LOCUS       NM_016622               3723 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein L35 (MRPL35),
            transcript variant 1, mRNA.
ACCESSION   NM_016622
VERSION     NM_016622.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3723)
  AUTHORS   Hou,W., Chen,J. and Wang,Y.
  TITLE     MRPL35 Induces Proliferation, Invasion, and Glutamine Metabolism in
            NSCLC Cells by Upregulating SLC7A5 Expression
  JOURNAL   Clin Respir J 18 (7), e13799 (2024)
   PUBMED   38987867
  REMARK    GeneRIF: MRPL35 Induces Proliferation, Invasion, and Glutamine
            Metabolism in NSCLC Cells by Upregulating SLC7A5 Expression.
REFERENCE   2  (bases 1 to 3723)
  AUTHORS   Zhao,C., Chen,L., Jin,Z., Liu,H., Ma,C., Zhou,H., Xu,L., Zhou,S.,
            Shi,Y., Li,W., Chen,Y., Dou,C. and Wang,X.
  TITLE     Knockdown of MRPL35 promotes cell apoptosis and inhibits cell
            proliferation in non-small-cell lung cancer
  JOURNAL   BMC Pulm Med 23 (1), 507 (2023)
   PUBMED   38093266
  REMARK    GeneRIF: Knockdown of MRPL35 promotes cell apoptosis and inhibits
            cell proliferation in non-small-cell lung cancer.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3723)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 3723)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3723)
  AUTHORS   Zhang,L., Lu,P., Yan,L., Yang,L., Wang,Y., Chen,J., Dai,J., Li,Y.,
            Kang,Z., Bai,T., Xi,Y., Xu,J., Sun,G. and Yang,T.
  TITLE     MRPL35 Is Up-Regulated in Colorectal Cancer and Regulates
            Colorectal Cancer Cell Growth and Apoptosis
  JOURNAL   Am J Pathol 189 (5), 1105-1120 (2019)
   PUBMED   30862482
  REMARK    GeneRIF: High MRPL35 expression Cooperate in Colorectal Cancer.
REFERENCE   6  (bases 1 to 3723)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3723)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   8  (bases 1 to 3723)
  AUTHORS   Koc,E.C., Burkhart,W., Blackburn,K., Moyer,M.B., Schlatzer,D.M.,
            Moseley,A. and Spremulli,L.L.
  TITLE     The large subunit of the mammalian mitochondrial ribosome. Analysis
            of the complement of ribosomal proteins present
  JOURNAL   J Biol Chem 276 (47), 43958-43969 (2001)
   PUBMED   11551941
REFERENCE   9  (bases 1 to 3723)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   10 (bases 1 to 3723)
  AUTHORS   Auffray,C., Behar,G., Bois,F., Bouchier,C., Da Silva,C.,
            Devignes,M.D., Duprat,S., Houlgatte,R., Jumeau,M.N., Lamy,B. et al.
  TITLE     [IMAGE: molecular integration of the analysis of the human genome
            and its expression]
  JOURNAL   C R Acad Sci III 318 (2), 263-272 (1995)
   PUBMED   7757816
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA443416.1, BQ421154.1,
            DB245340.1, BQ879834.1, BG108475.1, AL832982.1, BU195549.1,
            F11007.1, H11039.1 and AC009309.4.
            
            On Nov 23, 2018 this sequence version replaced NM_016622.3.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 39S subunit protein. Sequence
            analysis identified three transcript variants. Pseudogenes
            corresponding to this gene are found on chromosomes 6p, 10q, and
            Xp. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) is the predominant transcript
            and encodes isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.117495.1,
                                           SRR1803617.279807.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000337109.9/
                                                  ENSP00000338389.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-600               DA443416.1         1-600
            601-955             BQ421154.1         462-816
            956-1370            DB245340.1         162-576
            1371-1705           BQ879834.1         390-724
            1706-2127           BG108475.1         122-543
            2128-2780           AL832982.1         2100-2752
            2781-3186           BU195549.1         262-667
            3187-3255           F11007.1           32-100              c
            3256-3287           H11039.1           13-44               c
            3288-3723           AC009309.4         6784-7219           c
FEATURES             Location/Qualifiers
     source          1..3723
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p11.2"
     gene            1..3723
                     /gene="MRPL35"
                     /gene_synonym="bL35m; L35mt; MRP-L35"
                     /note="mitochondrial ribosomal protein L35"
                     /db_xref="GeneID:51318"
                     /db_xref="HGNC:HGNC:14489"
                     /db_xref="MIM:611841"
     exon            1..77
                     /gene="MRPL35"
                     /gene_synonym="bL35m; L35mt; MRP-L35"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..601
                     /gene="MRPL35"
                     /gene_synonym="bL35m; L35mt; MRP-L35"
                     /note="isoform a is encoded by transcript variant 1; 39S
                     ribosomal protein L35, mitochondrial; mitochondrial large
                     ribosomal subunit protein bL35m"
                     /codon_start=1
                     /product="large ribosomal subunit protein bL35m isoform a"
                     /protein_id="NP_057706.2"
                     /db_xref="CCDS:CCDS1988.1"
                     /db_xref="GeneID:51318"
                     /db_xref="HGNC:HGNC:14489"
                     /db_xref="MIM:611841"
                     /translation="MAASAFAGAVRAASGILRPLNILASSTYRNCVKNASLISALSTG
                     RFSHIQTPVVSSTPRLTTSERNLTCGHTSVILNRMAPVLPSVLKLPVRSLTYFSARKG
                     KRKTVKAVIDRFLRLHCGLWVRRKAGYKKKLWKKTPARKKRLREFVFCNKTQSKLLDK
                     MTTSFWKRRNWYVDDPYQKYHDRTNLKV"
     exon            78..267
                     /gene="MRPL35"
                     /gene_synonym="bL35m; L35mt; MRP-L35"
                     /inference="alignment:Splign:2.1.0"
     exon            268..412
                     /gene="MRPL35"
                     /gene_synonym="bL35m; L35mt; MRP-L35"
                     /inference="alignment:Splign:2.1.0"
     exon            413..3723
                     /gene="MRPL35"
                     /gene_synonym="bL35m; L35mt; MRP-L35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      728..733
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL35"
                     /gene_synonym="bL35m; L35mt; MRP-L35"
                     /note="hexamer: ATTAAA"
     polyA_site      756
                     /gene="MRPL35"
                     /gene_synonym="bL35m; L35mt; MRP-L35"
                     /note="major polyA site"
     regulatory      3143..3148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL35"
                     /gene_synonym="bL35m; L35mt; MRP-L35"
                     /note="hexamer: AATAAA"
     polyA_site      3168
                     /gene="MRPL35"
                     /gene_synonym="bL35m; L35mt; MRP-L35"
     regulatory      3704..3709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL35"
                     /gene_synonym="bL35m; L35mt; MRP-L35"
                     /note="hexamer: AATAAA"
     polyA_site      3723
                     /gene="MRPL35"
                     /gene_synonym="bL35m; L35mt; MRP-L35"
                     /note="major polyA site"
ORIGIN      
        1 aaacccaaag cggccgccgt aggcgaaggt gaagatggct gcctctgcct ttgctggtgc
       61 agtgagagca gcttcaggaa tcctacggcc cctgaatatt ttggcatctt caacctaccg
      121 caactgtgtc aagaatgcct ctcttatttc tgcattgtcc actggacgtt ttagtcatat
      181 tcagacacca gttgtttcct ccactcccag acttaccaca tctgagagaa acctgacatg
      241 tgggcatacc tcagtgatcc ttaatagaat ggcccccgtg cttccaagtg tcctgaagct
      301 gccagtcaga tctctaacat acttcagtgc aagaaaaggc aagagaaaga ccgtgaaagc
      361 tgtcatcgat aggtttcttc gacttcattg tggcctttgg gtgaggagaa aggctggcta
      421 taagaaaaaa ttatggaaaa agacacctgc aaggaagaag cgattgaggg aatttgtatt
      481 ctgcaataaa acccagagta aactcttaga taaaatgacg acgtccttct ggaagaggcg
      541 aaactggtac gttgatgatc cttatcagaa gtatcatgat cgaacaaacc tgaaagtata
      601 gatcagaagt ttcacttgtt tctcagttat tggatatgta tctttgtgta catatctttg
      661 caaaaatgga taagtacaaa acttgatgta aattgtacca atgaatacgt aaacatacag
      721 tgacaacatt aaacttagaa aagttttaaa acttaatgga tcagactttg ccagatttgg
      781 ttagggaaac agaaatttag aatggtgcat tatttttaac aaatggtatt ggcttaacta
      841 gttgtttcag ttatgctctt ttagttgcaa ggaatctcaa gtgggacaaa cataaaaaga
      901 ctcaaaagct acaagttagc tcaagcaatg tgacattatt tcaaggatat gtgccaggga
      961 attcaggaac cacctcacca accccatctc ccactcagaa atcacctccc agcctcagga
     1021 agagtagaaa ttgggtggtg ctcctcagca ggggaaggtg gatgtttagg cttgggctct
     1081 gcatgcatgt gacttgcttc tttttgcatt gttaactcca ttctctctat tcaccaactt
     1141 ctctacacag cttttgcata cttacagttt ctgttccttt gtaataactt taacttgcac
     1201 ctttgaggtt cttttctaca tgatgacctt cagctcctgc tgctagtctc caattgccaa
     1261 gggaatttaa ctgggccaga ctaccttttt atactaggtc tggttgggtc attgtctaga
     1321 gtagggattg gctgtcctta agtcaggagc ccgctttgta ttagcaggtt tgcatgcagc
     1381 aaaaaaacag ttatgtgagc agtttcactt ggaggttcac atggggtggc agcacactta
     1441 acatctaaca caccaggttc attgtgttca taacacttgt catttactgt aacaacattt
     1501 tttcatagga gagtaaatag cccttcagca tgctcattca tgaaacagaa gaggctgtac
     1561 aagtgaagac aagggctttt tatgcaagtt ttgaaagata ggtatttatt ttttctagag
     1621 acaggagttt tgctctgttg cccaggctgg agtgcagtgg tgcaatcata gctcattgaa
     1681 gcctcgcact cctgggctca agtggtcctc ctgcctcagc ttactgagta aggatatgta
     1741 tttcttaaaa gttagtttat ccacttcaga tttcatgttt tcatttgtaa ggataaactt
     1801 ttcccacaaa ttttcaacaa tcattgtaga aactaagggg gagaaagtaa tctcagttgt
     1861 tttagaaacg aaaaagttaa gcattgttta cttgaagtgg gcagggaagc agcactgagt
     1921 aaagttcaat tgagtggtta cagtctaggg cagtggttcc caactctccg atcagaatca
     1981 tctgggaagc attttcaaac agcaaagtac tttgaaaacc attattaaat agaattatgc
     2041 atgaattact gtttcagatc ctttaatgtg gtagttggta ataataagat gaaattcctc
     2101 tgttgttagt aaaattatga aattgaagtt ctgcagcatg tcaggccagg attattaggg
     2161 agattcctcg aaactagtgt gtgtttatta aaaggagaaa ggataacaat agaatgttct
     2221 aaaaccagaa gtccaagtgc gtgtctactt atgggaccaa taaataaaga acagacattt
     2281 gatttgaggt gaggtaaaag cctgaaacat ggaatggcat tctgttttga tggattttca
     2341 tttcttcgca cttctgagac ggcaaagcca accacttaga agccttccac atctttgtca
     2401 cctgcctggc tcctgctctc tgatgtacct ctgggtagtg agatggaaat ggtgcctgca
     2461 gaagttgggg agaaggatac ttttgcacag cctccatgat gtctttattg caaatatgga
     2521 tgacaagggt ctctgttaca ggggcctcag agcaccttcg tttctcctct agaccaggga
     2581 caggtgtaga gataaggact ggcaaccaga gcctcagcat ccaaagatgg actgaagtgg
     2641 gatggctgac aggcacataa cttacgggaa agggaatttc atacatacga tttttgtttt
     2701 gtgggtagga gggcttatca tcaacactga ttttataatc tgacaataaa tgtctttcat
     2761 taaagagttt acctaaatga tgttcgatta tatgtataat ttataaaata tttatgtata
     2821 gtttgtttat tcaggtatat gtataattta ttgaacacct actatgtccc agcatatcta
     2881 caaaactggg tacatacata ctgtctaact gctaatccac atttccagtc ttacaaagga
     2941 cataatgatt agttaagccc taatttagat ttgaggaaac tgaagctgag agagggttaa
     3001 gtaaattacc caaagtacag ctaataagac ccagaatctc agtctcactc cttgggatcc
     3061 tgtgtatttc cctgagtctt ctaacatatg aaaattcata tctaaatcaa caagtgactg
     3121 taatctggta ctataaatac taaataaaca cttcttcata acactgtacc aattcagctt
     3181 ttaaatttta ttactttgct ttcctgtcct ttgccaactc ttaacctagt taatcctagt
     3241 tctgttgaca ttggaccagg ctcagtaaat aaacgaatgg atttccagcc tttttttccc
     3301 atctgttcct gcttttagtc ctctgaatct gcttcttttc ttactgctgc tttattttac
     3361 agtgattttg tcaaacatag aatacaggac taaaaatgca aagaaattgg gtctgtgttt
     3421 aattttgatg tttcaaattt tgagcttcca agtctttgtg gccacccaat gaagtttgag
     3481 tctgcctgtt cagatgtgaa aggtaagggc tgcagcaggt ttaagggtgg cccttcacca
     3541 ccctgttgtc acctgcacag gcactccccc atttgcagat gaagaaatgt tcagagaaga
     3601 aaaatgatgg accaaacgtc tgtttgcaca attgaaactc taccagtgga ctattctatt
     3661 ttcacagcta cctagtttct gccgatgatt tttttaaatg tgaaataaac agtgatactt
     3721 tca
//
