LOCUS       NM_016491               1483 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein L37 (MRPL37),
            transcript variant 2, mRNA.
ACCESSION   NM_016491
VERSION     NM_016491.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1483)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1483)
  AUTHORS   Sundquist,K., Ahmad,A., Svensson,P.J., Zoller,B., Sundquist,J. and
            Memon,A.A.
  TITLE     Polymorphisms in PARK2 and MRPL37 are associated with higher risk
            of recurrent venous thromboembolism in a sex-specific manner
  JOURNAL   J Thromb Thrombolysis 46 (2), 154-165 (2018)
   PUBMED   29671165
  REMARK    GeneRIF: male VTE patients with MRPL37 polymorphism had a
            significantly higher risk of VTE recurrence
REFERENCE   3  (bases 1 to 1483)
  AUTHORS   Brown,A., Rathore,S., Kimanius,D., Aibara,S., Bai,X.C., Rorbach,J.,
            Amunts,A. and Ramakrishnan,V.
  TITLE     Structures of the human mitochondrial ribosome in native states of
            assembly
  JOURNAL   Nat Struct Mol Biol 24 (10), 866-869 (2017)
   PUBMED   28892042
REFERENCE   4  (bases 1 to 1483)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   5  (bases 1 to 1483)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   6  (bases 1 to 1483)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1483)
  AUTHORS   Levshenkova,E.V., Ukraintsev,K.E., Orlova,V.V., Alibaeva,R.A.,
            Kovriga,I.E., Zhugdernamzhilyn,O. and Frolova,E.I.
  TITLE     [The structure and specific features of the cDNA expression of the
            human gene MRPL37]
  JOURNAL   Bioorg Khim 30 (5), 499-506 (2004)
   PUBMED   15562971
  REMARK    GeneRIF: MRPL37 gene is widely represented in the lymphoma
            populations of Raji B cells and MT4 T cells, as well as in
            pancreas, liver, and lung embryonic fibroblasts, which may imply
            the MRPL37 involvement in the process of apoptosis.
REFERENCE   8  (bases 1 to 1483)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   9  (bases 1 to 1483)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   10 (bases 1 to 1483)
  AUTHORS   Graack,H.R., Bryant,M.L. and O'Brien,T.W.
  TITLE     Identification of mammalian mitochondrial ribosomal proteins (MRPs)
            by N-terminal sequencing of purified bovine MRPs and comparison to
            data bank sequences: the large subribosomal particle
  JOURNAL   Biochemistry 38 (50), 16569-16577 (1999)
   PUBMED   10600119
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK024572.1 and AI245012.1.
            
            On Feb 27, 2020 this sequence version replaced NM_016491.3.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 39S subunit protein. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 3' UTR and
            coding sequence compared to variant 1. The resulting isoform (2)
            has a shorter and distinct C-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK024572.1, AK026171.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000360840.9/
                                                  ENSP00000354086.5
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1271              AK024572.1         1-1271
            1272-1483           AI245012.1         5-216               c
FEATURES             Location/Qualifiers
     source          1..1483
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..1483
                     /gene="MRPL37"
                     /gene_synonym="L2mt; L37mt; mL37; MRP-L2; MRP-L37; MRPL2;
                     RPML2"
                     /note="mitochondrial ribosomal protein L37"
                     /db_xref="GeneID:51253"
                     /db_xref="HGNC:HGNC:14034"
                     /db_xref="MIM:611843"
     exon            1..423
                     /gene="MRPL37"
                     /gene_synonym="L2mt; L37mt; mL37; MRP-L2; MRP-L37; MRPL2;
                     RPML2"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1349
                     /gene="MRPL37"
                     /gene_synonym="L2mt; L37mt; mL37; MRP-L2; MRP-L37; MRPL2;
                     RPML2"
                     /note="isoform 2 is encoded by transcript variant 2;
                     ribosomal protein, mitochondrial, L2; 39S ribosomal
                     protein L37, mitochondrial; 39S ribosomal protein L2,
                     mitochondrial; mitochondrial large ribosomal subunit
                     protein mL37"
                     /codon_start=1
                     /product="large ribosomal subunit protein mL37 isoform 2"
                     /protein_id="NP_057575.2"
                     /db_xref="CCDS:CCDS589.1"
                     /db_xref="GeneID:51253"
                     /db_xref="HGNC:HGNC:14034"
                     /db_xref="MIM:611843"
                     /translation="MALASGPARRALAGSGQLGLGGFGAPRRGAYEWGVRSTRKSEPP
                     PLDRVYEIPGLEPITFAGKMHFVPWLARPIFPPWDRGYKDPRFYRSPPLHEHPLYKDQ
                     ACYIFHHRCRLLEGVKQALWLTKTKLIEGLPEKVLSLVDDPRNHIENQDECVLNVISH
                     ARLWQTTEEIPKRETYCPVIVDNLIQLCKSQILKHPSLARRICVQNSTFSATWNRESL
                     LLQVRGSGGARLSTKDPLPTIASREEIEATKNHVLETFYPISPIIDLHECNIYDVKND
                     TGFQEGYPYPYPHTLYLLDKANLRPHRLQPDQLRAKMILFAFGSALAQARLLYGNDAK
                     VLEQPVVVQSVGTDGRVFHFLVFQLNTTDLDCNEGVKNLAWVDSDQLLYQHFWCLPVI
                     KKRVVVEPVGPVGFKPETFRKFLALYLHGAA"
     exon            424..607
                     /gene="MRPL37"
                     /gene_synonym="L2mt; L37mt; mL37; MRP-L2; MRP-L37; MRPL2;
                     RPML2"
                     /inference="alignment:Splign:2.1.0"
     exon            608..723
                     /gene="MRPL37"
                     /gene_synonym="L2mt; L37mt; mL37; MRP-L2; MRP-L37; MRPL2;
                     RPML2"
                     /inference="alignment:Splign:2.1.0"
     exon            724..909
                     /gene="MRPL37"
                     /gene_synonym="L2mt; L37mt; mL37; MRP-L2; MRP-L37; MRPL2;
                     RPML2"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1067
                     /gene="MRPL37"
                     /gene_synonym="L2mt; L37mt; mL37; MRP-L2; MRP-L37; MRPL2;
                     RPML2"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1271
                     /gene="MRPL37"
                     /gene_synonym="L2mt; L37mt; mL37; MRP-L2; MRP-L37; MRPL2;
                     RPML2"
                     /inference="alignment:Splign:2.1.0"
     exon            1272..1483
                     /gene="MRPL37"
                     /gene_synonym="L2mt; L37mt; mL37; MRP-L2; MRP-L37; MRPL2;
                     RPML2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1457..1462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL37"
                     /gene_synonym="L2mt; L37mt; mL37; MRP-L2; MRP-L37; MRPL2;
                     RPML2"
                     /note="hexamer: AATAAA"
     polyA_site      1483
                     /gene="MRPL37"
                     /gene_synonym="L2mt; L37mt; mL37; MRP-L2; MRP-L37; MRPL2;
                     RPML2"
                     /note="major polyA site"
ORIGIN      
        1 ctcattcgtt cccagcaggc cctgcgcgcg gcaacatggc ggggtccagg tggaggtctt
       61 gaggctatca gatcggtatg gcattggcgt ccgggcccgc aaggcgggcg ctagctggct
      121 ccgggcagct cggccttggg ggcttcgggg ccccgagacg cggggcgtat gagtggggcg
      181 tgcgctccac gcggaagtcg gagcctcctc ccctggatag ggtgtacgag atccctggac
      241 tggagcccat cacctttgcg gggaagatgc acttcgtgcc ctggctggcg cggccgatct
      301 ttccgccctg ggaccgcggc tacaaggacc caaggttcta ccgctcgccc cctcttcacg
      361 agcatccgct gtacaaagac caggcctgct atatctttca ccaccgttgc cgccttctcg
      421 agggtgtaaa gcaggccctc tggctcacca agaccaagtt aatagaaggc cttcccgaga
      481 aagtgcttag ccttgttgat gatccaagga accacataga gaaccaagac gagtgcgttc
      541 tgaatgtgat ctctcacgcc cgtctctggc agaccactga ggaaatcccc aagagagaga
      601 cctactgccc ggtcatcgtg gacaacctaa tacagctgtg taaatctcag attctcaagc
      661 atccttctct ggccaggagg atctgtgtcc aaaactccac gttttctgct acctggaacc
      721 gagagtctct tctccttcaa gtccgtggtt ctggtggagc ccgactgagc actaaggatc
      781 ctctgcccac catcgcctcc agagaggaga ttgaagctac taagaatcat gttctagaga
      841 ccttctaccc catatcaccc atcatcgatc ttcatgaatg caatatttat gatgtgaaaa
      901 atgacacagg attccaggaa ggctatcctt acccctatcc ccataccctg tacttactgg
      961 acaaagccaa tttacgacca caccgccttc aaccagatca gctgcgggcc aagatgatcc
     1021 tgtttgcttt tggcagtgcc ctggctcagg cccggctcct ctatgggaat gatgccaagg
     1081 tcttggagca gcccgtggtg gtgcagagcg tgggcacgga tggacgtgtc ttccatttcc
     1141 tagtgtttca actgaatacc acagacctgg actgtaacga gggtgtcaag aatttggcct
     1201 gggtggactc agaccagctc ctctatcagc atttttggtg tctcccagtg atcaaaaaga
     1261 gagtggttgt ggaacctgtt ggcccagttg gtttcaagcc agagacattc agaaagtttt
     1321 tagctctata tttgcatggt gctgcgtgag cggaggaccc ctctgaatcc tgaaacccct
     1381 cttgcctctc ttccacggaa gagggcctgg gccccgtgga gcctcagtgc ccgtttggcc
     1441 tgctgctctc gctgacaata aagagccctt gcgttgcact gaa
//
