LOCUS       NM_023937                764 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein L34 (MRPL34),
            transcript variant 3, mRNA.
ACCESSION   NM_023937
VERSION     NM_023937.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 764)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 764)
  AUTHORS   Brown,A., Rathore,S., Kimanius,D., Aibara,S., Bai,X.C., Rorbach,J.,
            Amunts,A. and Ramakrishnan,V.
  TITLE     Structures of the human mitochondrial ribosome in native states of
            assembly
  JOURNAL   Nat Struct Mol Biol 24 (10), 866-869 (2017)
   PUBMED   28892042
REFERENCE   3  (bases 1 to 764)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   4  (bases 1 to 764)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   5  (bases 1 to 764)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 764)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   7  (bases 1 to 764)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   8  (bases 1 to 764)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Structural compensation for the deficit of rRNA with proteins in
            the mammalian mitochondrial ribosome. Systematic analysis of
            protein components of the large ribosomal subunit from mammalian
            mitochondria
  JOURNAL   J Biol Chem 276 (24), 21724-21736 (2001)
   PUBMED   11279069
REFERENCE   9  (bases 1 to 764)
  AUTHORS   Graack,H.R., Bryant,M.L. and O'Brien,T.W.
  TITLE     Identification of mammalian mitochondrial ribosomal proteins (MRPs)
            by N-terminal sequencing of purified bovine MRPs and comparison to
            data bank sequences: the large subribosomal particle
  JOURNAL   Biochemistry 38 (50), 16569-16577 (1999)
   PUBMED   10600119
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010463.6.
            
            On Jun 2, 2019 this sequence version replaced NM_023937.3.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 39S subunit protein. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7346977.8579.1, BC000071.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000252602.2/
                                                  ENSP00000252602.1
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression,
                                                  longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AC010463.6         68533-68618         c
            87-764              AC010463.6         67647-68324         c
FEATURES             Location/Qualifiers
     source          1..764
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..764
                     /gene="MRPL34"
                     /gene_synonym="bL34m; L34mt"
                     /note="mitochondrial ribosomal protein L34"
                     /db_xref="GeneID:64981"
                     /db_xref="HGNC:HGNC:14488"
                     /db_xref="MIM:611840"
     exon            1..86
                     /gene="MRPL34"
                     /gene_synonym="bL34m; L34mt"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..300
                     /gene="MRPL34"
                     /gene_synonym="bL34m; L34mt"
                     /note="isoform a is encoded by transcript variant 3; 39S
                     ribosomal protein L34, mitochondrial; MRP-L34;
                     mitochondrial large ribosomal subunit protein bL34m"
                     /codon_start=1
                     /product="large ribosomal subunit protein bL34m isoform a"
                     /protein_id="NP_076426.1"
                     /db_xref="CCDS:CCDS12356.1"
                     /db_xref="GeneID:64981"
                     /db_xref="HGNC:HGNC:14488"
                     /db_xref="MIM:611840"
                     /translation="MAVLAGSLLGPTSRSAALLGGRWLQPRAWLGFPDAWGLPTPQQA
                     RGKARGNEYQPSNIKRKNKHGWVRRLSTPAGVQVILRRMLKGRKSLSH"
     exon            87..764
                     /gene="MRPL34"
                     /gene_synonym="bL34m; L34mt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      740..745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL34"
                     /gene_synonym="bL34m; L34mt"
                     /note="hexamer: AATAAA"
     polyA_site      764
                     /gene="MRPL34"
                     /gene_synonym="bL34m; L34mt"
                     /note="major polyA site"
ORIGIN      
        1 actgcgggac ccactgcgga tatggctgtc ttggctggat ccctgttggg ccccacgagt
       61 aggtcggcag cgttgctggg tggcaggtgg ctccagcccc gggcctggct ggggttccca
      121 gacgcctggg gcctccccac cccgcagcag gcccggggca aggctcgcgg gaatgagtat
      181 cagccgagca acatcaaacg caagaacaag cacggctggg tccggcgcct gagcacgccg
      241 gccggcgtgc aggtcatcct tcgccgaatg ctcaagggcc gcaagtcgct gagccattga
      301 ggatcgcgac gcagtcggcg ggaccctcat ggaagcatcg ccctcgcctc ggaccttgcc
      361 tggcgctatt tttgcaggga gctggggagc aggaacgcct cggacctgag tgctctccat
      421 attgtggggt tgaagtctgg atgggagctt gccaagtccc tttttaggct ttttaattag
      481 gaagcatttc gaacctgcgc aacagaccaa agaacagtac aaagaacatc cgtgtaccca
      541 gtaccctgac taccgactac ctacaacccg tccctgcccc atcctgagtt cttttgaagc
      601 tgatctcagg catcggatta tttcttctgt aaatatttca gaatgtatct ctccaagatg
      661 agagctcatt aaaagacaat tacaaagctt atcacatcca aaagaattat caataatttt
      721 gaaatattat taaacgtgta ataaatgttc aaagttccac ttgc
//
