LOCUS       NM_022163                986 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein L46 (MRPL46), mRNA.
ACCESSION   NM_022163
VERSION     NM_022163.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 986)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 986)
  AUTHORS   Brown,A., Rathore,S., Kimanius,D., Aibara,S., Bai,X.C., Rorbach,J.,
            Amunts,A. and Ramakrishnan,V.
  TITLE     Structures of the human mitochondrial ribosome in native states of
            assembly
  JOURNAL   Nat Struct Mol Biol 24 (10), 866-869 (2017)
   PUBMED   28892042
REFERENCE   3  (bases 1 to 986)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   4  (bases 1 to 986)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   5  (bases 1 to 986)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 986)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   7  (bases 1 to 986)
  AUTHORS   Koc,E.C., Burkhart,W., Blackburn,K., Moyer,M.B., Schlatzer,D.M.,
            Moseley,A. and Spremulli,L.L.
  TITLE     The large subunit of the mammalian mitochondrial ribosome. Analysis
            of the complement of ribosomal proteins present
  JOURNAL   J Biol Chem 276 (47), 43958-43969 (2001)
   PUBMED   11551941
REFERENCE   8  (bases 1 to 986)
  AUTHORS   Carim-Todd,L., Sumoy,L., Andreu,N., Estivill,X. and Escarceller,M.
  TITLE     Cloning, mapping and expression analysis of C15orf4, a novel human
            gene with homology to the yeast mitochondrial ribosomal protein
            Ym130 gene
  JOURNAL   DNA Seq 12 (2), 91-96 (2001)
   PUBMED   11761714
  REMARK    GeneRIF: Expression is enriched in testis.  Positioned to
            chromosome 15q24 by radiation hybrid mapping.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC017883.1 and AF210056.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_022163.3.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 39S subunit protein. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF210056.1, BC017883.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2142670,
                                           SAMEA2144835 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000312475.5/
                                                  ENSP00000312311.4
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-583               BC017883.1         1-583
            584-986             AF210056.1         584-986
FEATURES             Location/Qualifiers
     source          1..986
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.3"
     gene            1..986
                     /gene="MRPL46"
                     /gene_synonym="C15orf4; LIECG2; mL46; P2ECSL"
                     /note="mitochondrial ribosomal protein L46"
                     /db_xref="GeneID:26589"
                     /db_xref="HGNC:HGNC:1192"
                     /db_xref="MIM:611851"
     exon            1..239
                     /gene="MRPL46"
                     /gene_synonym="C15orf4; LIECG2; mL46; P2ECSL"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..851
                     /gene="MRPL46"
                     /gene_synonym="C15orf4; LIECG2; mL46; P2ECSL"
                     /note="39S ribosomal protein L46, mitochondrial; L46mt;
                     MRP-L46; mitochondrial large ribosomal subunit protein
                     mL46"
                     /codon_start=1
                     /product="large ribosomal subunit protein mL46"
                     /protein_id="NP_071446.2"
                     /db_xref="CCDS:CCDS10341.1"
                     /db_xref="GeneID:26589"
                     /db_xref="HGNC:HGNC:1192"
                     /db_xref="MIM:611851"
                     /translation="MAAPVRRTLLGVAGGWRRFERLWAGSLSSRSLALAAAPSSNGSP
                     WRLLGALCLQRPPVVSKPLTPLQEEMASLLQQIEIERSLYSDHELRALDENQRLAKKK
                     ADLHDEEDEQDILLAQDLEDMWEQKFLQFKLGARITEADEKNDRTSLNRKLDRNLVLL
                     VREKFGDQDVWILPQAEWQPGETLRGTAERTLATLSENNMEAKFLGNAPCGHYTFKFP
                     QAMRTESNLGAKVFFFKALLLTGDFSQAGNKGHHVWVTKDELGDYLKPKYLAQVRRFV
                     SDL"
     exon            240..426
                     /gene="MRPL46"
                     /gene_synonym="C15orf4; LIECG2; mL46; P2ECSL"
                     /inference="alignment:Splign:2.1.0"
     exon            427..600
                     /gene="MRPL46"
                     /gene_synonym="C15orf4; LIECG2; mL46; P2ECSL"
                     /inference="alignment:Splign:2.1.0"
     exon            601..986
                     /gene="MRPL46"
                     /gene_synonym="C15orf4; LIECG2; mL46; P2ECSL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      967..972
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL46"
                     /gene_synonym="C15orf4; LIECG2; mL46; P2ECSL"
                     /note="hexamer: AATAAA"
     polyA_site      986
                     /gene="MRPL46"
                     /gene_synonym="C15orf4; LIECG2; mL46; P2ECSL"
                     /note="major polyA site"
ORIGIN      
        1 gagaacgaaa gatggcggcg cccgtaaggc ggacgctgtt aggggtggcg gggggttggc
       61 ggcggttcga gaggctctgg gccggcagtc taagctctcg cagcctggct cttgcagccg
      121 caccctcaag caacggatcc ccatggcgct tgttgggcgc gttgtgcctg cagcggccac
      181 ctgtagtctc caagccgttg accccattgc aggaagagat ggcgtctcta ctgcagcaga
      241 ttgagataga gagaagcctg tattcagacc acgagcttcg tgctctggat gaaaaccagc
      301 gactggcaaa gaagaaagct gaccttcatg atgaagaaga tgaacaggat atattgctgg
      361 cgcaagattt ggaagatatg tgggagcaga aatttctaca gttcaaactt ggagctcgca
      421 taacagaagc tgatgaaaag aatgaccgaa catccctgaa caggaagcta gacaggaacc
      481 ttgtcctgtt agtcagagag aagtttggag accaggatgt ttggatactg ccccaggcag
      541 agtggcagcc tggggagacc cttcgaggaa cagctgaacg aaccctggcc acactctcag
      601 aaaacaacat ggaagccaag ttcctaggaa atgcaccctg tgggcactac acattcaagt
      661 tcccccaggc aatgcggaca gagagtaacc tcggagccaa ggtgttcttc ttcaaagcac
      721 tgctattaac tggagacttt tcccaggctg ggaataaggg ccatcatgtg tgggtcacta
      781 aggatgagct gggtgactat ttgaaaccaa aatacctggc ccaagttagg aggtttgttt
      841 cagacctctg atgggccgag ctgcctgtgg acggtgctca gacaagtctg ggattagagc
      901 ctcaaggaca ttgtgtgatt gcctcacatt tgcaggtaat atcaagcagc aaactaaatt
      961 ctgagaaata aacgagtcta ttactg
//
