LOCUS       NM_022061               2305 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein L17 (MRPL17), mRNA.
ACCESSION   NM_022061
VERSION     NM_022061.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2305)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2305)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2305)
  AUTHORS   Brown,A., Rathore,S., Kimanius,D., Aibara,S., Bai,X.C., Rorbach,J.,
            Amunts,A. and Ramakrishnan,V.
  TITLE     Structures of the human mitochondrial ribosome in native states of
            assembly
  JOURNAL   Nat Struct Mol Biol 24 (10), 866-869 (2017)
   PUBMED   28892042
REFERENCE   4  (bases 1 to 2305)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   5  (bases 1 to 2305)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   6  (bases 1 to 2305)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   7  (bases 1 to 2305)
  AUTHORS   Tchernev,V.T., Mansfield,T.A., Giot,L., Kumar,A.M., Nandabalan,K.,
            Li,Y., Mishra,V.S., Detter,J.C., Rothberg,J.M., Wallace,M.R.,
            Southwick,F.S. and Kingsmore,S.F.
  TITLE     The Chediak-Higashi protein interacts with SNARE complex and signal
            transduction proteins
  JOURNAL   Mol Med 8 (1), 56-64 (2002)
   PUBMED   11984006
REFERENCE   8  (bases 1 to 2305)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   9  (bases 1 to 2305)
  AUTHORS   Hu,R.M., Han,Z.G., Song,H.D., Peng,Y.D., Huang,Q.H., Ren,S.X.,
            Gu,Y.J., Huang,C.H., Li,Y.B., Jiang,C.L., Fu,G., Zhang,Q.H.,
            Gu,B.W., Dai,M., Mao,Y.F., Gao,G.F., Rong,R., Ye,M., Zhou,J.,
            Xu,S.H., Gu,J., Shi,J.X., Jin,W.R., Zhang,C.K., Wu,T.M.,
            Huang,G.Y., Chen,Z., Chen,M.D. and Chen,J.L.
  TITLE     Gene expression profiling in the human
            hypothalamus-pituitary-adrenal axis and full-length cDNA cloning
  JOURNAL   Proc Natl Acad Sci U S A 97 (17), 9543-9548 (2000)
   PUBMED   10931946
REFERENCE   10 (bases 1 to 2305)
  AUTHORS   O'Brien,T.W., Fiesler,S.E., Denslow,N.D., Thiede,B.,
            Wittmann-Liebold,B., Mougey,E.B., Sylvester,J.E. and Graack,H.R.
  TITLE     Mammalian mitochondrial ribosomal proteins (2). Amino acid
            sequencing, characterization, and identification of corresponding
            gene sequences
  JOURNAL   J Biol Chem 274 (51), 36043-36051 (1999)
   PUBMED   10593885
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB228622.1, AF164797.1,
            BF513148.1, AL572779.3, BM725086.1 and DA876701.1.
            
            On May 17, 2019 this sequence version replaced NM_022061.3.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 39S subunit protein. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.251574.1,
                                           SRR1803615.87288.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142670, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000288937.7/
                                                  ENSP00000288937.6
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                DB228622.1         62-85
            25-892              AF164797.1         1-868
            893-1221            BF513148.1         132-460
            1222-1638           AL572779.3         250-666             c
            1639-2082           BM725086.1         13-456              c
            2083-2305           DA876701.1         341-563
FEATURES             Location/Qualifiers
     source          1..2305
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..2305
                     /gene="MRPL17"
                     /gene_synonym="bL17m; L17mt; LIP2; MRP-L17; MRP-L26;
                     RPL17L; RPML26"
                     /note="mitochondrial ribosomal protein L17"
                     /db_xref="GeneID:63875"
                     /db_xref="HGNC:HGNC:14053"
                     /db_xref="MIM:611830"
     exon            1..218
                     /gene="MRPL17"
                     /gene_synonym="bL17m; L17mt; LIP2; MRP-L17; MRP-L26;
                     RPL17L; RPML26"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..572
                     /gene="MRPL17"
                     /gene_synonym="bL17m; L17mt; LIP2; MRP-L17; MRP-L26;
                     RPL17L; RPML26"
                     /note="LYST-interacting protein LIP2; 39S ribosomal
                     protein L17, mitochondrial; LYST-interacting protein 2;
                     mitochondrial large ribosomal subunit protein bL17m"
                     /codon_start=1
                     /product="large ribosomal subunit protein bL17m"
                     /protein_id="NP_071344.1"
                     /db_xref="CCDS:CCDS31412.1"
                     /db_xref="GeneID:63875"
                     /db_xref="HGNC:HGNC:14053"
                     /db_xref="MIM:611830"
                     /translation="MRLSVAAAISHGRVFRRMGLGPESRIHLLRNLLTGLVRHERIEA
                     PWARVDEMRGYAEKLIDYGKLGDTNERAMRMADFWLTEKDLIPKLFQVLAPRYKDQTG
                     GYTRMLQIPNRSLDRAKMAVIEYKGNCLPPLPLPRRDSHLTLLNQLLQGLRQDLRQSQ
                     EASNHSSHTAQTPGI"
     exon            219..287
                     /gene="MRPL17"
                     /gene_synonym="bL17m; L17mt; LIP2; MRP-L17; MRP-L26;
                     RPL17L; RPML26"
                     /inference="alignment:Splign:2.1.0"
     exon            288..2305
                     /gene="MRPL17"
                     /gene_synonym="bL17m; L17mt; LIP2; MRP-L17; MRP-L26;
                     RPL17L; RPML26"
                     /inference="alignment:Splign:2.1.0"
     regulatory      753..758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL17"
                     /gene_synonym="bL17m; L17mt; LIP2; MRP-L17; MRP-L26;
                     RPL17L; RPML26"
                     /note="hexamer: AATATA"
     polyA_site      758
                     /gene="MRPL17"
                     /gene_synonym="bL17m; L17mt; LIP2; MRP-L17; MRP-L26;
                     RPL17L; RPML26"
                     /note="major polyA site"
     regulatory      837..842
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL17"
                     /gene_synonym="bL17m; L17mt; LIP2; MRP-L17; MRP-L26;
                     RPL17L; RPML26"
                     /note="hexamer: AGTAAA"
     polyA_site      870
                     /gene="MRPL17"
                     /gene_synonym="bL17m; L17mt; LIP2; MRP-L17; MRP-L26;
                     RPL17L; RPML26"
                     /note="major polyA site"
     regulatory      1893..1898
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL17"
                     /gene_synonym="bL17m; L17mt; LIP2; MRP-L17; MRP-L26;
                     RPL17L; RPML26"
                     /note="hexamer: AATAAA"
     polyA_site      1924
                     /gene="MRPL17"
                     /gene_synonym="bL17m; L17mt; LIP2; MRP-L17; MRP-L26;
                     RPL17L; RPML26"
ORIGIN      
        1 agtttccagt tccggcctcc aaggggcggg cagaagttgg aaacatgcgg ctgtcggtcg
       61 ctgcagcgat ctcccatggc cgcgtatttc gccgtatggg cctcggtccc gagtcccgca
      121 tccatctgtt gcggaacttg ctcacagggc tggtgcggca cgaacgcatc gaggcaccat
      181 gggcgcgtgt ggacgaaatg aggggctacg cggagaagct catcgactat gggaagctgg
      241 gagacactaa cgaacgagcc atgcgcatgg ctgacttctg gctcacagag aaggatttga
      301 tcccaaagct gtttcaagta ctggcccctc ggtacaaaga tcaaactggg ggctacacaa
      361 gaatgctgca gatcccaaat cggagtttgg atcgggccaa gatggcagtg atcgagtata
      421 aagggaattg cctcccaccc ctgcctctgc ctcgcagaga cagccacctt acactcctaa
      481 accagctgct gcagggtttg cggcaggacc tcaggcaaag ccaggaagca agcaaccaca
      541 gctcccacac agctcaaaca ccagggattt aactggatct gaagagtctg cagcccttaa
      601 tcagtaccca tgatcacagg cctttggagc acttttactc tctgagaaga actggagcta
      661 gagatgtaaa atggacagtc ttgatggggt tgagaacctt ctggggagcc agatgaccct
      721 ctctttgcac aatagataaa agtctttata tgaatatata taaatttatt tattttttcc
      781 ttcctgtggg atttctggag aatgagaatt atccaaatgc tcagtctacc tgagatagta
      841 aattcatggc ttatgcttct ggtccttaaa tttgggttat ttttggttag tgcaattttg
      901 tttttcttaa tgccagttta catgggaatg catcctataa ttccaaatgt tgccagaggt
      961 ggttgtgttt tgacatctgg tctcctagag atgagtgctt gggatttctt agagaaagat
     1021 tacttcctga caggggtagg ggagtgacaa tctgcaagtg aaacttcctt aaacaatcta
     1081 gtaccctgcg aaccttcagg ggatactgca atcagtcctc tgttttgagg caggatcaca
     1141 cattacctta atgtgttccc ttcaaccccc tgaatgggcc tgggaggaga ggacccaaga
     1201 actcagatgt tccaccagtt tggccaaagg ggtggagaca ttcagcagag gatgttgggc
     1261 tccaggataa gctccttcct cttggtgagg ggaaggggta agaaagaggg tctatgcgag
     1321 agaaggatta ggaaattaaa cctcctagga atttcctgga agtttttatt gttgtcaaat
     1381 ctggcctctc tgggaaccca gaaaagggaa atccggcttc agaatgtgag aagctgggag
     1441 cccctttctt ggcacagcca ggctgccgtt cccttgggtt cagaggcttt agtagggtag
     1501 tagttatgga aggacttaga aaggagccat cagtcttggt ccaaacactt gatagcagtg
     1561 cctgataatt gccatatccc cagtaaagtg ggtagaagag attttatctt aggctctatc
     1621 ttctgagtgt atttggccca ctgaacccat ccactgtctg agataataag taagagtaag
     1681 ggtaaaggga tcactggtgt agcagacatg gcttcagtga cagaacgaac tattctggtg
     1741 ctaatttagc tgtagctgcc ttagtctgat actcatctac tcccaacaga gctctttatc
     1801 tctttttctc tactatggtt tgttcttcac actatagcca gaaagctctt atattttaaa
     1861 tgaaatatag tagacactca aaacatttat gaaataaagc tacaactctg cttctgctaa
     1921 aaaatatacc cctcttctgt cttagcatga atatccaccc tagctaggta tctaggagtc
     1981 atacctaact tctagagaaa ccactttcct taaaaccaca tctttatttt aaatagatgg
     2041 attgtggctg ggctcctgta gcttttcctc ttagacccca gaaatatatc tccctttggg
     2101 acttccaaca gttccctaca tgctttttga gcatctgcta gttcccagca tcaatttagg
     2161 cagaagggat acaatatcca ctgttcatct aatagagact agagataaga aacaacctgt
     2221 accatcaatg agctcacaat aacaggccac tgccactacc acagtggcct caagggacac
     2281 tgcttcccct ttaatgtttt ggtcc
//
