LOCUS       NM_001393578            1446 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens MAS related GPR family member X1 (MRGPRX1), transcript
            variant 2, mRNA.
ACCESSION   NM_001393578
VERSION     NM_001393578.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1446)
  AUTHORS   Guo,L., Zhang,Y., Fang,G., Tie,L., Zhuang,Y., Xue,C., Liu,Q.,
            Zhang,M., Zhu,K., You,C., Xu,P., Yuan,Q., Zhang,C., Liu,L.,
            Rong,N., Peng,S., Liu,Y., Wang,C., Luo,X., Lv,Z., Kang,D., Yu,X.,
            Zhang,C., Jiang,Y., Dong,X., Zhou,J., Liu,Z., Yang,F., Eric Xu,H.
            and Sun,J.P.
  TITLE     Ligand recognition and G protein coupling of the human itch
            receptor MRGPRX1
  JOURNAL   Nat Commun 14 (1), 5004 (2023)
   PUBMED   37591889
  REMARK    GeneRIF: Ligand recognition and G protein coupling of the human
            itch receptor MRGPRX1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1446)
  AUTHORS   Gan,B., Yu,L., Yang,H., Jiao,H., Pang,B., Chen,Y., Wang,C., Lv,R.,
            Hu,H., Cao,Z. and Ren,R.
  TITLE     Mechanism of agonist-induced activation of the human itch receptor
            MRGPRX1
  JOURNAL   PLoS Biol 21 (6), e3001975 (2023)
   PUBMED   37347749
  REMARK    GeneRIF: Mechanism of agonist-induced activation of the human itch
            receptor MRGPRX1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1446)
  AUTHORS   Li,X., Yang,H., Han,Y., Yin,S., Shen,B., Wu,Y., Li,W. and Cao,Z.
  TITLE     Tick peptides evoke itch by activating MrgprC11/MRGPRX1 to
            sensitize TRPV1 in pruriceptors
  JOURNAL   J Allergy Clin Immunol 147 (6), 2236-2248 (2021)
   PUBMED   33358893
REFERENCE   4  (bases 1 to 1446)
  AUTHORS   Klein,A., Solinski,H.J., Malewicz,N.M., Ieong,H.F., Sypek,E.I.,
            Shimada,S.G., Hartke,T.V., Wooten,M., Wu,G., Dong,X., Hoon,M.A.,
            LaMotte,R.H. and Ringkamp,M.
  TITLE     Pruriception and neuronal coding in nociceptor subtypes in human
            and nonhuman primates
  JOURNAL   Elife 10, e64506 (2021)
   PUBMED   33891544
  REMARK    GeneRIF: Pruriception and neuronal coding in nociceptor subtypes in
            human and nonhuman primates.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1446)
  AUTHORS   Sanjel,B., Maeng,H.J. and Shim,W.S.
  TITLE     BAM8-22 and its receptor MRGPRX1 may attribute to cholestatic
            pruritus
  JOURNAL   Sci Rep 9 (1), 10888 (2019)
   PUBMED   31350433
  REMARK    GeneRIF: BAM8-22 and its receptor MRGPRX1 may attribute to
            cholestatic pruritus.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1446)
  AUTHORS   Premzl,M.
  TITLE     Comparative genomic analysis of eutherian Mas-related G
            protein-coupled receptor genes
  JOURNAL   Gene 540 (1), 16-19 (2014)
   PUBMED   24583173
REFERENCE   7  (bases 1 to 1446)
  AUTHORS   Solinski,H.J., Zierler,S., Gudermann,T. and Breit,A.
  TITLE     Human sensory neuron-specific Mas-related G protein-coupled
            receptors-X1 sensitize and directly activate transient receptor
            potential cation channel V1 via distinct signaling pathways
  JOURNAL   J Biol Chem 287 (49), 40956-40971 (2012)
   PUBMED   23074220
  REMARK    GeneRIF: analysis of the functional interactions between MRGPR-X1
            and TRPV1
REFERENCE   8  (bases 1 to 1446)
  AUTHORS   Liu,Q., Tang,Z., Surdenikova,L., Kim,S., Patel,K.N., Kim,A., Ru,F.,
            Guan,Y., Weng,H.J., Geng,Y., Undem,B.J., Kollarik,M., Chen,Z.F.,
            Anderson,D.J. and Dong,X.
  TITLE     Sensory neuron-specific GPCR Mrgprs are itch receptors mediating
            chloroquine-induced pruritus
  JOURNAL   Cell 139 (7), 1353-1365 (2009)
   PUBMED   20004959
REFERENCE   9  (bases 1 to 1446)
  AUTHORS   Lembo,P.M., Grazzini,E., Groblewski,T., O'Donnell,D., Roy,M.O.,
            Zhang,J., Hoffert,C., Cao,J., Schmidt,R., Pelletier,M., Labarre,M.,
            Gosselin,M., Fortin,Y., Banville,D., Shen,S.H., Strom,P., Payza,K.,
            Dray,A., Walker,P. and Ahmad,S.
  TITLE     Proenkephalin A gene products activate a new family of sensory
            neuron--specific GPCRs
  JOURNAL   Nat Neurosci 5 (3), 201-209 (2002)
   PUBMED   11850634
REFERENCE   10 (bases 1 to 1446)
  AUTHORS   Dong,X., Han,S., Zylka,M.J., Simon,M.I. and Anderson,D.J.
  TITLE     A diverse family of GPCRs expressed in specific subsets of
            nociceptive sensory neurons
  JOURNAL   Cell 106 (5), 619-632 (2001)
   PUBMED   11551509
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC023078.9.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CD051096.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000526914.2/ ENSP00000499076.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               AC023078.9         76033-76167         c
            136-1446            AC023078.9         70252-71562         c
FEATURES             Location/Qualifiers
     source          1..1446
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..1446
                     /gene="MRGPRX1"
                     /gene_synonym="GPCR; MGRG2; MRGX1; SNSR4"
                     /note="MAS related GPR family member X1"
                     /db_xref="GeneID:259249"
                     /db_xref="HGNC:HGNC:17962"
                     /db_xref="MIM:607227"
     exon            1..135
                     /gene="MRGPRX1"
                     /gene_synonym="GPCR; MGRG2; MRGX1; SNSR4"
                     /inference="alignment:Splign:2.1.0"
     exon            136..1446
                     /gene="MRGPRX1"
                     /gene_synonym="GPCR; MGRG2; MRGX1; SNSR4"
                     /inference="alignment:Splign:2.1.0"
     CDS             161..1129
                     /gene="MRGPRX1"
                     /gene_synonym="GPCR; MGRG2; MRGX1; SNSR4"
                     /note="G protein-coupled receptor MRGX1; G protein-coupled
                     receptor SNSR3; sensory neuron-specific G-protein coupled
                     receptor 3/4; Mas-related G protein-coupled receptor G2;
                     MAS-related GPR, member X1"
                     /codon_start=1
                     /product="mas-related G-protein coupled receptor member
                     X1"
                     /protein_id="NP_001380507.1"
                     /db_xref="CCDS:CCDS7846.1"
                     /db_xref="GeneID:259249"
                     /db_xref="HGNC:HGNC:17962"
                     /db_xref="MIM:607227"
                     /translation="MDPTISTLDTELTPINGTEETLCYKQTLSLTVLTCIVSLVGLTG
                     NAVVLWLLGCRMRRNAFSIYILNLAAADFLFLSGRLIYSLLSFISIPHTISKILYPVM
                     MFSYFAGLSFLSAVSTERCLSVLWPIWYRCHRPTHLSAVVCVLLWALSLLRSILEWML
                     CGFLFSGADSAWCQTSDFITVAWLIFLCVVLCGSSLVLLIRILCGSRKIPLTRLYVTI
                     LLTVLVFLLCGLPFGIQFFLFLWIHVDREVLFCHVHLVSIFLSALNSSANPIIYFFVG
                     SFRQRQNRQNLKLVLQRALQDASEVDEGGGQLPEEILELSGSRLEQ"
     regulatory      1415..1420
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRGPRX1"
                     /gene_synonym="GPCR; MGRG2; MRGX1; SNSR4"
                     /note="hexamer: AATAAA"
     polyA_site      1446
                     /gene="MRGPRX1"
                     /gene_synonym="GPCR; MGRG2; MRGX1; SNSR4"
                     /note="major polyA site"
ORIGIN      
        1 gactccagct cctgtatgca tctcctgaat taagcaacac agaagggttc tctgaagtca
       61 ctgaatccca gaaaggccct ccacctttag cacaagggac gtcttcacca ctggacaaag
      121 gagaaaaaga taaggggtca ccagactagg gtttctgagc atggatccaa ccatctcaac
      181 cttggacaca gaactgacac caatcaacgg aactgaggag actctttgct acaagcagac
      241 cttgagcctc acggtgctga cgtgcatcgt ttcccttgtc gggctgacag gaaacgcagt
      301 tgtgctctgg ctcctgggct gccgcatgcg caggaacgcc ttctccatct acatcctcaa
      361 cttggccgca gcagacttcc tcttcctcag cggccgcctt atatattccc tgttaagctt
      421 catcagtatc ccccatacca tctctaaaat cctctatcct gtgatgatgt tttcctactt
      481 tgcaggcctg agctttctga gtgccgtgag caccgagcgc tgcctgtccg tcctgtggcc
      541 catctggtac cgctgccacc gccccacaca cctgtcagcg gtggtgtgtg tcctgctctg
      601 ggccctgtcc ctgctgcgga gcatcctgga gtggatgtta tgtggcttcc tgttcagtgg
      661 tgctgattct gcttggtgtc aaacatcaga tttcatcaca gtcgcgtggc tgattttttt
      721 atgtgtggtt ctctgtgggt ccagcctggt cctgctgatc aggattctct gtggatcccg
      781 gaagataccg ctgaccaggc tgtacgtgac catcctgctc acagtactgg tcttcctcct
      841 ctgtggcctg ccctttggca ttcagttttt cctattttta tggatccacg tggacaggga
      901 agtcttattt tgtcatgttc atctagtttc tattttcctg tccgctctta acagcagtgc
      961 caaccccatc atttacttct tcgtgggctc ctttaggcag cgtcaaaata ggcagaacct
     1021 gaagctggtt ctccagaggg ctctgcagga cgcgtctgag gtggatgaag gtggagggca
     1081 gcttcctgag gaaatcctgg agctgtcggg aagcagattg gagcagtgag gaagagcctc
     1141 tgccctgtca gacaggactt tgagagcaac actgccctgc cacccttgac aattatatgc
     1201 gtttttctta gccttctgcc tcagaaatgt ctcagtggtt cctcaaggtc ttcaaataga
     1261 tgtttatcta acctgacagt tgcggttttc acccatggaa agcattagtc tgacagtaca
     1321 atgtttagat tctccttgat attaccaaca cattttccct gttatctcac actgaatctt
     1381 tcctacagaa cactttttct gcaattttct ttgtaataaa aggagttcct gtacaaaacc
     1441 ctaaaa
//
