LOCUS       NM_031939               5200 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens maestro (MRO), transcript variant 1, mRNA.
ACCESSION   NM_031939
VERSION     NM_031939.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5200)
  AUTHORS   Zouboulis,C.C., Nogueira da Costa,A., Fimmel,S. and Zouboulis,K.C.
  TITLE     Apocrine glands are bystanders in hidradenitis suppurativa and
            their involvement is gender specific
  JOURNAL   J Eur Acad Dermatol Venereol 34 (7), 1555-1563 (2020)
   PUBMED   32031713
REFERENCE   2  (bases 1 to 5200)
  AUTHORS   Kenigsberg,S., Lima,P.D., Maghen,L., Wyse,B.A., Lackan,C.,
            Cheung,A.N., Tsang,B.K. and Librach,C.L.
  TITLE     The elusive MAESTRO gene: Its human reproductive tissue-specific
            expression pattern
  JOURNAL   PLoS One 12 (4), e0174873 (2017)
   PUBMED   28406912
  REMARK    GeneRIF: study also shows a punctate nuclear expression pattern and
            disperse cytoplasmic expression pattern of the MRO protein in human
            granulosa-cumulus cells and in testicular germ cells, which was
            later validated by western blotting
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5200)
  AUTHORS   Smith,L., Van Hateren,N., Willan,J., Romero,R., Blanco,G.,
            Siggers,P., Walsh,J., Banerjee,R., Denny,P., Ponting,C. and
            Greenfield,A.
  TITLE     Candidate testis-determining gene, Maestro (Mro), encodes a novel
            HEAT repeat protein
  JOURNAL   Dev Dyn 227 (4), 600-607 (2003)
   PUBMED   12889070
  REMARK    GeneRIF: The sequence and function of the related mouse gene are
            described.
REFERENCE   4  (bases 1 to 5200)
  AUTHORS   Yanaihara,N., Kohno,T., Takakura,S., Takei,K., Otsuka,A.,
            Sunaga,N., Takahashi,M., Yamazaki,M., Tashiro,H., Fukuzumi,Y.,
            Fujimori,Y., Hagiwara,K., Tanaka,T. and Yokota,J.
  TITLE     Physical and transcriptional map of a 311-kb segment of chromosome
            18q21, a candidate lung tumor suppressor locus
  JOURNAL   Genomics 72 (2), 169-179 (2001)
   PUBMED   11401430
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC015864.5.
            
            On Apr 16, 2019 this sequence version replaced NM_031939.5.
            
            Summary: This gene is specifically transcribed in males before and
            after differentiation of testis, and the encoded protein may play
            an important role in a mammalian sex determination. Multiple
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.118955.1,
                                           SRR1660807.164425.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398439.8/ ENSP00000381465.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AC015864.5         105658-105777       c
            121-242             AC015864.5         105342-105463       c
            243-345             AC015864.5         95063-95165         c
            346-492             AC015864.5         92465-92611         c
            493-675             AC015864.5         90915-91097         c
            676-831             AC015864.5         87110-87265         c
            832-939             AC015864.5         85797-85904         c
            940-5200            AC015864.5         80891-85151         c
FEATURES             Location/Qualifiers
     source          1..5200
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.2"
     gene            1..5200
                     /gene="MRO"
                     /gene_synonym="B29; C18orf3"
                     /note="maestro"
                     /db_xref="GeneID:83876"
                     /db_xref="HGNC:HGNC:24121"
                     /db_xref="MIM:608080"
     exon            1..120
                     /gene="MRO"
                     /gene_synonym="B29; C18orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            121..242
                     /gene="MRO"
                     /gene_synonym="B29; C18orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            243..345
                     /gene="MRO"
                     /gene_synonym="B29; C18orf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..993
                     /gene="MRO"
                     /gene_synonym="B29; C18orf3"
                     /note="isoform a is encoded by transcript variant 1;
                     beside the Ma29 deletion; protein maestro; male-specific
                     transcription in the developing reproductive organs"
                     /codon_start=1
                     /product="protein maestro isoform a"
                     /protein_id="NP_114145.2"
                     /db_xref="CCDS:CCDS11947.1"
                     /db_xref="GeneID:83876"
                     /db_xref="HGNC:HGNC:24121"
                     /db_xref="MIM:608080"
                     /translation="MDQRQRRILGQPLSIPTSQPKQKRTSMISFFSKVSWKLRFQKRE
                     PLKNVFFILAERARDPSAKKRHMAMRNLGTMAYEAPDKVRKYKKIVLDLLVYGLYDPV
                     NLEVIHESMKTLTVVLGKIQGKGLGSFFIDITLQTRTLLDDENDSLRYSAFVLFGQLA
                     AFAGRKWKKFFTSQVKQTRDSLLIHLQDRNPQVAKACKTTFQACSPYLKLKEEYSFQS
                     EEDQRNTKLYQQLSHYHPEILQFFYANKIL"
     exon            346..492
                     /gene="MRO"
                     /gene_synonym="B29; C18orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            493..675
                     /gene="MRO"
                     /gene_synonym="B29; C18orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            676..831
                     /gene="MRO"
                     /gene_synonym="B29; C18orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            832..939
                     /gene="MRO"
                     /gene_synonym="B29; C18orf3"
                     /inference="alignment:Splign:2.1.0"
     exon            940..5200
                     /gene="MRO"
                     /gene_synonym="B29; C18orf3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5162..5167
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRO"
                     /gene_synonym="B29; C18orf3"
                     /note="hexamer: AATATA"
     regulatory      5179..5184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRO"
                     /gene_synonym="B29; C18orf3"
                     /note="hexamer: AATAAA"
     polyA_site      5185
                     /gene="MRO"
                     /gene_synonym="B29; C18orf3"
     polyA_site      5200
                     /gene="MRO"
                     /gene_synonym="B29; C18orf3"
                     /note="major polyA site"
ORIGIN      
        1 agaattgcca tctgcagaat ttctgcagaa agtgtcgacc aggctggcat gagggaagaa
       61 ggaggggaaa tcacagcaag gagaaggaaa aacacctcag catggcgtgg ggaagcaaag
      121 gaattcaggg ctgggaaaat ttagccgagt catcacattt ggctactacc cgggaaagca
      181 gccctcccga gtcaggaacg ggctccggtt catcacgtgg cagccgcctg caggagccgc
      241 agttccatgg accaaagaca gaggagaatc ctgggccagc ccctttccat ccctacttcc
      301 cagcccaagc agaaaaggac atcaatgata tctttctttt ccaaggtctc ttggaaactg
      361 aggttccaga agcgggagcc tctgaagaat gtgtttttca tcttggcaga aagagctcgg
      421 gaccccagtg ctaaaaagcg tcacatggca atgagaaact tgggaaccat ggcctatgaa
      481 gcccctgaca aggtgagaaa gtataagaaa attgtcctcg acctgctggt gtatggactg
      541 tatgaccctg tgaatttgga agtcatccat gagagtatga agactctgac cgtcgttctg
      601 ggcaagatcc aggggaaagg tttgggttcc ttcttcatag atatcaccct tcagaccagg
      661 actttattag atgacgagaa cgacagtctg agatactcgg cctttgtttt gtttgggcaa
      721 ttggctgcct ttgccgggag gaaatggaaa aaatttttca ccagtcaggt taagcagaca
      781 cgagattccc tcctgatcca tttacaggac agaaatcccc aggttgccaa ggcttgcaaa
      841 acaacatttc aagcctgttc tccatatctg aaactaaagg aggaatacag cttccagagt
      901 gaagaagatc aaaggaacac taagctctac cagcagctga gccactatca tccagagatc
      961 ctgcagttct tctacgcaaa taaaattctg taagcgcaga gcagcaggga aatggttctg
     1021 tatgagtgca ttgctgagcc atcatgttcc cctgttttat ctcactggat gcctcttctc
     1081 actgcttgcc tcttgggatt gtaatgggaa agagggtgct gggagagcaa tcaaaggcaa
     1141 aaataataca tggaattgta tgattttatc taaagtaaaa ttctagactg ctttcactta
     1201 tttcatttcc tccccataca aatttgatga gcaggtacac actttcttta aaacattcca
     1261 agtgtatata gattcagtgc ttatttctca gctttttctt tcttaagttc atctctgtca
     1321 cctagctttt atttttaata ctcaatttct gaggcttagg agaatacttg ttaccttaag
     1381 cgtttttttg tttttttgtt gttgttgttt tgtttttttt tagtgtattt gctattgata
     1441 ctttgctatt gataccttta cttgccaaga tttatttaaa gttggccaag ataccaagaa
     1501 ggtggcttgc aggggcatct ttggcttctc ataattttaa acagtcattg ctttcaagat
     1561 catgctaaac aagaattaat agagagaaaa aaatctataa agcatgtgtt gaaaatcctc
     1621 aggctcatga taacttacgg gataacaata gtaggtaaca ccgagtgctt acaattcagt
     1681 gggcacggtc aaagtgcttt ttgtaagttc tatttaatac ttgcgacaac cctgagatag
     1741 taagtattat tattgttctc attttataga tgagaaagct aacacatagg gaaattaggt
     1801 aactttcccc agataactca gtaaacagtg gagctggaat tcaaacatgt acggtctgac
     1861 ttcttgagcc catactcaat aatcatgcca tcctgccttt ccatggaata actgatggat
     1921 ggttagaaat gttaaaaaca aagcaaatgc aaacatctct gcttctgctc ctctactaag
     1981 cccagttaac ttttgatttt atatgtacta agtatacatt tttattaatt tatgtgagct
     2041 gagtgttttt attaattact ttttggctat taatgtcaat tattttggtg atcaatccta
     2101 gttatccaag gagtcacatc actcgtaaaa attacaagaa aaatctctaa gtccctctca
     2161 ccctccctct aaccagattg catcccaagc ttctatagaa actctggtac cacccctgaa
     2221 ttcagtatcc aggccacacc cggagcgttt tgttcaagac aatttaaaac acgggggatt
     2281 ataaaagcta tagctggatc ttaagtggca ttctgagaat gaggaactca attttctgct
     2341 gtagctccca gggacagggt ggtgtgacac agatgcgggg atgaggagag acctaggcga
     2401 gatgaggatg tgggagatgg cagacagagt ggcaagtgcc aggcaggaat ggattttctt
     2461 ccttcctgtt ctgaatctga agaacatgac agcaagagat tttaggaggg acacaggctc
     2521 acgagcaaat gggtggttct gagctgtaag ccccctgccc ctccctagca cccactcccc
     2581 ggatgctggc ctctttgaaa ttttgttgca aggttggttt aaacttgatg cagttccatt
     2641 aagtgatcag tgagtggtct gagaaatggc tgcatgtggc tggcattcaa aaaggtgggg
     2701 atagggtgag atgggtgggg ttacgtgctc tggagtagaa aaacctatgc agttaatgtc
     2761 cctctgtcgg ttaaaattgt ggaagatgcg gttggattat ttgactttaa gattcaatgg
     2821 taggctttta ttttggtggc ccccaatgag tcatgcctcc tgatactcat gtctttattt
     2881 agtcccttct gtttgaatct gggctgcctt tgtgacttgc tttaatcagg agattgtgat
     2941 aaatggcact gtgccgggca tagaaaccct ggcagtttcc tcgtttgaat tgtgggggaa
     3001 gccagctgcc acataaggag ttgaactacc aggaacaaat gagagtgcct gagatcacca
     3061 tgtgaaggag aacggagaca cccaacccac agcagagtct gaggcccgga cacatgacac
     3121 aagttgtccc ttccagccag acccgagctg ttgaagctac tccagctgac accatacgga
     3181 aaagagacga gcgtctccat caagcctgtg tcagttgcag aagcatgaac aaagaatcaa
     3241 atgattgttg ttttaagtca ttaacctttg ggataatttg tcacactgca ataagtaacc
     3301 agagaagatt ccttattatt aactgttgtc ttggctaatt ttgttttgct cttcataagt
     3361 cctctttgag tttaaattct atttccagaa atttatgtta tcatgaaatt tggtggcaag
     3421 agcaagggac tatgtttttt tgtttgtttg tttctgtttc tcaccatacc taccacagag
     3481 cctggccatg tgattaagga acatttgctg aatgactaaa tgattccaaa ttgtagaggg
     3541 aataaagtcc aatgtccagt ctgccatttc aggctttcaa ccttcgtttt cttctgttac
     3601 tctctttgct tcagacaagt ttgggtcctt tctcttctct caacatgtct tgttctccta
     3661 taccccctca cctttgctca gtctgctatt tctgtgttga gtcccctccc tgctcacctg
     3721 tacacaccca cctggaatca catgcacaca cacacacaca catttcacgt gtatctctta
     3781 tctgtactcc aatgcctagg tcaaagtcct gatcccccca atcaggggag agctcaagtc
     3841 tctgaattcc cagaacattc tagcaatatt ataccactta tatcttatct gaaaagtttt
     3901 tttttgtata tggctttatg tttttttttt tatcctgtta gattgaaact acagaaggca
     3961 gggctgtatc ttgtacatca ttgtatctcc ccggtgactg caaaagtact ctgtaaatga
     4021 atgttgatta gggggaaaaa tgtcagaaag tcatctgaag ctgtcattcc ttactgggag
     4081 gagcccattt tgacaaatga gggtcaccaa tttcattcct tataaccaat gtacaggtta
     4141 cttttatgct tgtgcatttc aagtttcccc ttccccacgt ttatctgaat gccaacccaa
     4201 aggtaatgtt ttgacatttc ttaattttga acattaattt tgaaccttat tgagcagttg
     4261 aatgaaagaa agaaaaaagg aatgttcaag tgccccgacc ctcatgctaa gtgcccaggg
     4321 tagagctttg cttggtccct gtgtctctgg tgctcatgag ataggtcttt ctttctttat
     4381 ttttattttt gagatggagc ctcactctgt cacccaggct ggagtgcaat gacacgatct
     4441 cggctcactg caacctccac ctcctgggtt caagcgattc tcctgtctca gcctcctgag
     4501 tagctgggat tacaggtgcc tgccaccatg gctggctaat ttttgtgttt ttagtagaga
     4561 cggggtttca ccatgttggc caggctggtc tcaaactcct gacctcaagt gatctgctca
     4621 ccttggtctc ccaaagtgct gggattacag gcgtgagcca ccgctcctgg ctgagatagg
     4681 tctttcttaa aggggagagg gaagtggtgg agagagagga gagaaaatga caaaggagga
     4741 ggctgagaat ctaacaggtg tgaccaattc tgctactgaa tgagagcaga agcctgtgaa
     4801 cttccagtta atagaccact taattggggg aacgcttcac acgttataaa aaagcactag
     4861 aatgttttga aagcgagaaa caacagctgt gtagggtagc tagcagttag tgttgtacag
     4921 aagacagata tttgtgcatt tctgcatttt ctaagtttgc tgcaatgagc atgtattact
     4981 ttcatagtta taaaacacat gcaaaatgcc cttttaaaat gaaaaaaaag tccatgagtg
     5041 taagtgatat atatgctttg gaaagcctgg gacggtcatt gtttactctc aatagtatgt
     5101 gtttgccttt gtctttttga gacattttgt tttaatctgt tgatgacaat aacctgttga
     5161 taatataact tgataacaaa taaaatgact tatgattgat
//
