LOCUS       NM_001039464            4343 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens maestro heat like repeat family member 7 (MROH7),
            transcript variant 1, mRNA.
ACCESSION   NM_001039464
VERSION     NM_001039464.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4343)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590093.10 and AL139244.21.
            
            On Nov 22, 2018 this sequence version replaced NM_001039464.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK302446.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000421030.7/ ENSP00000396622.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               AL590093.10        46140-46322
            184-218             AL590093.10        56303-56337
            219-1523            AL590093.10        57207-58511
            1524-1597           AL139244.21        9036-9109
            1598-1681           AL139244.21        12723-12806
            1682-1761           AL139244.21        14366-14445
            1762-1891           AL139244.21        14669-14798
            1892-1987           AL139244.21        16960-17055
            1988-2092           AL139244.21        17570-17674
            2093-2228           AL139244.21        17885-18020
            2229-2341           AL139244.21        22611-22723
            2342-2518           AL139244.21        23132-23308
            2519-2673           AL139244.21        23760-23914
            2674-2812           AL139244.21        26525-26663
            2813-3003           AL139244.21        30127-30317
            3004-3141           AL139244.21        36293-36430
            3142-3256           AL139244.21        39245-39359
            3257-3397           AL139244.21        44190-44330
            3398-3577           AL139244.21        45012-45191
            3578-3733           AL139244.21        45959-46114
            3734-3856           AL139244.21        46492-46614
            3857-3959           AL139244.21        50304-50406
            3960-4022           AL139244.21        52883-52945
            4023-4343           AL139244.21        53815-54135
FEATURES             Location/Qualifiers
     source          1..4343
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..4343
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /note="maestro heat like repeat family member 7"
                     /db_xref="GeneID:374977"
                     /db_xref="HGNC:HGNC:24802"
     exon            1..183
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /inference="alignment:Splign:2.1.0"
     exon            184..218
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /inference="alignment:Splign:2.1.0"
     exon            219..1523
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /inference="alignment:Splign:2.1.0"
     CDS             293..4264
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /note="isoform 1 is encoded by transcript variant 1; HEAT
                     repeat-containing protein 8; maestro heat-like
                     repeat-containing protein family member 7"
                     /codon_start=1
                     /product="maestro heat-like repeat-containing protein
                     family member 7 isoform 1"
                     /protein_id="NP_001034553.3"
                     /db_xref="CCDS:CCDS41342.2"
                     /db_xref="GeneID:374977"
                     /db_xref="HGNC:HGNC:24802"
                     /translation="MALSPGANLVFHEDPKMTPSPPSCGAPGLGSGTIPQPHPDMAQV
                     PMLNLLPSPGLALVPDLNDSLSPVSGEASGLVSENTPRPDDSRAIAPASLQITSSCSG
                     EALDLDSKDVSRPDSQGRLCPASNPILSPSSTEAPRLSSGNHPQSNSEDAFKCLSSKI
                     FKLGQRNSNPSRHELNPFIRHHSREGLVLGHCISRPSSKALLIPTSNSSLDLDSNPLL
                     NMGSRNTSKLNLNVAPDSHGTLIPDTNETITLASHNISESVSKGAFSTTWSTSSKETM
                     NVASSGHSRSDLSVTITQASYVTLIPGSSYGISLHSSTHEPNSTISPPSCMTLILGSN
                     ETLSLDSSLLFSDTSTLTLSSQQDDAKDNSIHTVPLEENLESWSEMASIKVGQFPLGF
                     PISNPAGKDAVTLQGIPEGAFDEVTSCLVKVPEKTEGGNNMALVENVTTLQKSQDLLE
                     AEGEKKTMIKKIMRQIQEEPLDSLSSSVRKQAMEILTQLSHTQPTLGMRERSELVNVC
                     VHSVFSLPSVQAMQEKDEAKAETIQALYHQTLEALQTLLKALFIEDPTPAGLKSILEA
                     LGPWMNSGKAHERARAVNTNVSVLNHMLLTLPFFMPLGFPALGLLLGRLILHIGDPDE
                     EIGCEALDGIIILYTILELQKRARDKEETNKKELYESNKHFLGPYNPVSPCQNILRVI
                     EEFGDFLGPQQIKDLLLAALEGLKGSSEAPGKDSREMMQLASEVMLSSVLEWYRHRAL
                     EVIPEIMQGIYMQLSHIQEPRARQVALLPVSLLASSFMTEVVVALLMCPLPLNSNGAE
                     MWRQLILCKPSCDVRDLLDLLLGSLKEKPVTKEGRASIVPLAAASGLCELLSVNSCMG
                     RVRRIYPQLLLALLIQVHYHIGLNLPGCVAPPKDTKKGAQPSPFVPVRWVVKVVKTLL
                     LRMGCSYETTFLEDQGGWELMEQVESHHRGVALLARAMVQYSCQELCRILYLLIPLLE
                     RGDEKHRITATAFFVELLQMEQVRRIPEEYSLGRMAEGLSHHDPIMKVLSIRGLVILA
                     RRSEKTAKVKALLPSMVKGLKNMDGMLVVEAVHNLKAVFKGRDQKLMDSAVYVEMLQI
                     LLPHFSDAREVVRSSCINLYGKVVQKLRAPRTQAMEEQLVSTLVPLLLTMQEGNSKVS
                     QKCVKTLLRCSYFMAWELPKRAYSRKPWDNQQQTVAKICKCLVNTHRDSAFIFLSQSL
                     EYAKNSRASLRKCSVMFIGSLVPCMESIMTEDRLNEVKAALDNLRHDPEASVCIYAAQ
                     VQDHILASCWQNSWLPHGNSWVCYSATTHRWSPSCENLPTSHQRRSWIMQALGSWKMS
                     LKK"
     exon            1524..1597
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1681
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1761
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1762..1891
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..1987
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2092
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2228
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /inference="alignment:Splign:2.1.0"
     exon            2229..2341
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /inference="alignment:Splign:2.1.0"
     exon            2342..2518
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /inference="alignment:Splign:2.1.0"
     exon            2519..2673
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /inference="alignment:Splign:2.1.0"
     exon            2674..2812
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /inference="alignment:Splign:2.1.0"
     exon            2813..3003
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3141
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /inference="alignment:Splign:2.1.0"
     exon            3142..3256
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /inference="alignment:Splign:2.1.0"
     exon            3257..3397
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /inference="alignment:Splign:2.1.0"
     exon            3398..3577
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /inference="alignment:Splign:2.1.0"
     exon            3578..3733
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /inference="alignment:Splign:2.1.0"
     exon            3734..3856
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /inference="alignment:Splign:2.1.0"
     exon            3857..3959
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /inference="alignment:Splign:2.1.0"
     exon            3960..4022
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /inference="alignment:Splign:2.1.0"
     exon            4023..4343
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4318..4323
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /note="hexamer: TATAAA"
     polyA_site      4343
                     /gene="MROH7"
                     /gene_synonym="C1orf175; HEATR8"
                     /note="major polyA site"
ORIGIN      
        1 gaggggcagc tctgggaaag tcctaggggt gggggcagtc tccacagcct cccacaaggg
       61 agttaccacc ttcccgcact tctgggtaca agtctcctgc tctggctgta ttccacagtt
      121 agaacttcat atctttggct tagagctgga ttttctgtta ccatgtggat gctccaggtg
      181 aaggggcccg ctcctgctta aaaacaccat gcatgcagac tgctgctggg aatgtgacag
      241 ttggctgttg gagagaagcg ggcactggca ttgagagacc tccagactgg acatggccct
      301 gagtccaggg gctaacctgg tcttccatga agacccaaag atgacaccaa gtcccccctc
      361 ctgtggggcc ccgggattag ggtctggtac catccctcag ccccacccag acatggctca
      421 ggtgcctatg ttgaatctgc tcccaagtcc tggcttggct ctcgttccag atcttaatga
      481 ttctttgagt ccagtctcag gggaggcctc aggcctggtg tctgaaaaca cccccagacc
      541 tgatgacagc agagctatcg ctccagcctc cctccagatc accagttctt gttctggtga
      601 agccctggac ctggattcca aggatgtctc aaggcctgac tcacaggggc gcctctgtcc
      661 agcctcaaac cccattctga gccctagctc tactgaggcc cctcgtctga gctctgggaa
      721 ccaccctcag tcaaattctg aagatgcctt caagtgcctc tcaagtaaga ttttcaagtt
      781 gggtcagaga aactccaacc cttctaggca tgaattaaac ccatttataa ggcaccattc
      841 cagagaaggt ctggttctgg gccactgcat ctctaggcca agctcaaaag cactccttat
      901 tccaacctca aactcttctc tggaccttga ctccaatcca ttgctcaaca tgggctcaag
      961 aaacacctcc aagctgaacc tgaatgtagc tccagattct catgggaccc taatcccaga
     1021 cacaaatgag accatcactt tggcttcaca taatatctct gagtctgttt caaaaggagc
     1081 ctttagtacc acctggagca caagttcaaa ggaaaccatg aatgtggctt ccagcggcca
     1141 ctccagatct gatttgagcg tgaccatcac tcaagcctcg tatgtgaccc tgattcctgg
     1201 ctccagctat ggtatcagcc tgcactccag cacccatgag cccaactcca ccatctctcc
     1261 accctcatgc atgactctaa tcctgggttc caatgagact ctgagcctgg actccagcct
     1321 cctgttcagc gacacctcca ccttgacgct gagcagtcag caggatgatg ccaaggacaa
     1381 cagcatccac actgtgcccc tggaggagaa tctggagagt tggagtgaga tggccagcat
     1441 taaggtgggc cagttcccgc tgggattccc catctccaac cccgcaggca aggacgccgt
     1501 gaccttgcaa ggcatccctg agggagcctt tgatgaagtg acctcatgcc tggtgaaggt
     1561 gccagagaag acagaaggtg gcaacaacat ggctctggtt gagaatgtca ccacccttca
     1621 gaagagccag gatctgctgg aggcagaagg agaaaagaag accatgataa agaagattat
     1681 gaggcagatc caggaggagc cactggattc tctctcaagc tccgtccgca agcaggccat
     1741 ggagatcctg acccagctga gccacaccca gcccaccctg ggcatgcggg agaggtcgga
     1801 gctggtgaac gtgtgtgtgc acagcgtgtt ctccctgccc tccgtgcagg cgatgcagga
     1861 gaaggacgag gccaaggctg agaccatcca ggctctttac catcagaccc tggaggccct
     1921 gcagacactg ctcaaagccc tctttatcga ggaccccact cctgctgggc tgaagagcat
     1981 cttggaggcc ctggggcctt ggatgaactc tgggaaggcc catgagcgag cacgggctgt
     2041 gaacaccaat gtctctgtgt tgaaccacat gcttctaact ctgcctttct ttatgccctt
     2101 ggggttcccg gcgctggggc ttctgctggg gagactcatc cttcacattg gggatcctga
     2161 tgaggagatt ggctgtgagg ctctggacgg catcatcatc ctctacacta ttctggagct
     2221 ccaaaaacga gccagagata aggaagagac caacaaaaag gagctatatg agagcaacaa
     2281 gcatttcctg gggccctaca accctgtgag cccgtgccag aacattctgc gggtgatcga
     2341 ggaatttgga gacttcctgg ggccccagca gataaaggac ctgctgctgg ccgccctgga
     2401 agggctgaaa ggcagctcag aggctccagg gaaggactcc agggagatga tgcagctggc
     2461 ctcggaggtc atgctcagct cggtgctgga gtggtaccgc cacagggcgc tggaggtgat
     2521 cccagaaatc atgcaaggca tctacatgca gctgagccac atccaggagc ctcgggcccg
     2581 ccaggtggcc ctgctgcccg tctccctcct ggctagctcc ttcatgaccg aggttgtggt
     2641 ggccctgctc atgtgccccc tcccactgaa cagcaatgga gcagagatgt ggaggcagct
     2701 gatactgtgt aagcccagct gtgatgtccg agacctcctg gatctgctcc tgggcagcct
     2761 gaaggagaag cccgtcacca aggagggccg ggcttccatc gtgcccctgg cggcagccag
     2821 cggcctgtgc gagctcctgt ccgtcaacag ctgcatgggc cgtgtgaggc gcatctaccc
     2881 tcagctgctc ctggccctgc tcattcaggt ccattaccac atcggcctca acctgcctgg
     2941 ctgcgtggct cctcccaagg acaccaagaa gggtgcacag ccctctccct tcgtacctgt
     3001 gcgctgggtg gtgaaagtgg tgaaaaccct gctactgagg atgggctgct cttatgagac
     3061 cacgtttctg gaggaccagg gtggctggga gctcatggag caggtggaga gccaccaccg
     3121 cggagtggcc ttgctggcaa gggccatggt gcagtactcc tgccaggagc tgtgccgcat
     3181 cctctacctg ctcatcccgc tcctggagcg aggcgacgag aagcacagga tcacggccac
     3241 cgccttcttc gtggagctcc tccagatgga gcaggtgcgc cggatccccg aggaatactc
     3301 tctggggcgg atggcagaag gcctgagcca ccacgacccc atcatgaagg tgctgtccat
     3361 tcgaggcctg gtcatcctgg cccgcaggtc tgagaagacc gccaaggtga aggccctcct
     3421 gccctccatg gtgaagggcc tgaagaacat ggatgggatg ctggtggtgg aagcggtcca
     3481 caacctcaag gctgtcttca aggggcggga ccagaagctg atggacagtg cggtctatgt
     3541 ggagatgctg cagatcctgc tgccgcactt cagcgacgca cgagaggtcg tgcgctcctc
     3601 ctgcatcaac ctgtatggga aggtggtcca gaagcttcgg gcaccacgca ctcaggccat
     3661 ggaggagcag ctggtcagca ccttggtgcc cctactgctg accatgcagg agggcaactc
     3721 caaggtaagc cagaagtgtg tgaagaccct gttacgctgt tcttacttca tggcttggga
     3781 gttgccaaaa agagcttata gccggaagcc ctgggacaac caacagcaga cagtggccaa
     3841 aatttgcaag tgccttgtga acacccaccg agacagcgcc ttcatattcc tcagccagag
     3901 cctggagtat gccaagaact cacgggcctc cctccggaag tgctcagtca tgttcatagg
     3961 gtccctggtc ccctgcatgg agagcataat gacagaagat cgtctgaatg aagtgaaagc
     4021 tgctctggat aacttgagac atgacccaga agcatcagtg tgcatctacg cagcccaggt
     4081 ccaggaccac atcctggcca gctgctggca gaactcctgg ctgccgcacg ggaactcatg
     4141 ggtgtgttac tcagccacca cccaccgctg gagccccagc tgtgagaacc tgcccacttc
     4201 ccaccagcgg cgctcctgga tcatgcaggc actgggctcc tggaagatgt ccttgaagaa
     4261 gtgacgtccc tgagccccaa accctcctca gggtggttga gttccagcca tgctccctat
     4321 aaatgtcatg tggcttacct ctc
//
