LOCUS       NM_032450               5349 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens maestro heat like repeat family member 1 (MROH1),
            transcript variant 1, mRNA.
ACCESSION   NM_032450
VERSION     NM_032450.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5349)
  AUTHORS   Li,L., Liu,X., Yang,S., Li,M., Wu,Y., Hu,S., Wang,W., Jiang,A.,
            Zhang,Q., Zhang,J., Ma,X., Hu,J., Zhao,Q., Liu,Y., Li,D., Hu,J.,
            Yang,C., Feng,W. and Wang,X.
  TITLE     The HEAT repeat protein HPO-27 is a lysosome fission factor
  JOURNAL   Nature 628 (8008), 630-638 (2024)
   PUBMED   38538795
  REMARK    GeneRIF: The HEAT repeat protein HPO-27 is a lysosome fission
            factor.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA934047.1, AL834309.1, AC104592.6, CN333563.1 and AC145291.3.
            
            On Jan 22, 2020 this sequence version replaced NM_032450.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853566.27315.1,
                                           SRR14038194.2735937.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326134.10/ ENSP00000321737.5
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               DA934047.1         1-116
            117-349             AL834309.1         1-233
            350-350             AC104592.6         91982-91982
            351-4763            AL834309.1         235-4647
            4764-5304           CN333563.1         118-658
            5305-5349           AC145291.3         7472-7516           c
FEATURES             Location/Qualifiers
     source          1..5349
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..5349
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /note="maestro heat like repeat family member 1"
                     /db_xref="GeneID:727957"
                     /db_xref="HGNC:HGNC:26958"
     exon            1..61
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            62..181
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            182..259
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..5163
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /note="isoform 1 is encoded by transcript variant 1; HEAT
                     repeat-containing protein 7A; HEAT repeat containing 7A;
                     maestro heat-like repeat-containing protein family member
                     1"
                     /codon_start=1
                     /product="maestro heat-like repeat-containing protein
                     family member 1 isoform 1"
                     /protein_id="NP_115826.3"
                     /db_xref="CCDS:CCDS47938.1"
                     /db_xref="GeneID:727957"
                     /db_xref="HGNC:HGNC:26958"
                     /translation="MTESSMKKLASTLLDAITDKDPLVQEQVCSALCSLGEARPVETL
                     RACEEYLRQHDKLAHPYRAAVLRAMERVLSSRASELDKDTASTIILLASSEMTKTKDL
                     VWDWQQAASGVLVAVGRQFISKVMEELLRRLHPGTLPHCAVLHTLASLSVANAFGVVP
                     FLPSVLSSLLPVLGVAKQDTVRVAFCSALQRFSEGALEYLANLDRAPDPTVRKDAFAT
                     DIFSAYDVLFHQWLQSREAKLRLAVVEALGPMSHLLPSERLEEQLPKLLPGILALYKK
                     HAETFYLSKSLGQILEAAVSVGSRTLETQLDALLAALHSQICVPVESSSPLVMSNQKE
                     VLRCFTVLACSSPDRLLAFLLPRLDTSNERTRVGTLQVVRHVINSAAAQMEDKKPFIL
                     SSMRLPLLDTNSKVKRAVVQVISAMAHHGYLEQPGGEAMIEYIVQQCALPPEQEPEKP
                     GPGSKDPKADSVRAISVRTLYLVSTTVDRMSHVLWPYLLQFLTPVRFTGALTPLCRSL
                     VHLAQKRQEAGADAFLIQYDAHASLPSPYAVTGRLLVVSSSPYLGDGRGAAALRLLSV
                     LHPNIHPLLGQHWETTVPLLLGYLDEHTEETLPQEEWEEKLLMFLRDTLAIISDNAWI
                     CQLSLELCRQLPCYDEAPQEKNFLYKCIGTTLGAASSKEVVRKHLQELLETARYQEEA
                     EREGLACCFGICAISHLEDTLAQLEDFVRSEVFRKSIGILNIFKDRSENEVEKVKSAL
                     ILCYGHVAARAPRELVLAKVESDILRNICQHFSTKVLGIKVETKDPALKLCLVQSVCM
                     VSRAICSSTQAGSFHFTRKAELVAQMMEFIRAEPPDSLRTPIRKKAMLTCTYLVSVEP
                     ALDEQARADVIHGCLHSIMALLPEPKEEDGGCQKSLYLETLHALEDLLTSLLQRNMTP
                     QGLQIMIEHLSPWIKSPRGHERARALGLSALLLRYFLEHLRVSALVPFHNLGLLIGLF
                     SPRCADLWPATRQEAVDCVYSLLYLQLGYEGFSRDYRDDVAERLLSLKDGLVHPDPAI
                     LFHTCHSVGQIIAKRLPPDQLISLLLTMFEALGDPEKNCSRAATVMINCLLQERGGVL
                     QEKVPEIVSVLRSKLQEAQGEHVLPAAQHSVYLLATQHCAAVVSSLLGSPLPLDSHTC
                     MLWRALAVEPRLAAQVLGLLLEKMSRDVPFKESRAFLLGRTPDRVATLLPLSATCALF
                     EVMSTPAAGPAVLELYPQLFVVLLLRVSCTVGVQLPRNLQAQERRGASPALATRNLEP
                     CSSAVDTLRSMLLRSGSEDVVQRMDLEGGWELLRTSAGHEEGATRLARAMAEHAGPRL
                     PLVLKTLACTHSSAYENQRVTTTAFLAELLNSNVANDLMLLDSLLESLAARQKDTCAS
                     VRRLVLRGLANLASGCPDKVRTHGPQLLTAMIGGLDDGDNPHSPVALEAMLGLARLVH
                     LVESWDLRSGLLHVAIRIRPFFDSEKMEFRTASIRLFGHLNKVCHGDCEDVFLDQVVG
                     GLAPLLLHLQDPQATVASACRFALRMCGPNLACEELSAAFQKHLQEGRALHFGEFLNT
                     TCKHLMHHFPDLLGRLLTTCLFYFKSSWENVRAAAPLFTGFLVLHSEPRQQPQVDLDQ
                     LIAALQILLKDPAPEVRTRAAEALGRLVKLA"
     exon            260..405
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            406..537
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            538..700
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            701..799
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            800..951
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1092
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1185
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1264
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1378
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1452
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1575
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1683
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            1684..1828
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1869
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            1870..2011
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2064
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2172
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2292
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2415
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2562
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            2563..2589
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            2590..2712
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            2713..2792
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            2793..2907
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            2908..3003
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3108
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            3109..3244
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            3245..3357
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            3358..3510
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            3511..3665
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            3666..3831
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            3832..4028
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            4029..4166
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            4167..4281
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            4282..4428
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            4429..4617
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            4618..4773
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            4774..4908
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            4909..5011
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            5012..5077
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     exon            5078..5349
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5330..5335
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /note="hexamer: AATAAA"
     polyA_site      5349
                     /gene="MROH1"
                     /gene_synonym="HEATR7A"
                     /note="major polyA site"
ORIGIN      
        1 actccgggcc cctgctgggc gggaaggcgg cgccccggcc gaggtggcgg cggctcctca
       61 ggacggaagc tcctgttttc ttgtcagccg ccagctgagg gccattcgca gcttctccag
      121 gccacctgca ttccttgtct cagagcctcc ctcctgcatc ctccaagcca gcagttgtgg
      181 gatgggagaa gaagttgtcc atgttcacac tgggtgaagg aagctgaaac cacagacatg
      241 actgagtcct ccatgaagaa gctggcctcc accctgctgg acgccatcac cgataaggac
      301 cccctggtgc aggagcaggt ctgcagtgcc ctgtgctccc tcggggaggc gcggccggtg
      361 gagacgctcc gtgcctgcga ggagtatctg cggcagcatg acaagctggc acacccatac
      421 cgagcagcgg tcctgagggc catggagagg gtcctgagca gtcgcgccag tgagctggac
      481 aaggacacag ccagcaccat catcctcctg gcctccagcg agatgaccaa gacgaaggac
      541 ctggtctggg actggcagca ggcggcgagt ggcgtcctgg tggccgtggg aagacagttc
      601 atcagcaagg tgatggagga gctgctgcgc aggctgcacc ctgggaccct gccacactgc
      661 gccgtgctgc acaccctcgc cagcctctcg gtggccaacg cgttcggcgt agtccccttc
      721 ctgccatccg tcctgagctc cctgctgccc gtgctgggcg tggccaagca ggacacggtg
      781 cgcgtggcct tctgctccgc tctgcagcgc ttcagcgagg gtgccctgga gtacctagcc
      841 aacctggacc gagccccaga ccccacggtc aggaaggacg cctttgccac cgacatcttc
      901 agcgcctacg atgttctctt ccatcagtgg ctgcagagtc gagaagccaa gctccgtctt
      961 gccgtggtgg aggctctggg gcctatgagc catctgctgc ccagtgagag gctggaagag
     1021 cagctgccca agctcctccc tgggattctc gccctctaca agaagcacgc agagaccttc
     1081 tacttgtcca agagcctggg ccagatcctc gaggcagctg tgagtgtggg cagccgcaca
     1141 ctggagaccc agctggatgc cctcttggct gcactgcact cccagatctg tgtgcctgtg
     1201 gagtcctcaa gccccctggt gatgagtaac cagaaggagg tgctgcgctg cttcactgtg
     1261 ctggcctgca gctcgcctga ccgcctactg gccttcctgc tgcccaggct ggacaccagc
     1321 aatgagagga cccgcgtggg caccctgcag gtggtcagac atgtcatcaa ctcagctgct
     1381 gctcagatgg aagataaaaa gccctttatc ctgtcttcca tgaggcttcc tctcctggac
     1441 accaacagca aggtgaagcg ggcagtggtg caggtgatta gcgccatggc ccaccacggc
     1501 tacctggagc agcctggagg tgaggcgatg atcgagtaca tcgtgcagca gtgcgcgctg
     1561 ccccccgagc aggagcctga gaagccaggc cccggcagca aggaccccaa ggccgacagc
     1621 gtgcgggcca tcagcgtgcg caccctctac ctggtcagca ccaccgtgga caggatgagt
     1681 cacgtcctct ggccatacct gctccagttc ctcacccctg tgcgcttcac tggggccctg
     1741 actccgctct gcaggagcct cgtgcatctg gcgcagaaga ggcaggaggc cggggccgac
     1801 gccttcctca tccagtacga cgcccatgcg agcctcccgt ctccctatgc tgtaaccgga
     1861 agactgttgg ttgtgtcttc cagcccctac ctaggggacg gacgtggggc agcggcgctg
     1921 cgcctcctca gtgttctgca cccaaacatt caccctttgc tgggtcagca ttgggaaacg
     1981 actgtcccgc tgctgctggg gtacctggat gagcacacag aagagaccct gccacaggag
     2041 gagtgggagg agaagctgtt gatgttcctg cgagacaccc tggccatcat ttctgacaac
     2101 gcgtggatct gccagctgag cctggagctg tgcaggcagc tgccctgcta cgatgaggca
     2161 ccccaggaga agaacttcct gtacaaatgc ataggcacca ccctgggtgc tgcttcaagt
     2221 aaggaggtgg tgaggaagca ccttcaagag ctgctggaga cggccagata ccaggaggag
     2281 gcagaacgcg agggcctcgc ctgctgcttc gggatctgtg ccatctccca cctcgaggac
     2341 acgctggccc agctggagga cttcgtgagg tcagaggtct tcagaaaatc cattggcatt
     2401 ctcaacattt ttaaggatcg aagtgagaac gaagtggaga aggtgaagag tgctctgatc
     2461 ctgtgctatg ggcacgtggc ggcccgggcc ccccgggagc tggtgctggc caaggtagag
     2521 tcagacatcc tccggaacat ctgccagcac ttcagcacca aggttctagg aataaaggta
     2581 gaaaccaagg acccagccct gaagctgtgc cttgtccaga gtgtgtgcat ggtcagccgc
     2641 gccatctgca gcagcaccca ggctggctcc ttccacttca cccggaaagc agagctggtg
     2701 gcacagatga tggagttcat cagggcagag cccccggact ccttgaggac acctattcgg
     2761 aagaaagcca tgctcacctg cacttacttg gtctccgtgg agccagcgct ggacgagcag
     2821 gcccgggcgg atgtgatcca tggctgcctg cacagcatca tggccctgct gcctgagccc
     2881 aaggaggagg acggaggctg ccagaagtcc ctgtatctgg agacactgca cgcccttgag
     2941 gatctgctga cgagcctcct gcagcggaac atgacccccc aaggcctgca gatcatgatt
     3001 gagcacctga gcccatggat caagtcccca agaggtcacg agcgggcgcg ggccctgggc
     3061 ctgagcgccc tcctgctgcg ctacttcctg gagcacctgc gtgtcagcgc cctggtgccc
     3121 ttccacaacc tgggccttct catcggcctc ttctccccac ggtgtgcgga cctgtggcct
     3181 gccacccgcc aggaggccgt ggactgtgtc tactccctgc tgtacctcca gctcggctat
     3241 gagggcttct cccgggacta ccgcgatgac gtggcggagc ggctcctcag cctcaaggac
     3301 ggcctcgtgc accctgaccc cgccattctc ttccacacct gccacagtgt aggccagatt
     3361 attgccaagc gcctcccccc agaccagctc atcagcctct tgctaaccat gtttgaggcc
     3421 ctgggagacc ccgaaaagaa ctgctcccga gcagctaccg tcatgatcaa ctgcctgctg
     3481 caggagcggg gcggtgtgct ccaggagaag gtgcccgaga tcgtgagcgt cctgcgctcc
     3541 aagcttcagg aggcccaggg agagcacgtc ctgccggccg cccagcacag cgtgtacctc
     3601 ctggccaccc agcactgcgc agccgtggtg tccagcctcc tgggcagccc cttgcccttg
     3661 gacagccaca cctgcatgct gtggcgggcg ctggcggtgg agcctcgcct agctgcccag
     3721 gtcctggggc tgctgctgga gaagatgagt agggacgtcc ctttcaagga gagccgggcc
     3781 ttcctgctgg gccgcacccc agaccgcgtg gccacgctgc tgcctctctc ggctacctgt
     3841 gcactgtttg aggtcatgtc cacgcctgca gcggggcccg cggtgctcga gctctacccc
     3901 cagctgtttg tggtgcttct gctgcgcgtc agctgcaccg tgggtgtcca gctgccccgg
     3961 aacctgcagg cccaggaaag gaggggtgcc agtccagccc tagccaccag gaacctggaa
     4021 ccctgcagct ctgcagtgga caccctgcgg tccatgctac tccgcagcgg cagcgaggat
     4081 gtggtacagc gcatggacct ggagggaggc tgggaactgc tcaggacctc ggcggggcat
     4141 gaggaggggg ccaccaggtt ggccagggcc atggctgagc acgcagggcc ccgactcccc
     4201 ctggtgctga agacgctggc atgcacacac agcagtgcgt atgagaacca gagggtgacc
     4261 accaccgcct tcctggccga gctgctgaac agcaacgtgg ccaacgacct catgctcttg
     4321 gactcgctgc tggagagcct ggcggctcgc cagaaggaca catgcgccag cgtgcggagg
     4381 ctggtgctcc gcggcctggc caacctggcc tccggctgcc ctgacaaggt gcgaacccac
     4441 ggcccccagc tcctcacagc catgattggc gggctggacg acggggacaa ccctcacagc
     4501 ccagtggccc tggaggccat gctgggcctt gcgaggctgg tgcacctggt ggagtcctgg
     4561 gacctgcgct cagggctgct gcacgtggcc atccgcatcc ggcctttctt cgacagtgag
     4621 aagatggagt tccggacggc atctatccgc ctctttgggc accttaacaa ggtctgccac
     4681 ggagactgtg aggacgtctt cctggaccag gtggtgggcg ggctggcgcc cctgctgctg
     4741 cacctgcagg accctcaggc caccgtggcc agcgcctgca ggtttgccct gcgcatgtgt
     4801 ggccccaatc tggcatgtga ggagctctca gctgctttcc agaaacacct gcaggagggc
     4861 cgagccctgc acttcgggga gttcctcaac accacctgca agcacctgat gcaccatttc
     4921 ccagacctgc tgggccgtct cctgaccacc tgcctgttct acttcaagag cagctgggag
     4981 aacgtccgag ctgctgcacc cctgttcacc gggttcctgg tgctgcactc ggagcccagg
     5041 cagcagccgc aggtggacct ggaccagctc attgcggcgc tccagatcct gctgaaggac
     5101 ccggcccccg aggtgcggac gagggctgct gaggccctgg gccgcctggt gaagctcgcc
     5161 taaggctccg gccagcaccc ccagcgagga gtatgcaccc agacctgtgc ctgagctcca
     5221 agacagggcc tcctgaggac cacagcctgg gcacacgact ggaggggcct ggccccagaa
     5281 caggcactgc tggggaccaa acccaagccc ttcagtgagg gatgtgccca ataaactcat
     5341 ctgctccca
//
