LOCUS       NM_181463                738 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein L55 (MRPL55),
            transcript variant 5, mRNA.
ACCESSION   NM_181463
VERSION     NM_181463.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 738)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 738)
  AUTHORS   Brown,A., Rathore,S., Kimanius,D., Aibara,S., Bai,X.C., Rorbach,J.,
            Amunts,A. and Ramakrishnan,V.
  TITLE     Structures of the human mitochondrial ribosome in native states of
            assembly
  JOURNAL   Nat Struct Mol Biol 24 (10), 866-869 (2017)
   PUBMED   28892042
REFERENCE   3  (bases 1 to 738)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   4  (bases 1 to 738)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   5  (bases 1 to 738)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 738)
  AUTHORS   Tsuritani,K., Irie,T., Yamashita,R., Sakakibara,Y., Wakaguri,H.,
            Kanai,A., Mizushima-Sugano,J., Sugano,S., Nakai,K. and Suzuki,Y.
  TITLE     Distinct class of putative 'non-conserved' promoters in humans:
            comparative studies of alternative promoters of human and mouse
            genes
  JOURNAL   Genome Res 17 (7), 1005-1014 (2007)
   PUBMED   17567985
REFERENCE   7  (bases 1 to 738)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   8  (bases 1 to 738)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   9  (bases 1 to 738)
  AUTHORS   O'Brien,T.W.
  TITLE     Evolution of a protein-rich mitochondrial ribosome: implications
            for human genetic disease
  JOURNAL   Gene 286 (1), 73-79 (2002)
   PUBMED   11943462
REFERENCE   10 (bases 1 to 738)
  AUTHORS   Koc,E.C., Burkhart,W., Blackburn,K., Moyer,M.B., Schlatzer,D.M.,
            Moseley,A. and Spremulli,L.L.
  TITLE     The large subunit of the mammalian mitochondrial ribosome. Analysis
            of the complement of ribosomal proteins present
  JOURNAL   J Biol Chem 276 (47), 43958-43969 (2001)
   PUBMED   11551941
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI458525.1, BU601595.1 and
            BQ012917.1.
            
            On Nov 23, 2018 this sequence version replaced NM_181463.2.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 39S subunit protein. Multiple
            transcript variants encoding two different isoforms were identified
            through sequence analysis. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (5) is the most commonly occurring
            transcript. Variants 1, 2, 3, 5, 6, 7, 8 encode the same isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BU601595.1, BM810741.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000336520.8/
                                                  ENSP00000337342.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               BI458525.1         13-163
            152-504             BU601595.1         155-507
            505-738             BQ012917.1         24-257              c
FEATURES             Location/Qualifiers
     source          1..738
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.13"
     gene            1..738
                     /gene="MRPL55"
                     /gene_synonym="AAVG5835; bL31m; L55nt; MRP-L55; PRO19675"
                     /note="mitochondrial ribosomal protein L55"
                     /db_xref="GeneID:128308"
                     /db_xref="HGNC:HGNC:16686"
                     /db_xref="MIM:611859"
     exon            1..151
                     /gene="MRPL55"
                     /gene_synonym="AAVG5835; bL31m; L55nt; MRP-L55; PRO19675"
                     /inference="alignment:Splign:2.1.0"
     exon            152..218
                     /gene="MRPL55"
                     /gene_synonym="AAVG5835; bL31m; L55nt; MRP-L55; PRO19675"
                     /inference="alignment:Splign:2.1.0"
     exon            219..302
                     /gene="MRPL55"
                     /gene_synonym="AAVG5835; bL31m; L55nt; MRP-L55; PRO19675"
                     /inference="alignment:Splign:2.1.0"
     CDS             277..663
                     /gene="MRPL55"
                     /gene_synonym="AAVG5835; bL31m; L55nt; MRP-L55; PRO19675"
                     /note="isoform a is encoded by transcript variant 5; 39S
                     ribosomal protein L55, mitochondrial; L55mt; mitochondrial
                     large ribosomal subunit protein mL55; mitochondrial large
                     ribosomal subunit protein bL31m"
                     /codon_start=1
                     /product="large ribosomal subunit protein mL55 isoform a"
                     /protein_id="NP_852128.1"
                     /db_xref="CCDS:CCDS1567.1"
                     /db_xref="GeneID:128308"
                     /db_xref="HGNC:HGNC:16686"
                     /db_xref="MIM:611859"
                     /translation="MAAVGSLLGRLRQSTVKATGPALRRLHTSSWRADSSRASLTRVH
                     RQAYARLYPVLLVKQDGSTIHIRYREPRRMLAMPIDLDTLSPEERRARLRKREAQLQS
                     RKEYEQELSDDLHVERYRQFWTRTKK"
     exon            303..504
                     /gene="MRPL55"
                     /gene_synonym="AAVG5835; bL31m; L55nt; MRP-L55; PRO19675"
                     /inference="alignment:Splign:2.1.0"
     exon            505..738
                     /gene="MRPL55"
                     /gene_synonym="AAVG5835; bL31m; L55nt; MRP-L55; PRO19675"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      738
                     /gene="MRPL55"
                     /gene_synonym="AAVG5835; bL31m; L55nt; MRP-L55; PRO19675"
                     /note="major polyA site"
ORIGIN      
        1 agtgacgtcg tgggctgcag cgcagcagca cccaacgcag tgagtacctt gatctcctgc
       61 gtggcctcgt ccctggtctt agttccaccg ggcagcggga gtcaggaccg cctgtcctca
      121 gacccctccg cagcgactgt ggcggccgca gtctagcagg aaaggagagg gagctttccc
      181 cgaagaccct cctggaccag ccccaggctc ctgtgctggt tgcacgccag ggcctgtact
      241 gaccacctcc acgtgccact ggggctgtaa ggaggaatgg cggccgtggg cagcctgctt
      301 ggccggctga ggcagagcac cgtgaaggcc accggacctg cactccgccg cctgcacaca
      361 tcctcctggc gagctgacag cagcagggcc tcactcactc gtgtgcaccg ccaggcttat
      421 gcacgactct accccgtgct gctggtgaag caggatggct ccaccatcca catccgctac
      481 agggagccac ggcgcatgct ggcgatgccc atagatctgg acaccctgtc tcctgaggag
      541 cgccgggcca ggctgcggaa gcgtgaggct cagctccagt cgaggaagga gtacgagcag
      601 gagctcagtg atgacttgca tgtggagcgc taccgacagt tctggaccag gaccaagaag
      661 tgaccgtggc tccagccacc ccgggacatt gctaagatgg gagggctgtt cttaaatcac
      721 tcgttcttga agctgcca
//
