LOCUS       NM_001370464            1480 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens MAS related GPR family member X3 (MRGPRX3), transcript
            variant 2, mRNA.
ACCESSION   NM_001370464 XM_011519882
VERSION     NM_001370464.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1480)
  AUTHORS   Chen,L.Y., You,Q., Lv,D.Z., Li,S.H. and Zhang,S.Y.
  TITLE     GPCR-mediated EGFR transactivation ameliorates skin toxicities
            induced by afatinib
  JOURNAL   Acta Pharmacol Sin 43 (6), 1534-1543 (2022)
   PUBMED   34552215
  REMARK    GeneRIF: GPCR-mediated EGFR transactivation ameliorates skin
            toxicities induced by afatinib.
REFERENCE   2  (bases 1 to 1480)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1480)
  AUTHORS   Schmid,C.D., Schledzewski,K., Mogler,C., Waldburger,N., Kalna,V.,
            Marx,A., Randi,A.M., Geraud,C., Goerdt,S. and Koch,P.S.
  TITLE     GPR182 is a novel marker for sinusoidal endothelial differentiation
            with distinct GPCR signaling activity in vitro
  JOURNAL   Biochem Biophys Res Commun 497 (1), 32-38 (2018)
   PUBMED   29408502
  REMARK    GeneRIF: Our data demonstrate that GPR182 is an endothelial
            subtype-specific marker for human sinusoidal EC of the liver,
            spleen, lymph node and bone marrow. In addition, we provide
            evidence for GPR182-dependent downstream signaling via ERK and SRF
            pathways that may be involved in regulating endothelial
            subtype-specific sinusoidal differentiation and sinusoidal
            functions such as permeability.
REFERENCE   4  (bases 1 to 1480)
  AUTHORS   Franco,R., Martinez-Pinilla,E., Navarro,G. and Zamarbide,M.
  TITLE     Potential of GPCRs to modulate MAPK and mTOR pathways in
            Alzheimer's disease
  JOURNAL   Prog Neurobiol 149-150, 21-38 (2017)
   PUBMED   28189739
  REMARK    GeneRIF: Potential of GPCRs to modulate MAPK and mTOR pathways in
            different stages of the neurodegenerative disease.
            Review article
REFERENCE   5  (bases 1 to 1480)
  AUTHORS   Burstein,E.S., Ott,T.R., Feddock,M., Ma,J.N., Fuhs,S., Wong,S.,
            Schiffer,H.H., Brann,M.R. and Nash,N.R.
  TITLE     Characterization of the Mas-related gene family: structural and
            functional conservation of human and rhesus MrgX receptors
  JOURNAL   Br J Pharmacol 147 (1), 73-82 (2006)
   PUBMED   16284629
REFERENCE   6  (bases 1 to 1480)
  AUTHORS   Kaisho,Y., Watanabe,T., Nakata,M., Yano,T., Yasuhara,Y.,
            Shimakawa,K., Mori,I., Sakura,Y., Terao,Y., Matsui,H. and
            Taketomi,S.
  TITLE     Transgenic rats overexpressing the human MrgX3 gene show cataracts
            and an abnormal skin phenotype
  JOURNAL   Biochem Biophys Res Commun 330 (3), 653-657 (2005)
   PUBMED   15809047
  REMARK    GeneRIF: overexpression of the human MrgX3 gene causes a
            disturbance of the normal cell-differentiation process
REFERENCE   7  (bases 1 to 1480)
  AUTHORS   Lembo,P.M., Grazzini,E., Groblewski,T., O'Donnell,D., Roy,M.O.,
            Zhang,J., Hoffert,C., Cao,J., Schmidt,R., Pelletier,M., Labarre,M.,
            Gosselin,M., Fortin,Y., Banville,D., Shen,S.H., Strom,P., Payza,K.,
            Dray,A., Walker,P. and Ahmad,S.
  TITLE     Proenkephalin A gene products activate a new family of sensory
            neuron--specific GPCRs
  JOURNAL   Nat Neurosci 5 (3), 201-209 (2002)
   PUBMED   11850634
REFERENCE   8  (bases 1 to 1480)
  AUTHORS   Dong,X., Han,S., Zylka,M.J., Simon,M.I. and Anderson,D.J.
  TITLE     A diverse family of GPCRs expressed in specific subsets of
            nociceptive sensory neurons
  JOURNAL   Cell 106 (5), 619-632 (2001)
   PUBMED   11551509
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC090099.14.
            
            On May 8, 2019 this sequence version replaced XM_011519882.2.
            
            Summary: This gene encodes a member of the mas-related/sensory
            neuron specific subfamily of G protein coupled receptors. The
            encoded protein may be involved in sensory neuron regulation and in
            the modulation of pain. [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CA455045.1, BE439409.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000621697.2/ ENSP00000481943.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-169               AC090099.14        118436-118604       c
            170-1480            AC090099.14        112687-113997       c
FEATURES             Location/Qualifiers
     source          1..1480
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..1480
                     /gene="MRGPRX3"
                     /gene_synonym="GPCR; MRGX3; SNSR1; SNSR2"
                     /note="MAS related GPR family member X3"
                     /db_xref="GeneID:117195"
                     /db_xref="HGNC:HGNC:17980"
                     /db_xref="MIM:607229"
     exon            1..169
                     /gene="MRGPRX3"
                     /gene_synonym="GPCR; MRGX3; SNSR1; SNSR2"
                     /inference="alignment:Splign:2.1.0"
     exon            170..1480
                     /gene="MRGPRX3"
                     /gene_synonym="GPCR; MRGX3; SNSR1; SNSR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1163
                     /gene="MRGPRX3"
                     /gene_synonym="GPCR; MRGX3; SNSR1; SNSR2"
                     /note="G protein-coupled receptor MRGX3; sensory
                     neuron-specific G-protein coupled receptor 1/2; G
                     protein-coupled receptor SNSR1; mas-related GPCR member
                     X3; G protein-coupled receptor SNSR2; MAS-related GPR,
                     member X3"
                     /codon_start=1
                     /product="mas-related G-protein coupled receptor member
                     X3"
                     /protein_id="NP_001357393.1"
                     /db_xref="CCDS:CCDS7830.1"
                     /db_xref="GeneID:117195"
                     /db_xref="HGNC:HGNC:17980"
                     /db_xref="MIM:607229"
                     /translation="MDSTIPVLGTELTPINGREETPCYKQTLSFTGLTCIVSLVALTG
                     NAVVLWLLGCRMRRNAVSIYILNLVAADFLFLSGHIICSPLRLINIRHPISKILSPVM
                     TFPYFIGLSMLSAISTERCLSILWPIWYHCRRPRYLSSVMCVLLWALSLLRSILEWMF
                     CDFLFSGANSVWCETSDFITIAWLVFLCVVLCGSSLVLLVRILCGSRKMPLTRLYVTI
                     LLTVLVFLLCGLPFGIQWALFSRIHLDWKVLFCHVHLVSIFLSALNSSANPIIYFFVG
                     SFRQRQNRQNLKLVLQRALQDTPEVDEGGGWLPQETLELSGSRLEQ"
     regulatory      1449..1454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRGPRX3"
                     /gene_synonym="GPCR; MRGX3; SNSR1; SNSR2"
                     /note="hexamer: AATAAA"
     polyA_site      1480
                     /gene="MRGPRX3"
                     /gene_synonym="GPCR; MRGX3; SNSR1; SNSR2"
                     /note="major polyA site"
ORIGIN      
        1 agcatcttcg taagcctgga ttgctcacca gctttcattt cagctcctgt aggcatctcc
       61 tgaattaagc aacacagaaa agtcctctga agtcactgaa tcccataaag gctctctacc
      121 tttagcacaa gggaggtctt caccactgga caaagaagga acgataaggg gtcatcagac
      181 tggggtttct gagcatggat tcaaccatcc cagtcttggg tacagaactg acaccaatca
      241 acggacgtga ggagactcct tgctacaagc agaccctgag cttcacgggg ctgacgtgca
      301 tcgtttccct tgtcgcgctg acaggaaacg cggttgtgct ctggctcctg ggctgccgca
      361 tgcgcaggaa cgctgtctcc atctacatcc tcaacctggt cgcggccgac ttcctcttcc
      421 ttagcggcca cattatatgt tcgccgttac gcctcatcaa tatccgccat cccatctcca
      481 aaatcctcag tcctgtgatg acctttccct actttatagg cctaagcatg ctgagcgcca
      541 tcagcaccga gcgctgcctg tccatcctgt ggcccatctg gtaccactgc cgccgcccca
      601 gatacctgtc atcagtcatg tgtgtcctgc tctgggccct gtccctgctg cggagtatcc
      661 tggagtggat gttctgtgac ttcctgttta gtggtgctaa ttctgtttgg tgtgaaacgt
      721 cagatttcat tacaatcgcg tggctggttt ttttatgtgt ggttctctgt gggtccagcc
      781 tggtcctgct ggtcaggatt ctctgtggat cccggaagat gccgctgacc aggctgtacg
      841 tgaccatcct cctcacagtg ctggtcttcc tcctctgtgg cctgcccttt ggcattcagt
      901 gggccctgtt ttccaggatc cacctggatt ggaaagtctt attttgtcat gtgcatctag
      961 tttccatttt cctgtccgct cttaacagca gtgccaaccc catcatttac ttcttcgtgg
     1021 gctcctttag gcagcgtcaa aataggcaga acctgaagct ggttctccag agggctctgc
     1081 aggacacgcc tgaggtggat gaaggtggag ggtggcttcc tcaggaaacc ctggagctgt
     1141 cgggaagcag attggagcag tgaggaagaa cctctgccct gtcagacagg actttgagag
     1201 caatgctgcc ctgccaccct tgacaattat atgcattttt cttagccttc tgcctcagaa
     1261 atgtctcagt ggtccctcaa ggtcttcgaa tagatgttta tctaacctga cagttgcagt
     1321 tttcacccat ggaaagcatt agtctgacag tacaatgttt ggattctcct tgatattacc
     1381 aatacatttt ccctgttatc ttgcactgaa tctttcctac tgaacacttt ttctgcactt
     1441 ttcattgtaa taaaaggagt tgctgtccac aaccctaaaa
//
