LOCUS       NM_016497                898 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein L51 (MRPL51), mRNA.
ACCESSION   NM_016497
VERSION     NM_016497.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 898)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 898)
  AUTHORS   Brown,A., Rathore,S., Kimanius,D., Aibara,S., Bai,X.C., Rorbach,J.,
            Amunts,A. and Ramakrishnan,V.
  TITLE     Structures of the human mitochondrial ribosome in native states of
            assembly
  JOURNAL   Nat Struct Mol Biol 24 (10), 866-869 (2017)
   PUBMED   28892042
REFERENCE   3  (bases 1 to 898)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   4  (bases 1 to 898)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   5  (bases 1 to 898)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 898)
  AUTHORS   Haque,M.E., Elmore,K.B., Tripathy,A., Koc,H., Koc,E.C. and
            Spremulli,L.L.
  TITLE     Properties of the C-terminal tail of human mitochondrial inner
            membrane protein Oxa1L and its interactions with mammalian
            mitochondrial ribosomes
  JOURNAL   J Biol Chem 285 (36), 28353-28362 (2010)
   PUBMED   20601428
REFERENCE   7  (bases 1 to 898)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   8  (bases 1 to 898)
  AUTHORS   Koc,E.C., Burkhart,W., Blackburn,K., Moyer,M.B., Schlatzer,D.M.,
            Moseley,A. and Spremulli,L.L.
  TITLE     The large subunit of the mammalian mitochondrial ribosome. Analysis
            of the complement of ribosomal proteins present
  JOURNAL   J Biol Chem 276 (47), 43958-43969 (2001)
   PUBMED   11551941
REFERENCE   9  (bases 1 to 898)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   10 (bases 1 to 898)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Proteomic analysis of the mammalian mitochondrial ribosome.
            Identification of protein components in the 28 S small subunit
  JOURNAL   J Biol Chem 276 (35), 33181-33195 (2001)
   PUBMED   11402041
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF212248.1, BC014329.1 and
            AC006064.10.
            
            On Nov 23, 2018 this sequence version replaced NM_016497.3.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 39S subunit protein. Pseudogenes
            corresponding to this gene are found on chromosomes 4p and 21q.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.458397.1,
                                           SRR1660805.184931.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000229238.5/
                                                  ENSP00000229238.3
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AF212248.1         30-33
            5-631               BC014329.1         15-641
            632-634             AF212248.1         662-664
            635-898             AC006064.10        48967-49230         c
FEATURES             Location/Qualifiers
     source          1..898
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..898
                     /gene="MRPL51"
                     /gene_synonym="bMRP64; CDA09; HSPC241; mL51; MRP64"
                     /note="mitochondrial ribosomal protein L51"
                     /db_xref="GeneID:51258"
                     /db_xref="HGNC:HGNC:14044"
                     /db_xref="MIM:611855"
     exon            1..205
                     /gene="MRPL51"
                     /gene_synonym="bMRP64; CDA09; HSPC241; mL51; MRP64"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..513
                     /gene="MRPL51"
                     /gene_synonym="bMRP64; CDA09; HSPC241; mL51; MRP64"
                     /EC_number="3.6.5.3"
                     /note="mitochondrial ribosomal protein bMRP64;
                     mitochondrial ribosomal protein 64; 39S ribosomal protein
                     L51, mitochondrial; L51mt; MRP-L51; bMRP-64; mitochondrial
                     large ribosomal subunit protein mL51"
                     /codon_start=1
                     /product="large ribosomal subunit protein mL51"
                     /protein_id="NP_057581.2"
                     /db_xref="CCDS:CCDS8547.1"
                     /db_xref="GeneID:51258"
                     /db_xref="HGNC:HGNC:14044"
                     /db_xref="MIM:611855"
                     /translation="MAGNLLSGAGRRLWDWVPLACRSFSLGVPRLIGIRLTLPPPKVV
                     DRWNEKRAMFGVYDNIGILGNFEKHPKELIRGPIWLRGWKGNELQRCIRKRKMVGSRM
                     FADDLHNLNKRIRYLYKHFNRHGKFR"
     exon            206..316
                     /gene="MRPL51"
                     /gene_synonym="bMRP64; CDA09; HSPC241; mL51; MRP64"
                     /inference="alignment:Splign:2.1.0"
     exon            317..898
                     /gene="MRPL51"
                     /gene_synonym="bMRP64; CDA09; HSPC241; mL51; MRP64"
                     /inference="alignment:Splign:2.1.0"
     regulatory      612..617
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL51"
                     /gene_synonym="bMRP64; CDA09; HSPC241; mL51; MRP64"
                     /note="hexamer: AATAAA"
     polyA_site      634
                     /gene="MRPL51"
                     /gene_synonym="bMRP64; CDA09; HSPC241; mL51; MRP64"
                     /note="major polyA site"
     polyA_site      665
                     /gene="MRPL51"
                     /gene_synonym="bMRP64; CDA09; HSPC241; mL51; MRP64"
     regulatory      874..879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL51"
                     /gene_synonym="bMRP64; CDA09; HSPC241; mL51; MRP64"
                     /note="hexamer: AATATA"
     polyA_site      898
                     /gene="MRPL51"
                     /gene_synonym="bMRP64; CDA09; HSPC241; mL51; MRP64"
ORIGIN      
        1 acagctgcct gggtaaggcc caagatggct gtcttcgcct tagtactcgt gtgaagttgg
       61 cggggacggt tcctgtcatc ttcttgggct tatttggtgt gctgttgaag gggggagact
      121 agagaaatgg cagggaacct cttatccggg gcaggtaggc gcctgtggga ctgggtgcct
      181 ctggcgtgca gaagcttctc tcttggtgtg cctagattga tcggtataag gctcactctc
      241 ccgcccccca aagtggttga tcgttggaac gagaaaaggg ccatgttcgg agtgtatgac
      301 aacatcggga tcctgggaaa ctttgaaaag caccccaaag aactgatcag ggggcccata
      361 tggcttcgag gttggaaagg gaatgaattg caacgttgta tccgaaagag gaaaatggtt
      421 ggaagtagaa tgttcgctga tgacctgcac aaccttaata aacgcatccg ctatctctac
      481 aaacacttta accgacatgg gaagtttcga tagaagagaa agctgagaac ttcggaaaag
      541 gctcatctgt caccctggag aagggaaact gtacttttcc ctgtgaggaa acggctttgt
      601 attttctctg taataaaatg gggcttcttt ggaatttgat agccacatac ttttgttttc
      661 ctctagatgc tgcctctact catgtagact atgaagtctt gactcatcct agatcttagg
      721 atcttaggtt tgggcttcac accacttgcc ttttacagtc tagctatacc taattccttt
      781 aaaaagaaaa gttggtgaga atgttattgg cgctttttga cataatgctg ttatgttaat
      841 agtgtttcta aagagccttc cacactgaaa tgaaatataa gagaaaaatg gagtcata
//
