LOCUS       NM_031420               1224 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein L9 (MRPL9), transcript
            variant 1, mRNA.
ACCESSION   NM_031420
VERSION     NM_031420.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1224)
  AUTHORS   Li,X.Y., He,X.Y., Zhao,H., Qi,L. and Lu,J.J.
  TITLE     Identification of a novel therapeutic target for lung cancer:
            Mitochondrial ribosome protein L9
  JOURNAL   Pathol Res Pract 248, 154625 (2023)
   PUBMED   37343379
  REMARK    GeneRIF: Identification of a novel therapeutic target for lung
            cancer: Mitochondrial ribosome protein L9.
REFERENCE   2  (bases 1 to 1224)
  AUTHORS   Zhang,H.M., Li,Z.Y., Dai,Z.T., Wang,J., Li,L.W., Zong,Q.B.,
            Li,J.P., Zhang,T.C. and Liao,X.H.
  TITLE     Interaction of MRPL9 and GGCT Promotes Cell Proliferation and
            Migration by Activating the MAPK/ERK Pathway in Papillary Thyroid
            Cancer
  JOURNAL   Int J Mol Sci 23 (19), 11989 (2022)
   PUBMED   36233293
  REMARK    GeneRIF: Interaction of MRPL9 and GGCT Promotes Cell Proliferation
            and Migration by Activating the MAPK/ERK Pathway in Papillary
            Thyroid Cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1224)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 1224)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1224)
  AUTHORS   Brown,A., Rathore,S., Kimanius,D., Aibara,S., Bai,X.C., Rorbach,J.,
            Amunts,A. and Ramakrishnan,V.
  TITLE     Structures of the human mitochondrial ribosome in native states of
            assembly
  JOURNAL   Nat Struct Mol Biol 24 (10), 866-869 (2017)
   PUBMED   28892042
REFERENCE   6  (bases 1 to 1224)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   7  (bases 1 to 1224)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   8  (bases 1 to 1224)
  AUTHORS   Koc,E.C., Burkhart,W., Blackburn,K., Moyer,M.B., Schlatzer,D.M.,
            Moseley,A. and Spremulli,L.L.
  TITLE     The large subunit of the mammalian mitochondrial ribosome. Analysis
            of the complement of ribosomal proteins present
  JOURNAL   J Biol Chem 276 (47), 43958-43969 (2001)
   PUBMED   11551941
REFERENCE   9  (bases 1 to 1224)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   10 (bases 1 to 1224)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Structural compensation for the deficit of rRNA with proteins in
            the mammalian mitochondrial ribosome. Systematic analysis of
            protein components of the large ribosomal subunit from mammalian
            mitochondria
  JOURNAL   J Biol Chem 276 (24), 21724-21736 (2001)
   PUBMED   11279069
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AW452832.1 and BC004517.2.
            
            On Nov 22, 2018 this sequence version replaced NM_031420.3.
            
            Summary: This is a nuclear gene encoding a protein component of the
            39S subunit of the mitochondrial ribosome. Alternative splicing
            results in multiple transcript variants. A pseudogene of this gene
            is found on chromosome 8. [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC004517.2, DA737045.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000368830.8/
                                                  ENSP00000357823.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AW452832.1         102-113             c
            13-1224             BC004517.2         1-1212
FEATURES             Location/Qualifiers
     source          1..1224
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..1224
                     /gene="MRPL9"
                     /gene_synonym="bL9m; L9mt"
                     /note="mitochondrial ribosomal protein L9"
                     /db_xref="GeneID:65005"
                     /db_xref="HGNC:HGNC:14277"
                     /db_xref="MIM:611824"
     exon            1..170
                     /gene="MRPL9"
                     /gene_synonym="bL9m; L9mt"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..821
                     /gene="MRPL9"
                     /gene_synonym="bL9m; L9mt"
                     /note="isoform 1 is encoded by transcript variant 1; 39S
                     ribosomal protein L9, mitochondrial; mitochondrial large
                     ribosomal subunit protein bL9m"
                     /codon_start=1
                     /product="large ribosomal subunit protein bL9m isoform 1"
                     /protein_id="NP_113608.1"
                     /db_xref="CCDS:CCDS1003.1"
                     /db_xref="GeneID:65005"
                     /db_xref="HGNC:HGNC:14277"
                     /db_xref="MIM:611824"
                     /translation="MAAPVVTAPGRALLRAGAGRLLRGGVQELLRPRHEGNAPDLACN
                     FSLSQNRGTVIVERWWKVPLAGEGRKPRLHRRHRVYKLVEDTKHRPKENLELILTQSV
                     ENVGVRGDLVSVKKSLGRNRLLPQGLAVYASPENKKLFEEEKLLRQEGKLEKIQTKAG
                     EATVKFLKSCRLEVGMKNNVKWELNPEIVARHFFKNLGVVVAPHTLKLPEEPITRWGE
                     YWCEVTVNGLDTVRVPMSVVNFEKPKTKRYKYWLAQQAAKAMAPTSPQI"
     exon            171..327
                     /gene="MRPL9"
                     /gene_synonym="bL9m; L9mt"
                     /inference="alignment:Splign:2.1.0"
     exon            328..452
                     /gene="MRPL9"
                     /gene_synonym="bL9m; L9mt"
                     /inference="alignment:Splign:2.1.0"
     exon            453..503
                     /gene="MRPL9"
                     /gene_synonym="bL9m; L9mt"
                     /inference="alignment:Splign:2.1.0"
     exon            504..605
                     /gene="MRPL9"
                     /gene_synonym="bL9m; L9mt"
                     /inference="alignment:Splign:2.1.0"
     exon            606..689
                     /gene="MRPL9"
                     /gene_synonym="bL9m; L9mt"
                     /inference="alignment:Splign:2.1.0"
     exon            690..1224
                     /gene="MRPL9"
                     /gene_synonym="bL9m; L9mt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1200..1205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL9"
                     /gene_synonym="bL9m; L9mt"
                     /note="hexamer: AATAAA"
     polyA_site      1224
                     /gene="MRPL9"
                     /gene_synonym="bL9m; L9mt"
                     /note="major polyA site"
ORIGIN      
        1 attctgtgcc tgtgaacatg gcggcgcccg ttgtcacggc cccgggcaga gctctgctgc
       61 gggcgggcgc tggacggctg cttcggggag gcgtccagga gctactgcgg ccgcgacatg
      121 aagggaacgc ccctgacctg gcctgcaact tcagcctttc tcaaaatcgg ggcacggtca
      181 tcgtggagcg ctggtggaag gtaccgctgg ccggggaggg ccggaagccg cgcctgcacc
      241 ggcgacatcg cgtctataag ctggtggagg acacgaagca tcggcccaaa gaaaacctgg
      301 agctcatcct gacgcagtcg gtggagaatg ttggagtccg gggtgacctg gtctcagtga
      361 agaaatcttt aggccggaat cgactccttc ctcagggact ggctgtatat gcatcccctg
      421 aaaacaagaa gctgtttgaa gaggagaaat tgctgagaca agaaggaaaa ttagagaaga
      481 tccagaccaa ggcaggtgag gcgacagtga aatttctaaa aagctgtcgc ctggaggtag
      541 ggatgaagaa caatgtcaaa tgggagctga accctgaaat agttgcccgc cacttcttta
      601 agaatcttgg tgttgtggtt gccccacata cattaaagtt accagaagag cctatcacac
      661 ggtggggcga gtattggtgt gaggtgacgg taaatgggct tgatactgtg agagtgccta
      721 tgtctgtcgt gaactttgag aagcccaaga ccaaaagata taagtactgg ttagcccagc
      781 aagctgccaa ggctatggcc cccaccagcc cccagatcta aatctactct ccctccaagg
      841 cagcaaagca gaatcgggag cagtggagca gaaatgtgca agcaccctga tctcactccc
      901 agctctgacc aaatacagaa ttttagagaa catctgaaga catcagactg cactgcgtat
      961 acatgttgaa ttcttcattt ttgccatctt taactgtcat cactggggca gggaagtcct
     1021 gttccagaag taccaggctg tagatttgat aagctagatg cagtagaccg aaaccatcca
     1081 aaacctgttt agcttcttcc tccattggag tttattggga caaacaggag agccagccat
     1141 tgtctccagt acttgcctca ttctcatcat ccaaactgaa catttgtatc ccaagcagaa
     1201 ataaagagaa tatgttcttt ttaa
//
