LOCUS       NM_032014                667 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein S24 (MRPS24), mRNA.
ACCESSION   NM_032014
VERSION     NM_032014.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 667)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 667)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   3  (bases 1 to 667)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   4  (bases 1 to 667)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 667)
  AUTHORS   Comuzzie,A.G., Cole,S.A., Laston,S.L., Voruganti,V.S., Haack,K.,
            Gibbs,R.A. and Butte,N.F.
  TITLE     Novel genetic loci identified for the pathophysiology of childhood
            obesity in the Hispanic population
  JOURNAL   PLoS One 7 (12), e51954 (2012)
   PUBMED   23251661
REFERENCE   6  (bases 1 to 667)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Proteomic analysis of the mammalian mitochondrial ribosome.
            Identification of protein components in the 28 S small subunit
  JOURNAL   J Biol Chem 276 (35), 33181-33195 (2001)
   PUBMED   11402041
REFERENCE   7  (bases 1 to 667)
  AUTHORS   Cavdar Koc,E., Burkhart,W., Blackburn,K., Moseley,A. and
            Spremulli,L.L.
  TITLE     The small subunit of the mammalian mitochondrial ribosome.
            Identification of the full complement of ribosomal proteins present
  JOURNAL   J Biol Chem 276 (22), 19363-19374 (2001)
   PUBMED   11279123
REFERENCE   8  (bases 1 to 667)
  AUTHORS   Koc,E.C., Burkhart,W., Blackburn,K., Moseley,A., Koc,H. and
            Spremulli,L.L.
  TITLE     A proteomics approach to the identification of mammalian
            mitochondrial small subunit ribosomal proteins
  JOURNAL   J Biol Chem 275 (42), 32585-32591 (2000)
   PUBMED   10938081
REFERENCE   9  (bases 1 to 667)
  AUTHORS   Mao,M., Fu,G., Wu,J.S., Zhang,Q.H., Zhou,J., Kan,L.X., Huang,Q.H.,
            He,K.L., Gu,B.W., Han,Z.G., Shen,Y., Gu,J., Yu,Y.P., Xu,S.H.,
            Wang,Y.X., Chen,S.J. and Chen,Z.
  TITLE     Identification of genes expressed in human CD34(+) hematopoietic
            stem/progenitor cells by expressed sequence tags and efficient
            full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 95 (14), 8175-8180 (1998)
   PUBMED   9653160
REFERENCE   10 (bases 1 to 667)
  AUTHORS   Xu,L., He,G.P., Li,A. and Ro,H.S.
  TITLE     Molecular characterization of the mouse ribosomal protein S24
            multigene family: a uniquely expressed intron-containing gene with
            cell-specific expression of three alternatively spliced mRNAs
  JOURNAL   Nucleic Acids Res 22 (4), 646-655 (1994)
   PUBMED   8127713
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA413186.1 and BC012167.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032014.2.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 28S subunit protein. A pseudogene
            corresponding to this gene is found on chromosome 11. Read-through
            transcription exists between this gene and the upstream upregulator
            of cell proliferation (URGCP) gene. [provided by RefSeq, Mar 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.140263.1,
                                           SRR1163657.40186.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000317534.6/
                                                  ENSP00000318158.5
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                CA413186.1         666-684             c
            20-667              BC012167.1         1-648
FEATURES             Location/Qualifiers
     source          1..667
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p13"
     gene            1..667
                     /gene="MRPS24"
                     /gene_synonym="bMRP-47; bMRP47; HSPC335; MRP-S24; S24mt"
                     /note="mitochondrial ribosomal protein S24"
                     /db_xref="GeneID:64951"
                     /db_xref="HGNC:HGNC:14510"
                     /db_xref="MIM:611986"
     exon            1..61
                     /gene="MRPS24"
                     /gene_synonym="bMRP-47; bMRP47; HSPC335; MRP-S24; S24mt"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..526
                     /gene="MRPS24"
                     /gene_synonym="bMRP-47; bMRP47; HSPC335; MRP-S24; S24mt"
                     /EC_number="3.6.5.3"
                     /note="mitochondrial 28S ribosomal protein S24; 28S
                     ribosomal protein S24, mitochondrial; mitochondrial small
                     ribosomal subunit protein uS3m"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS3m precursor"
                     /protein_id="NP_114403.1"
                     /db_xref="CCDS:CCDS5473.1"
                     /db_xref="GeneID:64951"
                     /db_xref="HGNC:HGNC:14510"
                     /db_xref="MIM:611986"
                     /translation="MAASVCSGLLGPRVLSWSRELPCAWRALHTSPVCAKNRAARVRV
                     SKGDKPVTYEEAHAPHYIAHRKGWLSLHTGNLDGEDHAAERTVEDVFLRKFMWGTFPG
                     CLADQLVLKRRGNQLEICAVVLRQLSPHKYYFLVGYSETLLSYFYKCPVRLHLQTVPS
                     KVVYKYL"
     exon            62..130
                     /gene="MRPS24"
                     /gene_synonym="bMRP-47; bMRP47; HSPC335; MRP-S24; S24mt"
                     /inference="alignment:Splign:2.1.0"
     exon            131..242
                     /gene="MRPS24"
                     /gene_synonym="bMRP-47; bMRP47; HSPC335; MRP-S24; S24mt"
                     /inference="alignment:Splign:2.1.0"
     exon            243..667
                     /gene="MRPS24"
                     /gene_synonym="bMRP-47; bMRP47; HSPC335; MRP-S24; S24mt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      648..653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS24"
                     /gene_synonym="bMRP-47; bMRP47; HSPC335; MRP-S24; S24mt"
                     /note="hexamer: AATAAA"
     polyA_site      667
                     /gene="MRPS24"
                     /gene_synonym="bMRP-47; bMRP47; HSPC335; MRP-S24; S24mt"
                     /note="major polyA site"
ORIGIN      
        1 cccgcgctcc gcttggccca agatggcggc ctccgtgtgc agcgggttgc tggggccacg
       61 ggtgctgtcc tggagccgag agctgccttg cgcttggcgc gccctgcaca cctccccggt
      121 ctgcgccaag aaccgggcgg cccgagtacg cgtaagcaag ggggacaagc cggtgaccta
      181 cgaggaggca cacgcgccgc actacatcgc ccaccgtaaa ggctggctgt cgctgcacac
      241 aggtaacctg gatggagagg accatgccgc agagcgaacg gtggaggatg ttttccttcg
      301 caagttcatg tggggtacct tcccaggctg cctggctgac cagctggttt taaagcgccg
      361 gggtaaccag ttggagatct gtgccgtggt cctgaggcag ttgtctccac acaagtacta
      421 cttcctcgtg ggctacagtg aaactttgct gtcctacttt tacaaatgtc ctgtgcgact
      481 ccacctccaa actgtgccct caaaggttgt gtataagtac ctctagaaca atcccctttt
      541 ttccatcaag ctgtagcctg cagagaatgg aaacgtggga aaggaatggt atgtggggga
      601 aatgcatccc ctcagaggac tgaggcatag tctctcatct gctattgaat aaagaccttc
      661 tatcttg
//
