LOCUS       NM_022839               3392 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein S11 (MRPS11),
            transcript variant 1, mRNA.
ACCESSION   NM_022839
VERSION     NM_022839.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3392)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3392)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3392)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   4  (bases 1 to 3392)
  AUTHORS   Lee,Y.H. and Song,G.G.
  TITLE     Meta-analysis of differentially expressed genes in ankylosing
            spondylitis
  JOURNAL   Genet Mol Res 14 (2), 5161-5170 (2015)
   PUBMED   26125709
  REMARK    GeneRIF: The downregulated gene with the largest effect size in
            ankylosing spondylitis was mitochondrial ribosomal protein S11
            (MRPS11). (Meta-analysis)
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3392)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   6  (bases 1 to 3392)
  AUTHORS   Ishiguchi,H., Izumi,H., Torigoe,T., Yoshida,Y., Kubota,H., Tsuji,S.
            and Kohno,K.
  TITLE     ZNF143 activates gene expression in response to DNA damage and
            binds to cisplatin-modified DNA
  JOURNAL   Int J Cancer 111 (6), 900-909 (2004)
   PUBMED   15300802
REFERENCE   7  (bases 1 to 3392)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   8  (bases 1 to 3392)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   9  (bases 1 to 3392)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Proteomic analysis of the mammalian mitochondrial ribosome.
            Identification of protein components in the 28 S small subunit
  JOURNAL   J Biol Chem 276 (35), 33181-33195 (2001)
   PUBMED   11402041
REFERENCE   10 (bases 1 to 3392)
  AUTHORS   Cavdar Koc,E., Burkhart,W., Blackburn,K., Moseley,A. and
            Spremulli,L.L.
  TITLE     The small subunit of the mammalian mitochondrial ribosome.
            Identification of the full complement of ribosomal proteins present
  JOURNAL   J Biol Chem 276 (22), 19363-19374 (2001)
   PUBMED   11279123
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB049944.1 and AC013489.17.
            
            On Nov 23, 2018 this sequence version replaced NM_022839.4.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 28S subunit protein that contains a
            high level of sequence similarity with ribosomal protein S11P
            family members. A pseudogene corresponding to this gene is found on
            chromosome 20. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Apr
            2016].
            
            Transcript Variant: This variant (1) is the predominant variant and
            it encodes isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK026165.1, SRR1803617.25214.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000325844.9/
                                                  ENSP00000317376.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-880               AB049944.1         256-1135
            881-3392            AC013489.17        152886-155397       c
FEATURES             Location/Qualifiers
     source          1..3392
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.3"
     gene            1..3392
                     /gene="MRPS11"
                     /gene_synonym="HCC-2; MRP-S11; S11mt; uS11m"
                     /note="mitochondrial ribosomal protein S11"
                     /db_xref="GeneID:64963"
                     /db_xref="HGNC:HGNC:14050"
                     /db_xref="MIM:611977"
     exon            1..75
                     /gene="MRPS11"
                     /gene_synonym="HCC-2; MRP-S11; S11mt; uS11m"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..595
                     /gene="MRPS11"
                     /gene_synonym="HCC-2; MRP-S11; S11mt; uS11m"
                     /note="isoform a is encoded by transcript variant 1; 28S
                     ribosomal protein S11, mitochondrial; cervical cancer
                     proto-oncogene 2 protein; mitochondrial small ribosomal
                     subunit protein uS11m"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS11m isoform a"
                     /protein_id="NP_073750.2"
                     /db_xref="CCDS:CCDS10342.1"
                     /db_xref="GeneID:64963"
                     /db_xref="HGNC:HGNC:14050"
                     /db_xref="MIM:611977"
                     /translation="MQAVRNAGSRFLRSWTWPQTAGRVVARTPAGTICTGARQLQDAA
                     AKQKVEQNAAPSHTKFSIYPPIPGEESSLRWAGKKFEEIPIAHIKASHNNTQIQVVSA
                     SNEPLAFASCGTEGFRNAKKGTGIAAQTAGIAAAARAKQKGVIHIRVVVKGLGPGRLS
                     AMHGLIMGGLEVISITDNTPIPHNGCRPRKARKL"
     exon            76..192
                     /gene="MRPS11"
                     /gene_synonym="HCC-2; MRP-S11; S11mt; uS11m"
                     /inference="alignment:Splign:2.1.0"
     exon            193..291
                     /gene="MRPS11"
                     /gene_synonym="HCC-2; MRP-S11; S11mt; uS11m"
                     /inference="alignment:Splign:2.1.0"
     exon            292..421
                     /gene="MRPS11"
                     /gene_synonym="HCC-2; MRP-S11; S11mt; uS11m"
                     /inference="alignment:Splign:2.1.0"
     exon            422..487
                     /gene="MRPS11"
                     /gene_synonym="HCC-2; MRP-S11; S11mt; uS11m"
                     /inference="alignment:Splign:2.1.0"
     exon            488..3392
                     /gene="MRPS11"
                     /gene_synonym="HCC-2; MRP-S11; S11mt; uS11m"
                     /inference="alignment:Splign:2.1.0"
     regulatory      857..862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS11"
                     /gene_synonym="HCC-2; MRP-S11; S11mt; uS11m"
                     /note="hexamer: AATAAA"
     polyA_site      880
                     /gene="MRPS11"
                     /gene_synonym="HCC-2; MRP-S11; S11mt; uS11m"
                     /note="major polyA site"
     regulatory      977..982
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS11"
                     /gene_synonym="HCC-2; MRP-S11; S11mt; uS11m"
                     /note="hexamer: TATAAA"
     polyA_site      1005
                     /gene="MRPS11"
                     /gene_synonym="HCC-2; MRP-S11; S11mt; uS11m"
     regulatory      1610..1615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS11"
                     /gene_synonym="HCC-2; MRP-S11; S11mt; uS11m"
                     /note="hexamer: AATAAA"
     polyA_site      1627
                     /gene="MRPS11"
                     /gene_synonym="HCC-2; MRP-S11; S11mt; uS11m"
     regulatory      3370..3375
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS11"
                     /gene_synonym="HCC-2; MRP-S11; S11mt; uS11m"
                     /note="hexamer: AATAAA"
     polyA_site      3392
                     /gene="MRPS11"
                     /gene_synonym="HCC-2; MRP-S11; S11mt; uS11m"
ORIGIN      
        1 aattcaagtc atgcaggctg tgagaaacgc ggggtcgcgg ttcctgcggt cctggacttg
       61 gccccagaca gccggcaggg tcgtggccag aacgccggcc gggaccatct gcacaggcgc
      121 tcgacagctc caagacgctg cggccaagca gaaagttgaa cagaacgcgg ctcccagcca
      181 caccaagttc agcatttacc ctcccattcc aggagaggag agctctctga ggtgggcagg
      241 aaagaaattt gaggagatcc caattgcaca cattaaagca tcccacaaca acacacagat
      301 ccaggtagtc tctgctagta atgagcccct tgcctttgct tcctgtggca cagagggatt
      361 tcggaatgcc aagaagggca caggcatcgc agcacagaca gcaggcatag ccgcagcggc
      421 gagagctaaa caaaagggcg tgatccacat ccgagttgtg gtgaaaggcc tggggccagg
      481 acgcttgtct gccatgcacg gactgatcat gggcggcctg gaagtgatct caatcacaga
      541 caacacccca atcccacaca acggctgccg ccccaggaag gctcggaagc tgtgatggga
      601 aggaggcctg cacttggacc tgacctcaag cctcagctcc agtgggacct tgtaaaatgc
      661 tccctgtcag agctctccag aatatgcttg ttggagatcc ttcaggcagt aagggagagt
      721 tttgcctcct tacacagtgg cctttgcttg cacctccagc tggagatggg tgtgccccag
      781 aagtaagctt tgcatctctt acaagagggg agctacaggg gcagccgtgg cctaggccca
      841 aactctgctc tgagaaaata aatatctgta ccacctgtca taattttgag attttttgct
      901 ttcagagtta cgtaattcct aattcctctt gaaaaagaga gtgtgaaatg aggtgaggcc
      961 tcagatgaaa gtaaaatata aatgtgagtt gctatttacc agacacttct ggtttcagat
     1021 atttcttttc tagcccctta cccaagattt ctagagctaa tcctagtaac ttttcttatt
     1081 aatgacttat aatttggccc caaattggag ctttttgcca cctacctctg gattctgatg
     1141 gatttcgcca ttatgggcat gtttaaagtt agccctaaac acaggatttt ctacaagtgg
     1201 acagtcaaac tccccacact aaagtggcag tcatcgttta cactccatgg gcttcagcag
     1261 tcccagcact aacgagagag tgccctaaaa gcggggaggg tagagttgta caaaacatga
     1321 ttcttggcca ggcacggtgg ctcacacctg taaccctggc actttgggag gccaaggcgg
     1381 gtggatcact tgagtccagt tagagaccag cctgggcaac atggtgaaac cccctctcta
     1441 ctaaaaatac aaaaattaac caggcatggt ggtgtgcgcc tgtaatccca gctactctgg
     1501 aggctgaggc atgaaaatcg cttgaaccca ggaggtggag gctgcagtga gctgagatca
     1561 tcctactgca ctccagccca ggtgacagcg agactgtctc aaaaaaataa ataaatataa
     1621 ataaaaattt aaaaaaatta aaaaaaaaaa cctgatgatt ctctagaaaa tagggtggat
     1681 ggcaggatgg gcttgagtag agtccaaatc tagaagtgca gaaagcaagt tgataaggaa
     1741 cctgggtagt gctggcagtg gggcacaact caggaccccc aggcaggact gactgctcct
     1801 ctgttggggc tctagggttc ctggatacgg cacagaggcc aaaggtgggg gctctagaga
     1861 cacgaccaga gagtcccctc ttccacaggc aaagactaag ggtgagagta tcaccagaag
     1921 ctgagaagga gtggtcaagt acacaaaagc actgttcctc ccagatgagt gcaggaaggg
     1981 ctgctgacca gaaggggaag gcactgtgga gttttacttc tgtgtccagc cagctaagta
     2041 ctgtgatctg cctgaactca gtataggaaa agacacagat gcccccttaa ataggcaaga
     2101 ggctgtgtta ggacaaagaa aggaggaaga tcacgaacca agacatgaat ttagaggaaa
     2161 aatgcctccc tactgccttc tctttagtcc ttagcaggtc ctatgaaggc catcttgtga
     2221 cagtgaccaa agaagcccaa ccggaggctt cttggatcaa agccactgtc ggaaggaatt
     2281 agactgtttc accgcaaaac tacatataaa cacaatgcat taaaacatgg tgcacttgaa
     2341 aattgcactt cgcgatttga tatggtttgg tggacagagg gcccgtagcc atcagacagt
     2401 tcaatcaggg tctgagcagg aaacagctca caaggtttaa gagaaaagct caatgaaagc
     2461 tctttgcaga ggcatgggta agattaagga aataaagaag gtggactaca aagcagctgc
     2521 caccctaggc tagaagaggc agggaagaac agttcctaga acctggcagg agctgccaca
     2581 gcagcagagt gcacctctgc caaaaccatg gcctgaggga gagggaagaa atgcctggct
     2641 gttcccggcc tgtagtccct tgctggggtc ccccttggct gatcccaaaa ggaagcaaaa
     2701 aggaagggaa ctcagtgttg tggtacttgg aggctcagcc tcccaggctg cagagtggat
     2761 ctggaggggc acgtagagga tagtaaacac aggaggcttc tgtggcttct gtaagtcctc
     2821 catacaccat aggtttttat tttggttttg gtttttgagt ctcgttgtca cccaggctgg
     2881 attgcagtgg tacgaccatg gttcactgca gcctcaaact cctgggctca agtgatcctc
     2941 cagcttcagc ctcctgtgag catctgggac tacaggcgca tgccaccaca catggataat
     3001 ttttgtattt tttgtattga gaccaggtct tgaactcctg gtctcaagca gtccccccac
     3061 ctcggcctcc caaagtgctg ggataacagg cgtgagccac tgcgcctgat ccacacacca
     3121 tagtttttaa aatgttattt tactcacaag agggctttgg aaaggaagat cctgcccagc
     3181 agagcctaca tgcgcagaca ggacagagga cccttaagga tcaatggtct tgttgccgga
     3241 aatggatgtc tggcgcaacc cccggagcta gttttgggga ggccgccttg ttgactgtgc
     3301 actggaaaat gcacattgct ttatcgtgag ctctcggtgc acagtgtggt ttccaggctc
     3361 tgagtggcca ataaagctgg tgctgtctta aa
//
