LOCUS       NM_180982               1111 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein L52 (MRPL52),
            transcript variant 3, mRNA.
ACCESSION   NM_180982
VERSION     NM_180982.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1111)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1111)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1111)
  AUTHORS   Li,X., Wang,M., Li,S., Chen,Y., Wang,M., Wu,Z., Sun,X., Yao,L.,
            Dong,H., Song,Y. and Xu,Y.
  TITLE     HIF-1-induced mitochondrial ribosome protein L52: a mechanism for
            breast cancer cellular adaptation and metastatic initiation in
            response to hypoxia
  JOURNAL   Theranostics 11 (15), 7337-7359 (2021)
   PUBMED   34158854
  REMARK    GeneRIF: HIF-1-induced mitochondrial ribosome protein L52: a
            mechanism for breast cancer cellular adaptation and metastatic
            initiation in response to hypoxia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1111)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   5  (bases 1 to 1111)
  AUTHORS   Brown,A., Rathore,S., Kimanius,D., Aibara,S., Bai,X.C., Rorbach,J.,
            Amunts,A. and Ramakrishnan,V.
  TITLE     Structures of the human mitochondrial ribosome in native states of
            assembly
  JOURNAL   Nat Struct Mol Biol 24 (10), 866-869 (2017)
   PUBMED   28892042
REFERENCE   6  (bases 1 to 1111)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1111)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 1111)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   9  (bases 1 to 1111)
  AUTHORS   O'Brien,T.W.
  TITLE     Evolution of a protein-rich mitochondrial ribosome: implications
            for human genetic disease
  JOURNAL   Gene 286 (1), 73-79 (2002)
   PUBMED   11943462
REFERENCE   10 (bases 1 to 1111)
  AUTHORS   Koc,E.C., Burkhart,W., Blackburn,K., Moyer,M.B., Schlatzer,D.M.,
            Moseley,A. and Spremulli,L.L.
  TITLE     The large subunit of the mammalian mitochondrial ribosome. Analysis
            of the complement of ribosomal proteins present
  JOURNAL   J Biol Chem 276 (47), 43958-43969 (2001)
   PUBMED   11551941
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ082981.1, BX248749.1 and
            AA282747.1.
            
            On Nov 24, 2018 this sequence version replaced NM_180982.2.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 39S subunit protein which has no
            bacterial homolog. Multiple transcript variants encoding different
            protein isoforms were identified through sequence analysis.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 1,
            resulting in a shorter protein (isoform c) compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.161862.1,
                                           ERR279865.2896.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000397496.7/
                                                  ENSP00000380633.3
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                BQ082981.1         5-58
            55-1106             BX248749.1         44-1095
            1107-1111           AA282747.1         6-10                c
FEATURES             Location/Qualifiers
     source          1..1111
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..1111
                     /gene="MRPL52"
                     /gene_synonym="mL52"
                     /note="mitochondrial ribosomal protein L52"
                     /db_xref="GeneID:122704"
                     /db_xref="HGNC:HGNC:16655"
                     /db_xref="MIM:611856"
     exon            1..54
                     /gene="MRPL52"
                     /gene_synonym="mL52"
                     /inference="alignment:Splign:2.1.0"
     CDS             27..395
                     /gene="MRPL52"
                     /gene_synonym="mL52"
                     /note="isoform c is encoded by transcript variant 3; 39S
                     ribosomal protein L52, mitochondrial; L52mt; MRP-L52;
                     mitochondrial large ribosomal subunit protein mL52"
                     /codon_start=1
                     /product="large ribosomal subunit protein mL52 isoform c"
                     /protein_id="NP_851313.1"
                     /db_xref="CCDS:CCDS9575.1"
                     /db_xref="GeneID:122704"
                     /db_xref="HGNC:HGNC:16655"
                     /db_xref="MIM:611856"
                     /translation="MAALGTVLFSVRRLHCSVAAWAGGQWRLQQGLAANPSGYGPLTE
                     LPDWSYADGRPAPPMKGQLRRKAERETFARRVVLLSQEMDAGLQAWQLRQQKLQEEQR
                     KQENALKPKGASLKSPLPSQ"
     exon            55..112
                     /gene="MRPL52"
                     /gene_synonym="mL52"
                     /inference="alignment:Splign:2.1.0"
     exon            113..180
                     /gene="MRPL52"
                     /gene_synonym="mL52"
                     /inference="alignment:Splign:2.1.0"
     exon            181..245
                     /gene="MRPL52"
                     /gene_synonym="mL52"
                     /inference="alignment:Splign:2.1.0"
     exon            246..1111
                     /gene="MRPL52"
                     /gene_synonym="mL52"
                     /inference="alignment:Splign:2.1.0"
     regulatory      391..396
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL52"
                     /gene_synonym="mL52"
                     /note="hexamer: AATAAA"
     polyA_site      421
                     /gene="MRPL52"
                     /gene_synonym="mL52"
                     /note="major polyA site"
     regulatory      1089..1094
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL52"
                     /gene_synonym="mL52"
                     /note="hexamer: AATAAA"
     polyA_site      1111
                     /gene="MRPL52"
                     /gene_synonym="mL52"
ORIGIN      
        1 ggctaccccg gctactcctg ctcagcatgg ctgctttagg gactgttctc ttcagtgtcc
       61 ggaggctgca ctgcagcgta gccgcttggg cgggcggcca gtggcgacta cagcagggac
      121 tggctgccaa cccctccggc tacgggcccc ttaccgagct cccagactgg tcatatgcgg
      181 atggccgccc tgctccccca atgaaaggcc agcttcgaag aaaagctgaa agggagacgt
      241 ttgcaagacg agttgtactg ctgtcacagg aaatggacgc tggattacaa gcatggcagc
      301 tcaggcagca gaagttgcag gaagaacaaa ggaagcagga aaatgctctt aaacccaaag
      361 gggcttcact gaagagccca cttccaagtc aataaaaagc aactcctgcc tcccttcctc
      421 accctgtctc tggatttctt ttctatcacc tagatgcttc atccagccag aagatagcct
      481 tcacgttccc catctgtctt cagagaaaaa gagctgggac accaagaaca agctgttaga
      541 tcactgcctg ggaggcttgg cttagtactc tcatctctgg ttccattcca gttcagctaa
      601 gtcttgcttt aaaattttta cctcctagct gggtgcggtg gctcacgcct gtaatcccag
      661 cactttggga ggctgaggcg ggcagatcac aagatcagga gttcgagacc agcctggcca
      721 acccagcctg gtcaacatgg tgaaaccctg tccctactaa agatacaaac aattagccgg
      781 gcgtggtggg gtgcgcttgt aatcccagct actcaggagg ctgaggcagg agaatcgctt
      841 aaactcggga ggtagaggtt gcagtgagcc aaggtcacac cattgcactc caacctgggc
      901 gacagggcga gactccgtct caaaaaaaaa aaaaaattta cctcctttgc aggccatagg
      961 actagcccaa ctatgagaaa tagctgttct gtgaacgtga aaaggggaca gcagttttcc
     1021 cagttttggc caggcagtca agcctttaac agctcatgca cagtttaggc catgtacagc
     1081 tggcatctaa taaatgtttt catgaaaaag a
//
