LOCUS       NM_020236               1175 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mitochondrial ribosomal protein L1 (MRPL1), mRNA.
ACCESSION   NM_020236
VERSION     NM_020236.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1175)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1175)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1175)
  AUTHORS   Greber,B.J. and Ban,N.
  TITLE     Structure and Function of the Mitochondrial Ribosome
  JOURNAL   Annu Rev Biochem 85, 103-132 (2016)
   PUBMED   27023846
  REMARK    Review article
REFERENCE   4  (bases 1 to 1175)
  AUTHORS   Maki-Nevala,S., Sarhadi,V.K., Knuuttila,A., Scheinin,I.,
            Ellonen,P., Lagstrom,S., Ronty,M., Kettunen,E.,
            Husgafvel-Pursiainen,K., Wolff,H. and Knuutila,S.
  TITLE     Driver Gene and Novel Mutations in Asbestos-Exposed Lung
            Adenocarcinoma and Malignant Mesothelioma Detected by Exome
            Sequencing
  JOURNAL   Lung 194 (1), 125-135 (2016)
   PUBMED   26463840
  REMARK    GeneRIF: MLRP1 could possibly serve as a candidate gene for
            alterations associated with asbestos exposure.
REFERENCE   5  (bases 1 to 1175)
  AUTHORS   Brown,A., Amunts,A., Bai,X.C., Sugimoto,Y., Edwards,P.C.,
            Murshudov,G., Scheres,S.H.W. and Ramakrishnan,V.
  TITLE     Structure of the large ribosomal subunit from human mitochondria
  JOURNAL   Science 346 (6210), 718-722 (2014)
   PUBMED   25278503
REFERENCE   6  (bases 1 to 1175)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   7  (bases 1 to 1175)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1175)
  AUTHORS   Zhang,Z. and Gerstein,M.
  TITLE     Identification and characterization of over 100 mitochondrial
            ribosomal protein pseudogenes in the human genome
  JOURNAL   Genomics 81 (5), 468-480 (2003)
   PUBMED   12706105
REFERENCE   9  (bases 1 to 1175)
  AUTHORS   Kenmochi,N., Suzuki,T., Uechi,T., Magoori,M., Kuniba,M., Higa,S.,
            Watanabe,K. and Tanaka,T.
  TITLE     The human mitochondrial ribosomal protein genes: mapping of 54
            genes to the chromosomes and implications for human disorders
  JOURNAL   Genomics 77 (1-2), 65-70 (2001)
   PUBMED   11543634
REFERENCE   10 (bases 1 to 1175)
  AUTHORS   Suzuki,T., Terasaki,M., Takemoto-Hori,C., Hanada,T., Ueda,T.,
            Wada,A. and Watanabe,K.
  TITLE     Structural compensation for the deficit of rRNA with proteins in
            the mammalian mitochondrial ribosome. Systematic analysis of
            protein components of the large ribosomal subunit from mammalian
            mitochondria
  JOURNAL   J Biol Chem 276 (24), 21724-21736 (2001)
   PUBMED   11279069
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC014356.1 and BU675164.1.
            
            On Nov 23, 2018 this sequence version replaced NM_020236.3.
            
            Summary: Mammalian mitochondrial ribosomal proteins are encoded by
            nuclear genes and help in protein synthesis within the
            mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a
            small 28S subunit and a large 39S subunit. They have an estimated
            75% protein to rRNA composition compared to prokaryotic ribosomes,
            where this ratio is reversed. Another difference between mammalian
            mitoribosomes and prokaryotic ribosomes is that the latter contain
            a 5S rRNA. Among different species, the proteins comprising the
            mitoribosome differ greatly in sequence, and sometimes in
            biochemical properties, which prevents easy recognition by sequence
            homology. This gene encodes a 39S subunit protein that belongs to
            the L1 ribosomal protein family. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.333808.1,
                                           SRR5189658.80789.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000315567.13/
                                                  ENSP00000315017.8
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1171              BC014356.1         4-1174
            1172-1175           BU675164.1         24-27               c
FEATURES             Location/Qualifiers
     source          1..1175
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q21.1"
     gene            1..1175
                     /gene="MRPL1"
                     /gene_synonym="BM022; L1MT; MRP-L1; uL1m"
                     /note="mitochondrial ribosomal protein L1"
                     /db_xref="GeneID:65008"
                     /db_xref="HGNC:HGNC:14275"
                     /db_xref="MIM:611821"
     exon            1..50
                     /gene="MRPL1"
                     /gene_synonym="BM022; L1MT; MRP-L1; uL1m"
                     /inference="alignment:Splign:2.1.0"
     CDS             20..997
                     /gene="MRPL1"
                     /gene_synonym="BM022; L1MT; MRP-L1; uL1m"
                     /note="39S ribosomal protein L1, mitochondrial;
                     mitochondrial large ribosomal subunit protein uL1m"
                     /codon_start=1
                     /product="large ribosomal subunit protein uL1m precursor"
                     /protein_id="NP_064621.3"
                     /db_xref="CCDS:CCDS3583.2"
                     /db_xref="GeneID:65008"
                     /db_xref="HGNC:HGNC:14275"
                     /db_xref="MIM:611821"
                     /translation="MAAAVRCMGRALIHHQRHSLSKMVYQTSLCSCSVNIRVPNRHFA
                     AATKSAKKTKKGAKEKTPDEKKDEIEKIKAYPYMEGEPEDDVYLKRLYPRQIYEVEKA
                     VHLLKKFQILDFTSPKQSVYLDLTLDMALGKKKNVEPFTSVLSLPYPFASEINKVAVF
                     TENASEVKIAEENGAAFAGGTSLIQKIWDDEIVADFYVAVPEIMPELNRLRKKLNKKY
                     PKLSRNSIGRDIPKMLELFKNGHEIKVDEERENFLQTKIATLDMSSDQIAANLQAVIN
                     EVCRHRPLNLGPFVVRAFLRSSTSEGLLLKIDPLLPKEVKNEESEKEDA"
     exon            51..162
                     /gene="MRPL1"
                     /gene_synonym="BM022; L1MT; MRP-L1; uL1m"
                     /inference="alignment:Splign:2.1.0"
     exon            163..421
                     /gene="MRPL1"
                     /gene_synonym="BM022; L1MT; MRP-L1; uL1m"
                     /inference="alignment:Splign:2.1.0"
     exon            422..505
                     /gene="MRPL1"
                     /gene_synonym="BM022; L1MT; MRP-L1; uL1m"
                     /inference="alignment:Splign:2.1.0"
     exon            506..577
                     /gene="MRPL1"
                     /gene_synonym="BM022; L1MT; MRP-L1; uL1m"
                     /inference="alignment:Splign:2.1.0"
     exon            578..689
                     /gene="MRPL1"
                     /gene_synonym="BM022; L1MT; MRP-L1; uL1m"
                     /inference="alignment:Splign:2.1.0"
     exon            690..796
                     /gene="MRPL1"
                     /gene_synonym="BM022; L1MT; MRP-L1; uL1m"
                     /inference="alignment:Splign:2.1.0"
     exon            797..878
                     /gene="MRPL1"
                     /gene_synonym="BM022; L1MT; MRP-L1; uL1m"
                     /inference="alignment:Splign:2.1.0"
     exon            879..1175
                     /gene="MRPL1"
                     /gene_synonym="BM022; L1MT; MRP-L1; uL1m"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1152..1157
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRPL1"
                     /gene_synonym="BM022; L1MT; MRP-L1; uL1m"
                     /note="hexamer: AATAAA"
     polyA_site      1175
                     /gene="MRPL1"
                     /gene_synonym="BM022; L1MT; MRP-L1; uL1m"
                     /note="major polyA site"
ORIGIN      
        1 gcaatccgga gtgcccaaca tggcggcggc cgtaaggtgc atgggtagag ccttgataca
       61 tcatcaaagg catagccttt ccaagatggt ttatcagaca tcactttgtt cttgttctgt
      121 aaacatccga gtgcccaaca gacattttgc tgctgctaca aagtctgcaa agaaaacaaa
      181 aaaaggtgct aaagaaaaaa caccagatga gaaaaaagat gaaatagaaa aaataaaagc
      241 atatccctat atggaaggcg aacctgagga tgatgtctat ttaaaacgct tatacccgag
      301 acagatatat gaggtggaga aagctgttca cttacttaag aaatttcaaa ttcttgactt
      361 tactagtcca aagcaaagtg tttatcttga tttgacactg gatatggcac tgggaaagaa
      421 gaaaaacgtg gagccattta ccagtgttct tagtttgcca tacccatttg cttccgaaat
      481 caataaagtt gctgtattta cagagaatgc atcagaggtc aaaatagcgg aagaaaatgg
      541 agctgcattt gcaggaggca ctagtctgat acagaagatt tgggatgatg aaattgttgc
      601 agacttttac gtagctgttc cagaaataat gcctgaactt aatcgattaa ggaagaaact
      661 gaataaaaaa tatccaaagc tttctcgaaa ttccattggc cgtgacatcc ccaaaatgct
      721 tgaattattt aaaaatggac atgaaattaa ggtagatgaa gaaagggaga actttctcca
      781 gaccaaaata gcaacattgg atatgtcaag tgaccagata gctgccaatc tgcaagcagt
      841 tattaatgaa gtttgtaggc acagaccgct gaatttgggt ccctttgtgg tacgtgcttt
      901 ccttcgtagt tcaacaagtg aaggtttatt actgaagatt gatccattgt tgcctaaaga
      961 agtaaaaaat gaagaaagtg aaaaagaaga tgcctaaatg tggtgaattg tgaaattact
     1021 ttcagtggtt taagaagcaa tggagaaaat gataatacag cataattttt acatttgatg
     1081 tcttgttatt gatcatactt gaaagtgaac tttaacattg aaaaatcgta cagtcatttc
     1141 aagaataaga aaataaaatt ttctctttgt ctgaa
//
