LOCUS       NM_016050               1605 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein L11 (MRPL11),
            transcript variant 1, mRNA.
ACCESSION   NM_016050
VERSION     NM_016050.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1605)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1605)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1605)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1605)
  AUTHORS   Brown,A., Rathore,S., Kimanius,D., Aibara,S., Bai,X.C., Rorbach,J.,
            Amunts,A. and Ramakrishnan,V.
  TITLE     Structures of the human mitochondrial ribosome in native states of
            assembly
  JOURNAL   Nat Struct Mol Biol 24 (10), 866-869 (2017)
   PUBMED   28892042
REFERENCE   5  (bases 1 to 1605)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1605)
  AUTHORS   Jager,S., Cimermancic,P., Gulbahce,N., Johnson,J.R., McGovern,K.E.,
            Clarke,S.C., Shales,M., Mercenne,G., Pache,L., Li,K., Hernandez,H.,
            Jang,G.M., Roth,S.L., Akiva,E., Marlett,J., Stephens,M., D'Orso,I.,
            Fernandes,J., Fahey,M., Mahon,C., O'Donoghue,A.J., Todorovic,A.,
            Morris,J.H., Maltby,D.A., Alber,T., Cagney,G., Bushman,F.D.,
            Young,J.A., Chanda,S.K., Sundquist,W.I., Kortemme,T.,
            Hernandez,R.D., Craik,C.S., Burlingame,A., Sali,A., Frankel,A.D.
            and Krogan,N.J.
  TITLE     Global landscape of HIV-human protein complexes
  JOURNAL   Nature 481 (7381), 365-370 (2011)
   PUBMED   22190034
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1605)
  AUTHORS   Han,M.J., Cimen,H., Miller-Lee,J.L., Koc,H. and Koc,E.C.
  TITLE     Purification of human mitochondrial ribosomal L7/L12 stalk proteins
            and reconstitution of functional hybrid ribosomes in Escherichia
            coli
  JOURNAL   Protein Expr Purif 78 (1), 48-54 (2011)
   PUBMED   21453772
REFERENCE   8  (bases 1 to 1605)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   9  (bases 1 to 1605)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   10 (bases 1 to 1605)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Structural compensation for the deficit of rRNA with proteins in
            the mammalian mitochondrial ribosome. Systematic analysis of
            protein components of the large ribosomal subunit from mammalian
            mitochondria
  JOURNAL   J Biol Chem 276 (24), 21724-21736 (2001)
   PUBMED   11279069
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU597133.1, AK290084.1,
            AL519939.3 and BU678208.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016050.4.
            
            Summary: This nuclear gene encodes a 39S subunit component of the
            mitochondial ribosome. Alternative splicing results in multiple
            transcript variants. Pseudogenes for this gene are found on
            chromosomes 5 and 12. [provided by RefSeq, May 2014].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290084.1, SRR14038196.170939.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000310999.11/
                                                  ENSP00000308897.7
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BU597133.1         4-30
            28-947              AK290084.1         6-925
            948-1125            AL519939.3         465-642             c
            1126-1605           BU678208.1         18-497              c
FEATURES             Location/Qualifiers
     source          1..1605
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.2"
     gene            1..1605
                     /gene="MRPL11"
                     /gene_synonym="CGI-113; L11MT; MRP-L11; uL11m"
                     /note="mitochondrial ribosomal protein L11"
                     /db_xref="GeneID:65003"
                     /db_xref="HGNC:HGNC:14042"
                     /db_xref="MIM:611826"
     exon            1..217
                     /gene="MRPL11"
                     /gene_synonym="CGI-113; L11MT; MRP-L11; uL11m"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..673
                     /gene="MRPL11"
                     /gene_synonym="CGI-113; L11MT; MRP-L11; uL11m"
                     /note="isoform a is encoded by transcript variant 1; 39S
                     ribosomal protein L11, mitochondrial; mitochondrial large
                     ribosomal subunit protein uL11m"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL11m isoform a"
                     /protein_id="NP_057134.1"
                     /db_xref="CCDS:CCDS8139.1"
                     /db_xref="GeneID:65003"
                     /db_xref="HGNC:HGNC:14042"
                     /db_xref="MIM:611826"
                     /translation="MSKLGRAARGLRKPEVGGVIRAIVRAGLAMPGPPLGPVLGQRGV
                     SINQFCKEFNERTKDIKEGIPLPTKILVKPDRTFEIKIGQPTVSYFLKAAAGIEKGAR
                     QTGKEVAGLVTLKHVYEIARIKAQDEAFALQDVPLSSVVRSIIGSARSLGIRVVKDLS
                     SEELAAFQKERAIFLAAQKEADLAAQEEAAKK"
     exon            218..313
                     /gene="MRPL11"
                     /gene_synonym="CGI-113; L11MT; MRP-L11; uL11m"
                     /inference="alignment:Splign:2.1.0"
     exon            314..407
                     /gene="MRPL11"
                     /gene_synonym="CGI-113; L11MT; MRP-L11; uL11m"
                     /inference="alignment:Splign:2.1.0"
     exon            408..567
                     /gene="MRPL11"
                     /gene_synonym="CGI-113; L11MT; MRP-L11; uL11m"
                     /inference="alignment:Splign:2.1.0"
     exon            568..1605
                     /gene="MRPL11"
                     /gene_synonym="CGI-113; L11MT; MRP-L11; uL11m"
                     /inference="alignment:Splign:2.1.0"
     regulatory      825..830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL11"
                     /gene_synonym="CGI-113; L11MT; MRP-L11; uL11m"
                     /note="hexamer: AATAAA"
     polyA_site      842
                     /gene="MRPL11"
                     /gene_synonym="CGI-113; L11MT; MRP-L11; uL11m"
                     /note="major polyA site"
     regulatory      1576..1581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL11"
                     /gene_synonym="CGI-113; L11MT; MRP-L11; uL11m"
                     /note="hexamer: AATAAA"
     polyA_site      1605
                     /gene="MRPL11"
                     /gene_synonym="CGI-113; L11MT; MRP-L11; uL11m"
ORIGIN      
        1 gtgaggaccc ttgacctctg gcccaagatg gtggcgccca gagcttcgct cttgctgctc
       61 ccctgaggtg aactgaagcc agcagccccg catcatgtca aagctcggcc gggccgcccg
      121 gggcctcagg aagcccgagg tcggcggtgt gatccgggcg atcgtgcggg caggcctggc
      181 catgcccggg cccccactag gcccagtgct gggtcagaga ggcgtttcca tcaaccagtt
      241 ttgcaaggag ttcaatgaga ggacaaagga catcaaggaa ggcattcctc tgcctaccaa
      301 gattttagtg aagcctgaca ggacatttga aattaagatt ggacagccca ctgtttccta
      361 cttcctgaag gcagcagctg ggattgaaaa gggggcccgg caaacaggga aagaggtggc
      421 aggcctggtg accttgaagc atgtgtatga gattgcccgc atcaaagctc aggatgaggc
      481 atttgccctg caggatgtac ccctgtcgtc tgttgtccgc tccatcatcg ggtctgcccg
      541 ttctctgggc attcgcgtgg tgaaggacct cagttcagaa gagcttgcag ctttccagaa
      601 ggaacgagcc atcttcctgg ctgctcagaa ggaggcagat ttggctgccc aagaagaagc
      661 tgccaagaag tgacccttgc cccaccaact cccagatttc aaaggaggta gttgcaaaag
      721 ctgtgcccaa ggggaggaag gaggtcacac caatatgatg atggttttca tgactttgaa
      781 tgatatattt ttgtacatct agctgtatcg aggcatcagg cctgaataaa catcctttct
      841 tacccactgt catcttctat cttgggacct cagggaaggg aaccagtact ggtggtagcc
      901 aatatgggca gacattagga aattggggtc ttcatactgc ttctcagatg tgcaaactga
      961 ggttcagcca agcaaagtaa cttgcccagg tccttttttt tcttttttaa gttataattt
     1021 tgttttattg cccaggttct gaattggtgc cagaggtagg aatagaaccc aggccttctc
     1081 atttgaaatc ctgtgttctt cccctcccca gggtgggaac tatggttgct agggctgagg
     1141 tgtattgctt acttcttcca tcaaaaatct cttttatctc tgaacaactt gccacctctg
     1201 cagaaacaag tccctgtgga gatctcagtt cagccccagg cagggttact acatggagta
     1261 cccagatccc aggggctact tcaggccctt ctactaagct cctgaccctg gctctgggtc
     1321 agatgttggc tgaacatgaa ctattgtagg gctgacagct acagaccaca gaaagagcaa
     1381 agcttcagta ggttcctgcc tgatggagaa gtcctcggga agcccttggc cttctatttc
     1441 ctcattgtcc tttcagagaa gagagcagga gttgggggag aaaggagatt cgcatttact
     1501 gaccatctgt tatgtgctag acacttcatt ttacactgag aaaatatgga aagcatagat
     1561 aaacacctaa aagaaaataa aaacctcatg ttatcccacc accca
//
