LOCUS       NM_001304731             735 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens myoregulin (MRLN), transcript variant 2, mRNA.
ACCESSION   NM_001304731 NR_038199 XR_110407 XR_110408
VERSION     NM_001304731.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 735)
  AUTHORS   Liu,A.Y., Rathod,N., Guerrero-Serna,G., Young,H.S. and
            Espinoza-Fonseca,L.M.
  TITLE     Functional Role of an Unusual Transmembrane Acidic Residue in the
            Calcium Pump Regulator Myoregulin
  JOURNAL   Biochemistry 62 (8), 1331-1336 (2023)
   PUBMED   37014032
  REMARK    GeneRIF: Functional Role of an Unusual Transmembrane Acidic Residue
            in the Calcium Pump Regulator Myoregulin.
REFERENCE   2  (bases 1 to 735)
  AUTHORS   Wu,X., Cao,Z., Chen,H., Ou,Q., Huang,X. and Wang,Y.
  TITLE     Downregulation of Linc-RNA activator of myogenesis lncRNA
            participates in FGF2-mediated proliferation of human periodontal
            ligament stem cells
  JOURNAL   J Periodontol 91 (3), 422-427 (2020)
   PUBMED   31378921
  REMARK    GeneRIF: downregulation of Linc-RAM lncRNA may participate in FGF-2
            mediated- proliferation of human PDLSCs
REFERENCE   3  (bases 1 to 735)
  AUTHORS   Yu,X., Zhang,Y., Li,T., Ma,Z., Jia,H., Chen,Q., Zhao,Y., Zhai,L.,
            Zhong,R., Li,C., Zou,X., Meng,J., Chen,A.K., Puri,P.L., Chen,M. and
            Zhu,D.
  TITLE     Long non-coding RNA Linc-RAM enhances myogenic differentiation by
            interacting with MyoD
  JOURNAL   Nat Commun 8, 14016 (2017)
   PUBMED   28091529
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 735)
  AUTHORS   Anderson,D.M., Anderson,K.M., Chang,C.L., Makarewich,C.A.,
            Nelson,B.R., McAnally,J.R., Kasaragod,P., Shelton,J.M., Liou,J.,
            Bassel-Duby,R. and Olson,E.N.
  TITLE     A micropeptide encoded by a putative long noncoding RNA regulates
            muscle performance
  JOURNAL   Cell 160 (4), 595-606 (2015)
   PUBMED   25640239
  REMARK    GeneRIF: The human and mouse MLN genes consist of three exons that
            span 16.5 and 15.0 kb, respectively, with the ORF located in exon
            3; findings identify MLN as an important regulator of skeletal
            muscle physiology.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022027.7, AB019391.1 and
            BG210823.1.
            
            On May 17, 2019 this sequence version replaced NM_001304731.1.
            
            Summary: This gene encodes a small peptide that shares structural
            similarity to the small peptides sarcolipin and phospholamban,
            which are key regulators of sarcoplasmic reticulum Ca(2+)-ATPases
            (SERCAs). This protein is thought to have a similar function to
            these peptides, regulating Ca(2+) reuptake in the sarcoplasmic
            reticulum by inhibiting the Ca(2+) pump activity of SERCAs.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Jun 2015].
            
            Transcript Variant: This variant (2) lacks an exon in the 5' UTR
            compared to variant 1. Both variants 1 and 2 encode the same
            protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB019391.1, W69924.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1970526, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000414264.6/ ENSP00000488748.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AC022027.7         6005-6014
            11-430              AB019391.1         1-420
            431-437             BG210823.1         229-235
            438-735             AC022027.7         22471-22768
FEATURES             Location/Qualifiers
     source          1..735
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q21.2"
     gene            1..735
                     /gene="MRLN"
                     /gene_synonym="Linc-RAM; LINC00948; M1; MLN; MUSER1"
                     /note="myoregulin"
                     /db_xref="GeneID:100507027"
                     /db_xref="HGNC:HGNC:48649"
                     /db_xref="MIM:616246"
     exon            1..102
                     /gene="MRLN"
                     /gene_synonym="Linc-RAM; LINC00948; M1; MLN; MUSER1"
                     /inference="alignment:Splign:2.1.0"
     exon            103..206
                     /gene="MRLN"
                     /gene_synonym="Linc-RAM; LINC00948; M1; MLN; MUSER1"
                     /inference="alignment:Splign:2.1.0"
     exon            207..735
                     /gene="MRLN"
                     /gene_synonym="Linc-RAM; LINC00948; M1; MLN; MUSER1"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..367
                     /gene="MRLN"
                     /gene_synonym="Linc-RAM; LINC00948; M1; MLN; MUSER1"
                     /note="muscle specific 1; muscle enriched RNA 1; long
                     intergenic non-protein coding RNA 948; Linc-RNA activator
                     of myogenesis"
                     /codon_start=1
                     /product="myoregulin"
                     /protein_id="NP_001291660.1"
                     /db_xref="CCDS:CCDS81467.1"
                     /db_xref="GeneID:100507027"
                     /db_xref="HGNC:HGNC:48649"
                     /db_xref="MIM:616246"
                     /translation="MTGKNWILISTTTPKSLEDEIVGRLLKILFVIFVDLISIIYVVI
                     TS"
     regulatory      413..418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRLN"
                     /gene_synonym="Linc-RAM; LINC00948; M1; MLN; MUSER1"
                     /note="hexamer: AATAAA"
     polyA_site      432
                     /gene="MRLN"
                     /gene_synonym="Linc-RAM; LINC00948; M1; MLN; MUSER1"
                     /note="major polyA site"
ORIGIN      
        1 agaccagtga gcctcctgat ccaccaagac catatggtgt ttttcataaa agagagagat
       61 cattcccttg actttggact tcgcttattg aacccctgga cagaatcaag gttgctaaga
      121 gaccacctgt gctgaataca ctttgttctg gcaagagcag aaaactgaga agccgtgtta
      181 cctaccacta cctgggatta attcagggag cgggataatt ctggatatga ctggtaaaaa
      241 ctggatatta atttctacta ctactcccaa aagtctagaa gatgaaattg tgggaagact
      301 tctaaaaatt ttgtttgtta tctttgttga cttaatttct attatatatg ttgtgataac
      361 ttcttagaaa gctgacttcc tttccatgta catttcaaac tgaattacag tgaataaaaa
      421 tttgtatttt aacttgttga gtgactcaca ttttatgaca ttgccaattt attctagaag
      481 ccaacaggac actgcaatac aaacaacatt gtgtattgtt tagttcttta tggtttatga
      541 aacattcaca tatactgaag tgaatttttt tccccaaaaa catctatcct actgagtcat
      601 gaaacttcta gatttttagc caggtgtggt ggctcacacc tgtaatccca gcactttgag
      661 aggcccaggt aggcggatcc cttgagtgca ggagttcgat acgggcctga gcaacctgaa
      721 gaaatcccat ctcta
//
