LOCUS       NM_014175               1729 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein L15 (MRPL15), mRNA.
ACCESSION   NM_014175
VERSION     NM_014175.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1729)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1729)
  AUTHORS   Xu,H., Zou,R., Li,F., Liu,J., Luan,N., Wang,S. and Zhu,L.
  TITLE     MRPL15 is a novel prognostic biomarker and therapeutic target for
            epithelial ovarian cancer
  JOURNAL   Cancer Med 10 (11), 3655-3673 (2021)
   PUBMED   33934540
  REMARK    GeneRIF: MRPL15 is a novel prognostic biomarker and therapeutic
            target for epithelial ovarian cancer.
REFERENCE   3  (bases 1 to 1729)
  AUTHORS   Gao,L., Li,J., Yan,M. and Aili,M.
  TITLE     Methylation factor MRPL15 identified as a potential biological
            target in Alzheimer's disease
  JOURNAL   Aging (Albany NY) 13 (10), 13560-13570 (2021)
   PUBMED   34016794
  REMARK    GeneRIF: Methylation factor MRPL15 identified as a potential
            biological target in Alzheimer's disease.
REFERENCE   4  (bases 1 to 1729)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1729)
  AUTHORS   Brown,A., Rathore,S., Kimanius,D., Aibara,S., Bai,X.C., Rorbach,J.,
            Amunts,A. and Ramakrishnan,V.
  TITLE     Structures of the human mitochondrial ribosome in native states of
            assembly
  JOURNAL   Nat Struct Mol Biol 24 (10), 866-869 (2017)
   PUBMED   28892042
REFERENCE   6  (bases 1 to 1729)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1729)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   8  (bases 1 to 1729)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   9  (bases 1 to 1729)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
REFERENCE   10 (bases 1 to 1729)
  AUTHORS   O'Brien,T.W., Fiesler,S.E., Denslow,N.D., Thiede,B.,
            Wittmann-Liebold,B., Mougey,E.B., Sylvester,J.E. and Graack,H.R.
  TITLE     Mammalian mitochondrial ribosomal proteins (2). Amino acid
            sequencing, characterization, and identification of corresponding
            gene sequences
  JOURNAL   J Biol Chem 274 (51), 36043-36051 (1999)
   PUBMED   10593885
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC000891.1, DA504537.1 and
            BM510276.1.
            
            On May 17, 2019 this sequence version replaced NM_014175.3.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 39S subunit protein that belongs to
            the EcoL15 ribosomal protein family. A pseudogene corresponding to
            this gene is found on chromosome 15q. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.12147.1,
                                           SRR1660807.85521.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000260102.9/
                                                  ENSP00000260102.4
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1111              BC000891.1         21-1131
            1112-1440           DA504537.1         241-569
            1441-1729           BM510276.1         147-435
FEATURES             Location/Qualifiers
     source          1..1729
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q11.23"
     gene            1..1729
                     /gene="MRPL15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7;
                     uL15m"
                     /note="mitochondrial ribosomal protein L15"
                     /db_xref="GeneID:29088"
                     /db_xref="HGNC:HGNC:14054"
                     /db_xref="MIM:611828"
     exon            1..151
                     /gene="MRPL15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7;
                     uL15m"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..934
                     /gene="MRPL15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7;
                     uL15m"
                     /EC_number="3.6.5.3"
                     /note="39S ribosomal protein L15, mitochondrial;
                     mitochondrial large ribosomal subunit protein uL15m"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL15m"
                     /protein_id="NP_054894.1"
                     /db_xref="CCDS:CCDS6158.1"
                     /db_xref="GeneID:29088"
                     /db_xref="HGNC:HGNC:14054"
                     /db_xref="MIM:611828"
                     /translation="MAGPLQGGGARALDLLRGLPRVSLANLKPNPGSKKPERRPRGRR
                     RGRKCGRGHKGERQRGTRPRLGFEGGQTPFYIRIPKYGFNEGHSFRRQYKPLSLNRLQ
                     YLIDLGRVDPSQPIDLTQLVNGRGVTIQPLKRDYGVQLVEEGADTFTAKVNIEVQLAS
                     ELAIAAIEKNGGVVTTAFYDPRSLDIVCKPVPFFLRGQPIPKRMLPPEELVPYYTDAK
                     NRGYLADPAKFPEARLELARKYGYILPDITKDELFKMLCTRKDPRQIFFGLAPGWVVN
                     MADKKILKPTDENLLKYYTS"
     exon            152..306
                     /gene="MRPL15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7;
                     uL15m"
                     /inference="alignment:Splign:2.1.0"
     exon            307..472
                     /gene="MRPL15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7;
                     uL15m"
                     /inference="alignment:Splign:2.1.0"
     exon            473..596
                     /gene="MRPL15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7;
                     uL15m"
                     /inference="alignment:Splign:2.1.0"
     exon            597..1729
                     /gene="MRPL15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7;
                     uL15m"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1082..1087
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7;
                     uL15m"
                     /note="hexamer: ATTAAA"
     regulatory      1096..1101
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7;
                     uL15m"
                     /note="hexamer: AACAAG"
     polyA_site      1112
                     /gene="MRPL15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7;
                     uL15m"
     polyA_site      1116
                     /gene="MRPL15"
                     /gene_synonym="HSPC145; L15mt; MRP-L15; MRP-L7; RPML7;
                     uL15m"
                     /note="major polyA site"
ORIGIN      
        1 gagcagctca gggcgccctt gaaagttctt ggatctgcgg gttatggccg gtcccttgca
       61 gggcggtggg gcccgggccc tggacctact ccggggcctg ccgcgtgtga gcctggccaa
      121 cttaaagccg aatcccggct ccaagaaacc ggagagaaga ccaagaggtc ggagaagagg
      181 tagaaaatgt ggcagaggcc ataaaggaga aaggcaaaga ggaacccggc cccgcttggg
      241 ctttgaggga ggccagactc cattttacat ccgaatccca aaatacgggt ttaacgaagg
      301 acatagtttc agacgccagt ataagccttt gagtctcaat agactgcagt atcttattga
      361 tttgggtcgt gttgatccta gtcaacctat tgacttaacc cagcttgtca atgggagagg
      421 tgtgaccatc cagccactta aaagggatta tggtgtccag ctggttgagg agggtgctga
      481 cacctttacg gcaaaagtta atattgaagt acagttggct tcagaactag ctattgctgc
      541 cattgaaaaa aatggtggtg ttgttactac agccttctat gatccaagaa gtctggacat
      601 tgtatgcaaa cctgttccat tctttcttcg tggacaaccc attccaaaaa gaatgcttcc
      661 accagaagaa ctggtaccat attacactga tgcaaagaac cgtgggtacc tggcggatcc
      721 tgccaaattt cctgaagcac gacttgaact cgccaggaag tatggttata tcttacctga
      781 tatcactaaa gatgaactct tcaaaatgct ctgtactagg aaggatccaa ggcagatttt
      841 ctttggtctt gctccaggat gggtggtgaa tatggccgat aagaaaatcc taaaacctac
      901 agatgaaaat ctccttaagt attatacctc atgaattccc gtccaaggaa gcagagttgt
      961 taaagagtac tggaataggg gctgaaggat ctatattccc ttattgcatt ttccttatgt
     1021 ataattttcc agatggtgat gttacttttc agtgtactca tatgtctcat tttcatctaa
     1081 aattaaatgg caggaaacaa ggactgcata gagaaactga gtctgtgtgg gttctgtctc
     1141 aaagatacaa actccctgat agtctatgga aggaaaatga caactatttt agaatatttc
     1201 tagtttgttt tttcagtgat cttttcatcc aggccttgtt actgttacag atcagaatga
     1261 aatgcacaag tggaatggga ttgacctgta ggcctgctct gccgagatga gagcagatgg
     1321 aatgagttgg tgacccctct taatctgtag cctcagggaa acacggctac ccaatgccaa
     1381 gatggtaaac cctcaactcg aagagtaaga tcaggacgta tgcttaaggt gtaaggctga
     1441 ggagtagctg gtaggcagta tgtttgccag tgacattgaa ggtgagagaa acaaaaatta
     1501 caaatgaatt tattttctca attctgtggt agaagtgtta caggcaggcc tttgttctta
     1561 gagctcccaa gatggtggtg gccactccca agatggcagc aagccttttg ttctctgacc
     1621 tggggttctt ggcctcacgg attccaaaga atggaacctt gggccatgtg gtcagtgtta
     1681 tagctctagt agaagtcatg ggtcacggaa gagaactgtg gaacccagt
//
