LOCUS       NM_016070               5609 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein S23 (MRPS23), mRNA.
ACCESSION   NM_016070
VERSION     NM_016070.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5609)
  AUTHORS   Wang,Q., Chen,G., Liu,L., Peng,X., Yang,X., Yang,L. and Li,C.
  TITLE     MRPS23 is a novel prognostic biomarker and promotes glioma
            progression
  JOURNAL   Aging (Albany NY) 16 (3), 2457-2474 (2024)
   PUBMED   38301044
  REMARK    GeneRIF: MRPS23 is a novel prognostic biomarker and promotes glioma
            progression.
REFERENCE   2  (bases 1 to 5609)
  AUTHORS   Ittiwut,C., Ittiwut,R., Kuptanon,C., Matsuhashi,T., Shimura,M.,
            Sugiyama,Y., Onuki,T., Ohtake,A., Murayama,K., Vatanavicharn,N.,
            Dejputtawat,W., Tantisirivit,N., Kor-Anantakul,P., Kamolvisit,W.,
            Suphapeetiporn,K. and Shotelersuk,V.
  TITLE     Genetic, metabolic and clinical delineation of an MRPS23-associated
            mitochondrial disorder
  JOURNAL   Sci Rep 13 (1), 22005 (2023)
   PUBMED   38086984
  REMARK    GeneRIF: Genetic, metabolic and clinical delineation of an
            MRPS23-associated mitochondrial disorder.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5609)
  AUTHORS   Oviya,R.P., Thangaretnam,K.P., Ramachandran,B., Ramanathan,P.,
            Jayavelu,S., Gopal,G. and Rajkumar,T.
  TITLE     Mitochondrial ribosomal small subunit (MRPS) MRPS23 protein-protein
            interaction reveals phosphorylation by CDK11-p58 affecting cell
            proliferation and knockdown of MRPS23 sensitizes breast cancer
            cells to CDK1 inhibitors
  JOURNAL   Mol Biol Rep 49 (10), 9521-9534 (2022)
   PUBMED   35962848
  REMARK    GeneRIF: Mitochondrial ribosomal small subunit (MRPS) MRPS23
            protein-protein interaction reveals phosphorylation by CDK11-p58
            affecting cell proliferation and knockdown of MRPS23 sensitizes
            breast cancer cells to CDK1 inhibitors.
REFERENCE   4  (bases 1 to 5609)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 5609)
  AUTHORS   Oviya,R.P., Gopal,G., Shirley,S.S., Sridevi,V., Jayavelu,S. and
            Rajkumar,T.
  TITLE     Mitochondrial ribosomal small subunit proteins (MRPS) MRPS6 and
            MRPS23 show dysregulation in breast cancer affecting tumorigenic
            cellular processes
  JOURNAL   Gene 790, 145697 (2021)
   PUBMED   33964376
  REMARK    GeneRIF: Mitochondrial ribosomal small subunit proteins (MRPS)
            MRPS6 and MRPS23 show dysregulation in breast cancer affecting
            tumorigenic cellular processes.
REFERENCE   6  (bases 1 to 5609)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5609)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   8  (bases 1 to 5609)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   9  (bases 1 to 5609)
  AUTHORS   Cavdar Koc,E., Burkhart,W., Blackburn,K., Moseley,A. and
            Spremulli,L.L.
  TITLE     The small subunit of the mammalian mitochondrial ribosome.
            Identification of the full complement of ribosomal proteins present
  JOURNAL   J Biol Chem 276 (22), 19363-19374 (2001)
   PUBMED   11279123
REFERENCE   10 (bases 1 to 5609)
  AUTHORS   Koc,E.C., Burkhart,W., Blackburn,K., Moseley,A., Koc,H. and
            Spremulli,L.L.
  TITLE     A proteomics approach to the identification of mammalian
            mitochondrial small subunit ribosomal proteins
  JOURNAL   J Biol Chem 275 (42), 32585-32591 (2000)
   PUBMED   10938081
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX479815.1, BC000242.1,
            AF151896.1, AW299554.1, BI962985.1 and AC015845.8.
            
            On Nov 23, 2018 this sequence version replaced NM_016070.3.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 28S subunit protein. A pseudogene
            corresponding to this gene is found on chromosome 7p. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BM846582.1, SRR1660805.26027.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000313608.13/
                                                  ENSP00000320184.8
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BX479815.1         30-35
            7-838               BC000242.1         1-832
            839-989             AF151896.1         814-964
            990-1444            AW299554.1         20-474              c
            1445-1464           BI962985.1         473-492
            1465-5609           AC015845.8         72662-76806         c
FEATURES             Location/Qualifiers
     source          1..5609
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..5609
                     /gene="MRPS23"
                     /gene_synonym="CGI-138; COXPD46; HSPC329; MRP-S23; mS23"
                     /note="mitochondrial ribosomal protein S23"
                     /db_xref="GeneID:51649"
                     /db_xref="HGNC:HGNC:14509"
                     /db_xref="MIM:611985"
     exon            1..78
                     /gene="MRPS23"
                     /gene_synonym="CGI-138; COXPD46; HSPC329; MRP-S23; mS23"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..607
                     /gene="MRPS23"
                     /gene_synonym="CGI-138; COXPD46; HSPC329; MRP-S23; mS23"
                     /note="28S ribosomal protein S23, mitochondrial; S23mt;
                     mitochondrial small ribosomal subunit protein mS23"
                     /codon_start=1
                     /product="small ribosomal subunit protein mS23"
                     /protein_id="NP_057154.2"
                     /db_xref="CCDS:CCDS11598.1"
                     /db_xref="GeneID:51649"
                     /db_xref="HGNC:HGNC:14509"
                     /db_xref="MIM:611985"
                     /translation="MAGSRLETVGSIFSRTRDLVRAGVLKEKPLWFDVYDAFPPLREP
                     VFQRPRVRYGKAKAPIQDIWYHEDRIRAKFYSVYGSGQRAFDLFNPNFKSTCQRFVEK
                     YTELQKLGETDEEKLFVETGKALLAEGVILRRVGEARTQHGGSHVSRKSEHLSVRPQT
                     ALEENETQKEVPQDQHLEAPADQSKGLLPP"
     exon            79..249
                     /gene="MRPS23"
                     /gene_synonym="CGI-138; COXPD46; HSPC329; MRP-S23; mS23"
                     /inference="alignment:Splign:2.1.0"
     exon            250..327
                     /gene="MRPS23"
                     /gene_synonym="CGI-138; COXPD46; HSPC329; MRP-S23; mS23"
                     /inference="alignment:Splign:2.1.0"
     exon            328..454
                     /gene="MRPS23"
                     /gene_synonym="CGI-138; COXPD46; HSPC329; MRP-S23; mS23"
                     /inference="alignment:Splign:2.1.0"
     exon            455..5609
                     /gene="MRPS23"
                     /gene_synonym="CGI-138; COXPD46; HSPC329; MRP-S23; mS23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      883..888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS23"
                     /gene_synonym="CGI-138; COXPD46; HSPC329; MRP-S23; mS23"
                     /note="hexamer: TATAAA"
     polyA_site      904
                     /gene="MRPS23"
                     /gene_synonym="CGI-138; COXPD46; HSPC329; MRP-S23; mS23"
                     /note="major polyA site"
     regulatory      5583..5588
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS23"
                     /gene_synonym="CGI-138; COXPD46; HSPC329; MRP-S23; mS23"
                     /note="hexamer: AATAAA"
     polyA_site      5609
                     /gene="MRPS23"
                     /gene_synonym="CGI-138; COXPD46; HSPC329; MRP-S23; mS23"
ORIGIN      
        1 agcagctagt cacgctcggt accaggcgca gatcatggca ggcagccggc tggaaaccgt
       61 agggagcatc ttctctcgga ctcgggacct ggttcgggcc ggggtgctga aggagaagcc
      121 cctgtggttt gacgtatatg acgcctttcc cccgctgagg gagcccgtct tccaaaggcc
      181 tcgagtgcga tatggcaaag ccaaagctcc catccaagac atctggtacc acgaggatcg
      241 gattagagcg aagttttatt cagtgtatgg gtctggtcaa agagcttttg atctattcaa
      301 tccaaacttc aagtctacct gtcaacggtt tgtggagaag tacactgagc tacagaaact
      361 tggagaaaca gatgaagaga agttatttgt ggaaacaggg aaggctttat tggcagaagg
      421 tgtcatttta agacgagtag gcgaagcaag gactcaacac ggaggtagtc acgtttcccg
      481 gaaatccgaa cacttgagtg tcagaccaca gactgcgttg gaagaaaacg agactcagaa
      541 agaagttcca caggaccagc atttggaggc acctgcagac cagtcgaaag gtctcttgcc
      601 tccctgaagg acctgtatac tgtgtatgct ggcattcaca ctctactcac tggctgaatg
      661 ttgagctatt tttaaacagt tgaactgtgt aaatgtttct tgatctctaa ggtattatgt
      721 ttgccttctc ttagttattt ctgggttgtc acaaagctca gtatcatggt ttgacagaag
      781 cagttatgtg aacttttatg ttaggacatt actaaataaa gaattcccta gctgcttata
      841 aagtaaattt actttgaatt gtaaataaca tgaagaaacc tttataaaga ttgttcaaat
      901 gggactcaat ctgactaggc ttgctttgat gtttgttagt atgtgggctg gctacatctg
      961 attcccgggt acatatttct tctgatccat cagacttata cgtgtacaca tgttgtggaa
     1021 ccttggctag ctggttttgt ctgcagagaa tctttgtact tcttgctata gaacgattat
     1081 ctctccactt gagaggccaa gctgacttgc gctttgtggt aagagtgagg acctgtcatt
     1141 gctgatacac aaagaccaaa actgtaactt taatgtcatg gattgagtgt gctggagaca
     1201 gttaacatag gcctgcacag actaggctgt tcagtaaata cttgttgaat gaatgagtga
     1261 acgaatggtt atatccagct aaagactgga ttcatatggt gtagataaca ggattgccaa
     1321 gaaaggaggc agctaattta ggtgatgctc tccaccagca tccacctgcc tccctggggc
     1381 caaagtgtgc ctacaagtcc ttatcaactt ccctgccttc ctcgtttccc caggttttac
     1441 taaatacatg aaatatccct ctgagattgc agcctttgta tatgtggtca agccagtggt
     1501 ttttagctgt tagtagtaag ctgcttcaga aattccctat tttaaaactc atgtagattt
     1561 tctacccagt gattctttgt gtatgctctc atctctcctg gtacactgtg aggcaggtcc
     1621 acatctcaca gtctgtatat agtacacatc catgcacgtg ggtgcttggt tcatgcaggt
     1681 gaatgaatac attaggcaaa agcagctctc agccatgctg cttccccctc gacctttatc
     1741 actgtttcac aactgcttgc atttggagaa tgctttactt ttccgtaggg aagtaaattt
     1801 catccattca gagacattac acaaccattg agaccaaaca tcgggccaga ccttgggaag
     1861 aggacttaaa aagcaggtga aagacacagt ctattctcag aggaacaatt gaggggtcac
     1921 tcatctcttt aaaccttagg tttctggttt tttaagggca ggtttttttt gccacaatga
     1981 tgaatattta aaaaatgttt ttttccttca tgtctggatt gatgtcccat ttttgctatt
     2041 tttgtttgtt ttcctcctct gtagattttt aatttttttt tttttttttt tttttttttt
     2101 gcgatggagt atcactttgt ttcccaggct ggagtacagt ggagccatct tggcccactg
     2161 caacctccgc ctcccaggtt caagcagttc ttctgcctca gcctcccaag tagctgggat
     2221 tacaggtgta tgctatgacg cccggctaat ttttgtattt ttagtagaaa cgggctttta
     2281 accatgttgc ccaggctgat ctcaaactgc tggcctcaag tgatccaccc atctcaacct
     2341 cccaaaatgc tgggattacg ggtgttagcc accatgcctg gccttaattt tttttttttt
     2401 taattttgtt ttaggagatg ggggtctcac tgtgttaccc aggctgggtg cagtggtgca
     2461 taccctgccg cagtcttaac tcctgggctg aagccatcct ggctcacttc ccgaatagct
     2521 aggactatag gcatgtgcca ccacgcctgg ctctttaaca ttttttttgt ttgttttttt
     2581 ttgtagagat ggagtcttgc tatgttgccc aggctggcct ggtctcaaac tcctggcctc
     2641 aagcgatcct cctgcctcag ccgcccaaag tgctgggatt acaggcctga gcgaccgtac
     2701 tggggctgaa gacttttaaa gaagttattt gttgcataat tctttaaaaa aattatacat
     2761 gcacatggtt caaaacttaa cagtaaaaag ctagtctccc acccctgttc cccagccacc
     2821 cttttcccct tccctgaggc catcactatc accatttcct tgtgcgctct tccagaaata
     2881 ttttgggcat ggacaggaca ctatgcatac tgttctgtac cttgcttttc tagttactat
     2941 gtctcagaga tccactgtga tttaatcagt gcccgattga agaaaatgtt ctttgtttta
     3001 ctgtgttgca aatgggctgc tagagttatg ggatgctgga tcaaggagca gatcattttg
     3061 agttttgata tcttcgtcca tagaaattgt gcttaactat actctcatag caatgtatga
     3121 gaatgcgttc ccctacacat tctgatcttg ttaaaccaga ctgggactct ggaccagaag
     3181 ggaaagacca tccctgtata gcaaatatct ggatggggag aaagctgctg tcactcattg
     3241 acttctttag gttaagtctt agtgatcaaa acatagtgaa agatatgaag cttactttgg
     3301 aaactcagaa ctatttccac agtttgggca aaagctgtca tcagatcccc atcacgtttt
     3361 ggagagaatg gaagcatgac cgcattcttg gctttaaaga gcttaaaatc aggccgggct
     3421 ccatggctca cgcctgtaat cccagcactt tgggaggcca aggtgggcgg atcacctgag
     3481 gtcaggagtt cgagaccagc ctggccaaca tagtgaaacc ccatctttac taaaaataca
     3541 aaaaaattag ctgggcgtgc gggcgtgtgc ctgtaatacc agctacccgg gaggctgagg
     3601 caggagaatc gctggaaccc aggaggcaga ggctgcagtt gagccgagat tgtgccactg
     3661 cactccagct tgggcgacag agcaagaccc tgtctcaaaa aaaaaaaaaa aaaaatctta
     3721 aaatcgagtt gggactacaa gagtgacttg tgaaacagca agatgaacag gaatcctttt
     3781 aaactttgat ataaaagtac agtagaggtt caggggcaag gaatcagttc tggatttgtc
     3841 taggaatact gcatgagagc ctggaaaggc agtgggatgg acatgtacat gcggtttctt
     3901 tgggcaggaa caccctccct tctaccatgg tctgtaggaa ttgaaccttc cgtgccgttt
     3961 tcaaatgctg tctgtgctcg gaaaatacat aatatcaagt cccttactga accccctaca
     4021 gattgtgttc ataaggtgct tcactgctgt tggtctacct ggcctactgt ttgtactcct
     4081 gcctcattta ctgtggcctt cattcaagta gtaatgatta tttacctatt aagagtatag
     4141 ggtgggcgtg gtggctcatg taatcccagc actttgggaa gtcaagatgg gtagatcact
     4201 tgaagtcagg agtttgagac cagcctgggc aacatgatga aaccccatct ctactaaaaa
     4261 tacaaaagtt agctggatgt ggtggcagcc tcctgtaatc ccaactactc ggcaggctga
     4321 ggcaggagaa tcgcttgaac ccaggaggtg gaggttacag tgagctgaga tcatgctaca
     4381 gcaccccagc ctgggcgaca gaagagagac actgtctcaa aaaaaaaaaa aaaaaaagta
     4441 taaaggaggg cagaaattct tattctttta acccattgaa acattaaaca gcctttcagg
     4501 agcagaccct cctacggatt tgctgaatcc aaggcgagga aggcatatat ccaggttaca
     4561 gtgaagtttg ccccagacaa gtaatgaaga tttgggttct agatctggat actccaggca
     4621 gtttttacta tgtgaccctg tgcctgtcac agtatttcag cctgtaaaat atggacaatg
     4681 tttgcctttt tggcttccag ttagctttgt gaggattaat tgagatgagt gcaaagctca
     4741 tttgtaatgt gtggctggtg gttttattac tattttgagc agtagtggaa aagcccattt
     4801 gaactggtag gatgagataa gatcatggtg gccttgacaa ctacatggag gagccagttg
     4861 ggtatgggaa agtttgagca gggaaagaaa gaatgtagtg aaagcagtgt caggtcaaag
     4921 aaaggtttgc ctaggagtga tgtaaagaat gggatggagg agtgggcagg gaaggaggaa
     4981 agaggagaca tgtcagaggg accaaaaagg aggcagcaag tccaaggtca caaacctgag
     5041 tgactagaaa acttagcagc atcactaaca cccagttggt gacgtggaac tggtgctctc
     5101 ctgggagaga gcttcaattc tcaacctact aagttgaagg tgatggtgct atatctaagt
     5161 ggcagacaga gataagggat aggtgtctac aggggcaaga tttggagcca ggagaagaaa
     5221 tgagctctcc aagggtagtg gggagagatc tgggatgttg ggggctggca ggtaaatgct
     5281 ttaagtgata gaataggagg aatgagaaag ccagcaaaag aaattcacgt cccatgtctt
     5341 ccatcatcta tatgtctgac ttgtttaagt ggtcctggat tcaccaaatt ttatagagct
     5401 ctgcctctgc ctttattggg taggcctgat ttttgatgat gtccttaaaa ggctagcctg
     5461 attcttcttg tagttttgta gaacactttg tatcgagagt tctctgataa tgaaagtggt
     5521 attacagaat aatctgcccc cgaaggactc ctgattttgt taaagtgata cctttctctg
     5581 taaataaatg atggcgtgcc acttaaaaa
//
