LOCUS       NM_152503               3502 bp    mRNA    linear   PRI 02-JUN-2024
DEFINITION  Homo sapiens maestro heat like repeat family member 8 (MROH8),
            transcript variant 1, mRNA.
ACCESSION   NM_152503
VERSION     NM_152503.8
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3502)
  AUTHORS   Potkin,S.G., Guffanti,G., Lakatos,A., Turner,J.A., Kruggel,F.,
            Fallon,J.H., Saykin,A.J., Orro,A., Lupoli,S., Salvi,E., Weiner,M.
            and Macciardi,F.
  CONSRTM   Alzheimer's Disease Neuroimaging Initiative
  TITLE     Hippocampal atrophy as a quantitative trait in a genome-wide
            association study identifying novel susceptibility genes for
            Alzheimer's disease
  JOURNAL   PLoS One 4 (8), e6501 (2009)
   PUBMED   19668339
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3502)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   3  (bases 1 to 3502)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
REFERENCE   4  (bases 1 to 3502)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL031659.9, ABBA01006615.1 and
            AL136172.16.
            
            On Feb 16, 2023 this sequence version replaced NM_152503.7.
            
            Summary: The protein encoded by this gene belongs to the maestro
            heat-like repeat family. The exact function of this gene is not
            known, however, in a genome-wide association study using
            hippocampal atrophy as a quantitative trait, this gene has been
            associated with Alzheimer's disease (PMID:19668339). Alternatively
            spliced transcript variants encoding different isoforms have been
            found for this gene. [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030006.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000710289.2/ ENSP00000518179.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               AL031659.9         19655-19808         c
            155-191             ABBA01006615.1     2549-2585           c
            192-355             AL031659.9         19483-19646         c
            356-477             AL031659.9         14255-14376         c
            478-623             AL031659.9         12172-12317         c
            624-746             AL031659.9         8381-8503           c
            747-826             AL031659.9         357-436             c
            827-971             AL136172.16        68465-68609         c
            972-1067            AL136172.16        67433-67528         c
            1068-1172           AL136172.16        64636-64740         c
            1173-1308           AL136172.16        57347-57482         c
            1309-1433           AL136172.16        53290-53414         c
            1434-1586           AL136172.16        50735-50887         c
            1587-1747           AL136172.16        47383-47543         c
            1748-1883           AL136172.16        38605-38740         c
            1884-2074           AL136172.16        33182-33372         c
            2075-2212           AL136172.16        30472-30609         c
            2213-2327           AL136172.16        30077-30191         c
            2328-2468           AL136172.16        29271-29411         c
            2469-2633           AL136172.16        24746-24910         c
            2634-2789           AL136172.16        23563-23718         c
            2790-2912           AL136172.16        21897-22019         c
            2913-3012           AL136172.16        19829-19928         c
            3013-3078           AL136172.16        18172-18237         c
            3079-3250           AL136172.16        12237-12408         c
            3251-3502           AL136172.16        10740-10991         c
FEATURES             Location/Qualifiers
     source          1..3502
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.23"
     gene            1..3502
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /note="maestro heat like repeat family member 8"
                     /db_xref="GeneID:140699"
                     /db_xref="HGNC:HGNC:16125"
     exon            1..355
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..3227
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /note="isoform 1 is encoded by transcript variant 1;
                     maestro heat-like repeat-containing protein family member
                     8"
                     /codon_start=1
                     /product="protein MROH8 isoform 1"
                     /protein_id="NP_689716.4"
                     /db_xref="GeneID:140699"
                     /db_xref="HGNC:HGNC:16125"
                     /translation="MPLSRRGRGSRLAGSRAATSNLPRATALSPKSAGRGALSISHAQ
                     LLTRRRHSSEQVPPESEPRADFRSGKWLQEPATGDARDSRQALRARMSSKHRICSQEE
                     VVIPCAYDSDSESVDLELSNLEIIKKGSSSIELTDLDIPDIPGLHCEPLSHSPRHLTQ
                     QDPLSEAIVEKLIQSIQKVFNGELKGELEKLKFLGDLSSLSQALPYDETAKSFIHSHI
                     ADIVHTLNVLVQEERPHSLSSSMRQEVFVTIADLSYQDVHLLLGSEDRAELFSLTIKS
                     IITLPSVRTLTQIQEIMPNGTCNTECLYRQTFQAFSEMLQSLVVKDPHLENLDTIIKH
                     LVPWLQSVKDHERERATASMAQVLKCLSKHLNLKLPLRFQRLGHLVALMALLCGDPQE
                     KVAEEAAEGIHSLLHITLRLKYITHDKKDQQNLKRALTKCREFLELHSSAAKCFYNCP
                     FRIAQVFEGFLDSNELCQFIMTTFDTLKTLKHPCIQRSAGELLLTLAKNTESQFEKVP
                     EIMGVICAQLSIISQPRVRQQIINTVSLFISRPKYTDIVLSFLLCHPVPYNRHLAEVW
                     RMLSVELPSTTWILWRLLRKLQKCHNEPAQEKMAYVAVAATDALYEVFLGNRLRAATF
                     RLFPQLLMTLLIQIHHSIGLTMSDVDIPSGLYTEQEVPSEVTPLCFAMQATKTLLLRT
                     CCLQEFNIMEKNKGWALLGGKDGHLQGLFLLANALLERNQLLAQKVMYLLVPLLNRGN
                     DKHKLTSAGFFVELLRSPVAKRLPSIYSVARFKDWLQDGNHLFRILGLRGLYNLVGHQ
                     EMREDIKSLLPYIVDSLRETDEKIVLSAIQILLQLVRTMDFTTLAAMMRTLFSLFGDV
                     RSDVHRFSVTLFGAAIKSVKNPDKKSIENQVLDSLVPLLLYSQDENDAVAEESRQVLT
                     ICAQFLKWKLPQEVYSKDPWHIKPTEAGTICRFFEKKCKGKINILEQTLMYSKNPKLP
                     IRRSAVLFVGLLSKYMDHNELRRMGTDWIEDDLRDLLCDPEPSLCIIASQTLLLVQMA
                     RAEPKPKQRVNWLQKLMGRSSA"
     exon            356..477
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /inference="alignment:Splign:2.1.0"
     exon            478..623
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /inference="alignment:Splign:2.1.0"
     exon            624..746
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /inference="alignment:Splign:2.1.0"
     exon            747..826
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /inference="alignment:Splign:2.1.0"
     exon            827..971
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1067
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1172
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1308
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1433
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1586
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1747
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /inference="alignment:Splign:2.1.0"
     exon            1748..1883
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..2074
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2212
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /inference="alignment:Splign:2.1.0"
     exon            2213..2327
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /inference="alignment:Splign:2.1.0"
     exon            2328..2468
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /inference="alignment:Splign:2.1.0"
     exon            2469..2633
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /inference="alignment:Splign:2.1.0"
     exon            2634..2789
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /inference="alignment:Splign:2.1.0"
     exon            2790..2912
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3012
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3078
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /inference="alignment:Splign:2.1.0"
     exon            3079..3250
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /inference="alignment:Splign:2.1.0"
     exon            3251..3502
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3419..3424
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /note="hexamer: AATAAA"
     polyA_site      3443
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /note="major polyA site"
     regulatory      3475..3480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
                     /note="hexamer: AATAAA"
     polyA_site      3500
                     /gene="MROH8"
                     /gene_synonym="C20orf131; C20orf132"
ORIGIN      
        1 actcccacca gctcgcagcc ctccttcgga ccctcgatcc gagagcgccc cagccagagc
       61 ttgtgcccat gcccctgtcc cgcaggggaa ggggatcccg cctggccggc tctcgagcgg
      121 cgactagtaa cctcccgcgg gcgacagccc tctccccaaa gagtgccggc cgcggggccc
      181 tgtctataag ccacgcgcaa ctcctcaccc ggcggcgcca ttcctccgag caggtcccgc
      241 cggagtccga gccgcgggct gacttccgct cgggaaagtg gctccaagag cccgccacag
      301 gggacgccag ggactcgcgg caggctctgc gggccaggat gagttctaag cacaggatct
      361 gtagtcagga agaagtagtg atcccctgtg cctatgacag tgattcagaa agtgtggatt
      421 tggagctgag caacttagag attattaaaa aaggctcaag tagcattgaa ctgacagact
      481 tggacatccc tgacatccct ggactccatt gtgagcccct gtcacatagc cccagacacc
      541 tgacccaaca ggacccgctc agtgaggcca ttgttgagaa actgatccag tccatccaga
      601 aggttttcaa tggtgagcta aagggtgaac ttgaaaagct gaaattccta ggagatctgt
      661 cttctctcag ccaagcttta ccttatgatg aaaccgcaaa atcattcatt cacagccaca
      721 tagcagacat tgtgcatacc ttaaatgtac tggtacaaga ggaacgcccg cattctctgt
      781 ccagttccat gcgccaggag gtctttgtca ccatcgctga tctcagttac caagatgtcc
      841 atttgctgtt gggctctgaa gatcgagctg agttgttcag tcttaccatc aagagtataa
      901 tcactctgcc ctctgtaagg acccttaccc agatacagga aatcatgccc aatgggacct
      961 gcaacacaga gtgtctttac aggcagacgt ttcaggcatt ctctgagatg ctccagagtt
     1021 tggtggtaaa agacccacat ttggaaaatc ttgacaccat tattaagcac ttggtcccct
     1081 ggttacagtc agtcaaagac catgagcggg aacgggccac ggccagcatg gctcaagttc
     1141 tgaagtgcct atccaaacat ctcaacttga agcttccact gcgattccaa agacttggac
     1201 acctagtggc tctgatggca ctgctctgtg gggacccaca ggaaaaggtg gctgaggagg
     1261 ctgcagaggg cattcactcc ctgctgcata tcaccctgag gctgaagtat atcactcatg
     1321 acaagaaaga tcagcaaaac ttgaaaagag cattgacaaa atgtcgagaa ttcctggagc
     1381 tccacagctc tgccgctaaa tgcttctaca actgtccctt cagaattgcc caggtctttg
     1441 aaggttttct tgattcaaat gagctctgcc agtttataat gactacattt gataccctga
     1501 aaaccctgaa acatccctgc atccagcgat cagcaggaga attactgcta actttggcaa
     1561 aaaatacaga gtcccaattt gagaaggtgc cagaaattat gggagttatc tgtgcccagt
     1621 tatccataat cagccagcct agagtccgcc aacaaatcat aaataccgtg agtttattta
     1681 tatccagacc caagtacaca gatatagtgc tcagcttcct tctgtgtcat ccagtgccgt
     1741 ataacaggca cctggctgag gtgtggagaa tgctgtcggt ggagcttccc agcacgacct
     1801 ggattctgtg gaggctcctg aggaagctgc agaaatgcca taatgagcct gcacaggaga
     1861 agatggcata tgtggctgtg gctgcaacag atgcccttta tgaggtgttt ttgggaaaca
     1921 ggcttcgagc agctacgttc cgactctttc ctcagcttct catgacactg cttatccaga
     1981 ttcatcacag catcggcctc accatgtctg atgtcgacat cccaagtggc ctgtacacag
     2041 aacaggaagt gccttcagag gtcacccctt tgtgctttgc catgcaggct acaaagactc
     2101 tcctcctcag aacatgctgc ttgcaggaat tcaacatcat ggaaaagaat aaaggatggg
     2161 ctctcctggg aggaaaagat ggccatcttc agggactatt tctccttgcc aacgcattgc
     2221 tggaaagaaa tcagctcctt gcacagaagg tcatgtactt attagtccct cttcttaacc
     2281 gagggaatga taaacataaa ctcacatctg caggcttttt tgtggagctt ctccggagtc
     2341 cagtggccaa gagactgccc agcatatact ctgttgcccg ctttaaagac tggctacaag
     2401 atggaaatca tctctttaga attctcggcc tgaggggact gtacaatctt gttggacacc
     2461 aggagatgag agaagacatc aagagcctgt tgccatacat tgtagacagc ttgcgtgaaa
     2521 ccgatgagaa gatcgttctg tcagccatcc agatactcct gcaacttgtt agaacaatgg
     2581 atttcactac cctggctgcc atgatgagga ccctgttctc cttatttggt gatgtgagat
     2641 ctgatgttca tcgtttctcc gtgactctct ttggagccgc cataaagtct gtaaaaaacc
     2701 cagataagaa gagtatagag aaccaagtcc tggacagctt ggtcccacta cttctgtatt
     2761 ctcaggatga aaatgatgca gtagctgagg agagcaggca agtcctaact atatgtgccc
     2821 agttcctgaa gtggaagctg ccccaagaag tgtactccaa agatccctgg cacatcaaac
     2881 ctactgaagc aggaacaatc tgcagattct ttgaaaaaaa gtgcaagggg aaaattaaca
     2941 tcctagaaca aacactgatg tactccaaga acccaaaact tcccatcaga agatcagcag
     3001 tcttgtttgt aggcctttta tcgaagtaca tggatcacaa tgagctcagg aggatgggta
     3061 ctgactggat agaggacgat ctgagagacc tgctgtgtga ccctgagccc tcgctgtgca
     3121 tcatcgcttc ccagactctg ttactagtcc agatggcgag ggccgaacca aaacctaagc
     3181 agagagtgaa ctggttgcag aagctcatgg gcaggtcctc tgcctagaaa cacaaggcaa
     3241 gcaacatcag agacagaatc ttgctatgtt gtgcggcaag ctagtcttga actcatggcc
     3301 tcaagtcatc ctcctgtgtc agcctcccaa agtgctggga ttacaagcat gcaccacggc
     3361 acccagcaga attccagtct tgagaaacag gtcaaggaca gcttcaaaag agattctaaa
     3421 taaatgttaa tgttacaatg ttagtatgtc tgcttaattg ccaacaatat taagaataaa
     3481 gtaacttttt tttttttttt ga
//
