LOCUS       NM_031901               1085 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein S21 (MRPS21),
            transcript variant 1, mRNA.
ACCESSION   NM_031901
VERSION     NM_031901.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1085)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1085)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   3  (bases 1 to 1085)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   4  (bases 1 to 1085)
  AUTHORS   McGue,M., Zhang,Y., Miller,M.B., Basu,S., Vrieze,S., Hicks,B.,
            Malone,S., Oetting,W.S. and Iacono,W.G.
  TITLE     A genome-wide association study of behavioral disinhibition
  JOURNAL   Behav Genet 43 (5), 363-373 (2013)
   PUBMED   23942779
REFERENCE   5  (bases 1 to 1085)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 1085)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1085)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   8  (bases 1 to 1085)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   9  (bases 1 to 1085)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Proteomic analysis of the mammalian mitochondrial ribosome.
            Identification of protein components in the 28 S small subunit
  JOURNAL   J Biol Chem 276 (35), 33181-33195 (2001)
   PUBMED   11402041
REFERENCE   10 (bases 1 to 1085)
  AUTHORS   Cavdar Koc,E., Burkhart,W., Blackburn,K., Moseley,A. and
            Spremulli,L.L.
  TITLE     The small subunit of the mammalian mitochondrial ribosome.
            Identification of the full complement of ribosomal proteins present
  JOURNAL   J Biol Chem 276 (22), 19363-19374 (2001)
   PUBMED   11279123
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC242988.1.
            
            On Feb 27, 2020 this sequence version replaced NM_031901.5.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 28S subunit protein that belongs to
            the ribosomal protein S21P family. Pseudogenes corresponding to
            this gene are found on chromosomes 1p, 1q, 9p, 10p, 10q, 16q, and
            17q. Available sequence data analyses identified splice variants
            that differ in the 5' UTR; both transcripts encode the same
            protein. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) is the predominant transcript.
            Variants 1 and 2 both encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG501852.1, BQ340207.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000614145.5/
                                                  ENSP00000480129.1
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression,
                                                  longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AC242988.1         170048-170085
            39-153              AC242988.1         170522-170636
            154-1085            AC242988.1         184235-185166
FEATURES             Location/Qualifiers
     source          1..1085
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     gene            1..1085
                     /gene="MRPS21"
                     /gene_synonym="bS21m; MDS016; MRP-S21; RPMS21"
                     /note="mitochondrial ribosomal protein S21"
                     /db_xref="GeneID:54460"
                     /db_xref="HGNC:HGNC:14046"
                     /db_xref="MIM:611984"
     exon            1..38
                     /gene="MRPS21"
                     /gene_synonym="bS21m; MDS016; MRP-S21; RPMS21"
                     /inference="alignment:Splign:2.1.0"
     exon            39..153
                     /gene="MRPS21"
                     /gene_synonym="bS21m; MDS016; MRP-S21; RPMS21"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..334
                     /gene="MRPS21"
                     /gene_synonym="bS21m; MDS016; MRP-S21; RPMS21"
                     /EC_number="3.6.5.3"
                     /note="mitochondrial 28S ribosomal protein S21; 28S
                     ribosomal protein S21, mitochondrial; S21mt; mitochondrial
                     small ribosomal subunit protein bS21m"
                     /codon_start=1
                     /product="small ribosomal subunit protein bS21m"
                     /protein_id="NP_114107.2"
                     /db_xref="CCDS:CCDS950.1"
                     /db_xref="GeneID:54460"
                     /db_xref="HGNC:HGNC:14046"
                     /db_xref="MIM:611984"
                     /translation="MAKHLKFIARTVMVQEGNVESAYRTLNRILTMDGLIEDIKHRRY
                     YEKPCCRRQRESYERCRRIYNMEMARKINFLMRKNRADPWQGC"
     exon            154..1085
                     /gene="MRPS21"
                     /gene_synonym="bS21m; MDS016; MRP-S21; RPMS21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      430..435
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS21"
                     /gene_synonym="bS21m; MDS016; MRP-S21; RPMS21"
                     /note="hexamer: AATAAA"
     polyA_site      455
                     /gene="MRPS21"
                     /gene_synonym="bS21m; MDS016; MRP-S21; RPMS21"
                     /note="major polyA site"
     regulatory      467..472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS21"
                     /gene_synonym="bS21m; MDS016; MRP-S21; RPMS21"
                     /note="hexamer: AATATA"
     polyA_site      487
                     /gene="MRPS21"
                     /gene_synonym="bS21m; MDS016; MRP-S21; RPMS21"
     regulatory      1064..1069
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS21"
                     /gene_synonym="bS21m; MDS016; MRP-S21; RPMS21"
                     /note="hexamer: AATAAA"
     polyA_site      1085
                     /gene="MRPS21"
                     /gene_synonym="bS21m; MDS016; MRP-S21; RPMS21"
ORIGIN      
        1 gagaaccctt ccggtgggct aggtactgag cgcgcgaggc tctacagagt gaaggtttaa
       61 atccaaggtc atggcaaaac atctgaagtt catcgccagg actgtgatgg tacaggaagg
      121 gaacgtggaa agcgcataca ggaccctaaa cagaatcctc actatggatg ggctcattga
      181 ggacattaag catcggcggt attatgagaa gccatgctgc cggcgacaga gggaaagcta
      241 tgaaaggtgc cggcggatct acaacatgga aatggctcgc aagatcaact tcttgatgcg
      301 aaagaatcgg gcagatccgt ggcagggctg ctgaggcctg tgggtgggac acccagtgcg
      361 aaaccctcat ccagttttct ctccatctct tttctttgta caatcccatt tcctattacc
      421 attctctgca ataaactcaa atcacatgtc tgcaagaagg cctccaaata tagaaacaat
      481 cccattagtc agcagtggac cctgtctttt attaagtgaa agaagaaact gagtctgaaa
      541 gtactctagg agtagaatgg tatttgccag ggactggagg agggggcagt gaggagttat
      601 tgtttaatgg gtacagagtt tcagtttggg cagatgaaaa agttcaggag acgatggcct
      661 ggcatggtgg ctcacgcctg ttatcccaac actttgggag gctgaggcgg gcggctcact
      721 tgaggccagg agtttgagac cagcttggcc aatgtggtga aaccccatct ctactaaaaa
      781 tacaaaaaaa aattggccgg gcgtggtggt gcacgcctgt aatcccagat acttgggtgg
      841 ctgaggcagg agaattgctt gaactgggga ggaagaggtt gcagtgagcc aagatcatgc
      901 cactgcactc caacctgggc gacagagtga gactccatct caaaacaaaa aaacggagat
      961 ggatgatgaa tggtgatggc ggttgctcaa aaagttgaat gtacttaatg ccactgaact
     1021 atacccttaa atggtcacga tggtaaattt tgtgttttac tacaataaaa acttttttga
     1081 aagtc
//
