LOCUS       NM_145255               1749 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein L10 (MRPL10),
            transcript variant 1, mRNA.
ACCESSION   NM_145255
VERSION     NM_145255.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1749)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1749)
  AUTHORS   Brown,A., Rathore,S., Kimanius,D., Aibara,S., Bai,X.C., Rorbach,J.,
            Amunts,A. and Ramakrishnan,V.
  TITLE     Structures of the human mitochondrial ribosome in native states of
            assembly
  JOURNAL   Nat Struct Mol Biol 24 (10), 866-869 (2017)
   PUBMED   28892042
REFERENCE   3  (bases 1 to 1749)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   4  (bases 1 to 1749)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 1749)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1749)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   7  (bases 1 to 1749)
  AUTHORS   Koc,E.C., Burkhart,W., Blackburn,K., Moyer,M.B., Schlatzer,D.M.,
            Moseley,A. and Spremulli,L.L.
  TITLE     The large subunit of the mammalian mitochondrial ribosome. Analysis
            of the complement of ribosomal proteins present
  JOURNAL   J Biol Chem 276 (47), 43958-43969 (2001)
   PUBMED   11551941
REFERENCE   8  (bases 1 to 1749)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   9  (bases 1 to 1749)
  AUTHORS   Goldschmidt-Reisin,S., Kitakawa,M., Herfurth,E.,
            Wittmann-Liebold,B., Grohmann,L. and Graack,H.R.
  TITLE     Mammalian mitochondrial ribosomal proteins. N-terminal amino acid
            sequencing, characterization, and identification of corresponding
            gene sequences
  JOURNAL   J Biol Chem 273 (52), 34828-34836 (1998)
   PUBMED   9857009
REFERENCE   10 (bases 1 to 1749)
  AUTHORS   Piatyszek,M.A., Denslow,N.D. and O'Brien,T.W.
  TITLE     RNA binding proteins of the large subunit of bovine mitochondrial
            ribosomes
  JOURNAL   Nucleic Acids Res 16 (6), 2565-2583 (1988)
   PUBMED   3129699
  REMARK    GeneRIF: Analyzes the RNA binding properties of orthologous bovine
            39S ribosomal subunit proteins, including MRPL10.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA137043.1, BC039852.1 and
            AI221522.1.
            
            On Nov 22, 2018 this sequence version replaced NM_145255.3.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 39S subunit protein. Sequence
            analysis identified three transcript variants that encode two
            different isoforms. A pseudogene corresponding to this gene is
            found on chromosome 5q. [provided by RefSeq, Nov 2010].
            
            Transcript Variant: This variant (1) is the predominant transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039852.1, DT220477.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000351111.7/
                                                  ENSP00000324100.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DA137043.1         1-21
            22-1561             BC039852.1         1-1540
            1562-1749           AI221522.1         6-193               c
FEATURES             Location/Qualifiers
     source          1..1749
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.32"
     gene            1..1749
                     /gene="MRPL10"
                     /gene_synonym="L10MT; MRP-L10; MRP-L8; MRPL8; RPML8;
                     uL10m"
                     /note="mitochondrial ribosomal protein L10"
                     /db_xref="GeneID:124995"
                     /db_xref="HGNC:HGNC:14055"
                     /db_xref="MIM:611825"
     exon            1..82
                     /gene="MRPL10"
                     /gene_synonym="L10MT; MRP-L10; MRP-L8; MRPL8; RPML8;
                     uL10m"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..816
                     /gene="MRPL10"
                     /gene_synonym="L10MT; MRP-L10; MRP-L8; MRPL8; RPML8;
                     uL10m"
                     /EC_number="3.6.5.3"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; 39S ribosomal protein L10, mitochondrial; L8mt;
                     39S ribosomal protein L8, mitochondrial; mitochondrial
                     large ribosomal subunit protein uL10m"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL10m isoform a
                     precursor"
                     /protein_id="NP_660298.2"
                     /db_xref="CCDS:CCDS11516.1"
                     /db_xref="GeneID:124995"
                     /db_xref="HGNC:HGNC:14055"
                     /db_xref="MIM:611825"
                     /translation="MAAAVAGMLRGGLLPQAGRLPTLQTVRYGSKAVTRHRRVMHFQR
                     QKLMAVTEYIPPKPAIHPSCLPSPPSPPQEEIGLIRLLRREIAAVFQDNRMIAVCQNV
                     ALSAEDKLLMRHQLRKHKILMKVFPNQVLKPFLEDSKYQNLLPLFVGHNMLLVSEEPK
                     VKEMVRILRTVPFLPLLGGCIDDTILSRQGFINYSKLPSLPLVQGELVGGLTCLTAQT
                     HSLLQHQPLQLTTLLDQYIREQREKDSVMSANGKPDPDTVPDS"
     exon            83..252
                     /gene="MRPL10"
                     /gene_synonym="L10MT; MRP-L10; MRP-L8; MRPL8; RPML8;
                     uL10m"
                     /inference="alignment:Splign:2.1.0"
     exon            253..417
                     /gene="MRPL10"
                     /gene_synonym="L10MT; MRP-L10; MRP-L8; MRPL8; RPML8;
                     uL10m"
                     /inference="alignment:Splign:2.1.0"
     exon            418..562
                     /gene="MRPL10"
                     /gene_synonym="L10MT; MRP-L10; MRP-L8; MRPL8; RPML8;
                     uL10m"
                     /inference="alignment:Splign:2.1.0"
     exon            563..1749
                     /gene="MRPL10"
                     /gene_synonym="L10MT; MRP-L10; MRP-L8; MRPL8; RPML8;
                     uL10m"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1541..1546
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL10"
                     /gene_synonym="L10MT; MRP-L10; MRP-L8; MRPL8; RPML8;
                     uL10m"
                     /note="hexamer: AATAAA"
     polyA_site      1561
                     /gene="MRPL10"
                     /gene_synonym="L10MT; MRP-L10; MRP-L8; MRPL8; RPML8;
                     uL10m"
                     /note="major polyA site"
     regulatory      1720..1725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL10"
                     /gene_synonym="L10MT; MRP-L10; MRP-L8; MRPL8; RPML8;
                     uL10m"
                     /note="hexamer: ATTAAA"
     polyA_site      1749
                     /gene="MRPL10"
                     /gene_synonym="L10MT; MRP-L10; MRP-L8; MRPL8; RPML8;
                     uL10m"
ORIGIN      
        1 actcggcttc cgtccattct tccggtggag atggctgcgg ccgtggcggg gatgctgcga
       61 gggggtctcc tgccccaggc gggccggctg cctaccctcc agactgtccg ctatggctcc
      121 aaggctgtta cccgccaccg tcgtgtgatg cactttcagc ggcagaagct gatggctgtg
      181 actgaatata tccccccgaa accagccatc cacccatcat gcctgccatc tcctcccagc
      241 cccccacagg aggagatagg cctcatcagg cttctccgcc gggagatagc agcagttttc
      301 caggacaacc gaatgatagc cgtctgccag aatgtggctc tgagtgcaga ggacaagctt
      361 cttatgcgac accagctgcg gaaacacaag atcctgatga aggtcttccc caaccaggtc
      421 ctgaagccct tcctggagga ttccaagtac caaaatctgc tgcccctttt tgtggggcac
      481 aacatgctgc tggtcagtga agagcccaag gtcaaggaga tggtacggat cttaaggact
      541 gtgccattcc tgccgctgct aggtggctgc attgatgaca ccatcctcag caggcagggc
      601 tttatcaact actccaagct ccccagcctg cccctggtgc agggggagct tgtaggaggc
      661 ctcacctgcc tcacagccca gacccactcc ctgctccagc accagcccct ccagctgacc
      721 accctgttgg accagtacat cagagagcaa cgcgagaagg attctgtcat gtcggccaat
      781 gggaagccag atcctgacac tgttccggac tcgtagccag cctgtttagc cagccctgcg
      841 cataaataca ctctgcgtta ttggctgtgc tctcctcaat gggacatgtg gaagaacttg
      901 gggtcgggga gtgtgtttgt cacttggttt tcactagtaa tgatattgtc aggtataggg
      961 ccacttggag atgcagagga ttccatttca gatgtcagtc accggcttcg tccttagttt
     1021 tcccaacttg ggacgtgata ggagcaaagt ctctccattc tccaggtcca aggcagagat
     1081 cctgaaaaga tagggctatt gtcccctgcc tccttggtca ctgcctcttg ctgcacgggc
     1141 tcctgagccc acccccttgg ggcacaacct gccactgcca cagtagctca accaagcagt
     1201 tgtgctgaga atggcacctg gtgagagcct gctgtgtgcc aggctttgtg ctgagtgctg
     1261 tacatgtatt agttccttta ctgctgacca cattgtaccc atttcacaga gaaggagcag
     1321 agaaattaag tggcttgctc aaggtcatgc agttagtaag tggcagaaca gggacttgaa
     1381 ccaagccctc tgctctgaag accgcgtcct gaatttcttc actagagctt cctcatcagg
     1441 ttacccagaa gtgggtccca tccaccatcc aggtgtgctt ggatgttagt tctccaccct
     1501 cgaggtgtac gctgtgaaaa gtttgggagc actgctttat aataaaatga aatatattct
     1561 acttccttta ttttgtggtt tacacggttg tcctccctct aaacttactc tcaggggctt
     1621 ctctgtcatc tgactttcct cactcttgct tcccttccta ggaaaatcct cttcccctat
     1681 acctgttccc acaaatggca tcccgcgcat gcttgcccta ttaaaggcag ctgacagctg
     1741 tacccacta
//
