LOCUS       NM_054032               1444 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens MAS related GPR family member X4 (MRGPRX4), mRNA.
ACCESSION   NM_054032
VERSION     NM_054032.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1444)
  AUTHORS   Chien,D.C., Limjunyawong,N., Cao,C., Meixiong,J., Peng,Q., Ho,C.Y.,
            Fay,J.F., Roth,B.L. and Dong,X.
  TITLE     MRGPRX4 mediates phospho-drug-associated pruritus in a humanized
            mouse model
  JOURNAL   Sci Transl Med 16 (746), eadk8198 (2024)
   PUBMED   38718132
  REMARK    GeneRIF: MRGPRX4 mediates phospho-drug-associated pruritus in a
            humanized mouse model.
REFERENCE   2  (bases 1 to 1444)
  AUTHORS   Kotliar,I.B., Ceraudo,E., Kemelmakher-Liben,K., Oren,D.A.,
            Lorenzen,E., Dodig-Crnkovic,T., Horioka-Duplix,M., Huber,T.,
            Schwenk,J.M. and Sakmar,T.P.
  TITLE     Itch receptor MRGPRX4 interacts with the receptor
            activity-modifying proteins
  JOURNAL   J Biol Chem 299 (5), 104664 (2023)
   PUBMED   37003505
  REMARK    GeneRIF: Itch receptor MRGPRX4 interacts with the receptor
            activity-modifying proteins.
REFERENCE   3  (bases 1 to 1444)
  AUTHORS   Cao,C., Kang,H.J., Singh,I., Chen,H., Zhang,C., Ye,W., Hayes,B.W.,
            Liu,J., Gumpper,R.H., Bender,B.J., Slocum,S.T., Krumm,B.E.,
            Lansu,K., McCorvy,J.D., Kroeze,W.K., English,J.G., DiBerto,J.F.,
            Olsen,R.H.J., Huang,X.P., Zhang,S., Liu,Y., Kim,K., Karpiak,J.,
            Jan,L.Y., Abraham,S.N., Jin,J., Shoichet,B.K., Fay,J.F. and
            Roth,B.L.
  TITLE     Structure, function and pharmacology of human itch GPCRs
  JOURNAL   Nature 600 (7887), 170-175 (2021)
   PUBMED   34789874
  REMARK    GeneRIF: Structure, function and pharmacology of human itch GPCRs.
REFERENCE   4  (bases 1 to 1444)
  AUTHORS   Yu,H., Wangensteen,K., Deng,T., Li,Y. and Luo,W.
  TITLE     MRGPRX4 in Cholestatic Pruritus
  JOURNAL   Semin Liver Dis 41 (3), 358-367 (2021)
   PUBMED   34161994
  REMARK    GeneRIF: MRGPRX4 in Cholestatic Pruritus.
            Review article
REFERENCE   5  (bases 1 to 1444)
  AUTHORS   Yu,H., Zhao,T., Liu,S., Wu,Q., Johnson,O., Wu,Z., Zhuang,Z.,
            Shi,Y., Peng,L., He,R., Yang,Y., Sun,J., Wang,X., Xu,H., Zeng,Z.,
            Zou,P., Lei,X., Luo,W. and Li,Y.
  TITLE     MRGPRX4 is a bile acid receptor for human cholestatic itch
  JOURNAL   Elife 8, e48431 (2019)
   PUBMED   31500698
  REMARK    GeneRIF: Taken together, these data strongly suggest that MRGPRX4
            is a novel bile acid receptor that likely underlies cholestatic
            itch in human, providing a promising new drug target for anti-itch
            therapies.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1444)
  AUTHORS   Meixiong,J., Vasavda,C., Snyder,S.H. and Dong,X.
  TITLE     MRGPRX4 is a G protein-coupled receptor activated by bile acids
            that may contribute to cholestatic pruritus
  JOURNAL   Proc Natl Acad Sci U S A 116 (21), 10525-10530 (2019)
   PUBMED   31068464
  REMARK    GeneRIF: data support a model whereby both bile acids and bilirubin
            contribute to cholestatic itch via agonism at MRGPRX4
REFERENCE   7  (bases 1 to 1444)
  AUTHORS   Kozlitina,J., Risso,D., Lansu,K., Olsen,R.H.J., Sainz,E.,
            Luiselli,D., Barik,A., Frigerio-Domingues,C., Pagani,L.,
            Wooding,S., Kirchner,T., Niaura,R., Roth,B. and Drayna,D.
  TITLE     An African-specific haplotype in MRGPRX4 is associated with menthol
            cigarette smoking
  JOURNAL   PLoS Genet 15 (2), e1007916 (2019)
   PUBMED   30768591
  REMARK    GeneRIF: data indicate that genetic variation in MRGPRX4
            contributes to inter-individual and inter-ethnic differences in the
            preference for mentholated cigarettes.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1444)
  AUTHORS   Lembo,P.M., Grazzini,E., Groblewski,T., O'Donnell,D., Roy,M.O.,
            Zhang,J., Hoffert,C., Cao,J., Schmidt,R., Pelletier,M., Labarre,M.,
            Gosselin,M., Fortin,Y., Banville,D., Shen,S.H., Strom,P., Payza,K.,
            Dray,A., Walker,P. and Ahmad,S.
  TITLE     Proenkephalin A gene products activate a new family of sensory
            neuron--specific GPCRs
  JOURNAL   Nat Neurosci 5 (3), 201-209 (2002)
   PUBMED   11850634
REFERENCE   9  (bases 1 to 1444)
  AUTHORS   Dong,X., Han,S., Zylka,M.J., Simon,M.I. and Anderson,D.J.
  TITLE     A diverse family of GPCRs expressed in specific subsets of
            nociceptive sensory neurons
  JOURNAL   Cell 106 (5), 619-632 (2001)
   PUBMED   11551509
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC095509.1, AC090099.14 and CN835944.1.
            
            On Jun 9, 2009 this sequence version replaced NM_054032.2.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC095509.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000314254.3/ ENSP00000314042.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-409               BC095509.1         11-419
            410-410             AC090099.14        77929-77929         c
            411-560             BC095509.1         421-570
            561-561             AC090099.14        77778-77778         c
            562-667             BC095509.1         572-677
            668-668             AC090099.14        77671-77671         c
            669-1442            BC095509.1         679-1452
            1443-1444           CN835944.1         9-10                c
FEATURES             Location/Qualifiers
     source          1..1444
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..1444
                     /gene="MRGPRX4"
                     /gene_synonym="GPCR; MRGX4; SNSR6"
                     /note="MAS related GPR family member X4"
                     /db_xref="GeneID:117196"
                     /db_xref="HGNC:HGNC:17617"
                     /db_xref="MIM:607230"
     exon            1..1444
                     /gene="MRGPRX4"
                     /gene_synonym="GPCR; MRGX4; SNSR6"
                     /inference="alignment:Splign:2.1.0"
     CDS             421..1389
                     /gene="MRGPRX4"
                     /gene_synonym="GPCR; MRGX4; SNSR6"
                     /note="G protein-coupled receptor MRGX4; sensory
                     neuron-specific G-protein coupled receptor 5/6; G
                     protein-coupled receptor SNSR6; G protein-coupled receptor
                     SNSR5; MAS-related GPR, member X4; Mas-related G
                     protein-coupled receptor X4"
                     /codon_start=1
                     /product="mas-related G-protein coupled receptor member
                     X4"
                     /protein_id="NP_473373.2"
                     /db_xref="CCDS:CCDS7831.1"
                     /db_xref="GeneID:117196"
                     /db_xref="HGNC:HGNC:17617"
                     /db_xref="MIM:607230"
                     /translation="MDPTVPVFGTKLTPINGREETPCYNQTLSFTVLTCIISLVGLTG
                     NAVVLWLLGYRMRRNAVSIYILNLAAADFLFLSFQIIRLPLRLINISHLIRKILVSVM
                     TFPYFTGLSMLSAISTERCLSVLWPIWYRCRRPTHLSAVVCVLLWGLSLLFSMLEWRF
                     CDFLFSGADSSWCETSDFIPVAWLIFLCVVLCVSSLVLLVRILCGSRKMPLTRLYVTI
                     LLTVLVFLLCGLPFGILGALIYRMHLNLEVLYCHVYLVCMSLSSLNSSANPIIYFFVG
                     SFRQRQNRQNLKLVLQRALQDKPEVDKGEGQLPEESLELSGSRLGP"
ORIGIN      
        1 cttcctgtcc atggatgacc agtcctagtc acgagtgtgt cacaaccacc tctttgtgta
       61 tctgaattcc tccacctgaa agaaaatttc agacccagga tagattaatc atcgggtcca
      121 aagccctggc cggatgagtg ggggtgtttt gatcctaatg ttattcccat gtcagcacag
      181 aacttgtgtg gcagtagaga gatgtcaggc ttcagagtca acaagaactg gatttcaaac
      241 tggatttgag gacccccacc tttggtaagt gacttattat ctgcgagcct ctgtttctct
      301 cttctttaaa tgaggacagt aaatcccata cggcagggtg gtggggagaa tcagagatga
      361 tacagctggt gatcacatct ggtttgtgtt cccaggggca ccagactagg gtttctgagc
      421 atggatccaa ccgtcccagt cttcggtaca aaactgacac caatcaacgg acgtgaggag
      481 actccttgct acaatcagac cctgagcttc acggtgctga cgtgcatcat ttcccttgtc
      541 ggactgacag gaaacgcggt tgtgctctgg ctcctgggct accgcatgcg caggaacgct
      601 gtctccatct acatcctcaa cctggccgca gcagacttcc tcttcctcag cttccagatt
      661 atacgtttgc cattacgcct catcaatatc agccatctca tccgcaaaat cctcgtttct
      721 gtgatgacct ttccctactt tacaggcctg agtatgctga gcgccatcag caccgagcgc
      781 tgcctgtctg ttctgtggcc catctggtac cgctgccgcc gccccacaca cctgtcagcg
      841 gtcgtgtgtg tcctgctctg gggcctgtcc ctgctgttta gtatgctgga gtggaggttc
      901 tgtgacttcc tgtttagtgg tgctgattct agttggtgtg aaacgtcaga tttcatccca
      961 gtcgcgtggc tgattttttt atgtgtggtt ctctgtgttt ccagcctggt cctgctggtc
     1021 aggatcctct gtggatcccg gaagatgccg ctgaccaggc tgtacgtgac catcctgctc
     1081 acagtgctgg tcttcctcct ctgcggcctg cccttcggca ttctgggggc cctaatttac
     1141 aggatgcacc tgaatttgga agtcttatat tgtcatgttt atctggtttg catgtccctg
     1201 tcctctctaa acagtagtgc caaccccatc atttacttct tcgtgggctc ctttaggcag
     1261 cgtcaaaata ggcagaacct gaagctggtt ctccagaggg ctctgcagga caagcctgag
     1321 gtggataaag gtgaagggca gcttcctgag gaaagcctgg agctgtcggg aagcagattg
     1381 gggccatgag ggagagcctc tgccctgtca gtcagacggg actttgagag caacactgtc
     1441 ctgc
//
