LOCUS       NM_145729                883 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein L24 (MRPL24),
            transcript variant 1, mRNA.
ACCESSION   NM_145729
VERSION     NM_145729.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 883)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 883)
  AUTHORS   Brown,A., Rathore,S., Kimanius,D., Aibara,S., Bai,X.C., Rorbach,J.,
            Amunts,A. and Ramakrishnan,V.
  TITLE     Structures of the human mitochondrial ribosome in native states of
            assembly
  JOURNAL   Nat Struct Mol Biol 24 (10), 866-869 (2017)
   PUBMED   28892042
REFERENCE   3  (bases 1 to 883)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   4  (bases 1 to 883)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   5  (bases 1 to 883)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 883)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   7  (bases 1 to 883)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   8  (bases 1 to 883)
  AUTHORS   O'Brien,T.W., Liu,J., Sylvester,J.E., Mougey,E.B.,
            Fischel-Ghodsian,N., Thiede,B., Wittmann-Liebold,B. and Graack,H.R.
  TITLE     Mammalian mitochondrial ribosomal proteins (4). Amino acid
            sequencing, characterization, and identification of corresponding
            gene sequences
  JOURNAL   J Biol Chem 275 (24), 18153-18159 (2000)
   PUBMED   10751423
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG706700.1, BC016700.1 and
            AA730909.1.
            
            On Nov 23, 2018 this sequence version replaced NM_145729.2.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 39S subunit protein which is more
            than twice the size of its E.coli counterpart (EcoL24). Sequence
            analysis identified two transcript variants that encode the same
            protein. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) is the longer transcript and
            it encodes the same protein as variant 2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222500.1, AK223066.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000361531.6/
                                                  ENSP00000354525.2
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 BG706700.1         49-50
            3-881               BC016700.1         5-883
            882-883             AA730909.1         10-11               c
FEATURES             Location/Qualifiers
     source          1..883
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.1"
     gene            1..883
                     /gene="MRPL24"
                     /gene_synonym="L24mt; MRP-L18; MRP-L24; uL24m"
                     /note="mitochondrial ribosomal protein L24"
                     /db_xref="GeneID:79590"
                     /db_xref="HGNC:HGNC:14037"
                     /db_xref="MIM:611836"
     exon            1..77
                     /gene="MRPL24"
                     /gene_synonym="L24mt; MRP-L18; MRP-L24; uL24m"
                     /inference="alignment:Splign:2.1.0"
     exon            78..320
                     /gene="MRPL24"
                     /gene_synonym="L24mt; MRP-L18; MRP-L24; uL24m"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..788
                     /gene="MRPL24"
                     /gene_synonym="L24mt; MRP-L18; MRP-L24; uL24m"
                     /note="39S ribosomal protein L24, mitochondrial;
                     mitochondrial large ribosomal subunit protein uL24m"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL24m"
                     /protein_id="NP_663781.1"
                     /db_xref="CCDS:CCDS1155.1"
                     /db_xref="GeneID:79590"
                     /db_xref="HGNC:HGNC:14037"
                     /db_xref="MIM:611836"
                     /translation="MRLSALLALASKVTLPPHYRYGMSPPGSVADKRKNPPWIRRRPV
                     VVEPISDEDWYLFCGDTVEILEGKDAGKQGKVVQVIRQRNWVVVGGLNTHYRYIGKTM
                     DYRGTMIPSEAPLLHRQVKLVDPMDRKPTEIEWRFTEAGERVRVSTRSGRIIPKPEFP
                     RADGIVPETWIDGPKDTSVEDALERTYVPCLKTLQEEVMEAMGIKETRKYKKVYWY"
     exon            321..416
                     /gene="MRPL24"
                     /gene_synonym="L24mt; MRP-L18; MRP-L24; uL24m"
                     /inference="alignment:Splign:2.1.0"
     exon            417..520
                     /gene="MRPL24"
                     /gene_synonym="L24mt; MRP-L18; MRP-L24; uL24m"
                     /inference="alignment:Splign:2.1.0"
     exon            521..651
                     /gene="MRPL24"
                     /gene_synonym="L24mt; MRP-L18; MRP-L24; uL24m"
                     /inference="alignment:Splign:2.1.0"
     exon            652..883
                     /gene="MRPL24"
                     /gene_synonym="L24mt; MRP-L18; MRP-L24; uL24m"
                     /inference="alignment:Splign:2.1.0"
     regulatory      862..867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL24"
                     /gene_synonym="L24mt; MRP-L18; MRP-L24; uL24m"
                     /note="hexamer: AATAAA"
     polyA_site      883
                     /gene="MRPL24"
                     /gene_synonym="L24mt; MRP-L18; MRP-L24; uL24m"
                     /note="major polyA site"
ORIGIN      
        1 atgtgctgaa aatccgaagt gccgcggaaa gtggaggtga gggccgcccg ccctagaggt
       61 gcccgtccga gaggcagagc tgacaaggaa ggtttcgagc gttttgctgg caaagggatt
      121 tcttacaacc tccaggcatg cgtctttctg ccctgctggc cttggcatcc aaggtcactc
      181 tgccccccca ttaccgctat gggatgagcc ccccaggctc tgttgcagac aagaggaaga
      241 accccccatg gatcaggcgg cgcccagtgg ttgtggaacc catctctgat gaagactggt
      301 atctgttctg tggggacacg gtggagatcc tagaaggcaa ggatgccggg aagcagggca
      361 aagtggttca agttatccgg cagcgaaact gggtggtcgt gggagggctg aacacacatt
      421 accgctacat tggcaagacc atggattacc ggggaaccat gatccctagt gaagccccct
      481 tgctccaccg ccaggtcaaa cttgtggatc ctatggacag gaaacccact gagatcgagt
      541 ggagatttac tgaagcagga gagcgggtac gagtctccac acgatcaggg agaattatcc
      601 ctaaacccga atttcccaga gctgatggca tcgtccctga aacgtggatt gatggcccca
      661 aagacacatc agtggaagat gctttagaaa gaacctatgt gccctgtcta aagacactgc
      721 aggaggaggt gatggaggcc atggggatca aggagacccg gaaatacaag aaggtctatt
      781 ggtattgagc ctggggcaga gcagctcctc cccaacttct gtcccagcct tgaaggctga
      841 ggcacttctt tttcagatgc caataaagag cactttatga gtc
//
