LOCUS       NM_014050              15557 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein L42 (MRPL42),
            transcript variant 1, mRNA.
ACCESSION   NM_014050
VERSION     NM_014050.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 15557)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 15557)
  AUTHORS   Hao,C., Duan,H., Li,H., Wang,H., Liu,Y., Fan,Y. and Zhang,C.
  TITLE     Knockdown of MRPL42 suppresses glioma cell proliferation by
            inducing cell cycle arrest and apoptosis
  JOURNAL   Biosci Rep 38 (2) (2018)
   PUBMED   29531015
  REMARK    GeneRIF: MRPL42 is a novel oncogene in glioma and might help us
            develop promising targetted therapies for glioma patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 15557)
  AUTHORS   Brown,A., Rathore,S., Kimanius,D., Aibara,S., Bai,X.C., Rorbach,J.,
            Amunts,A. and Ramakrishnan,V.
  TITLE     Structures of the human mitochondrial ribosome in native states of
            assembly
  JOURNAL   Nat Struct Mol Biol 24 (10), 866-869 (2017)
   PUBMED   28892042
REFERENCE   4  (bases 1 to 15557)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   5  (bases 1 to 15557)
  AUTHORS   Wang,X., Wang,J., Xing,C.Y., Zang,R., Pu,Y.Y. and Yin,Z.X.
  TITLE     [Comparative analysis of the role of CD4(+) and CD8(+) T cells in
            severe asthma development]
  JOURNAL   Mol Biol (Mosk) 49 (3), 482-490 (2015)
   PUBMED   26107902
  REMARK    GeneRIF: MPO and BPI in CD4(+)T-lymphocytes, and PDHA1 and MRPL42
            in CD8(+) T-lymphocytes might be used as specific biomarkers of
            severe asthma progression.
REFERENCE   6  (bases 1 to 15557)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 15557)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   8  (bases 1 to 15557)
  AUTHORS   Koc,E.C., Burkhart,W., Blackburn,K., Moyer,M.B., Schlatzer,D.M.,
            Moseley,A. and Spremulli,L.L.
  TITLE     The large subunit of the mammalian mitochondrial ribosome. Analysis
            of the complement of ribosomal proteins present
  JOURNAL   J Biol Chem 276 (47), 43958-43969 (2001)
   PUBMED   11551941
REFERENCE   9  (bases 1 to 15557)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   10 (bases 1 to 15557)
  AUTHORS   Cavdar Koc,E., Burkhart,W., Blackburn,K., Moseley,A. and
            Spremulli,L.L.
  TITLE     The small subunit of the mammalian mitochondrial ribosome.
            Identification of the full complement of ribosomal proteins present
  JOURNAL   J Biol Chem 276 (22), 19363-19374 (2001)
   PUBMED   11279123
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC025260.29.
            
            On May 17, 2019 this sequence version replaced NM_014050.3.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a protein identified as belonging to
            both the 28S and the 39S subunits. Alternative splicing results in
            multiple transcript variants. Pseudogenes corresponding to this
            gene are found on chromosomes 4q, 6p, 6q, 7p, and 15q. [provided by
            RefSeq, May 2011].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.48438.1,
                                           SRR1803615.266571.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000549982.6/
                                                  ENSP00000449884.1
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AC025260.29        94217-94257         c
            42-205              AC025260.29        92416-92579         c
            206-269             AC025260.29        84754-84817         c
            270-354             AC025260.29        82299-82383         c
            355-518             AC025260.29        74111-74274         c
            519-15557           AC025260.29        45557-60595         c
FEATURES             Location/Qualifiers
     source          1..15557
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q22"
     gene            1..15557
                     /gene="MRPL42"
                     /gene_synonym="HSPC204; L31MT; L42MT; mL42; MRP-L31;
                     MRP-L42; MRP-S32; MRPL31; MRPS32; PTD007; RPML31; S32MT"
                     /note="mitochondrial ribosomal protein L42"
                     /db_xref="GeneID:28977"
                     /db_xref="HGNC:HGNC:14493"
                     /db_xref="MIM:611847"
     exon            1..41
                     /gene="MRPL42"
                     /gene_synonym="HSPC204; L31MT; L42MT; mL42; MRP-L31;
                     MRP-L42; MRP-S32; MRPL31; MRPS32; PTD007; RPML31; S32MT"
                     /inference="alignment:Splign:2.1.0"
     exon            42..205
                     /gene="MRPL42"
                     /gene_synonym="HSPC204; L31MT; L42MT; mL42; MRP-L31;
                     MRP-L42; MRP-S32; MRPL31; MRPS32; PTD007; RPML31; S32MT"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..564
                     /gene="MRPL42"
                     /gene_synonym="HSPC204; L31MT; L42MT; mL42; MRP-L31;
                     MRP-L42; MRP-S32; MRPL31; MRPS32; PTD007; RPML31; S32MT"
                     /note="39S ribosomal protein L42, mitochondrial; 28S
                     ribosomal protein S32, mitochondrial; 39S ribosomal
                     protein L31, mitochondrial; mitochondrial large ribosomal
                     subunit protein mL42"
                     /codon_start=1
                     /product="large ribosomal subunit protein mL42 precursor"
                     /protein_id="NP_054769.1"
                     /db_xref="CCDS:CCDS9045.1"
                     /db_xref="GeneID:28977"
                     /db_xref="HGNC:HGNC:14493"
                     /db_xref="MIM:611847"
                     /translation="MAVAAVKWVMSKRTILKHLFPVQNGALYCVCHKSTYSPLPDDYN
                     CNVELALTSDGRTIVCYHPSVDIPYEHTKPIPRPDPVHNNEETHDQVLKTRLEEKVEH
                     LEEGPMIEQLSKMFFTTKHRWYPHGRYHRCRKNLNPPKDR"
     exon            206..269
                     /gene="MRPL42"
                     /gene_synonym="HSPC204; L31MT; L42MT; mL42; MRP-L31;
                     MRP-L42; MRP-S32; MRPL31; MRPS32; PTD007; RPML31; S32MT"
                     /inference="alignment:Splign:2.1.0"
     exon            270..354
                     /gene="MRPL42"
                     /gene_synonym="HSPC204; L31MT; L42MT; mL42; MRP-L31;
                     MRP-L42; MRP-S32; MRPL31; MRPS32; PTD007; RPML31; S32MT"
                     /inference="alignment:Splign:2.1.0"
     exon            355..518
                     /gene="MRPL42"
                     /gene_synonym="HSPC204; L31MT; L42MT; mL42; MRP-L31;
                     MRP-L42; MRP-S32; MRPL31; MRPS32; PTD007; RPML31; S32MT"
                     /inference="alignment:Splign:2.1.0"
     exon            519..15557
                     /gene="MRPL42"
                     /gene_synonym="HSPC204; L31MT; L42MT; mL42; MRP-L31;
                     MRP-L42; MRP-S32; MRPL31; MRPS32; PTD007; RPML31; S32MT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1823..1828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL42"
                     /gene_synonym="HSPC204; L31MT; L42MT; mL42; MRP-L31;
                     MRP-L42; MRP-S32; MRPL31; MRPS32; PTD007; RPML31; S32MT"
                     /note="hexamer: AATAAA"
     polyA_site      1847
                     /gene="MRPL42"
                     /gene_synonym="HSPC204; L31MT; L42MT; mL42; MRP-L31;
                     MRP-L42; MRP-S32; MRPL31; MRPS32; PTD007; RPML31; S32MT"
                     /note="major polyA site"
     regulatory      1981..1986
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL42"
                     /gene_synonym="HSPC204; L31MT; L42MT; mL42; MRP-L31;
                     MRP-L42; MRP-S32; MRPL31; MRPS32; PTD007; RPML31; S32MT"
                     /note="hexamer: GATAAA"
     polyA_site      2002
                     /gene="MRPL42"
                     /gene_synonym="HSPC204; L31MT; L42MT; mL42; MRP-L31;
                     MRP-L42; MRP-S32; MRPL31; MRPS32; PTD007; RPML31; S32MT"
                     /note="major polyA site"
     regulatory      3092..3097
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL42"
                     /gene_synonym="HSPC204; L31MT; L42MT; mL42; MRP-L31;
                     MRP-L42; MRP-S32; MRPL31; MRPS32; PTD007; RPML31; S32MT"
                     /note="hexamer: AATAAA"
     polyA_site      3113
                     /gene="MRPL42"
                     /gene_synonym="HSPC204; L31MT; L42MT; mL42; MRP-L31;
                     MRP-L42; MRP-S32; MRPL31; MRPS32; PTD007; RPML31; S32MT"
                     /note="major polyA site"
     regulatory      12248..12253
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL42"
                     /gene_synonym="HSPC204; L31MT; L42MT; mL42; MRP-L31;
                     MRP-L42; MRP-S32; MRPL31; MRPS32; PTD007; RPML31; S32MT"
                     /note="hexamer: ATTAAA"
     polyA_site      12273
                     /gene="MRPL42"
                     /gene_synonym="HSPC204; L31MT; L42MT; mL42; MRP-L31;
                     MRP-L42; MRP-S32; MRPL31; MRPS32; PTD007; RPML31; S32MT"
                     /note="major polyA site"
     regulatory      15535..15540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL42"
                     /gene_synonym="HSPC204; L31MT; L42MT; mL42; MRP-L31;
                     MRP-L42; MRP-S32; MRPL31; MRPS32; PTD007; RPML31; S32MT"
                     /note="hexamer: AATAAA"
     polyA_site      15557
                     /gene="MRPL42"
                     /gene_synonym="HSPC204; L31MT; L42MT; mL42; MRP-L31;
                     MRP-L42; MRP-S32; MRPL31; MRPS32; PTD007; RPML31; S32MT"
ORIGIN      
        1 attgaaacaa gatggcgggt tcgtggtgag aagccgtcaa ggagtagaaa ttggtatgct
       61 tagaagcaga ttctaaaagc agtttctctt cagaacatct tttttcatac cacttgataa
      121 gcatcttgaa acaccatggc tgtagctgca gtaaaatggg tgatgtcaaa gagaactatc
      181 ttgaaacatt tatttccagt ccaaaatgga gctttatatt gtgtttgtca taaatctacg
      241 tattctcctc taccagatga ctataattgc aacgtagagc ttgctctgac ttctgatggc
      301 aggacaatag tatgctacca cccttctgtg gacattccat atgaacacac aaaacctatc
      361 cctcggccag atcctgtgca taataatgaa gaaacacatg atcaagtgct gaaaaccaga
      421 ttggaagaaa aagttgaaca ccttgaggaa ggacctatga tagaacaact tagcaaaatg
      481 ttctttacta ctaagcaccg ttggtatcct catggacggt atcacagatg tcgtaagaat
      541 ctgaatcctc caaaagacag atgatgcgga ggttcctggg ggaatcaaag agaaatgtgc
      601 ctcatttgcc atttgagaaa atgcagtctg gtgtattcag taatatatag taaagtaata
      661 atgataaaat atcttttcat atattagaat gtgtactttt atataaagta attctggatt
      721 tgacattctc atttagagaa acctattttc ttttttcttt ttctatttta gtgtttcatt
      781 tatgtgcggt ctccaattta ggacttttcc atagtgccaa agccatacat attcagtaga
      841 acatcaataa attacatcag aaattcaaca ctttattata aaacgggctt cgtgttagat
      901 aattttgcta aacagtaggc tactgtaagt gttctgagca tatttaagac aggctagcat
      961 tttcaattta caatattttc aactgatagt aggtttattg ggatgtaacc ctatgataag
     1021 ttgagaaaca tctctttttg tgtgtctact gtgatttaag tatttttaat catcagccaa
     1081 gcattgttag tagtataaat atgattaata aaaatgtgca tggctttcct gaaggagatt
     1141 ttttaattgc ctttgagaat aaactcataa ggtctaccaa gaaaataaat gttatgatgt
     1201 ttcagttggc ttctaggaaa taattaaatt agtgatattt taatcaggtt ttactatctg
     1261 ctaggcccct tccatcaatt cttattaaat tctcaaaata atcctttgaa aagggagtat
     1321 aattacattt tacagtgact cgaaccttac ccaaacaagt gggagagcca ggagccaaac
     1381 tatcaggctc caaagctttt ttttagtgca tcacaatgac aaaggggtgg ttttctttca
     1441 cccaagaatg tgctttcctg gaaatttttc tagatagaat attatgtaat ttgttttgaa
     1501 ggtttttttt cctgactgtc ttaaagatta tgctagcttt agaacacatg caaacagctg
     1561 cagctctgtg attaaaatgt taaggtcact agaatagtgt taggaaaatg ttaatagata
     1621 attctgctgc ctctattagc ttatgtatga tccttaatag cattgcttcc ccttcagttt
     1681 ctatttagga ggtgaagaat cttttaataa ggtagaaagt tgctttattt aaatttgtac
     1741 tgtagaatgt ttgtgataca gtatttgtaa aattgatatg aaaaataatt tctcaaagtc
     1801 tattgtttga tctagttatt ttaataaagg aactctagaa gtttcaagtg gccagtgaag
     1861 tgtgaggaat agagagtaaa ggaaataatt aataatggtg accctctgtt aagtggttta
     1921 ctttttccat taatataaat ttcatttgga aagattaaaa aaacaagttt gattgaactt
     1981 gataaatcag aaatatttac cagctttgtc gatggtgtat tcttgaaaaa tgtttggttt
     2041 tctttcaggt tgacttatat ccaaaattct acaaattctt agctatgtta taaatgtaga
     2101 aagaagtgaa aaatcaaaat atgattatga agattttctt ctcttccgag tacaaagctc
     2161 tgctaaataa ggatttaccc aagatgccca catccacata cttatgtgtc agtgctttgg
     2221 agaattaact ttgactttat tctactggaa gtatagatta acactgtgct ttctgggatt
     2281 ttgcttttca tgggttgctg atttttaatt ttgctaaata agcacatagt ccgtgatcac
     2341 cagcatcacc tgccctctgt tcctcccccg tcccccaggg ataagaacct gttatccacc
     2401 atcagtaaca ttttatgaaa gatctactta tttgtctgtt ttgcagacat tttaaaattc
     2461 gtaaagtggg atgcttcttt aatttaaata catttagctt catgaaaaac tcactacaca
     2521 gttcttgttc aagcattatt gggaaaccac cagagggcac tctcacccag ggcttaattt
     2581 gaacatctcg cccaaaagtg acttttaaaa gcacttaatt agcagagaat ttggatgttc
     2641 attagttgag aatgactagt agaataaatg gtaatagtga aattaagtgc tggaatattc
     2701 tgagtagacc aatagcaaaa actgattttt tttttttttt aaagaaaagg tcttgctgtg
     2761 tcgcccagga tggagtgcag tggcacaatc acattgcact gcaacctcaa tatcctgggc
     2821 tcaagcaatc ctcccaccgc agcctcccga attgctgaga ctacacatgt gtgctaccat
     2881 gcctggctaa ttgttttaat tttttttata gagacggggt ttcgccatgt tgcccaggct
     2941 ggtcttgaac tcctgggctc aaagcgatcc acccaccttg gcctccaaaa gtatgggatt
     3001 acaggtgtga gccactgtgc ccagccttat tttttttttt taagataata ttgttaacat
     3061 tttgtatttc tctgcataaa tatatttcaa aaataaaaat agagctcata atatatgctg
     3121 ttttgtaatg cttttttcac ttaataggaa ttttttccgt atcattaagt actctgattt
     3181 aatgggtgca tattattcta taatctggct tgtcataatt taattaactc cctgctgtta
     3241 gacaaaatca ttgtttctgt tccatcttgt gaataatgct gttattaaca tcctggtgga
     3301 ttattaccat tttctttttt tatttttttt ttaaatttat ttcttctttt ttttttctta
     3361 taatctcatc agaagctggc aagatcatta ctgttttctt agatttgttt ctgtaagtgc
     3421 aatcgttgaa tcaccatgtc cggcatccat gtttatgtac atttttaaag tcagtggttt
     3481 aaactgtata ctttttgggt tttggagatg gaggtttgct ctgcccaagc tggaatgcaa
     3541 tggcgcgatc ttggctcact gcagcctcca cctcccgggt tcaagtgatt ctcctgcctc
     3601 agcctcctta agtagttggg attacaagtg tgcaccacca tactcaggta attttgcatt
     3661 tttagtagag acagggtttc accatgttgg tcaggctggt ctcgaactcc tgacctcaag
     3721 tgtccacaca ccttggcctc ccaaagtgct gggtgggatt ataggtgtga gcctccatgc
     3781 ctggcctaaa ctgcatactc ctaacatcag tatatagaaa tattttctct ttagttctat
     3841 taaaatttta aaaaatcttt atcaatttag taggcaaaga ctggaaaatg ttttaatttg
     3901 atcagccact ttaatgtatg tctcatttca aagcatataa agtatacaag tttcaggtcc
     3961 tagcttaaac ctataagagg ccttattatg ggcttatttc ctttgcagcc ctttaccata
     4021 atgtgtttct tctacctccc ctgcacaaca ttgtttatat gccccctaaa atgtaacttc
     4081 tttagattct gttgttacgt gcaacactgt atatctctcc atagcactta atcagagttt
     4141 gtaattaggc atctttttgt gtgattattt ggtaaatgtc catatcccct actagcctat
     4201 aagctccatg acttctaggt accctgtctg actacgtgta tcactgtttc taccgcctaa
     4261 cattgcctag cacattcatt gcttcacagg catctgaata tggttttata aaatacattg
     4321 ctctagtgca caggatttta agctaaggat ttcatgaatg ggatttgggg taggggcatc
     4381 tatgaaattc ctgaaattgt gtagaatttt gagaatatgt gttttcctgg ggatagagta
     4441 tgtagtttct cagcaactca ttacagtctg tcacatcatg ccctaattct acttgcctgt
     4501 agctaaacac ctaataacat tagaactgaa atgatagtga tatgcaagat agcacgtgtg
     4561 gtttccacat attctaagag gcatcttcaa ttagattcca aaaattttta agaaaaaaag
     4621 atataatgtg ccatcatttt ggatggttct gggcacttca ggtaaaccct tactcaaaga
     4681 atactttttc agtttcaatg tgtattttta aaatttccag aagatgagtt gaatatcagc
     4741 ccacaaacac tggtagtaag caaactattt tatttgctaa aggcataaat aaatgtctcc
     4801 tttgctttta ggcaaaggga atgcttcttc agattttttt ttttccccag aagttcaaaa
     4861 taacttgctc atagtcttcc caaaataatt ttcaaacatt ctaacaccaa agaaagatac
     4921 tcccaattga gctcagccat cagcctccta ctatttttta atgtgctgtt taaccttgtg
     4981 aatgtgagaa tattttgaat gcactgggaa ggaatactca ggaacaatat gtaatgtgct
     5041 ttctagtttt gcacaaaggc attcattttg atttagtaac aacctcatac ttacatagca
     5101 tatccttctg cagaaatgct tcacagccat gactgcttga attcttgtca tgttgcttgt
     5161 aaatgagctc ctgtttttag atggagaaat ggaggcagag tctcacaatt acatgtgaga
     5221 atagcaagta gaaccttatg attacttctg agtctttttt tttttttttt ttttgagatg
     5281 gagtttcact tttgtcaccc aggctggagt gcagtacagt ggccagtggc atgatctcag
     5341 cccactgcaa cctccgcctc ataggctcaa gcaattctcc tgcctcagcc tcccgagtag
     5401 ctgggattat gagcgtgcac cagcatgcct ggctgatttt ttgtattttc agtagagatg
     5461 gggtttcacc acgttggcca ggctggtctt gaactcctga cctcaggtga tctgcccacc
     5521 ttggcccccc aaaatactgg gattacaagg gtgagccact gtgcccagcc tcttctgagt
     5581 cttcaattca gcaagaatgt ctcttttttt tttttttttt tttttgggac agagtcttgc
     5641 tcttgttgcc ttggctggag tgtagtggca cattctcagc tcactgcaac ctccacctcc
     5701 cgggttcaag cgattctcct gcctcagctt cccaagtagc tgggactata ggcatgcaac
     5761 accatgtccg gctaattttt tgtatttagt agagatgggg tttctccatg ttggtcaggc
     5821 tggtctcaaa ctcctgacct caggtgatcc acctgctttc gcctcctgaa gtgctgggat
     5881 tacaggcatg agccaccacg cccggccaag aatgtctttt ctttataatg ttgtctctaa
     5941 gcatgtaatc ttttcggcaa attttattaa gcacctatag agttcaagcc actgtgggtt
     6001 caaagatagc cctcattcct gattgacaaa gtatcttgct atgaccatcc cttctttccc
     6061 ctctagtcaa aattagtctc ttcttcactc ataatgcaaa gtacattgga ttactattat
     6121 gccacttact tgaataattg tcttgatgag taatatatgt agtcagtaac atggttaagt
     6181 gtggcaattt ggattgatcc cattggactt ttcaattgct gcatccaggt gtaattacca
     6241 taagagcata gaagatagaa tcgtaaagct gaaagacatc ttaaagatga tttttgggga
     6301 ctgatttgga aacagatcca aagacactaa ttgacttgcc caagatcaca gattgtggca
     6361 gaaccaacca atgtcttttt taaacattaa ggacatctta tatgtatatt tatgcatata
     6421 catactgatg aaatgtgcct ttagcaatag atgtgtccag tgatgtacta atgaagattt
     6481 aacaactggt tctaacttgt aatgtttgcc agtttccatg actgggtctt acaagttgtt
     6541 gtgcactgac tccatcattc cactggatgt gcccctgaaa tcatatattt actactaaaa
     6601 ccattagatt gtttccttgt tccagttatg cattcagaga cactccacct tattttctga
     6661 ttacatttgc agggagaaat aactccttac ttgtcagttt cagccttcac ttttagtttc
     6721 tttttctttt cctttttcca acccagtata ccttagaaac tttcagtttc ttttaaggat
     6781 ttaataactt gcttataagt gtttaaaatg acttaatggg ttctatcttt taagggaact
     6841 ttggatgaat ccttgaatat cagttatcta ttgccaatta acaaatcacc ccaaagctca
     6901 ttggcttaaa acaacaatct ttcattagtt tgcgttcttc caggtaattc ttatagtctg
     6961 gatccagctc agcttatctt ggctggactt gcccatgcag ctgaggtcac tagttgggtt
     7021 gttgaggctg gctagtccta gatggtgtca ctcatatgtc tggtattgag tgactgtcac
     7081 ctggggcatt agggggactg tgtctctcat catccagcaa gctaggcctg gattcttcac
     7141 atggctttag gatttcaaga gtatgagatt ggggctgggc atgatgactc acacctgtaa
     7201 tcccagcact ttgggaggcc aaggttgggg gatttcttga gcccaggagt tcaagaccag
     7261 cctgggcaac atagtgagag cccatctgta aaaaaaaaaa ttttttgaga tggagtttcg
     7321 cccttgttgc ccaggctgga gtgcaatggc gcaatctcag cccaccagaa cctttgcctc
     7381 ttgggttcaa gcgattctcc tgcctcagtc tcctgagtag ctgagattac aggcatgagc
     7441 caccacgccc agctaatttt gtatttttag tagagatggg tttctccgtg ttggtcaggc
     7501 tggtcttgaa ttccccacct caggtgatct gcctgcctca gcctcccaaa gtgctgggat
     7561 tacaggtgtg agccaccacg cctggtcttc tacaaaaaaa ttttaaaaaa ttagctgggg
     7621 gtggggaggg tggggtggtg ctgcatgcct gtagtcccag ctatttggga ggctgagatg
     7681 ggaggattgc ttgagcccat gagattgagg ctgtagtgag ccatgattgt gccactgcac
     7741 tctaggctgg gcaacagaac aagcacctgt atcaaaacaa acaaaaaagt gcaagattgg
     7801 aagcttcgag gcttcttgag gcctagtctc agaactggca caatatcact tcataaggct
     7861 atctcagatt caagggagta agaggagaga tgctacctat taaaaggaga agcagcaaat
     7921 actatggcca ttctcttcac aatagttgtc accaaaacgt aatcgatttg tttatgggtt
     7981 tacattgtca tgtctccaca ggacaatgca catggtatgt ttgtcagaac ccagttggag
     8041 ttttgtttcc cagcatccaa aggaaatccc taactttcat tttttcttcc cgtaagcagc
     8101 cccgaacact tacttataag ccatctctac ctgaattagc aatcatggat aagctcaata
     8161 actgatcatt tccttatcag tttaaaccat atatatttta acactgtctc tttttcacac
     8221 acactagtta gctaagaatg agctgggggg ctgggcgtgg tagttcacac ctgtaatccc
     8281 agcactttag gaggcggagg tgggcggatc acttgaggtc aggagtttga gaccagccta
     8341 gctaacatgg tgaaaccccg tctctactaa aaatgcaaaa attagctggg tgtggtggca
     8401 ggcatctgta atcctagcta ctcaggaggc tgaggcagga gaatcccttg aacccaggag
     8461 gcagaggttg cagtgggcca agatcacacc actgcactcc agtctgggtg ataaaacgag
     8521 attccgtctc aaaaaaaaaa aaaaaactgc caaaacgctt tttgcaaagt ggttgtacca
     8581 ttttatattc tcaccaccat gaatgaaagt tccaattgct atattcttgc cctcatttga
     8641 taatattttt agttttagcc attctaatgg atatatagta ataatttgat ggttttaatt
     8701 tgcatttctc tgatgatcaa taacattaag ttttgattca ggtacttgtt gggcactcat
     8761 atctttggtg aaatatctgt tcaaatcatt tgctcttttt tttttcttag cacttaaaaa
     8821 agactttttg ccaggcacag tggcacatgc ctgtagacct agctactcag gaggctaaga
     8881 caggaggatc acttgagtcc agaagttctg ggttgtagtg agctatgtca atcaggtgtt
     8941 tgcactaagt tcagcataaa tgtagtgacc tcctgggtca ctgggaccca gagttgccta
     9001 aggagcgtca gaagtggagc aggtcaaaac tcctgtgctg atcagtagtg ggatcacacc
     9061 tgtgaatagc cactgcactg cagcctgggc aacatagtga gatcctcatc tcctgaaaaa
     9121 aaaaaaaaac tttagttttt aaaagtagtt ttaggttctg agcaaaattg agaggagggt
     9181 acagaaataa cttatatatc ctcagtgctc ccctccccca tgcctccctc atcaccatcc
     9241 cccagcagag tggcacattg gttacaattg ataaacctac actgacacat cattatcacc
     9301 caaagcctat tgtttccatt agggttcact cttggtgctg tacaatctat gggtttgaac
     9361 aaaggtacaa tgacatgtat ccatctttat agtcatgcag agtctacact gtcctaaaaa
     9421 cccttggctc tgcctcttcg tcgtgtcctc cccactgacc cccggctacc actggtcttt
     9481 tcactgtctc cgtaagtttt tcctttttca gaacgccata tagttggaat cataaagtat
     9541 atatagcctt ttcacattgg tttctttcac tggataatat gcatttgttt cctctatgtc
     9601 ttttcacagt ttgatagctc atttcttttt agcatcgagt aatactccat tgtctgggtg
     9661 tacaacagtt tatccattca cctgctgaag gacatcttgg ttgattgctt ccaagttttg
     9721 gcaattatga ataaaattgc tatagatatc catgtgtagg tttttgtgtc catttaagct
     9781 ttcaactcct ttgggtaaat accaaagagc acaattgttg gattgaatgc taagagaatg
     9841 tttcgttttg taaaaaacca ccaaactgtc ctacagagag gctgtaccat tttgcattcc
     9901 caccagcagt gaataagggt tcctattgct caacatccct gtcagcactt ggtgttagtg
     9961 ttctgaattt tggccattct aaaaggtgtg tagtggtgtc tcacttgttt tgtgtttttc
    10021 tctgctcaga cagctcatcc acatcacatt tattttaatt tgcatttccc tgataatatg
    10081 tgatatggaa catctattta ctcattattt tttcttctta tgattgaagt tataatattt
    10141 ctttaaatat tttggataaa tcttttgtca gatatatgca ctggaaatat ttttatgggg
    10201 gaccagtgtt aagattagat ctgtttaaag agaaaggaga gaaagtttca ggcagggaat
    10261 gcaatcgatg tgaaggtttg gggtaatttg tttcatttat ctttaacacc atgttatgga
    10321 tggcaaaata acttcactgg ctttttttat caagaaaaga cttacctttt ctgaatgcaa
    10381 cagtattagt aaacctaatg gtgacaataa aagcgattct gaataaatga aaaccaatag
    10441 attgttctag ttttactcat aaatataatt cttcatatac tgagttcagt tttttagcca
    10501 taaatgaaga catgggaaaa ccataacatg ttatttgctg agaagttctg gcaaatgaag
    10561 caataaaata atcaaaacta aatcaacatt taaatacaga acataaagag ataaatccaa
    10621 aaccagaaga tctctttgaa agaaaaacct aagtaattaa aaaactgaaa gcacagatat
    10681 tcattatttc acaaataaac gttaatgctt tttagacatc tttaagcaac tttagattgc
    10741 taaaactaaa aaatgcaatt aagacaataa tcttatatat agacaataat tgtcttaata
    10801 ataatcagca tcaaagattc ttagaaatgt tgggagactg tgtggcaaag aaagtacttc
    10861 aattaccagt taccaacaca caacaatttg aaatatccag gaagatcaac ccatagaaca
    10921 aagaaagcta ataaattacc ttttcttgca attggtttga tgtaccatta atatatagat
    10981 attactaata tggcaattag tttatatgct atttgaatat gatagtaata tgaaggaaga
    11041 ttctcttttt tccacttcat tgccaacaaa cagctaactc taaacaacag taaagtgtgg
    11101 aataaattac tttgttaatt aatgtggttt gaagctttgt aggaatccaa ttggatggat
    11161 agcagcagtg gtaagagaac attccggaat aattacctaa attaaggagc ttgccctaga
    11221 atgtaaatca acctactata tctttttatt tgaaaaagtc ttggtagaaa aagcatatca
    11281 actgaactgt acagtgtgtt cagtgactta gtaaagaaca taacttgtgt aaaggctaat
    11341 gcaataagtt tgagattgtt ctctttatgt aatagtttgg aaaacaaaca actgtgatta
    11401 catttagaga tatgatgatt atctagaggg aaagttctgt tgagcatatt tgaacattta
    11461 attattgctg caagaagcca gtttggtccc agctttataa agatatacat tgggctgggt
    11521 gcggtggctc atgcctgtaa tcccagcact ttgggaggcc gaggcaggcg gatcacctga
    11581 ggtcagaggt tcgagaccag cctggccaac atggtgaaac cccatctcta ctaaaaatac
    11641 aaaaattagc tgggcgtggt ggcacacacc tgtattcctt gctactcggg aggctaaggc
    11701 aggagaatcg cttgaaccca ggaagcagag gttgcagtga gccaagattg tgccactgca
    11761 caccagcctg gataaaaaga gtgaaactct gcctcaaaat aaaataataa aatgaaataa
    11821 agatataaat tggccagcta gagttacctg aagttactat cttcaattat ctgaagacag
    11881 ttctgatagc ttcagaattc tttcatacaa ggcaggaatg caacttgttt tttaatggca
    11941 gataaaatca aagagcaaaa gcaaaaggta gaagcttgaa agaccagagt tgctacagat
    12001 tgttattaca tgttccataa tttaacaatt gtcattgaag ttggtgattg tcttgatatt
    12061 gcacatctgt aagaagtaat caaactattg tgaatttgat agaatgcttt aagttttatt
    12121 ttccaacaaa agaatgtcta catacggcaa attcatagat ctggaatcca tttatgtcat
    12181 caaaagagga tttaaattta attgtaagct tatatgatac attgttctaa ctggcaacta
    12241 atgaaggatt aaaaatgaat tttgaaaata ccacaccact tgcttcattt tggataaaag
    12301 ttaaaagtga atattctgag tatgctgaaa ttagtttaaa aacttttttt tcccattccg
    12361 accattatcc ctttgtaaat ctggtttcat cttatgaata atatttttta aaaaccatgg
    12421 aaacagttta gatatacatc aatccatgaa agtagtagta ttgtcaatct accctggatt
    12481 acatatttta acgagaaaga aaccagctca tttgtgacat ttagaatttt tttttttttt
    12541 tttttttttt gagagagagg gtctcattca ttttattgcc caggctggag tgcagtggtg
    12601 caatcgtagc tcactgtaac cttgaacttc tgggctcaag caatcctctc acctcagcct
    12661 gcagctggag cttcaggtgt ctgccatcac gcctggcaaa tttatttttt gtagagacca
    12721 agtctccttg tgttacccag gttggtatca aactcctggt ctcaagtgat cctcccatct
    12781 cggcccccac aagtgttgag atgacaggtg tgagccacct tgcttgacct aaaaactttt
    12841 gaatattaat atgcattgtg tttattcaaa gtatatctaa tggtctaata aacagaatca
    12901 ctacttcaat tataatcttc agttataatt gaagaatgac aaaaagttga gttatagaaa
    12961 ttatattaat cttaaattca cattttcagt gaaagttttt aaataatttt ttctctttcc
    13021 gttttatgtg tgttccaatt ctatttattg aaatttaatt ttatatccat taacataatt
    13081 aaaaattggg gcttttaaaa aatgtttttc attctactaa tttcatttta taatttataa
    13141 aagtactaga ccacaatgga ttaaagaact atcctttcat cacagatagt tcaatgactc
    13201 ctgttttttt ttagaccgag tcttgctctg tcaccccagc tggagtgcag tggtgtgatc
    13261 ttggctcact gcaacctccg tctcccaggt tcaagcaagt ctcctgcctc agccttccga
    13321 gtagctggga ctacaggtgc ccaccaccac acccggctaa tttttgtatt tttagtagag
    13381 acggggtttc accatgttgg tcaggctggt cttgaactcc tgacctcatg atctgcctgc
    13441 ctcggcctcc caaagtgcta ggattacagg cgtgagccac catgcccagc caactcctgt
    13501 tttatagtgt actttctgga atattattca gctttctctt gaattctttt agtaactagg
    13561 agttcactac gtttccatgg acctaactcc aataatgatt ggacagtttt ctccctctgc
    13621 tttttctttc tttctttctt tttttttttt ttttttttga gatggcgtct cctctgtcaa
    13681 tctcggttca ttgcaacctc cacctcccaa gctcaagcga ttcttgtgcc tcagcctcct
    13741 gagtagctgg gattacaggc acccaccacc acacctggct aatttttttt tttggtagag
    13801 acagggtttc accatgttga ccaggctggt cttgaactcc cgacctcagg tgatctggct
    13861 gccttggcct cccaaagtgc tgacattaca ggcatgagcc actgcacctg gccattattg
    13921 gacagtttta atggaaagtg tttccttata ttgagtggaa atcagtctgc ttatggttta
    13981 taatcctcag acttgattct ccccctgaat ctatatgaaa taaatttact cctatttgaa
    14041 aatatttgtc atattccttc ttatttttct ttaagcttta ttttttctta ttatccatat
    14101 gacatgtttc cagaactctc ccttatcctg attgtcctcc tttagacaca tgcttttaat
    14161 gatatatttc ttaaaatgta ttacccagga caacatattt ttttttactg tggacagtat
    14221 acttttacga atggtgccaa taatgcatta cattttttag cagtcatgtc atcctcttga
    14281 tttgcattga gtcatcattt cttaagaggg aatcaggata tcaaaatagt ctccaaactc
    14341 agctgattcc ttctgcagat acactctcca cccttcttga ttccttttcg ggagaaaaga
    14401 aaaaagttta ttttcattgc taacctcact gatttttaat tttaccattt aaatgttagt
    14461 aacagctggt aatgtaacca aagaagattt ttggcagggg atgatgcatt cagagccttc
    14521 actctggcta cagggagacc atggaggatg ggctggaacg gaagcacgat ggactcctgg
    14581 gcacaccgtt aagtgactga tggagtcatt cagctgacaa atgataatgg cctggattaa
    14641 ggaaggagaa gaggggacca agaaatgcca gagatacata ggaagtaaaa attaataggc
    14701 cttggcaact attttttttt tttttttttg agacagagac ttgctgtgtt gcccaggctg
    14761 gagtgcagtg gggtgatctc ggctcactgc aacctctgcc tcctggattc aagcaatttt
    14821 cgtgcctcaa cctcctgagt agctgggact acaggtgtgc atcaccattc ccaggtaatt
    14881 tttgtatttt tagtatagat ggagtttcgc cattctggcc aggctggtct cgagctcctg
    14941 acctcaagtg attcgcccgc gtcggcctcc caaagggctg ggattacaga catcagccac
    15001 tgcacctggg ttggcaacta atttacacgg aatggcagag agtgattaat gaaaaagcgg
    15061 ggagaaaagc tgctcttgac atctgaaagc tgacttggca ttcacagcta ggctatgtta
    15121 ttttcctatt gggcataagt ctcacagaat accaacatta aacaagatga ctctgaaacc
    15181 ttaataaagt gagaaaaaac aagtccactt tgtaattttg tctaagcaca ggcaaaaaga
    15241 gggtcatggt gccatccaga aaataccaaa aatcaccctc tctcagctaa aatgagcaac
    15301 tgctacttta ccagtgacag ctttgtccca gctctagtct gccttcccta tagagaagat
    15361 gtattgagat aatcatgaaa ttctccttct ttctgatagt atccaatctg gagcaaaccc
    15421 gtttccttag accctctccc aatcccaaat tctatactag gttcttctaa acactctcat
    15481 actgagacac cccatggttc cctatgttgt gtgttcttct ttgctgcaat gagtaataaa
    15541 ctcaacttgt ttaacta
//
