc ttcgaagagc tacagaatat
      481 gctccaaaga agagaattga gcccctgagt cctgagttgg tggcagctgc atctgctgtg
      541 gcagattctc tcccttttga taagcaaaca accaagtcag agctgctgag ccagctccag
      601 cagcatgagg aagagtcaag ggcacagaga gatgcaaagc gacctaaaat tagtttcagt
      661 aacataatat cagatatgaa agttgccaga tctgctacag ctagagttcg ttcaagacca
      721 gagcttcgga ttcagtttga tgaaggctat gacaattatc ctggccagga gaagacggat
      781 gatcttaaaa aaaggaaaaa tatattcaca gggaaaagac ttaatatttt tgacatgatg
      841 gcagttacta aagaagcacc tgaaacagac acatcacctt cactttggga tgtggaattt
      901 gctaagcagt tagccacagt aaatgaacaa ccccttcaga atggatttga agagctgatc
      961 cagtggacaa aagaggggaa actatgggag ttcccaatta acaatgaagc aggttttgat
     1021 gatgatggtt cagaatttca tgaacatata tttctggaga aacacctgga gagctttcca
     1081 aaacaaggac caattcgcca cttcatggag ctggtgactt gtggcctttc caaaaaccca
     1141 tatcttagtg ttaaacagaa ggttgaacac atagagtggt ttagaaatta ttttaatgaa
     1201 aaaaaggata ttctaaaaga aagtaacata cagttcaatt aagaccatgg aaatttttat
     1261 ttcaaacaat tagagatgga tattacaact aaataaaata attttactag agtttgtata
     1321 tgttatgttg attattacat ttgatttggc tggtataaat gttacattgt tttcaaaaat
     1381 atgatggtaa ctgaaaaata ttcttgcatg gagaaaaatc atcagtattc ataggttcaa
     1441 aagaatatct gggaattagt aatacattta agacaacaac tcctaa
//
