LOCUS       NM_007208               1708 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein L3 (MRPL3), mRNA.
ACCESSION   NM_007208
VERSION     NM_007208.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1708)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1708)
  AUTHORS   Brown,A., Rathore,S., Kimanius,D., Aibara,S., Bai,X.C., Rorbach,J.,
            Amunts,A. and Ramakrishnan,V.
  TITLE     Structures of the human mitochondrial ribosome in native states of
            assembly
  JOURNAL   Nat Struct Mol Biol 24 (10), 866-869 (2017)
   PUBMED   28892042
REFERENCE   3  (bases 1 to 1708)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   4  (bases 1 to 1708)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   5  (bases 1 to 1708)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 1708)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1708)
  AUTHORS   Richter,R., Rorbach,J., Pajak,A., Smith,P.M., Wessels,H.J.,
            Huynen,M.A., Smeitink,J.A., Lightowlers,R.N. and
            Chrzanowska-Lightowlers,Z.M.
  TITLE     A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into
            the human mitochondrial ribosome
  JOURNAL   EMBO J 29 (6), 1116-1125 (2010)
   PUBMED   20186120
REFERENCE   8  (bases 1 to 1708)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   9  (bases 1 to 1708)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   10 (bases 1 to 1708)
  AUTHORS   Ou,J.H., Yen,T.S., Wang,Y.F., Kam,W.K. and Rutter,W.J.
  TITLE     Cloning and characterization of a human ribosomal protein gene with
            enhanced expression in fetal and neoplastic cells
  JOURNAL   Nucleic Acids Res 15 (21), 8919-8934 (1987)
   PUBMED   2891103
  REMARK    Erratum:[Nucleic Acids Res 1988 May 11;16(9):4196]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC398662.1, BC003375.2 and
            X06323.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_007208.3.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 39S subunit protein that belongs to
            the L3P ribosomal protein family. A pseudogene corresponding to
            this gene is found on chromosome 13q. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X06323.1, BC003375.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000264995.8/
                                                  ENSP00000264995.2
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                DC398662.1         46-101
            57-1546             BC003375.2         1-1490
            1547-1708           X06323.1           1473-1634
FEATURES             Location/Qualifiers
     source          1..1708
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.1"
     gene            1..1708
                     /gene="MRPL3"
                     /gene_synonym="COXPD9; MRL3; RPML3; uL3m"
                     /note="mitochondrial ribosomal protein L3"
                     /db_xref="GeneID:11222"
                     /db_xref="HGNC:HGNC:10379"
                     /db_xref="MIM:607118"
     exon            1..242
                     /gene="MRPL3"
                     /gene_synonym="COXPD9; MRL3; RPML3; uL3m"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1197
                     /gene="MRPL3"
                     /gene_synonym="COXPD9; MRL3; RPML3; uL3m"
                     /note="mitochondrial 60S ribosomal protein L3; 39S
                     ribosomal protein L3, mitochondrial; L3mt; MRP-L3;
                     mitochondrial large ribosomal subunit protein uL3m"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL3m"
                     /protein_id="NP_009139.1"
                     /db_xref="CCDS:CCDS3071.1"
                     /db_xref="GeneID:11222"
                     /db_xref="HGNC:HGNC:10379"
                     /db_xref="MIM:607118"
                     /translation="MPGWRLLTQVGAQVLGRLGDGLGAALGPGNRTHIWLFVRGLHGK
                     SGTWWDEHLSEENVPFIKQLVSDEDKAQLASKLCPLKDEPWPIHPWEPGSFRVGLIAL
                     KLGMMPLWTKDGQKHVVTLLQVQDCHVLKYTSKENCNGKMATLSVGGKTVSRFRKATS
                     ILEFYRELGLPPKQTVKIFNITDNAAIKPGTPLYAAHFRPGQYVDVTAKTIGKGFQGV
                     MKRWGFKGQPATHGQTKTHRRPGAVATGDIGRVWPGTKMPGKMGNIYRTEYGLKVWRI
                     NTKHNIIYVNGSVPGHKNCLVKVKDSKLPAYKDLGKNLPFPTYFPDGDEEELPEDLYD
                     ENVCQPGAPSITFA"
     exon            243..427
                     /gene="MRPL3"
                     /gene_synonym="COXPD9; MRL3; RPML3; uL3m"
                     /inference="alignment:Splign:2.1.0"
     exon            428..519
                     /gene="MRPL3"
                     /gene_synonym="COXPD9; MRL3; RPML3; uL3m"
                     /inference="alignment:Splign:2.1.0"
     exon            520..618
                     /gene="MRPL3"
                     /gene_synonym="COXPD9; MRL3; RPML3; uL3m"
                     /inference="alignment:Splign:2.1.0"
     exon            619..718
                     /gene="MRPL3"
                     /gene_synonym="COXPD9; MRL3; RPML3; uL3m"
                     /inference="alignment:Splign:2.1.0"
     exon            719..779
                     /gene="MRPL3"
                     /gene_synonym="COXPD9; MRL3; RPML3; uL3m"
                     /inference="alignment:Splign:2.1.0"
     exon            780..888
                     /gene="MRPL3"
                     /gene_synonym="COXPD9; MRL3; RPML3; uL3m"
                     /inference="alignment:Splign:2.1.0"
     exon            889..966
                     /gene="MRPL3"
                     /gene_synonym="COXPD9; MRL3; RPML3; uL3m"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1044
                     /gene="MRPL3"
                     /gene_synonym="COXPD9; MRL3; RPML3; uL3m"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1708
                     /gene="MRPL3"
                     /gene_synonym="COXPD9; MRL3; RPML3; uL3m"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1520..1525
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL3"
                     /gene_synonym="COXPD9; MRL3; RPML3; uL3m"
                     /note="hexamer: ATTAAA"
     polyA_site      1546
                     /gene="MRPL3"
                     /gene_synonym="COXPD9; MRL3; RPML3; uL3m"
                     /note="major polyA site"
     regulatory      1690..1695
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL3"
                     /gene_synonym="COXPD9; MRL3; RPML3; uL3m"
                     /note="hexamer: AATAAA"
     polyA_site      1708
                     /gene="MRPL3"
                     /gene_synonym="COXPD9; MRL3; RPML3; uL3m"
                     /note="major polyA site"
ORIGIN      
        1 gcagagagca tcggccggcg accgttccgg cggccattgc gaaaacttcc ccacggctac
       61 tgcgtccacg tggcggtggc gtggggactc cctgaaagca gagcggcagg gcgcccggaa
      121 gtcgtgagtc gagtcttccc gggctaatcc atgccgggtt ggaggctgct gacgcaggtc
      181 ggcgcccagg tgctgggtcg actcggggac ggcctgggtg ctgccctggg cccggggaac
      241 agaacacaca tctggctttt tgttagaggt cttcatggaa agagtggtac atggtgggat
      301 gagcatcttt ctgaagaaaa tgtcccattc attaagcagt tggtctctga tgaagataaa
      361 gcccaattag caagtaaact gtgtcctctg aaagatgaac catggcctat acatccttgg
      421 gaaccaggtt cctttagagt tggtcttatt gccttgaagc tgggcatgat gcctttatgg
      481 accaaggatg gtcaaaagca tgtggtcaca ttacttcagg tacaagactg tcatgtctta
      541 aaatatacgt caaaggaaaa ctgtaatgga aaaatggcaa ccctgtctgt aggaggaaaa
      601 actgtatcac gttttcgtaa agctacatcc atattggaat tttaccggga acttggattg
      661 ccgccgaaac agacagttaa aatctttaat ataacagata atgctgcaat taaaccaggc
      721 actcctcttt atgctgctca ctttcgtcca ggacagtatg tggatgtcac agccaaaact
      781 attggtaaag gttttcaagg tgtcatgaaa agatggggat ttaaaggcca gcctgctacg
      841 catggtcaaa cgaaaaccca caggagacct ggagctgttg caactggtga tattggcaga
      901 gtctggcctg gaactaaaat gcctggaaaa atgggaaaca tatacaggac agaatatgga
      961 ctgaaagtgt ggagaataaa cacaaagcac aacataatct atgtaaatgg ctctgtacct
     1021 ggacataaaa attgcttagt aaaggtcaaa gattctaaac tgcctgcata taaggatctc
     1081 ggtaaaaatc taccattccc tacatatttt cctgatggag atgaagagga actgccagaa
     1141 gatttgtatg atgaaaacgt gtgtcagccc ggtgcgcctt ctattacatt tgcctaacat
     1201 ctttggacgt ggcagaacct tacatattct gtgagcttcg atgagccaga gtgatatcat
     1261 aaccaccaga aatcatactc tcctttctta gtcacaacaa aatcacacat gtcatctttg
     1321 tcaagggcat aaatatatca ttcatacccc cattaaattt tgttagaaaa attaccacat
     1381 taaatatatg agttaagtag attggatttg ctgaaattgg tgttgggcat attagcaaaa
     1441 tattcttaat ttgtggactc gattcttttt tactacatat ttcccaagtt atcttaagat
     1501 gtctgtaaat ttaactttta ttaaagtttt gtcaatcttt gtgaaatagt ggttgtggaa
     1561 cagtagaaaa ccatatgggg actatagtgc aacctatttg ggtaaagaaa ccatttgcta
     1621 aaatggagaa agtaaataga tttttattta aattacagaa acatgttaaa ggccggacaa
     1681 aggaaagaca ataaaatcat aaattatc
//
