LOCUS       NM_017840               1083 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein L16 (MRPL16), mRNA.
ACCESSION   NM_017840
VERSION     NM_017840.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1083)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1083)
  AUTHORS   Brown,A., Rathore,S., Kimanius,D., Aibara,S., Bai,X.C., Rorbach,J.,
            Amunts,A. and Ramakrishnan,V.
  TITLE     Structures of the human mitochondrial ribosome in native states of
            assembly
  JOURNAL   Nat Struct Mol Biol 24 (10), 866-869 (2017)
   PUBMED   28892042
REFERENCE   3  (bases 1 to 1083)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   4  (bases 1 to 1083)
  AUTHORS   Hasegawa,Y., Taylor,D., Ovchinnikov,D.A., Wolvetang,E.J., de
            Torrente,L. and Mar,J.C.
  TITLE     Variability of Gene Expression Identifies Transcriptional
            Regulators of Early Human Embryonic Development
  JOURNAL   PLoS Genet 11 (8), e1005428 (2015)
   PUBMED   26288249
  REMARK    GeneRIF: Results from a study on gene expression variability
            markers in early-stage human embryos shows that MRPL16 is a
            putative variability and gene expression level marker for the
            3-day, 8-cell embryo stage.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1083)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   6  (bases 1 to 1083)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1083)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   8  (bases 1 to 1083)
  AUTHORS   Koc,E.C., Burkhart,W., Blackburn,K., Moyer,M.B., Schlatzer,D.M.,
            Moseley,A. and Spremulli,L.L.
  TITLE     The large subunit of the mammalian mitochondrial ribosome. Analysis
            of the complement of ribosomal proteins present
  JOURNAL   J Biol Chem 276 (47), 43958-43969 (2001)
   PUBMED   11551941
REFERENCE   9  (bases 1 to 1083)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   10 (bases 1 to 1083)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Structural compensation for the deficit of rRNA with proteins in
            the mammalian mitochondrial ribosome. Systematic analysis of
            protein components of the large ribosomal subunit from mammalian
            mitochondria
  JOURNAL   J Biol Chem 276 (24), 21724-21736 (2001)
   PUBMED   11279069
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AA454132.1 and AB049642.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017840.3.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 39S subunit protein. [provided by
            RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF183428.1, AK000491.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000300151.5/
                                                  ENSP00000300151.4
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               AA454132.1         95-243
            150-162             AB049642.1         128-140
            163-175             AA454132.1         256-268
            176-1083            AB049642.1         154-1061
FEATURES             Location/Qualifiers
     source          1..1083
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..1083
                     /gene="MRPL16"
                     /gene_synonym="L16mt; MRP-L16; PNAS-111; uL16m"
                     /note="mitochondrial ribosomal protein L16"
                     /db_xref="GeneID:54948"
                     /db_xref="HGNC:HGNC:14476"
                     /db_xref="MIM:611829"
     exon            1..175
                     /gene="MRPL16"
                     /gene_synonym="L16mt; MRP-L16; PNAS-111; uL16m"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..876
                     /gene="MRPL16"
                     /gene_synonym="L16mt; MRP-L16; PNAS-111; uL16m"
                     /EC_number="3.6.5.3"
                     /note="39S ribosomal protein L16, mitochondrial;
                     mitochondrial large ribosomal subunit protein uL16m"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL16m"
                     /protein_id="NP_060310.1"
                     /db_xref="CCDS:CCDS7976.1"
                     /db_xref="GeneID:54948"
                     /db_xref="HGNC:HGNC:14476"
                     /db_xref="MIM:611829"
                     /translation="MWRLLARASAPLLRVPLSDSWALLPASAGVKTLLPVPSFEDVSI
                     PEKPKLRFIERAPLVPKVRREPKNLSDIRGPSTEATEFTEGNFAILALGGGYLHWGHF
                     EMMRLTINRSMDPKNMFAIWRVPAPFKPITRKSVGHRMGGGKGAIDHYVTPVKAGRLV
                     VEMGGRCEFEEVQGFLDQVAHKLPFAAKAVSRGTLEKMRKDQEERERNNQNPWTFERI
                     ATANMLGIRKVLSPYDLTHKGKYWGKFYMPKRV"
     exon            176..241
                     /gene="MRPL16"
                     /gene_synonym="L16mt; MRP-L16; PNAS-111; uL16m"
                     /inference="alignment:Splign:2.1.0"
     exon            242..390
                     /gene="MRPL16"
                     /gene_synonym="L16mt; MRP-L16; PNAS-111; uL16m"
                     /inference="alignment:Splign:2.1.0"
     exon            391..1083
                     /gene="MRPL16"
                     /gene_synonym="L16mt; MRP-L16; PNAS-111; uL16m"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1058..1063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL16"
                     /gene_synonym="L16mt; MRP-L16; PNAS-111; uL16m"
                     /note="hexamer: AATAAA"
     polyA_site      1083
                     /gene="MRPL16"
                     /gene_synonym="L16mt; MRP-L16; PNAS-111; uL16m"
                     /note="major polyA site"
ORIGIN      
        1 gccccactga gcggtgtcct gagccgatta cagctaggta gtggagcgcc gctgcttacc
       61 tgggtgcagg agacagccgg agtcgctggg ggagctccgc gccgccggac gcccgtgacc
      121 atgtggaggc tgctggctcg cgctagtgcg ccgctcctgc gggtgccctt gtcagattcc
      181 tgggcactcc tccccgccag tgctggcgta aagacactgc tcccagtacc aagttttgaa
      241 gatgtttcca ttcctgaaaa acccaagctt agatttattg aaagggcacc acttgtgcca
      301 aaagtaagaa gagaacctaa aaatttaagt gacatacggg gaccttccac tgaagctacg
      361 gagtttacag aaggcaattt tgcaatcttg gcattgggtg gtggctacct gcattggggc
      421 cactttgaaa tgatgcgcct gacaatcaac cgctctatgg accccaagaa catgtttgcc
      481 atatggcgag taccagcccc tttcaagccc atcactcgca aaagtgttgg gcatcgcatg
      541 gggggaggca aaggtgctat tgaccactac gtgacacctg tgaaggctgg ccgccttgtt
      601 gtagagatgg gtgggcgttg tgaatttgaa gaagtgcaag gtttccttga ccaggttgcc
      661 cacaagttgc ccttcgcagc aaaggctgtg agccgcggga ctctagagaa gatgcgaaaa
      721 gatcaagagg aaagagaacg taacaaccag aacccctgga catttgagcg aatagccact
      781 gccaacatgc tgggcatacg gaaagtactg agcccatatg acttgaccca caaggggaaa
      841 tactggggca agttctacat gcccaaacgt gtgtagtgag tgtaggagat aactgtatat
      901 aggctactga aagaaggatt ctgcatttct attcccctca gcctacccac tgaagtcttt
      961 gggtagctct taagccataa ctaaggagca gcatttgagt agatttctga aaaacaatgt
     1021 tatttgttga tttaaaaaga aaactgtatt tttattaaat aaaatttaaa catcacttca
     1081 gga
//
