LOCUS       NM_018141               2100 bp    mRNA    linear   PRI 18-MAR-2025
DEFINITION  Homo sapiens mitochondrial ribosomal protein S10 (MRPS10),
            transcript variant 2, mRNA.
ACCESSION   NM_018141
VERSION     NM_018141.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2100)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2100)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   3  (bases 1 to 2100)
  AUTHORS   Amunts,A., Brown,A., Toots,J., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Ribosome. The structure of the human mitochondrial ribosome
  JOURNAL   Science 348 (6230), 95-98 (2015)
   PUBMED   25838379
REFERENCE   4  (bases 1 to 2100)
  AUTHORS   Orvedahl,A., Sumpter,R. Jr., Xiao,G., Ng,A., Zou,Z., Tang,Y.,
            Narimatsu,M., Gilpin,C., Sun,Q., Roth,M., Forst,C.V., Wrana,J.L.,
            Zhang,Y.E., Luby-Phelps,K., Xavier,R.J., Xie,Y. and Levine,B.
  TITLE     Image-based genome-wide siRNA screen identifies selective autophagy
            factors
  JOURNAL   Nature 480 (7375), 113-117 (2011)
   PUBMED   22020285
REFERENCE   5  (bases 1 to 2100)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2100)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   7  (bases 1 to 2100)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   8  (bases 1 to 2100)
  AUTHORS   Jia,L., Young,M.F., Powell,J., Yang,L., Ho,N.C., Hotchkiss,R.,
            Robey,P.G. and Francomano,C.A.
  TITLE     Gene expression profile of human bone marrow stromal cells:
            high-throughput expressed sequence tag sequencing analysis
  JOURNAL   Genomics 79 (1), 7-17 (2002)
   PUBMED   11827452
REFERENCE   9  (bases 1 to 2100)
  AUTHORS   Cavdar Koc,E., Burkhart,W., Blackburn,K., Moseley,A. and
            Spremulli,L.L.
  TITLE     The small subunit of the mammalian mitochondrial ribosome.
            Identification of the full complement of ribosomal proteins present
  JOURNAL   J Biol Chem 276 (22), 19363-19374 (2001)
   PUBMED   11279123
REFERENCE   10 (bases 1 to 2100)
  AUTHORS   Koc,E.C., Burkhart,W., Blackburn,K., Moseley,A., Koc,H. and
            Spremulli,L.L.
  TITLE     A proteomics approach to the identification of mammalian
            mitochondrial small subunit ribosomal proteins
  JOURNAL   J Biol Chem 275 (42), 32585-32591 (2000)
   PUBMED   10938081
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG776014.1, BC012560.1,
            AW974308.1, AI754661.1, AI683142.1, AW300686.1 and AF113220.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018141.3.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 28S subunit protein that belongs to
            the ribosomal protein S10P family. Pseudogenes corresponding to
            this gene are found on chromosomes 1q, 3p, and 9p. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012560.1, AK098446.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000053468.4/
                                                  ENSP00000053468.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                BG776014.1         36-70
            36-717              BC012560.1         40-721
            718-890             AW974308.1         1-173               c
            891-1359            BC012560.1         895-1363
            1360-1681           AI754661.1         6-327               c
            1682-2086           AI683142.1         11-415              c
            2087-2099           AW300686.1         1-13                c
            2100-2100           AF113220.1         2095-2095
FEATURES             Location/Qualifiers
     source          1..2100
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..2100
                     /gene="MRPS10"
                     /gene_synonym="MRP-S10; PNAS-122; S10mt; uS10m"
                     /note="mitochondrial ribosomal protein S10"
                     /db_xref="GeneID:55173"
                     /db_xref="HGNC:HGNC:14502"
                     /db_xref="MIM:611976"
     exon            1..60
                     /gene="MRPS10"
                     /gene_synonym="MRP-S10; PNAS-122; S10mt; uS10m"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..618
                     /gene="MRPS10"
                     /gene_synonym="MRP-S10; PNAS-122; S10mt; uS10m"
                     /EC_number="3.6.5.3"
                     /note="isoform 2 is encoded by transcript variant 2;
                     mitochondrial 28S ribosomal protein S10; 28S ribosomal
                     protein S10, mitochondrial; mitochondrial small ribosomal
                     subunit protein uS10m"
                     /codon_start=1
                     /product="small ribosomal subunit protein uS10m isoform 2"
                     /protein_id="NP_060611.2"
                     /db_xref="CCDS:CCDS4866.1"
                     /db_xref="GeneID:55173"
                     /db_xref="HGNC:HGNC:14502"
                     /db_xref="MIM:611976"
                     /translation="MAARTAFGAVCRRLWQGLGNFSVNTSKGNTAKNGGLLLSTNMKW
                     VQFSNLHVDVPKDLTKPVVTISDEPDILYKRLSVLVKGHDKAVLDSYEYFAVLAAKEL
                     GISIKVHEPPRKIERFTLLQSVHIYKKHRVQYEMRTLYRCLELEHLTGSTADVYLEYI
                     QRNLPEGVAMEVTKTQLEQLPEHIKEPIWETLSEEKEESKS"
     exon            61..125
                     /gene="MRPS10"
                     /gene_synonym="MRP-S10; PNAS-122; S10mt; uS10m"
                     /inference="alignment:Splign:2.1.0"
     exon            126..198
                     /gene="MRPS10"
                     /gene_synonym="MRP-S10; PNAS-122; S10mt; uS10m"
                     /inference="alignment:Splign:2.1.0"
     exon            199..335
                     /gene="MRPS10"
                     /gene_synonym="MRP-S10; PNAS-122; S10mt; uS10m"
                     /inference="alignment:Splign:2.1.0"
     exon            336..444
                     /gene="MRPS10"
                     /gene_synonym="MRP-S10; PNAS-122; S10mt; uS10m"
                     /inference="alignment:Splign:2.1.0"
     exon            445..534
                     /gene="MRPS10"
                     /gene_synonym="MRP-S10; PNAS-122; S10mt; uS10m"
                     /inference="alignment:Splign:2.1.0"
     exon            535..2100
                     /gene="MRPS10"
                     /gene_synonym="MRP-S10; PNAS-122; S10mt; uS10m"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      863
                     /gene="MRPS10"
                     /gene_synonym="MRP-S10; PNAS-122; S10mt; uS10m"
                     /note="major polyA site"
     regulatory      1138..1143
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS10"
                     /gene_synonym="MRP-S10; PNAS-122; S10mt; uS10m"
                     /note="hexamer: AATATA"
     polyA_site      1164
                     /gene="MRPS10"
                     /gene_synonym="MRP-S10; PNAS-122; S10mt; uS10m"
     regulatory      2070..2075
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPS10"
                     /gene_synonym="MRP-S10; PNAS-122; S10mt; uS10m"
                     /note="hexamer: ATTAAA"
     polyA_site      2100
                     /gene="MRPS10"
                     /gene_synonym="MRP-S10; PNAS-122; S10mt; uS10m"
                     /note="major polyA site"
ORIGIN      
        1 gggaccggca agatggcggc gcggacagcg ttcggtgctg tgtgccggcg cctctggcag
       61 ggattgggga atttttctgt aaacacttct aagggcaata cagccaaaaa tggtggcttg
      121 cttctcagta ccaatatgaa gtgggtacag ttttcaaacc tacacgttga tgttccaaag
      181 gatttgacca aacctgtggt aacaatctct gatgaaccag acatattata taagcgcctc
      241 tcggttttgg tgaaaggtca cgataaggct gtattggaca gttatgaata ttttgctgtg
      301 cttgctgcta aagaacttgg tatctctatt aaagtacatg aacctccaag gaaaatagag
      361 cgatttactc ttctccaatc agtgcatatt tacaagaagc acagagttca gtatgaaatg
      421 agaacacttt acagatgttt agagttagaa catctaactg gaagcacagc agatgtctac
      481 ttggaatata ttcagcgaaa cttacctgaa ggggttgcca tggaagtaac aaagacacaa
      541 ttagaacagt taccagaaca catcaaggag ccaatctggg aaacactatc agaagaaaaa
      601 gaagaaagca agtcataaag cctcagggag gccatttttg cctaaatttg aaatgagggt
      661 gggccagatg agtatgttta agtggagagt gcttccagct gagatgattt gagtctgccc
      721 taactgctcc attgagttct cgtgccctca tcagctgagg gcagggaatg gaactttaat
      781 ggaagaacca cttttatcta ttctttttat tcattgtttc agttctgatt tcagcaaaca
      841 tgagcaaacc actttgactg aaagcagaaa gagtgaaaat tctattttgt tacgctactg
      901 gtgttcaatt attagtttgt accattttta atttatgtca gttgatgcat ctgaaaataa
      961 gtgcttggag tgttcgtacc cttatttttt tttaagattc ctagaaggaa tctttggtta
     1021 attcagattg agcagttaaa gtttttgcta tttacctttg tgcaggctgg catatgctaa
     1081 tttgggggtg gtaaccaacc gattttatct catgtaagca ttacattttg aagactgaat
     1141 atacttcaca gcagatcaaa cacatttatg gcatgcactg acctcttctt ggagcccaga
     1201 actttataga gttgcctacc agggttactg taatggaatt tatgatctta agaaattact
     1261 agttgtatta tttatcctat gattcattca ttcaataagc ttttactgca taaactttac
     1321 atccagcact gtagttaagt acccaaaatt gaatagaaat aatggctttt gaaaatcgca
     1381 caaagcaggc caggcacggt ggctcacgcc tgtaatccca gcattttggg aggccgaggc
     1441 aggcggatca cgaggtcaag agatccagac catcctggct aacacggtga aaccccgtct
     1501 ctaataaaaa tacaaaaatt agctggacat ggtggcacgt gcctgtaatc ccagctactc
     1561 aggaggctga ggcaggagaa ttgcgtgaac ccgggcccgg tggaggctgc agtgagacga
     1621 gatcgcgcca ctgcactcca gcctggcgac agagcgagac gccgtctcaa aaaaaaaaaa
     1681 agaaaattgt gcaaagcata ggtaaatatt tttctttatt aagcttctca ctgagaagcc
     1741 ctctttattt tggtaaatgt cactctgttt gttaggagat gtctgctttt ccatgaaatg
     1801 aaatagtggc taaagccctg aaagaggcaa gactacaatg ggctgaaaca gttggtatag
     1861 caaccccaga gaagtgcttc attttctttt tatagtagaa gcaggtccat gtcttttgtg
     1921 gtttcctgca catctttgga gtagttatga cttctcagtt tttcccccct taaactgcat
     1981 tgcctattct tttttcctga catgctatca ggtatcagtg tgttgaatac atactgcttg
     2041 tgtatcagac ttacgttact gtcatcacca ttaaaagaat tgcagctttg tgccccatga
//
