LOCUS       NM_014078               1260 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein L13 (MRPL13), mRNA.
ACCESSION   NM_014078
VERSION     NM_014078.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1260)
  AUTHORS   Wang,L., Xia,Y., Zhang,Z., Liu,X., Shi,J., Wang,Y., Li,J.,
            Zhnag,X., Geng,Z., Song,X. and Zuo,L.
  TITLE     [High expression of MRPL13 promotes cell cycle progression and
            proliferation of gastric cancer cells by inhibiting p53 signaling
            to affect long-term prognosis]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 43 (9), 1558-1566 (2023)
   PUBMED   37814870
  REMARK    GeneRIF: [High expression of MRPL13 promotes cell cycle progression
            and proliferation of gastric cancer cells by inhibiting p53
            signaling to affect long-term prognosis].
REFERENCE   2  (bases 1 to 1260)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1260)
  AUTHORS   Ye,H. and Zhang,N.
  TITLE     Identification of the Upregulation of MRPL13 as a Novel Prognostic
            Marker Associated with Overall Survival Time and Immunotherapy
            Response in Breast Cancer
  JOURNAL   Comput Math Methods Med 2021, 1498924 (2021)
   PUBMED   34868337
  REMARK    GeneRIF: Identification of the Upregulation of MRPL13 as a Novel
            Prognostic Marker Associated with Overall Survival Time and
            Immunotherapy Response in Breast Cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1260)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1260)
  AUTHORS   Lee,Y.K., Lim,J.J., Jeoun,U.W., Min,S., Lee,E.B., Kwon,S.M., Lee,C.
            and Yoon,G.
  TITLE     Lactate-mediated mitoribosomal defects impair mitochondrial
            oxidative phosphorylation and promote hepatoma cell invasiveness
  JOURNAL   J Biol Chem 292 (49), 20208-20217 (2017)
   PUBMED   28978646
  REMARK    GeneRIF: the combination of elevated glycolysis and deficient
            MRPL13 activity was closely linked to CLN1-mediated tumor activity
            in human hepatoma cells
REFERENCE   6  (bases 1 to 1260)
  AUTHORS   Mukhopadhyay,R., Ray,P.S., Arif,A., Brady,A.K., Kinter,M. and
            Fox,P.L.
  TITLE     DAPK-ZIPK-L13a axis constitutes a negative-feedback module
            regulating inflammatory gene expression
  JOURNAL   Mol Cell 32 (3), 371-382 (2008)
   PUBMED   18995835
  REMARK    GeneRIF: DAPK-ZIPK-L13a axis forms a unique regulatory module that
            first represses, then repermits inflammatory gene expression.
REFERENCE   7  (bases 1 to 1260)
  AUTHORS   Shen,X.Y., Zacal,N., Singh,G. and Rainbow,A.J.
  TITLE     Alterations in mitochondrial and apoptosis-regulating gene
            expression in photodynamic therapy-resistant variants of HT29 colon
            carcinoma cells
  JOURNAL   Photochem Photobiol 81 (2), 306-313 (2005)
   PUBMED   15560738
REFERENCE   8  (bases 1 to 1260)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   9  (bases 1 to 1260)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   10 (bases 1 to 1260)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Structural compensation for the deficit of rRNA with proteins in
            the mammalian mitochondrial ribosome. Systematic analysis of
            protein components of the large ribosomal subunit from mammalian
            mitochondria
  JOURNAL   J Biol Chem 276 (24), 21724-21736 (2001)
   PUBMED   11279069
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC021744.2, CN362173.1 and
            AC107877.4.
            
            On May 17, 2019 this sequence version replaced NM_014078.5.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 39S subunit protein. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BG623051.1, BU155290.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000306185.8/
                                                  ENSP00000306548.3
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-740               BC021744.2         237-976
            741-853             CN362173.1         312-424
            854-1260            AC107877.4         54926-55332         c
FEATURES             Location/Qualifiers
     source          1..1260
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.12"
     gene            1..1260
                     /gene="MRPL13"
                     /gene_synonym="L13; L13A; L13mt; RPL13; RPML13; uL13m"
                     /note="mitochondrial ribosomal protein L13"
                     /db_xref="GeneID:28998"
                     /db_xref="HGNC:HGNC:14278"
                     /db_xref="MIM:610200"
     exon            1..83
                     /gene="MRPL13"
                     /gene_synonym="L13; L13A; L13mt; RPL13; RPML13; uL13m"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..593
                     /gene="MRPL13"
                     /gene_synonym="L13; L13A; L13mt; RPL13; RPML13; uL13m"
                     /EC_number="3.6.5.3"
                     /note="39S ribosomal protein L13, mitochondrial; MRP-L13;
                     mitochondrial large ribosomal subunit protein uL13m"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL13m"
                     /protein_id="NP_054797.2"
                     /db_xref="CCDS:CCDS6332.1"
                     /db_xref="GeneID:28998"
                     /db_xref="HGNC:HGNC:14278"
                     /db_xref="MIM:610200"
                     /translation="MSSFSRAPQQWATFARIWYLLDGKMQPPGKLAAMASIRLQGLHK
                     PVYHALSDCGDHVVIMNTRHIAFSGNKWEQKVYSSHTGYPGGFRQVTAAQLHLRDPVA
                     IVKLAIYGMLPKNLHRRTMMERLHLFPDEYIPEDILKNLVEELPQPRKIPKRLDEYTQ
                     EEIDAFPRLWTPPEDYRL"
     exon            84..207
                     /gene="MRPL13"
                     /gene_synonym="L13; L13A; L13mt; RPL13; RPML13; uL13m"
                     /inference="alignment:Splign:2.1.0"
     exon            208..301
                     /gene="MRPL13"
                     /gene_synonym="L13; L13A; L13mt; RPL13; RPML13; uL13m"
                     /inference="alignment:Splign:2.1.0"
     exon            302..362
                     /gene="MRPL13"
                     /gene_synonym="L13; L13A; L13mt; RPL13; RPML13; uL13m"
                     /inference="alignment:Splign:2.1.0"
     exon            363..449
                     /gene="MRPL13"
                     /gene_synonym="L13; L13A; L13mt; RPL13; RPML13; uL13m"
                     /inference="alignment:Splign:2.1.0"
     exon            450..571
                     /gene="MRPL13"
                     /gene_synonym="L13; L13A; L13mt; RPL13; RPML13; uL13m"
                     /inference="alignment:Splign:2.1.0"
     exon            572..1260
                     /gene="MRPL13"
                     /gene_synonym="L13; L13A; L13mt; RPL13; RPML13; uL13m"
                     /inference="alignment:Splign:2.1.0"
     regulatory      828..833
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL13"
                     /gene_synonym="L13; L13A; L13mt; RPL13; RPML13; uL13m"
                     /note="hexamer: AATAAA"
     polyA_site      853
                     /gene="MRPL13"
                     /gene_synonym="L13; L13A; L13mt; RPL13; RPML13; uL13m"
                     /note="major polyA site"
ORIGIN      
        1 gagtgacccg gcgtggctac taggagaagg acgtacggtc ctgctagtag aggaatatgt
       61 cgagtttctc tagggcgccc cagcaatggg ccacttttgc tagaatatgg tatctcttag
      121 atgggaaaat gcagccacct ggcaaacttg ctgctatggc atctataaga cttcagggat
      181 tacataaacc tgtgtaccat gcactgagtg actgtgggga tcatgttgtt ataatgaaca
      241 caagacacat tgcattttct ggaaacaaat gggaacaaaa agtatactct tcgcatactg
      301 gctacccagg tggatttaga caagtaacag ctgctcagct tcacctgagg gatccagtgg
      361 caattgtaaa actagctatt tatggcatgc tgccaaaaaa ccttcacaga agaacaatga
      421 tggaaaggtt gcatcttttt ccagatgagt atattccaga agatattctt aagaatttag
      481 tagaggagct tcctcaacca cgaaaaatac ctaaacgtct agatgagtac acacaagaag
      541 aaatagacgc cttcccaaga ttgtggactc cacctgaaga ttatcggcta taagagaata
      601 agaattgcag aaaataacag tgaagtgatt gaaactttct tctgatgagt ttctctaacc
      661 tacaggatgg agtaaaacaa ctgctacagt tcagcacctg ttttatgtgc cgaatcactg
      721 tggggaaagg tcaggaaggt atagtccttc aataggaaat tgtaattaaa atataatttt
      781 atagaaccat ttttatgtaa tctgatttga atgttatagt tgataataat aaaatcactt
      841 acttggttga ctatttagtg ttgcatttaa tgataaaaaa cagaccctgt gtatagaatt
      901 gcagttacac attccaaaaa tgcctctcca tgcagatttt ctcaagtttg caggtcacta
      961 ttcttgtccc ttgtgaacaa gctctacctt cacttttcat ttcagtggct ttttttatct
     1021 aacttgtcat ccatctaaat tcatatttgc agcttagtag ggtaaagttt gccctgaaat
     1081 atttataaac tgctatcttt ttctgtgtcc catatagcct cttggcccca caatgacacc
     1141 agaatacata atgcctgtct gctcgttaga aatccctctt ccctgccagt gattctgttt
     1201 gtagactctc cacactgttt tcccatatct gtcctgttgg cttccattca tctctgtact
//
