LOCUS       NM_016175               1168 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens MRN complex interacting protein (MRNIP), transcript
            variant 1, mRNA.
ACCESSION   NM_016175
VERSION     NM_016175.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1168)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1168)
  AUTHORS   Staples,C.J., Barone,G., Myers,K.N., Ganesh,A., Gibbs-Seymour,I.,
            Patil,A.A., Beveridge,R.D., Daye,C., Beniston,R., Maslen,S.,
            Ahel,I., Skehel,J.M. and Collis,S.J.
  TITLE     MRNIP/C5orf45 Interacts with the MRN Complex and Contributes to the
            DNA Damage Response
  JOURNAL   Cell Rep 16 (10), 2565-2575 (2016)
   PUBMED   27568553
  REMARK    GeneRIF: these data reveal that MRNIP is an important component of
            the human DNA damage response.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BF965313.1, BC069051.1, BQ642639.1 and BC050714.1.
            
            On Nov 23, 2018 this sequence version replaced NM_016175.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069051.1, SRR1163657.157251.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292586.11/ ENSP00000292586.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BF965313.1         25-33
            10-480              BC069051.1         1-471
            481-712             BQ642639.1         295-526
            713-1167            BC069051.1         704-1158
            1168-1168           BC050714.1         978-978
FEATURES             Location/Qualifiers
     source          1..1168
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q35.3"
     gene            1..1168
                     /gene="MRNIP"
                     /gene_synonym="C5orf45"
                     /note="MRN complex interacting protein"
                     /db_xref="GeneID:51149"
                     /db_xref="HGNC:HGNC:30817"
                     /db_xref="MIM:617154"
     exon            1..87
                     /gene="MRNIP"
                     /gene_synonym="C5orf45"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1053
                     /gene="MRNIP"
                     /gene_synonym="C5orf45"
                     /note="isoform 1 is encoded by transcript variant 1;
                     UPF0544 protein C5orf45; MRN-interacting protein"
                     /codon_start=1
                     /product="MRN complex-interacting protein isoform 1"
                     /protein_id="NP_057259.2"
                     /db_xref="CCDS:CCDS34319.1"
                     /db_xref="GeneID:51149"
                     /db_xref="HGNC:HGNC:30817"
                     /db_xref="MIM:617154"
                     /translation="MASLQRSRVLRCCSCRLFQAHQVKKSVKWTCKACGEKQSFLQAY
                     GEGSGADCRRHVQKLNLLQGQVSELPLRSLEETVSASEEENVGHQQAGNVKQQEKSQP
                     SESRWLKYLEKDSQELELEGTGVCFSKQPSSKMEEPGPRFSQDLPRKRKWSRSTVQPP
                     CSRGVQDSGGSEVAWGPQKGQAGLTWKVKQGSSPCLQENSADCSAGELRGPGKELWSP
                     IQQVTATSSKWAQFVLPPRKSSHVDSEQPRSLQRDPRPAGPAQAKQGTPRAQASREGL
                     SRPTAAVQLPRATHPVTSGSERPCGKTSWDARTPWAEGGPLVLEAQNPRPTRLCDLFI
                     TGEDFDDDV"
     exon            88..147
                     /gene="MRNIP"
                     /gene_synonym="C5orf45"
                     /inference="alignment:Splign:2.1.0"
     exon            148..236
                     /gene="MRNIP"
                     /gene_synonym="C5orf45"
                     /inference="alignment:Splign:2.1.0"
     exon            237..312
                     /gene="MRNIP"
                     /gene_synonym="C5orf45"
                     /inference="alignment:Splign:2.1.0"
     exon            313..470
                     /gene="MRNIP"
                     /gene_synonym="C5orf45"
                     /inference="alignment:Splign:2.1.0"
     exon            471..558
                     /gene="MRNIP"
                     /gene_synonym="C5orf45"
                     /inference="alignment:Splign:2.1.0"
     exon            559..1168
                     /gene="MRNIP"
                     /gene_synonym="C5orf45"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1149..1154
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRNIP"
                     /gene_synonym="C5orf45"
                     /note="hexamer: AATAAA"
     polyA_site      1168
                     /gene="MRNIP"
                     /gene_synonym="C5orf45"
                     /note="major polyA site"
ORIGIN      
        1 ctggcgactg cacaagcagg gatggcgtcg cttcagcgtt ctcgggtgct acgctgctgc
       61 agctgccgcc tcttccaggc gcaccaggta aaaaagagtg tcaagtggac atgcaaagct
      121 tgtggagaga agcagtcctt tttgcaggct tatggtgaag gctctggtgc tgattgtaga
      181 cgccatgtcc aaaagttaaa tctactacag ggacaagttt cagagctgcc actcaggtct
      241 ctagaagaaa ctgtcagtgc cagtgaagaa gaaaacgtgg gacaccagca ggctgggaat
      301 gtgaagcagc aggaaaaatc gcagccctca gagagtcgct ggctgaagta tctagaaaag
      361 gactcccaag aactggagct ggaaggaaca ggagtgtgtt tcagcaaaca gccttcatcc
      421 aaaatggagg agccaggccc ccgcttcagt caagacctgc ctagaaaaag gaagtggagc
      481 aggagcaccg tccagcctcc gtgcagccgt ggcgtgcagg actcgggtgg ctctgaggtc
      541 gcctggggac cccagaaggg acaggctggc ctgacatgga aggtgaaaca aggcagcagc
      601 ccctgcctcc aggagaactc tgcagactgc agtgccgggg agctgagggg tcctgggaag
      661 gagctatgga gtcccatcca gcaggttaca gccacatcct ctaaatgggc gcaatttgtc
      721 ctgccaccta gaaaaagttc acatgtggac agtgagcagc caaggtctct tcagagggac
      781 cccaggccag ctggtccagc acaggctaag caagggaccc ccagagcaca ggcctcaaga
      841 gaaggcctca gcaggcccac tgccgctgtc cagcttcctc gggccacaca ccccgtcaca
      901 tctgggtctg agaggccttg cgggaagacc tcatgggacg caaggactcc ctgggcagag
      961 ggtgggcccc tggtcctgga ggcacagaat cctcgaccca cacgactatg tgacctcttt
     1021 ataactgggg aagacttcga tgatgatgtg tgatctggga ctggcaggtt attaatcgag
     1081 atacacttgt taggagggac agggttcccc taaggcactt ttaaagatac tctgtaagaa
     1141 ccattaacaa taaacttact gtcaatca
//
