LOCUS       NM_021134                673 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein L23 (MRPL23),
            transcript variant 1, mRNA.
ACCESSION   NM_021134
VERSION     NM_021134.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 673)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 673)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 673)
  AUTHORS   Brown,A., Rathore,S., Kimanius,D., Aibara,S., Bai,X.C., Rorbach,J.,
            Amunts,A. and Ramakrishnan,V.
  TITLE     Structures of the human mitochondrial ribosome in native states of
            assembly
  JOURNAL   Nat Struct Mol Biol 24 (10), 866-869 (2017)
   PUBMED   28892042
REFERENCE   4  (bases 1 to 673)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   5  (bases 1 to 673)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   6  (bases 1 to 673)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   7  (bases 1 to 673)
  AUTHORS   O'Brien,T.W.
  TITLE     Evolution of a protein-rich mitochondrial ribosome: implications
            for human genetic disease
  JOURNAL   Gene 286 (1), 73-79 (2002)
   PUBMED   11943462
REFERENCE   8  (bases 1 to 673)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   9  (bases 1 to 673)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Structural compensation for the deficit of rRNA with proteins in
            the mammalian mitochondrial ribosome. Systematic analysis of
            protein components of the large ribosomal subunit from mammalian
            mitochondria
  JOURNAL   J Biol Chem 276 (24), 21724-21736 (2001)
   PUBMED   11279069
REFERENCE   10 (bases 1 to 673)
  AUTHORS   Tsang,P., Gilles,F., Yuan,L., Kuo,Y.H., Lupu,F., Samara,G.,
            Moosikasuwan,J., Goye,A., Zelenetz,A.D., Selleri,L. et al.
  TITLE     A novel L23-related gene 40 kb downstream of the imprinted H19 gene
            is biallelically expressed in mid-fetal and adult human tissues
  JOURNAL   Hum Mol Genet 4 (9), 1499-1507 (1995)
   PUBMED   8541832
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN310387.1 and BC027710.2.
            
            On Nov 23, 2018 this sequence version replaced NM_021134.3.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 39S subunit protein. The gene is
            biallelically expressed, despite its location within a region of
            imprinted genes on chromosome 11. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD248886.1, U26596.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000397298.8/
                                                  ENSP00000380466.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                CN310387.1         113-200
            89-673              BC027710.2         64-648
FEATURES             Location/Qualifiers
     source          1..673
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.5"
     gene            1..673
                     /gene="MRPL23"
                     /gene_synonym="L23MRP; RPL23; RPL23L; uL23m"
                     /note="mitochondrial ribosomal protein L23"
                     /db_xref="GeneID:6150"
                     /db_xref="HGNC:HGNC:10322"
                     /db_xref="MIM:600789"
     exon            1..48
                     /gene="MRPL23"
                     /gene_synonym="L23MRP; RPL23; RPL23L; uL23m"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..493
                     /gene="MRPL23"
                     /gene_synonym="L23MRP; RPL23; RPL23L; uL23m"
                     /note="isoform 1 is encoded by transcript variant 1; L23
                     mitochondrial-related protein; ribosomal protein related
                     to L23 (mitochondrial); 39S ribosomal protein L23,
                     mitochondrial; L23mt; MRP-L23; mitochondrial large
                     ribosomal subunit protein uL23m"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL23m isoform 1"
                     /protein_id="NP_066957.3"
                     /db_xref="CCDS:CCDS31336.1"
                     /db_xref="GeneID:6150"
                     /db_xref="HGNC:HGNC:10322"
                     /db_xref="MIM:600789"
                     /translation="MARNVVYPLYRLGGPQLRVFRTNFFIQLVRPGVAQPEDTVQFRI
                     PMEMTRVDLRNYLEGIYNVPVAAVRTRVQHGSNKRRDHRNVRIKKPDYKVAYVQLAHG
                     QTFTFPDLFPEKDESPEGSAADDLYSMLEEERQQRQSSDPRRGGVPSWFGL"
     exon            49..171
                     /gene="MRPL23"
                     /gene_synonym="L23MRP; RPL23; RPL23L; uL23m"
                     /inference="alignment:Splign:2.1.0"
     exon            172..254
                     /gene="MRPL23"
                     /gene_synonym="L23MRP; RPL23; RPL23L; uL23m"
                     /inference="alignment:Splign:2.1.0"
     exon            255..328
                     /gene="MRPL23"
                     /gene_synonym="L23MRP; RPL23; RPL23L; uL23m"
                     /inference="alignment:Splign:2.1.0"
     exon            329..673
                     /gene="MRPL23"
                     /gene_synonym="L23MRP; RPL23; RPL23L; uL23m"
                     /inference="alignment:Splign:2.1.0"
     regulatory      649..654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL23"
                     /gene_synonym="L23MRP; RPL23; RPL23L; uL23m"
                     /note="hexamer: AATAAA"
     polyA_site      673
                     /gene="MRPL23"
                     /gene_synonym="L23MRP; RPL23; RPL23L; uL23m"
                     /note="major polyA site"
ORIGIN      
        1 ctcgcggacc ccggaagcgc gcgtggccgc catggcgcgg aatgtggtgt accccctgta
       61 ccggctgggt ggcccacaac ttcgggtgtt ccgaaccaac ttcttcattc agctggtgcg
      121 gcccggtgtg gcccagcccg aggacaccgt gcagttccgg atccccatgg aaatgacaag
      181 ggtggacctc aggaattacc tcgagggcat ctataacgtg cccgtggctg ctgtgcggac
      241 acgggtgcag catggctcta acaagagaag agatcacaga aacgtgagga tcaagaagcc
      301 ggactacaag gtcgcctacg tgcagctggc ccatggacag accttcacgt tcccagatct
      361 gtttcccgag aaagacgaga gccctgaagg cagcgctgcc gacgacctct acagcatgct
      421 cgaggaggag aggcagcaga ggcagagcag cgacccgcgg cggggcggcg tccccagctg
      481 gttcgggctg tgacggggtg gccagcaggg acgcgcccca ggtgggcagc tgtggcagag
      541 cagcgacccg cggcggggcg gcatccccag ctggttcggg ccgtgacggg gcggccagca
      601 gggacgcgcc ccaggtgggc agctgtggca gagcagtccc gacacctaaa taaaagtctt
      661 gctgcaggag aaa
//
