LOCUS       NM_016504                686 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein L27 (MRPL27), mRNA.
ACCESSION   NM_016504
VERSION     NM_016504.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 686)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 686)
  AUTHORS   Zhuang,L., Meng,Z. and Yang,Z.
  TITLE     MRPL27 contributes to unfavorable overall survival and disease-free
            survival from cholangiocarcinoma patients
  JOURNAL   Int J Med Sci 18 (4), 936-943 (2021)
   PUBMED   33456351
  REMARK    GeneRIF: MRPL27 contributes to unfavorable overall survival and
            disease-free survival from cholangiocarcinoma patients.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 686)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 686)
  AUTHORS   Brown,A., Rathore,S., Kimanius,D., Aibara,S., Bai,X.C., Rorbach,J.,
            Amunts,A. and Ramakrishnan,V.
  TITLE     Structures of the human mitochondrial ribosome in native states of
            assembly
  JOURNAL   Nat Struct Mol Biol 24 (10), 866-869 (2017)
   PUBMED   28892042
REFERENCE   5  (bases 1 to 686)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   6  (bases 1 to 686)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 686)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 686)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   9  (bases 1 to 686)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   10 (bases 1 to 686)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Structural compensation for the deficit of rRNA with proteins in
            the mammalian mitochondrial ribosome. Systematic analysis of
            protein components of the large ribosomal subunit from mammalian
            mitochondria
  JOURNAL   J Biol Chem 276 (24), 21724-21736 (2001)
   PUBMED   11279069
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF151084.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016504.2.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 39S subunit protein. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF151084.1, SRR1163658.334646.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153932, SAMN03267769
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000225969.9/
                                                  ENSP00000225969.4
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-686               AF151084.1         2-687
FEATURES             Location/Qualifiers
     source          1..686
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.33"
     gene            1..686
                     /gene="MRPL27"
                     /gene_synonym="bL27m; L27mt"
                     /note="mitochondrial ribosomal protein L27"
                     /db_xref="GeneID:51264"
                     /db_xref="HGNC:HGNC:14483"
                     /db_xref="MIM:611837"
     exon            1..54
                     /gene="MRPL27"
                     /gene_synonym="bL27m; L27mt"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..461
                     /gene="MRPL27"
                     /gene_synonym="bL27m; L27mt"
                     /note="39S ribosomal protein L27, mitochondrial; MRP-L27;
                     mitochondrial large ribosomal subunit protein bL27m"
                     /codon_start=1
                     /product="large ribosomal subunit protein bL27m"
                     /protein_id="NP_057588.1"
                     /db_xref="CCDS:CCDS11564.1"
                     /db_xref="GeneID:51264"
                     /db_xref="HGNC:HGNC:14483"
                     /db_xref="MIM:611837"
                     /translation="MASVVLALRTRTAVTSLLSPTPATALAVRYASKKSGGSSKNLGG
                     KSSGRRQGIKKMEGHYVHAGNIIATQRHFRWHPGAHVGVGKNKCLYALEEGIVRYTKE
                     VYVPHPRNTEAVDLITRLPKGAVLYKTFVHVVPAKPEGTFKLVAML"
     exon            55..186
                     /gene="MRPL27"
                     /gene_synonym="bL27m; L27mt"
                     /inference="alignment:Splign:2.1.0"
     exon            187..254
                     /gene="MRPL27"
                     /gene_synonym="bL27m; L27mt"
                     /inference="alignment:Splign:2.1.0"
     exon            255..686
                     /gene="MRPL27"
                     /gene_synonym="bL27m; L27mt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      644..649
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL27"
                     /gene_synonym="bL27m; L27mt"
                     /note="hexamer: AATAAA"
     polyA_site      686
                     /gene="MRPL27"
                     /gene_synonym="bL27m; L27mt"
                     /note="major polyA site"
ORIGIN      
        1 gagtgatcga aagcatggcg tcggtggtgt tggcgctgag gacccggaca gccgttacat
       61 ccttgctaag ccccactccg gctacagctc ttgctgtcag atacgcatcc aagaagtcgg
      121 gtggtagctc caaaaacctc ggtggaaagt catcaggcag acgccaaggc attaagaaaa
      181 tggaaggtca ctatgttcat gctgggaaca tcattgcaac acagcgccat ttccgctggc
      241 acccaggtgc ccatgtgggt gttgggaaga ataaatgtct gtatgccctg gaagagggga
      301 tagtccgcta cactaaggag gtctacgtgc ctcatcccag aaacacggag gctgtggatc
      361 tgatcaccag gctgcccaag ggtgctgtgc tctacaagac ttttgtccac gtggttcctg
      421 ccaagcctga gggcaccttc aaactggtag ctatgctttg atgtcctgtt gaggccatcg
      481 gacagagact ggagcccagg tgacaggaga tggtgatacc agaagtcaag ggttggggtg
      541 gcgacacggc ctcccgagga agaggtctgc ttgatggtga ctctgcagga gactctgaag
      601 tgactgctgg gaaacccttt gggagacctg acctggggcc aaaaataaag tgagccagcg
      661 tcatgaacgc atgctattta gggaca
//
