LOCUS       NM_015969               1786 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein S17 (MRPS17), mRNA.
ACCESSION   NM_015969
VERSION     NM_015969.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1786)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1786)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1786)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   4  (bases 1 to 1786)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   5  (bases 1 to 1786)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1786)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   7  (bases 1 to 1786)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   8  (bases 1 to 1786)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Proteomic analysis of the mammalian mitochondrial ribosome.
            Identification of protein components in the 28 S small subunit
  JOURNAL   J Biol Chem 276 (35), 33181-33195 (2001)
   PUBMED   11402041
REFERENCE   9  (bases 1 to 1786)
  AUTHORS   Cavdar Koc,E., Burkhart,W., Blackburn,K., Moseley,A. and
            Spremulli,L.L.
  TITLE     The small subunit of the mammalian mitochondrial ribosome.
            Identification of the full complement of ribosomal proteins present
  JOURNAL   J Biol Chem 276 (22), 19363-19374 (2001)
   PUBMED   11279123
REFERENCE   10 (bases 1 to 1786)
  AUTHORS   Mao,M., Fu,G., Wu,J.S., Zhang,Q.H., Zhou,J., Kan,L.X., Huang,Q.H.,
            He,K.L., Gu,B.W., Han,Z.G., Shen,Y., Gu,J., Yu,Y.P., Xu,S.H.,
            Wang,Y.X., Chen,S.J. and Chen,Z.
  TITLE     Identification of genes expressed in human CD34(+) hematopoietic
            stem/progenitor cells by expressed sequence tags and efficient
            full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 95 (14), 8175-8180 (1998)
   PUBMED   9653160
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC092579.3.
            
            On Nov 25, 2018 this sequence version replaced NM_015969.2.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 28S subunit protein that belongs to
            the ribosomal protein S17P family. The encoded protein is
            moderately conserved between human mitochondrial and prokaryotic
            ribosomal proteins. Pseudogenes corresponding to this gene are
            found on chromosomes 1p, 3p, 6q, 14p, 18q, and Xq. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1051098.1, BC047445.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000285298.9/
                                                  ENSP00000285298.4
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AC092579.3         11256-11309
            55-194              AC092579.3         12558-12697
            195-1786            AC092579.3         14288-15879
FEATURES             Location/Qualifiers
     source          1..1786
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p11.2"
     gene            1..1786
                     /gene="MRPS17"
                     /gene_synonym="HSPC011; MRP-S17; RPMS17; S17mt; uS17m"
                     /note="mitochondrial ribosomal protein S17"
                     /db_xref="GeneID:51373"
                     /db_xref="HGNC:HGNC:14047"
                     /db_xref="MIM:611980"
     exon            1..54
                     /gene="MRPS17"
                     /gene_synonym="HSPC011; MRP-S17; RPMS17; S17mt; uS17m"
                     /inference="alignment:Splign:2.1.0"
     exon            55..194
                     /gene="MRPS17"
                     /gene_synonym="HSPC011; MRP-S17; RPMS17; S17mt; uS17m"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..464
                     /gene="MRPS17"
                     /gene_synonym="HSPC011; MRP-S17; RPMS17; S17mt; uS17m"
                     /note="28S ribosomal protein S17, mitochondrial;
                     mitochondrial small ribosomal subunit protein uS17m"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS17m"
                     /protein_id="NP_057053.1"
                     /db_xref="CCDS:CCDS5520.1"
                     /db_xref="GeneID:51373"
                     /db_xref="HGNC:HGNC:14047"
                     /db_xref="MIM:611980"
                     /translation="MSVVRSSVHARWIVGKVIGTKMQKTAKVRVTRLVLDPYLLKYFN
                     KRKTYFAHDALQQCTVGDIVLLRALPVPRAKHVKHELAEIVFKVGKVIDPVTGKPCAG
                     TTYLESPLSSETTQLSKNLEELNISSAQ"
     exon            195..1786
                     /gene="MRPS17"
                     /gene_synonym="HSPC011; MRP-S17; RPMS17; S17mt; uS17m"
                     /inference="alignment:Splign:2.1.0"
     regulatory      521..526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS17"
                     /gene_synonym="HSPC011; MRP-S17; RPMS17; S17mt; uS17m"
                     /note="hexamer: AAGAAA"
     polyA_site      548
                     /gene="MRPS17"
                     /gene_synonym="HSPC011; MRP-S17; RPMS17; S17mt; uS17m"
                     /note="major polyA site"
     regulatory      598..603
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS17"
                     /gene_synonym="HSPC011; MRP-S17; RPMS17; S17mt; uS17m"
                     /note="hexamer: AGTAAA"
     polyA_site      627
                     /gene="MRPS17"
                     /gene_synonym="HSPC011; MRP-S17; RPMS17; S17mt; uS17m"
                     /note="major polyA site"
     regulatory      1767..1772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS17"
                     /gene_synonym="HSPC011; MRP-S17; RPMS17; S17mt; uS17m"
                     /note="hexamer: AATAAA"
     polyA_site      1786
                     /gene="MRPS17"
                     /gene_synonym="HSPC011; MRP-S17; RPMS17; S17mt; uS17m"
ORIGIN      
        1 atcccgctgc gaccggcgct ccccggggca ggtggctgca tagtcttggc ggaggtgacc
       61 aaagccacgt aatgtccgta gttcgctcat ccgtccatgc cagatggatt gtggggaagg
      121 tgattgggac aaaaatgcaa aagactgcta aagtgagagt gaccaggctt gttctggatc
      181 cctatttatt aaagtatttt aataagcgga aaacctactt tgctcacgat gcccttcagc
      241 agtgcacagt tggggatatt gtgcttctca gagctttacc tgttccacga gcaaagcatg
      301 tgaaacatga actggctgag atcgttttca aagttggaaa agtcatagat ccagtgacag
      361 gaaagccctg tgctggaact acctacctgg agagtccgtt gagttcggaa accacccagc
      421 taagcaaaaa tctggaagaa ctcaatatct cttcagcaca gtgaagcggg agtggaagaa
      481 ggatctaaag ggaaaaactg acatgtttat gttatggaaa aagaaatttt tctaagtttc
      541 atcacaaact gtgtccagtt tctctgtggt gtttatgaaa tagctaaaag caaatgaagt
      601 aaagggcata ctatggtttt tcacaaaggt ttatggtcgt gtttcaaatt ttcatcattt
      661 cagtgaacat acttccacgt tacattaagt gtgcctagca gtctgttgca ttttgtaagc
      721 tcacagtttt ttgttttgag atggaatctc actctgtcac ccaggctgga gtgcagtggt
      781 gcaatcttgg ctcactgcaa gctccgcctc ccgggttcac gccgttctcc tgcctcagcc
      841 tcccgagtag ctgggactac aggcgcctgc caccatgccc agctaatttt tttttttttt
      901 tttttggtat ttttagtaga gacggggttt caccgtgtta gccaggatgg tcttgatctc
      961 ctgacctcgt gatctgcctg ccttggcctc tcagagtgct gggattacag gcgtgagcca
     1021 ctgtgcttag caagctcact gttttagaag gttttatttt tgtcttttga gacagggttt
     1081 tgctttgttg tgggggctgg agtgcagtgg tatgatcttg gctcactgca gccttgacct
     1141 ccctggctct agcatctttc caccccagcc ttctgagtag ctgggaacac aggagcgtac
     1201 cactacactt ggctgatttt ttgtaaattt tgtagagaca gggtctccct gtgttgccca
     1261 ggttggtctc ggactcctgg gagcaatctg cccatcttgg cctaacagtg ctgggattac
     1321 aggcctgagc cactgtgccc agccggtttc ctttatttca ttcaaaggaa ttttgaattt
     1381 atcttagaac ctttattttg aaggaagaaa gtcttttttt tttttgagct ggagtttcac
     1441 tcttgttgcc caggctggag tgcaatggca tgatctcagc ccaccacgac ctccgcctcc
     1501 caggttcaag tgattctgct tcagcctcct gagtagctag gattacaggc atgtgccacc
     1561 acgcccagct aattttgtat ttttagtagg gatggggttt ctccatgttt gtcaggctag
     1621 tcttgaactc cggacctcag gtgatccgcc cgcctgggcc tctcaaagtg cttggattac
     1681 aggcatgagc cactgcatgt aatgaccagc cactggtcag aattctttca atcaagctgt
     1741 gttaataaga atattgatgt gtggaaaata aaattttaca attctg
//
