LOCUS       NM_001545                894 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein L58 (MRPL58),
            transcript variant 1, mRNA.
ACCESSION   NM_001545
VERSION     NM_001545.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 894)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 894)
  AUTHORS   Kummer,E., Schubert,K.N., Schoenhut,T., Scaiola,A. and Ban,N.
  TITLE     Structural basis of translation termination, rescue, and recycling
            in mammalian mitochondria
  JOURNAL   Mol Cell 81 (12), 2566-2582 (2021)
   PUBMED   33878294
REFERENCE   3  (bases 1 to 894)
  AUTHORS   Pan,X., Tan,J., Weng,X., Du,R., Jiang,Y., Weng,Y., Zhou,D. and
            Shen,Y.
  TITLE     ICT1 Promotes Osteosarcoma Cell Proliferation and Inhibits
            Apoptosis via STAT3/BCL-2 Pathway
  JOURNAL   Biomed Res Int 2021, 8971728 (2021)
   PUBMED   33585660
  REMARK    GeneRIF: ICT1 Promotes Osteosarcoma Cell Proliferation and Inhibits
            Apoptosis via STAT3/BCL-2 Pathway.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 894)
  AUTHORS   Peng,X., Yan,B. and Shen,Y.
  TITLE     MiR-1301-3p inhibits human breast cancer cell proliferation by
            regulating cell cycle progression and apoptosis through directly
            targeting ICT1
  JOURNAL   Breast Cancer 25 (6), 742-752 (2018)
   PUBMED   29951881
  REMARK    GeneRIF: miR-1301-3p inhibits cell proliferation via inducing cell
            cycle arrest and apoptosis through targeting ICT1, and might be a
            therapeutic target for BC.
REFERENCE   5  (bases 1 to 894)
  AUTHORS   Li,G.Y., Liu,J.Z., Zhang,L., Liu,G.Z., Li,S.J., Xiao,T.W.,
            Wang,J.X., Wang,L.X. and Hou,M.
  TITLE     Knockdown of immature colon carcinoma transcript 1 induces
            suppression of proliferation, S-phase arrest and apoptosis in
            leukemia cells
  JOURNAL   Oncol Rep 39 (3), 1269-1275 (2018)
   PUBMED   29328466
  REMARK    GeneRIF: High ICT1 expression is associated with leukemia.
REFERENCE   6  (bases 1 to 894)
  AUTHORS   Handa,Y., Hikawa,Y., Tochio,N., Kogure,H., Inoue,M., Koshiba,S.,
            Guntert,P., Inoue,Y., Kigawa,T., Yokoyama,S. and Nameki,N.
  TITLE     Solution structure of the catalytic domain of the mitochondrial
            protein ICT1 that is essential for cell vitality
  JOURNAL   J Mol Biol 404 (2), 260-273 (2010)
   PUBMED   20869366
REFERENCE   7  (bases 1 to 894)
  AUTHORS   Antonicka,H., Ostergaard,E., Sasarman,F., Weraarpachai,W.,
            Wibrand,F., Pedersen,A.M., Rodenburg,R.J., van der Knaap,M.S.,
            Smeitink,J.A., Chrzanowska-Lightowlers,Z.M. and Shoubridge,E.A.
  TITLE     Mutations in C12orf65 in patients with encephalomyopathy and a
            mitochondrial translation defect
  JOURNAL   Am J Hum Genet 87 (1), 115-122 (2010)
   PUBMED   20598281
REFERENCE   8  (bases 1 to 894)
  AUTHORS   Richter,R., Rorbach,J., Pajak,A., Smith,P.M., Wessels,H.J.,
            Huynen,M.A., Smeitink,J.A., Lightowlers,R.N. and
            Chrzanowska-Lightowlers,Z.M.
  TITLE     A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into
            the human mitochondrial ribosome
  JOURNAL   EMBO J 29 (6), 1116-1125 (2010)
   PUBMED   20186120
  REMARK    GeneRIF: ICT1 may be essential for hydrolysis of prematurely
            terminated peptidyl-tRNA moieties in stalled mitoribosomes.
REFERENCE   9  (bases 1 to 894)
  AUTHORS   van Belzen,N., Diesveld,M.P., van der Made,A.C., Nozawa,Y.,
            Dinjens,W.N., Vlietstra,R., Trapman,J. and Bosman,F.T.
  TITLE     Identification of mRNAs that show modulated expression during colon
            carcinoma cell differentiation
  JOURNAL   Eur J Biochem 234 (3), 843-848 (1995)
   PUBMED   8575443
REFERENCE   10 (bases 1 to 894)
  AUTHORS   Bae,Y.M., Kim,T.J., Park,W.S., Chung,D.H., Choi,E.Y., Lee,G.K.,
            Song,H.G., Kim,C.W., Kim,B.K. and Ahn,H.S.
  TITLE     A novel T-cell differentiation antigen expressed in immature human
            thymocytes and neuroglial cells
  JOURNAL   Cell Immunol 165 (1), 118-124 (1995)
   PUBMED   7545548
  REMARK    Erratum:[Cell Immunol 1995 Dec;166(2):296]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB456649.1 and BC015335.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001545.2.
            
            Summary: The protein encoded by this gene is a peptidyl-tRNA
            hydrolase and a vital component of the large mitochondrial
            ribosome. The encoded protein serves as a ribosome release factor
            for this ribosome, which translates mitochondrial genes. This
            protein may be responsible for degrading prematurely-terminated
            polypeptides and for reusing stalled ribosomes. Two transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Dec 2014].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the predominant isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.125951.1,
                                           SRR1163655.667687.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000301585.10/
                                                  ENSP00000301585.5
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DB456649.1         7-17
            12-894              BC015335.1         1-883
FEATURES             Location/Qualifiers
     source          1..894
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.1"
     gene            1..894
                     /gene="MRPL58"
                     /gene_synonym="DS-1; DS1; ICT1; mL62; MRP-L58"
                     /note="mitochondrial ribosomal protein L58"
                     /db_xref="GeneID:3396"
                     /db_xref="HGNC:HGNC:5359"
                     /db_xref="MIM:603000"
     exon            1..203
                     /gene="MRPL58"
                     /gene_synonym="DS-1; DS1; ICT1; mL62; MRP-L58"
                     /inference="alignment:Splign:2.1.0"
     CDS             18..638
                     /gene="MRPL58"
                     /gene_synonym="DS-1; DS1; ICT1; mL62; MRP-L58"
                     /EC_number="3.1.1.29"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; immature colon carcinoma transcript 1 protein;
                     peptidyl-tRNA hydrolase ICT1, mitochondrial; digestion
                     substraction 1; 39S ribosomal protein L58, mitochondrial;
                     mitochondrial large ribosomal subunit protein ICT1;
                     mitochondrial large ribosomal subunit protein mL62"
                     /codon_start=1
                     /product="large ribosomal subunit protein mL62 isoform 1
                     precursor"
                     /protein_id="NP_001536.1"
                     /db_xref="CCDS:CCDS11711.1"
                     /db_xref="GeneID:3396"
                     /db_xref="HGNC:HGNC:5359"
                     /db_xref="MIM:603000"
                     /translation="MAATRCLRWGLSRAGVWLLPPPARCPRRALHKQKDGTEFKSIYS
                     LDKLYPESQGSDTAWRVPNGAKQADSDIPLDRLTISYCRSSGPGGQNVNKVNSKAEVR
                     FHLATAEWIAEPVRQKIAITHKNKINRLGELILTSESSRYQFRNLADCLQKIRDMITE
                     ASQTPKEPTKEDVKLHRIRIENMNRERLRQKRIHSAVKTSRRVDMD"
     exon            204..240
                     /gene="MRPL58"
                     /gene_synonym="DS-1; DS1; ICT1; mL62; MRP-L58"
                     /inference="alignment:Splign:2.1.0"
     exon            241..300
                     /gene="MRPL58"
                     /gene_synonym="DS-1; DS1; ICT1; mL62; MRP-L58"
                     /inference="alignment:Splign:2.1.0"
     exon            301..383
                     /gene="MRPL58"
                     /gene_synonym="DS-1; DS1; ICT1; mL62; MRP-L58"
                     /inference="alignment:Splign:2.1.0"
     exon            384..553
                     /gene="MRPL58"
                     /gene_synonym="DS-1; DS1; ICT1; mL62; MRP-L58"
                     /inference="alignment:Splign:2.1.0"
     exon            554..894
                     /gene="MRPL58"
                     /gene_synonym="DS-1; DS1; ICT1; mL62; MRP-L58"
                     /inference="alignment:Splign:2.1.0"
     regulatory      877..882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL58"
                     /gene_synonym="DS-1; DS1; ICT1; mL62; MRP-L58"
                     /note="hexamer: AATAAA"
     polyA_site      894
                     /gene="MRPL58"
                     /gene_synonym="DS-1; DS1; ICT1; mL62; MRP-L58"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcaaga cctgagcatg gcggccacca ggtgcctgcg ctggggcctg agccgagccg
       61 gagtctggct gctcccaccg cccgcacggt gcccacgccg ggcgctgcac aagcagaaag
      121 acggcactga gttcaagagc atctacagcc tggacaagct ctaccccgaa tctcagggct
      181 cggacaccgc ctggagggtc ccgaatggtg caaagcaagc cgacagtgac atccctctag
      241 atcgcttgac aatatcttat tgtcggagta gtggtcctgg ggggcagaat gtgaacaaag
      301 tgaattccaa ggcagaagtc aggttccatt tggcaactgc cgagtggatc gcggagcccg
      361 tgcggcagaa gatagccatc acgcataaaa acaagatcaa caggttagga gagttgatcc
      421 tcacctctga gagcagccgc tatcagttcc ggaatctggc agattgcctg cagaaaattc
      481 gagacatgat cactgaggcc agccagacac cgaaggagcc aacaaaagaa gatgttaaac
      541 ttcatagaat caggatagaa aacatgaatc gggaaaggct gagacaaaag agaattcatt
      601 ctgctgtaaa gacaagcagg agggtcgaca tggactgaaa tcaccctctg cagctgggag
      661 ggctcttctg ggcgtccggg cagctgcagc tgagaggact ttcacaccat aaggagattt
      721 ctgtttttct ttttggctgt taatgcttgt ctataacatt ggagccatca caagaatgtt
      781 catttggaat gaaggctgca ggcactggtt gcagacgtct ttataggcag tcaccatgtt
      841 gtcaaacctt aataatgcac ctcatgtatt agtcacaata aaaatcagaa ctca
//
