LOCUS       NM_014046               1398 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein S18B (MRPS18B), mRNA.
ACCESSION   NM_014046
VERSION     NM_014046.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1398)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1398)
  AUTHORS   Kovalevska,L.M., Malysheva,T.A., Kalman,S.S., Rozumenko,A.V.,
            Verbova,L.V., Rozumenko,V.D. and Kashuba,E.V.
  TITLE     Expression pattern of MRPS18 family genes in gliomas
  JOURNAL   Exp Oncol 43 (3), 204-208 (2021)
   PUBMED   34591434
  REMARK    GeneRIF: Expression pattern of MRPS18 family genes in gliomas.
REFERENCE   3  (bases 1 to 1398)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1398)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1398)
  AUTHORS   Buchynska,L.G., Iurchenko,N.P., Kashuba,E.V., Brieieva,O.V.,
            Glushchenko,N.M., Mints,M., Lukianova,N.Y. and Chekhun,V.F.
  TITLE     Overexpression of the mitochondrial ribosomal protein S18-2 in the
            invasive breast carcinomas
  JOURNAL   Exp Oncol 40 (4), 303-308 (2018)
   PUBMED   30593750
  REMARK    GeneRIF: trend for increasing expression of the S18-2 protein in
            tumors correlates with the aggressiveness of malignant breast
            cancer.
REFERENCE   6  (bases 1 to 1398)
  AUTHORS   Kashuba,E., Yurchenko,M., Yenamandra,S.P., Snopok,B.,
            Isaguliants,M., Szekely,L. and Klein,G.
  TITLE     EBV-encoded EBNA-6 binds and targets MRS18-2 to the nucleus,
            resulting in the disruption of pRb-E2F1 complexes
  JOURNAL   Proc Natl Acad Sci U S A 105 (14), 5489-5494 (2008)
   PUBMED   18391203
  REMARK    GeneRIF: EBNA-6 {ebna-3c} binds to MRPS18-2 , and targets it to the
            nucleus; binding targets the small pocket of pRb, which is a site
            of interaction with E2F1. The MRPS18-2 competes with the binding of
            E2F1 to pRb, thereby raising the level of free E2F1
REFERENCE   7  (bases 1 to 1398)
  AUTHORS   Shiina,T., Ota,M., Shimizu,S., Katsuyama,Y., Hashimoto,N.,
            Takasu,M., Anzai,T., Kulski,J.K., Kikkawa,E., Naruse,T., Kimura,N.,
            Yanagiya,K., Watanabe,A., Hosomichi,K., Kohara,S., Iwamoto,C.,
            Umehara,Y., Meyer,A., Wanner,V., Sano,K., Macquin,C., Ikeo,K.,
            Tokunaga,K., Gojobori,T., Inoko,H. and Bahram,S.
  TITLE     Rapid evolution of major histocompatibility complex class I genes
            in primates generates new disease alleles in humans via hitchhiking
            diversity
  JOURNAL   Genetics 173 (3), 1555-1570 (2006)
   PUBMED   16702430
REFERENCE   8  (bases 1 to 1398)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   9  (bases 1 to 1398)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Proteomic analysis of the mammalian mitochondrial ribosome.
            Identification of protein components in the 28 S small subunit
  JOURNAL   J Biol Chem 276 (35), 33181-33195 (2001)
   PUBMED   11402041
REFERENCE   10 (bases 1 to 1398)
  AUTHORS   Cavdar Koc,E., Burkhart,W., Blackburn,K., Moseley,A. and
            Spremulli,L.L.
  TITLE     The small subunit of the mammalian mitochondrial ribosome.
            Identification of the full complement of ribosomal proteins present
  JOURNAL   J Biol Chem 276 (22), 19363-19374 (2001)
   PUBMED   11279123
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG773408.1, AF100761.1 and
            BE220785.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014046.3.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 28S subunit protein that belongs to
            the ribosomal protein S18P family. The encoded protein is one of
            three that has significant sequence similarity to bacterial S18
            proteins. The primary sequences of the three human mitochondrial
            S18 proteins are no more closely related to each other than they
            are to the prokaryotic S18 proteins. Pseudogenes corresponding to
            this gene are found on chromosomes 1q and 2q. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.963164.1, AF151017.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000259873.5/
                                                  ENSP00000259873.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                BG773408.1         123-142
            21-1396             AF100761.1         7-1382
            1397-1398           BE220785.1         8-9                 c
FEATURES             Location/Qualifiers
     source          1..1398
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..1398
                     /gene="MRPS18B"
                     /gene_synonym="C6orf14; HSPC183; HumanS18a; MRP-S18-2;
                     MRPS18-2; mS40; PTD017; S18amt"
                     /note="mitochondrial ribosomal protein S18B"
                     /db_xref="GeneID:28973"
                     /db_xref="HGNC:HGNC:14516"
                     /db_xref="MIM:611982"
     exon            1..104
                     /gene="MRPS18B"
                     /gene_synonym="C6orf14; HSPC183; HumanS18a; MRP-S18-2;
                     MRPS18-2; mS40; PTD017; S18amt"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..803
                     /gene="MRPS18B"
                     /gene_synonym="C6orf14; HSPC183; HumanS18a; MRP-S18-2;
                     MRPS18-2; mS40; PTD017; S18amt"
                     /note="mitochondrial ribosomal protein S18-2; 28S
                     ribosomal protein S18b, mitochondrial; S18mt-b; mrps18-b;
                     MRP-S18-b; 28S ribosomal protein S18-2, mitochondrial;
                     mitochondrial small ribosomal subunit protein mS40;
                     mitochondrial small ribosomal subunit protein bS18m-B;
                     mitochondrial small ribosomal subunit protein bS18b"
                     /codon_start=1
                     /product="small ribosomal subunit protein mS40"
                     /protein_id="NP_054765.1"
                     /db_xref="CCDS:CCDS4682.1"
                     /db_xref="GeneID:28973"
                     /db_xref="HGNC:HGNC:14516"
                     /db_xref="MIM:611982"
                     /translation="MAASVLNTVLRRLPMLSLFRGSHRVQVPLQTLCTKAPSEEDSLS
                     SVPISPYKDEPWKYLESEEYQERYGSRPVWADYRRNHKGGVPPQRTRKTCIRRNKVVG
                     NPCPICRDHKLHVDFRNVKLLEQFVCAHTGIIFYAPYTGVCVKQHKRLTQAIQKARDH
                     GLLIYHIPQVEPRDLDFSTSHGAVSATPPAPTLVSGDPWYPWYNWKQPPERELSRLRR
                     LYQGHLQEESGPPPESMPKMPPRTPAEASSTGQTGPQSAL"
     exon            105..213
                     /gene="MRPS18B"
                     /gene_synonym="C6orf14; HSPC183; HumanS18a; MRP-S18-2;
                     MRPS18-2; mS40; PTD017; S18amt"
                     /inference="alignment:Splign:2.1.0"
     exon            214..311
                     /gene="MRPS18B"
                     /gene_synonym="C6orf14; HSPC183; HumanS18a; MRP-S18-2;
                     MRPS18-2; mS40; PTD017; S18amt"
                     /inference="alignment:Splign:2.1.0"
     exon            312..380
                     /gene="MRPS18B"
                     /gene_synonym="C6orf14; HSPC183; HumanS18a; MRP-S18-2;
                     MRPS18-2; mS40; PTD017; S18amt"
                     /inference="alignment:Splign:2.1.0"
     exon            381..447
                     /gene="MRPS18B"
                     /gene_synonym="C6orf14; HSPC183; HumanS18a; MRP-S18-2;
                     MRPS18-2; mS40; PTD017; S18amt"
                     /inference="alignment:Splign:2.1.0"
     exon            448..507
                     /gene="MRPS18B"
                     /gene_synonym="C6orf14; HSPC183; HumanS18a; MRP-S18-2;
                     MRPS18-2; mS40; PTD017; S18amt"
                     /inference="alignment:Splign:2.1.0"
     exon            508..1398
                     /gene="MRPS18B"
                     /gene_synonym="C6orf14; HSPC183; HumanS18a; MRP-S18-2;
                     MRPS18-2; mS40; PTD017; S18amt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1375..1380
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS18B"
                     /gene_synonym="C6orf14; HSPC183; HumanS18a; MRP-S18-2;
                     MRPS18-2; mS40; PTD017; S18amt"
                     /note="hexamer: AATAAA"
     polyA_site      1398
                     /gene="MRPS18B"
                     /gene_synonym="C6orf14; HSPC183; HumanS18a; MRP-S18-2;
                     MRPS18-2; mS40; PTD017; S18amt"
                     /note="major polyA site"
ORIGIN      
        1 aattcctgtc ctgggcgtac gtcaagatgg cggcgtctgt attaaacacc gtgctgaggc
       61 ggcttcctat gctatctctc ttccgaggtt ctcacagagt tcaggttccc ctccagactc
      121 tttgcaccaa agctccctct gaggaagatt ctttgtcctc agttcccatt tctccttata
      181 aggatgagcc ctggaaatat ctggaatcag aagaatacca ggagcgatat ggttctcgcc
      241 ccgtctgggc tgactaccgc cgcaaccaca agggtggtgt acccccacag cggactcgga
      301 agacatgtat tcgtcggaat aaagttgttg ggaatccctg ccccatctgt cgagatcaca
      361 agttgcatgt tgactttagg aacgtgaagc tcttggagca atttgtctgc gcccacacgg
      421 gtatcatctt ctatgctcca tacacaggag tctgtgtgaa gcagcacaag cggttgaccc
      481 aggccatcca gaaagccagg gatcatggtc tcctcattta ccacatcccc caggttgaac
      541 cacgggacct tgacttcagt acctctcatg gggctgtgag tgctactccg ccagccccca
      601 ccctggtctc aggtgacccc tggtacccat ggtacaactg gaaacagcca ccggagagag
      661 aactgtctcg ccttcgccgg ctttaccagg gtcatctcca agaagagagt ggccccccac
      721 ctgagtcaat gcccaagatg ccccctagaa caccagcgga agcctcctcc actgggcaga
      781 caggccctca gagtgctctg taggagctgt agactgggaa gagaggccag gcgtggtggc
      841 tcactcctgt aatcccagca ctttgggaag ccaaggtggg ctgatcactt gatcccagga
      901 gtttgagacc agcctgggca ccatggtgaa acctcgtctt taccaaaaaa tacaaaaatt
      961 agctgggtgt ggtggtgcac acctgtagtc tcaactattg gggaggctaa ggtaggatca
     1021 cttgatccca ggaggcggag gttgcagtga gttgcagtca cacccctgca ctccagcctg
     1081 ggtgacagct agaccctgtc tcaaaaaaaa aaaaaaagac tgggaagaga gctagaggga
     1141 ctaggagata atgtgtatgt aggtttatgt gatgggatat caccctgaag agttgtgtct
     1201 tttgtggcca gtgacaaatc caggaaatga atgttgctga tagggataaa tcttgaggct
     1261 gagggcgggt ggtacagatg tgtatgggaa accccaaccc ctatatattg taaatagatg
     1321 ggctgggcta aacattgttg ccgtttcata cttctaccaa ctcagctttt acacaataaa
     1381 gctctactgt ctctggtt
//
