LOCUS       NM_002949               1009 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens mitochondrial ribosomal protein L12 (MRPL12), mRNA.
ACCESSION   NM_002949
VERSION     NM_002949.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1009)
  AUTHORS   Rai,A.K., Sanghvi,S., Muthukumaran,N.S., Chandrasekera,D.,
            Kadam,A., Kishore,J., Kyriazis,I.D., Tomar,D., Ponnalagu,D.,
            Shettigar,V., Khan,M., Singh,H., Goukassian,D., Katare,R. and
            Garikipati,V.N.S.
  TITLE     Role of mitochondrial ribosomal protein L7/L12 (MRPL12) in diabetic
            ischemic heart disease
  JOURNAL   Free Radic Biol Med 222, 531-538 (2024)
   PUBMED   38977138
  REMARK    GeneRIF: Role of mitochondrial ribosomal protein L7/L12 (MRPL12) in
            diabetic ischemic heart disease.
REFERENCE   2  (bases 1 to 1009)
  AUTHORS   Paluch,K.V., Platz,K.R., Rudisel,E.J., Erdmann,R.R., Laurin,T.R.
            and Dittenhafer-Reed,K.E.
  TITLE     The role of lysine acetylation in the function of mitochondrial
            ribosomal protein L12
  JOURNAL   Proteins 92 (5), 583-592 (2024)
   PUBMED   38146092
  REMARK    GeneRIF: The role of lysine acetylation in the function of
            mitochondrial ribosomal protein L12.
REFERENCE   3  (bases 1 to 1009)
  AUTHORS   Sun,Y., Liu,Y., Wang,P., Chang,L. and Huang,J.
  TITLE     The m6A Reader YTHDC2 Suppresses Lung Adenocarcinoma Tumorigenesis
            by Destabilizing MRPL12
  JOURNAL   Mol Biotechnol 66 (5), 1051-1061 (2024)
   PUBMED   38129673
  REMARK    GeneRIF: The m6A Reader YTHDC2 Suppresses Lung Adenocarcinoma
            Tumorigenesis by Destabilizing MRPL12.
REFERENCE   4  (bases 1 to 1009)
  AUTHORS   Ji,X., Yang,Z., Li,C., Zhu,S., Zhang,Y., Xue,F., Sun,S., Fu,T.,
            Ding,C., Liu,Y. and Wan,Q.
  TITLE     Mitochondrial ribosomal protein L12 potentiates hepatocellular
            carcinoma by regulating mitochondrial biogenesis and metabolic
            reprogramming
  JOURNAL   Metabolism 152, 155761 (2024)
   PUBMED   38104924
  REMARK    GeneRIF: Mitochondrial ribosomal protein L12 potentiates
            hepatocellular carcinoma by regulating mitochondrial biogenesis and
            metabolic reprogramming.
REFERENCE   5  (bases 1 to 1009)
  AUTHORS   Ji,X., Yang,X., Gu,X., Chu,L., Sun,S., Sun,J., Song,P., Mu,Q.,
            Wang,Y., Sun,X., Su,D., Su,T., Hou,S., Lu,Y., Ma,C., Liu,M.,
            Zhang,T., Zhang,W., Liu,Y. and Wan,Q.
  TITLE     CUL3 induces mitochondrial dysfunction via MRPL12 ubiquitination in
            renal tubular epithelial cells
  JOURNAL   FEBS J 290 (22), 5340-5352 (2023)
   PUBMED   37526061
  REMARK    GeneRIF: CUL3 induces mitochondrial dysfunction via MRPL12
            ubiquitination in renal tubular epithelial cells.
REFERENCE   6  (bases 1 to 1009)
  AUTHORS   Koc,E.C., Burkhart,W., Blackburn,K., Moyer,M.B., Schlatzer,D.M.,
            Moseley,A. and Spremulli,L.L.
  TITLE     The large subunit of the mammalian mitochondrial ribosome. Analysis
            of the complement of ribosomal proteins present
  JOURNAL   J Biol Chem 276 (47), 43958-43969 (2001)
   PUBMED   11551941
REFERENCE   7  (bases 1 to 1009)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   8  (bases 1 to 1009)
  AUTHORS   Graack,H.R., Bryant,M.L. and O'Brien,T.W.
  TITLE     Identification of mammalian mitochondrial ribosomal proteins (MRPs)
            by N-terminal sequencing of purified bovine MRPs and comparison to
            data bank sequences: the large subribosomal particle
  JOURNAL   Biochemistry 38 (50), 16569-16577 (1999)
   PUBMED   10600119
REFERENCE   9  (bases 1 to 1009)
  AUTHORS   Marty,L., Taviaux,S. and Fort,P.
  TITLE     Expression and human chromosomal localization to 17q25 of the
            growth-regulated gene encoding the mitochondrial ribosomal protein
            MRPL12
  JOURNAL   Genomics 41 (3), 453-457 (1997)
   PUBMED   9169145
REFERENCE   10 (bases 1 to 1009)
  AUTHORS   Marty,L. and Fort,P.
  TITLE     A delayed-early response nuclear gene encoding MRPL12, the
            mitochondrial homologue to the bacterial translational regulator
            L7/L12 protein
  JOURNAL   J Biol Chem 271 (19), 11468-11476 (1996)
   PUBMED   8626705
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC139530.3, DA648796.1,
            BC002344.2 and AF105278.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002949.3.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 39S subunit protein which forms
            homodimers. In prokaryotic ribosomes, two L7/L12 dimers and one L10
            protein form the L8 protein complex. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.348680.1,
                                           SRR1803613.225094.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000333676.8/
                                                  ENSP00000333837.3
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC139530.3         26319-26321         c
            4-18                DA648796.1         1-15
            19-836              BC002344.2         1-818
            837-1009            AF105278.1         567-739
FEATURES             Location/Qualifiers
     source          1..1009
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..1009
                     /gene="MRPL12"
                     /gene_synonym="5c5-2; bL12m; L12mt; MRP-L31/34; MRPL7;
                     MRPL7/L12; RPML12"
                     /note="mitochondrial ribosomal protein L12"
                     /db_xref="GeneID:6182"
                     /db_xref="HGNC:HGNC:10378"
                     /db_xref="MIM:602375"
     exon            1..209
                     /gene="MRPL12"
                     /gene_synonym="5c5-2; bL12m; L12mt; MRP-L31/34; MRPL7;
                     MRPL7/L12; RPML12"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..732
                     /gene="MRPL12"
                     /gene_synonym="5c5-2; bL12m; L12mt; MRP-L31/34; MRPL7;
                     MRPL7/L12; RPML12"
                     /note="39S ribosomal protein L12, mitochondrial; MRP-L12;
                     mitochondrial large ribosomal subunit protein bL12m"
                     /codon_start=1
                     /product="large ribosomal subunit protein bL12m"
                     /protein_id="NP_002940.2"
                     /db_xref="CCDS:CCDS11785.1"
                     /db_xref="GeneID:6182"
                     /db_xref="HGNC:HGNC:10378"
                     /db_xref="MIM:602375"
                     /translation="MLPAAARPLWGPCLGLRAAAFRLARRQVPCVCAVRHMRSSGHQR
                     CEALAGAPLDNAPKEYPPKIQQLVQDIASLTLLEISDLNELLKKTLKIQDVGLVPMGG
                     VMSGAVPAAAAQEAVEEDIPIAKERTHFTVRLTEAKPVDKVKLIKEIKNYIQGINLVQ
                     AKKLVESLPQEIKANVAKAEAEKIKAALEAVGGTVVLE"
     exon            210..396
                     /gene="MRPL12"
                     /gene_synonym="5c5-2; bL12m; L12mt; MRP-L31/34; MRPL7;
                     MRPL7/L12; RPML12"
                     /inference="alignment:Splign:2.1.0"
     exon            397..480
                     /gene="MRPL12"
                     /gene_synonym="5c5-2; bL12m; L12mt; MRP-L31/34; MRPL7;
                     MRPL7/L12; RPML12"
                     /inference="alignment:Splign:2.1.0"
     exon            481..615
                     /gene="MRPL12"
                     /gene_synonym="5c5-2; bL12m; L12mt; MRP-L31/34; MRPL7;
                     MRPL7/L12; RPML12"
                     /inference="alignment:Splign:2.1.0"
     exon            616..1009
                     /gene="MRPL12"
                     /gene_synonym="5c5-2; bL12m; L12mt; MRP-L31/34; MRPL7;
                     MRPL7/L12; RPML12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      992..997
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL12"
                     /gene_synonym="5c5-2; bL12m; L12mt; MRP-L31/34; MRPL7;
                     MRPL7/L12; RPML12"
                     /note="hexamer: AATACA"
     polyA_site      1009
                     /gene="MRPL12"
                     /gene_synonym="5c5-2; bL12m; L12mt; MRP-L31/34; MRPL7;
                     MRPL7/L12; RPML12"
                     /note="major polyA site"
ORIGIN      
        1 gtcatttccg gctcgaatgc ccggcagccg tggcggctag agcgttcctc cccagctcga
       61 atgcccggcg gccgaggcgg ctagagcgtc gcctcctccc ggggaaccgc gtgtgacctt
      121 ccagcccgcg gaccgatgct gccggcggcc gctcgccccc tgtgggggcc ttgccttggg
      181 cttcgggccg ctgcgttccg ccttgccagg cgacaggtgc catgtgtctg tgccgtgcga
      241 catatgagga gcagcggcca tcagaggtgt gaggccctcg ctggtgcacc cctggataac
      301 gcccccaagg agtacccccc caagatacag cagctggtcc aggacatcgc cagcctcact
      361 ctcttggaaa tctcagacct caacgagctc ctgaagaaaa cgttgaagat ccaggatgtc
      421 gggcttgtgc cgatgggtgg tgtgatgtct ggggctgtcc ctgctgcagc agcccaggag
      481 gcggtggaag aagatatccc catagcgaaa gaacggacac atttcaccgt ccgcctgacc
      541 gaggcgaagc ccgtggacaa agtgaagctg atcaaggaaa tcaagaacta catccaaggc
      601 atcaacctcg tccaggcaaa gaagctggtg gagtccctgc cccaggaaat caaagccaat
      661 gtcgccaaag ctgaggcgga gaagatcaag gcggccctgg aggcggtggg cggcaccgtg
      721 gttctggagt agcctccagc tcggaggact tgtgttcagg ggtcctgggc cccgggcgag
      781 gtcccgccct cccgtggtca ctggctccgc ccccagcacc aggcgcccag tggagccgtt
      841 tgggagaatt gcctgcgcca cgcagcgggg ccggacaggc cgcacagacc tactgtggcg
      901 ggagggaggg gcggctgctg cctggtgacg gcacccggag gcccaccagg acgcgccacc
      961 ggtgaatgtg cctctggtgg ctgctgagaa aaatacactg tgcagctca
//
