LOCUS       NP_009139                348 aa            linear   PRI 20-SEP-2024
DEFINITION  large ribosomal subunit protein uL3m [Homo sapiens].
ACCESSION   NP_009139
VERSION     NP_009139.1
DBSOURCE    REFSEQ: accession NM_007208.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 348)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (residues 1 to 348)
  AUTHORS   Brown,A., Rathore,S., Kimanius,D., Aibara,S., Bai,X.C., Rorbach,J.,
            Amunts,A. and Ramakrishnan,V.
  TITLE     Structures of the human mitochondrial ribosome in native states of
            assembly
  JOURNAL   Nat Struct Mol Biol 24 (10), 866-869 (2017)
   PUBMED   28892042
REFERENCE   3  (residues 1 to 348)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   4  (residues 1 to 348)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   5  (residues 1 to 348)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (residues 1 to 348)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 348)
  AUTHORS   Richter,R., Rorbach,J., Pajak,A., Smith,P.M., Wessels,H.J.,
            Huynen,M.A., Smeitink,J.A., Lightowlers,R.N. and
            Chrzanowska-Lightowlers,Z.M.
  TITLE     A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into
            the human mitochondrial ribosome
  JOURNAL   EMBO J 29 (6), 1116-1125 (2010)
   PUBMED   20186120
REFERENCE   8  (residues 1 to 348)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   9  (residues 1 to 348)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   10 (residues 1 to 348)
  AUTHORS   Ou,J.H., Yen,T.S., Wang,Y.F., Kam,W.K. and Rutter,W.J.
  TITLE     Cloning and characterization of a human ribosomal protein gene with
            enhanced expression in fetal and neoplastic cells
  JOURNAL   Nucleic Acids Res 15 (21), 8919-8934 (1987)
   PUBMED   2891103
  REMARK    Erratum:[Nucleic Acids Res 1988 May 11;16(9):4196]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC398662.1, BC003375.2 and
            X06323.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 39S subunit protein that belongs to
            the L3P ribosomal protein family. A pseudogene corresponding to
            this gene is found on chromosome 13q. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X06323.1, BC003375.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000264995.8/
                                                  ENSP00000264995.2
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..348
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.1"
     Protein         1..348
                     /product="large ribosomal subunit protein uL3m"
                     /note="mitochondrial 60S ribosomal protein L3; 39S
                     ribosomal protein L3, mitochondrial; L3mt; MRP-L3;
                     mitochondrial large ribosomal subunit protein uL3m"
                     /calculated_mol_wt=38502
     Region          3..340
                     /region_name="Ribosomal_L3"
                     /note="Ribosomal protein L3; cl46849"
                     /db_xref="CDD:481189"
     CDS             1..348
                     /gene="MRPL3"
                     /gene_synonym="COXPD9; MRL3; RPML3; uL3m"
                     /coded_by="NM_007208.4:151..1197"
                     /db_xref="CCDS:CCDS3071.1"
                     /db_xref="GeneID:11222"
                     /db_xref="HGNC:HGNC:10379"
                     /db_xref="MIM:607118"
ORIGIN      
        1 mpgwrlltqv gaqvlgrlgd glgaalgpgn rthiwlfvrg lhgksgtwwd ehlseenvpf
       61 ikqlvsdedk aqlasklcpl kdepwpihpw epgsfrvgli alklgmmplw tkdgqkhvvt
      121 llqvqdchvl kytskencng kmatlsvggk tvsrfrkats ilefyrelgl ppkqtvkifn
      181 itdnaaikpg tplyaahfrp gqyvdvtakt igkgfqgvmk rwgfkgqpat hgqtkthrrp
      241 gavatgdigr vwpgtkmpgk mgniyrteyg lkvwrintkh niiyvngsvp ghknclvkvk
      301 dsklpaykdl gknlpfptyf pdgdeeelpe dlydenvcqp gapsitfa
//
