LOCUS       NM_024026               2233 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein L57 (MRPL57), mRNA.
ACCESSION   NM_024026
VERSION     NM_024026.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2233)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2233)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2233)
  AUTHORS   Brown,A., Rathore,S., Kimanius,D., Aibara,S., Bai,X.C., Rorbach,J.,
            Amunts,A. and Ramakrishnan,V.
  TITLE     Structures of the human mitochondrial ribosome in native states of
            assembly
  JOURNAL   Nat Struct Mol Biol 24 (10), 866-869 (2017)
   PUBMED   28892042
REFERENCE   4  (bases 1 to 2233)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   5  (bases 1 to 2233)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   6  (bases 1 to 2233)
  AUTHORS   Koc,E.C., Cimen,H., Kumcuoglu,B., Abu,N., Akpinar,G., Haque,M.E.,
            Spremulli,L.L. and Koc,H.
  TITLE     Identification and characterization of CHCHD1, AURKAIP1, and CRIF1
            as new members of the mammalian mitochondrial ribosome
  JOURNAL   Front Physiol 4, 183 (2013)
   PUBMED   23908630
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2233)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2233)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   9  (bases 1 to 2233)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   10 (bases 1 to 2233)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Proteomic analysis of the mammalian mitochondrial ribosome.
            Identification of protein components in the 28 S small subunit
  JOURNAL   J Biol Chem 276 (35), 33181-33195 (2001)
   PUBMED   11402041
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL158032.32.
            
            On Nov 23, 2018 this sequence version replaced NM_024026.4.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a protein which belongs to an
            undetermined ribosomal subunit and which seems to be specific to
            animal mitoribosomes. Pseudogenes corresponding to this gene are
            found on chromosomes 1p, 1q, 3p, 5q, 8q, 14q, and Y. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.663564.1,
                                           SRR1660807.250558.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000309594.5/
                                                  ENSP00000310726.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-60                AL158032.32        39522-39581
            61-2233             AL158032.32        39776-41948
FEATURES             Location/Qualifiers
     source          1..2233
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.11"
     gene            1..2233
                     /gene="MRPL57"
                     /gene_synonym="bMRP63; mL63; MRP63"
                     /note="mitochondrial ribosomal protein L57"
                     /db_xref="GeneID:78988"
                     /db_xref="HGNC:HGNC:14514"
                     /db_xref="MIM:611997"
     exon            1..60
                     /gene="MRPL57"
                     /gene_synonym="bMRP63; mL63; MRP63"
                     /inference="alignment:Splign:2.1.0"
     exon            61..2233
                     /gene="MRPL57"
                     /gene_synonym="bMRP63; mL63; MRP63"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..374
                     /gene="MRPL57"
                     /gene_synonym="bMRP63; mL63; MRP63"
                     /note="mitochondrial ribosomal protein bMRP63; ribosomal
                     protein 63, mitochondrial; hMRP63; mitochondrial ribosomal
                     protein 63; mitochondrial large ribosomal subunit protein
                     mL63"
                     /codon_start=1
                     /product="large ribosomal subunit protein mL63"
                     /protein_id="NP_076931.1"
                     /db_xref="CCDS:CCDS9296.1"
                     /db_xref="GeneID:78988"
                     /db_xref="HGNC:HGNC:14514"
                     /db_xref="MIM:611997"
                     /translation="MFLTALLWRGRIPGRQWIGKHRRPRFVSLRAKQNMIRRLEIEAE
                     NHYWLSMPYMTREQERGHAAVRRREAFEAIKAAATSKFPPHRFIADQLDHLNVTKKWS
                     "
     regulatory      486..491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL57"
                     /gene_synonym="bMRP63; mL63; MRP63"
                     /note="hexamer: ATTAAA"
     polyA_site      505
                     /gene="MRPL57"
                     /gene_synonym="bMRP63; mL63; MRP63"
                     /note="major polyA site"
     regulatory      641..646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL57"
                     /gene_synonym="bMRP63; mL63; MRP63"
                     /note="hexamer: AATAAA"
     polyA_site      661
                     /gene="MRPL57"
                     /gene_synonym="bMRP63; mL63; MRP63"
                     /note="major polyA site"
     regulatory      2216..2221
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL57"
                     /gene_synonym="bMRP63; mL63; MRP63"
                     /note="hexamer: AATAAA"
     polyA_site      2233
                     /gene="MRPL57"
                     /gene_synonym="bMRP63; mL63; MRP63"
ORIGIN      
        1 gcttacgcca cggcgtctgc tggcggccgc ggagacgcag agtcttgagc agcgcggcag
       61 gcaccatgtt cctgactgcg ctcctctggc gcggccgcat tcccggccgt cagtggatcg
      121 ggaagcaccg gcggccgcgg ttcgtgtcgt tgcgcgccaa gcagaacatg atccgccgcc
      181 tggagatcga ggcggagaac cattactggc tgagcatgcc ctacatgacc cgggagcagg
      241 agcgcggcca cgccgcggtg cgcaggaggg aggccttcga ggccataaag gcggccgcca
      301 cttccaagtt ccccccgcat agattcattg cggaccagct cgaccatctc aatgtcacca
      361 agaaatggtc ctaatcctga gtcgtcaccc ttggatttta tggatcacgg agctgaccat
      421 ctttacctgg tcctggaact gaaaaactgt agcttgtgtg aaaatgagcc tttggaccag
      481 tctttattaa aacaaacaaa catgagtagt ctgcatatcg aatatctaga gctctaaacc
      541 cccaatactt aaaagtctaa ttgctgtcct gtggtttcat tagtctgata ggaagatagg
      601 gatttcctca gtcacagatg atattttgaa ggaaagctgc aataaagcca caatgatttg
      661 aggtctttgc ttaagtatga gatacttgat gggggcttta tcatgcaaca ttagtttgct
      721 taccttaaga attgcccaaa aatgaaagaa aatatgagct tttcagttaa acatactcct
      781 aaaaacattt tccgggattt tactactaaa attggacatt taagcgaagt aaaagaggcc
      841 gggtgcggtg gctcacgcct gtaatcccaa cactttagga gtccaaggcg ggcggatcac
      901 ttgaggtcag gagttcaaga ccagcttggc caaggtgata aaacccgtct ctactaatac
      961 aaaaaaaatt agctgggtat gttggtgcag gcttgcaatc ccagctactt gggacgctga
     1021 ggtgggagga tcgcctgaac ctcagaggca gaggttgcaa tgaagcggag gttgcagtga
     1081 gccgagagca tgccgctgca ctccagcctg ggagactgca tctcaaaaaa gaaaaataaa
     1141 cgaagtaaaa gatatttatc agagctgtta caggaaggtg tattttttag ctattttggc
     1201 agggtgctgt ggtgcttgca tgtagtccca gctattcagg aatattgctt gagtccagct
     1261 tgggcaacat agcgagaccc tatctaaaat aacaataata tatggccagg cgggatggct
     1321 cacgcctgta atcccagcac tttgggaggc tgaggcgggc agatcacttg aggccaggag
     1381 ttcaagacca gcccaaccaa catggtgaaa ccctgtctcc actgaaaata cataaaatta
     1441 gccgggtgca gtggtgaggc ctgtaatccc agctactcag gaggctgagg caggagaatc
     1501 gcttgcaccc aggaggtgga ggctgcagta agtcgagatt gtgtcactgc actctagcct
     1561 gggcgacaga aaaagaaaat ttaggtgggg aaaaaaatca gaattgcgtc tgtgggaaca
     1621 ggaataaagg agaaaccact attgactggg aagacacaca aagaactttg tcaaagttgt
     1681 atggctgagg cccacacggt ggctcacttc tgtaatccca tcactttggg aggcttaggc
     1741 agaaggatca cctgagatca ggagttccag accagcctgg ccaacatggc gaaaccccat
     1801 ctctactaaa aatacaaaaa ttagccgggc gtggtggctt acgcctgtaa tcccagcact
     1861 ttgggaggcc aaggtgggcg gatcacaagg tcaggagttc gagaccagcc tggccaatat
     1921 ggtgaaaccc catctctact aaaaatataa aaatcagcaa aaaaaattta gccaggcttg
     1981 gtcatgcatg cctgtaatcc tagctactgg gaaggctgag gaaggagaat tgcttgaacc
     2041 caggtggtgg aggttgcagt gagctgagat cgtgccactg ctctccagcc tgcatgacgg
     2101 gagtgagaca ccatctcaaa aaatacatat aataatataa ataaaaatat cttttttgaa
     2161 aataatttaa tataccatgt aatttaccag ttgaagatgt tcgctttcag aatataataa
     2221 aaatagtcaa aaa
//
