LOCUS       NM_030811               1016 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein S26 (MRPS26), mRNA.
ACCESSION   NM_030811
VERSION     NM_030811.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1016)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1016)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   3  (bases 1 to 1016)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   4  (bases 1 to 1016)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 1016)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1016)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   7  (bases 1 to 1016)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   8  (bases 1 to 1016)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   9  (bases 1 to 1016)
  AUTHORS   Cavdar Koc,E., Burkhart,W., Blackburn,K., Moseley,A. and
            Spremulli,L.L.
  TITLE     The small subunit of the mammalian mitochondrial ribosome.
            Identification of the full complement of ribosomal proteins present
  JOURNAL   J Biol Chem 276 (22), 19363-19374 (2001)
   PUBMED   11279123
REFERENCE   10 (bases 1 to 1016)
  AUTHORS   Goldschmidt-Reisin,S., Kitakawa,M., Herfurth,E.,
            Wittmann-Liebold,B., Grohmann,L. and Graack,H.R.
  TITLE     Mammalian mitochondrial ribosomal proteins. N-terminal amino acid
            sequencing, characterization, and identification of corresponding
            gene sequences
  JOURNAL   J Biol Chem 273 (52), 34828-34836 (1998)
   PUBMED   9857009
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI115733.1 and BC013018.2.
            
            On Nov 23, 2018 this sequence version replaced NM_030811.3.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 28S subunit protein. This gene lies
            adjacent to and downstream of the gonadotropin-releasing hormone
            precursor gene. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.62827.1,
                                           SRR1163658.80605.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000380325.4/
                                                  ENSP00000369682.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BI115733.1         108-117
            11-1016             BC013018.2         1-1006
FEATURES             Location/Qualifiers
     source          1..1016
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p13"
     gene            1..1016
                     /gene="MRPS26"
                     /gene_synonym="C20orf193; dJ534B8.3; GI008; MRP-S13;
                     MRP-S26; MRPS13; mS26; NY-BR-87; RPMS13"
                     /note="mitochondrial ribosomal protein S26"
                     /db_xref="GeneID:64949"
                     /db_xref="HGNC:HGNC:14045"
                     /db_xref="MIM:611988"
     exon            1..229
                     /gene="MRPS26"
                     /gene_synonym="C20orf193; dJ534B8.3; GI008; MRP-S13;
                     MRP-S26; MRPS13; mS26; NY-BR-87; RPMS13"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..635
                     /gene="MRPS26"
                     /gene_synonym="C20orf193; dJ534B8.3; GI008; MRP-S13;
                     MRP-S26; MRPS13; mS26; NY-BR-87; RPMS13"
                     /note="serologically defined breast cancer antigen
                     NY-BR-87; 28S ribosomal protein S26, mitochondrial; S13mt;
                     S26mt; 28S ribosomal protein S13, mitochondrial;
                     mitochondrial small ribosomal subunit protein mS26"
                     /codon_start=1
                     /product="small ribosomal subunit protein mS26"
                     /protein_id="NP_110438.1"
                     /db_xref="CCDS:CCDS13043.1"
                     /db_xref="GeneID:64949"
                     /db_xref="HGNC:HGNC:14045"
                     /db_xref="MIM:611988"
                     /translation="MLRALSRLGAGTPCRPRAPLVLPARGRKTRHDPLAKSKIERVNM
                     PPAVDPAEFFVLMERYQHYRQTVRALRMEFVSEVQRKVHEARAGVLAERKALKDAAEH
                     RELMAWNQAENRRLHELRIARLRQEEREQEQRQALEQARKAEEVQAWAQRKEREVLQL
                     QEEVKNFITRENLEARVEAALDSRKNYNWAITREGLVVRPQRRDS"
     exon            230..376
                     /gene="MRPS26"
                     /gene_synonym="C20orf193; dJ534B8.3; GI008; MRP-S13;
                     MRP-S26; MRPS13; mS26; NY-BR-87; RPMS13"
                     /inference="alignment:Splign:2.1.0"
     exon            377..500
                     /gene="MRPS26"
                     /gene_synonym="C20orf193; dJ534B8.3; GI008; MRP-S13;
                     MRP-S26; MRPS13; mS26; NY-BR-87; RPMS13"
                     /inference="alignment:Splign:2.1.0"
     exon            501..1016
                     /gene="MRPS26"
                     /gene_synonym="C20orf193; dJ534B8.3; GI008; MRP-S13;
                     MRP-S26; MRPS13; mS26; NY-BR-87; RPMS13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      995..1000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS26"
                     /gene_synonym="C20orf193; dJ534B8.3; GI008; MRP-S13;
                     MRP-S26; MRPS13; mS26; NY-BR-87; RPMS13"
                     /note="hexamer: AATAAA"
     polyA_site      1016
                     /gene="MRPS26"
                     /gene_synonym="C20orf193; dJ534B8.3; GI008; MRP-S13;
                     MRP-S26; MRPS13; mS26; NY-BR-87; RPMS13"
                     /note="major polyA site"
ORIGIN      
        1 agtgaggaga ctcggccatg ctacgcgcgc tgagccgcct gggcgcgggg accccgtgca
       61 ggccccgggc ccctctggtg ctgccagcgc gcggccgcaa gacccgccac gacccgctgg
      121 ccaaatccaa gatcgagcga gtgaacatgc cgcccgcggt ggaccctgcg gagttcttcg
      181 tgctgatgga gcgttaccag cactaccgcc agaccgtgcg cgccctcagg atggagttcg
      241 tgtccgaggt gcagaggaag gtgcacgagg cccgagccgg ggttctggcg gagcgcaagg
      301 ccctgaagga cgccgccgag caccgcgagc tgatggcctg gaaccaggcg gagaaccggc
      361 ggctgcacga gctgcggata gcgaggctgc ggcaggagga gcgggagcag gagcagcggc
      421 aggcgttgga gcaggcccgc aaggccgaag aggtgcaggc ctgggcgcag cgcaaggagc
      481 gggaagtgct gcagctgcag gaagaggtga aaaacttcat cacccgagag aacctggagg
      541 cacgggtgga agcagcattg gactcccgga agaactacaa ctgggccatc accagagagg
      601 ggctggtggt caggccacaa cgcagggact cctaggggcc cagtaaggac agtgcccgcc
      661 agggaccatg tatgtatcat ggcggaagag ttggccctga cctggaataa agcagttggt
      721 gttgcttatg aggaaggttc agccttatcc agcacagcct tcacgttttg ccctctgctg
      781 tcaccacttg gtcagaaact tccaaacgca gtgccctgtt ctgccggtgt gtacagcctc
      841 agcgcaccag gagaccctag agtggtttcc atctcacaga gaatcagaca gggccacagc
      901 cccctcaggc agccaggtca tctgagtatc attaagagta gtgatgggaa gattacagtc
      961 tgagggccaa acgtgcctgc ttcctgtttt tgtaaataaa gttttgttgg aacaca
//
