LOCUS       NM_001039165            4108 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens MAS related GPR family member E (MRGPRE), mRNA.
ACCESSION   NM_001039165 XM_171536 XM_939384
VERSION     NM_001039165.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4108)
  AUTHORS   Premzl,M.
  TITLE     Comparative genomic analysis of eutherian Mas-related G
            protein-coupled receptor genes
  JOURNAL   Gene 540 (1), 16-19 (2014)
   PUBMED   24583173
REFERENCE   2  (bases 1 to 4108)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   3  (bases 1 to 4108)
  AUTHORS   Gourraud,P.A., Sdika,M., Khankhanian,P., Henry,R.G., Beheshtian,A.,
            Matthews,P.M., Hauser,S.L., Oksenberg,J.R., Pelletier,D. and
            Baranzini,S.E.
  TITLE     A genome-wide association study of brain lesion distribution in
            multiple sclerosis
  JOURNAL   Brain 136 (Pt 4), 1012-1024 (2013)
   PUBMED   23412934
REFERENCE   4  (bases 1 to 4108)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
REFERENCE   5  (bases 1 to 4108)
  AUTHORS   Dong,X., Han,S., Zylka,M.J., Simon,M.I. and Anderson,D.J.
  TITLE     A diverse family of GPCRs expressed in specific subsets of
            nociceptive sensory neurons
  JOURNAL   Cell 106 (5), 619-632 (2001)
   PUBMED   11551509
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109309.5.
            
            On May 17, 2019 this sequence version replaced NM_001039165.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK293940.1, SRR1660809.330456.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142853, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000389832.7/ ENSP00000374482.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-277               AC109309.5         102425-102701
            278-4108            AC109309.5         105982-109812
FEATURES             Location/Qualifiers
     source          1..4108
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..4108
                     /gene="MRGPRE"
                     /gene_synonym="GPR167; MGRF; MRGE"
                     /note="MAS related GPR family member E"
                     /db_xref="GeneID:116534"
                     /db_xref="HGNC:HGNC:30694"
                     /db_xref="MIM:607232"
     exon            1..277
                     /gene="MRGPRE"
                     /gene_synonym="GPR167; MGRF; MRGE"
                     /inference="alignment:Splign:2.1.0"
     exon            278..4108
                     /gene="MRGPRE"
                     /gene_synonym="GPR167; MGRF; MRGE"
                     /inference="alignment:Splign:2.1.0"
     CDS             339..1277
                     /gene="MRGPRE"
                     /gene_synonym="GPR167; MGRF; MRGE"
                     /note="mas-related G protein-coupled MRGE; G-protein
                     coupled receptor 167; Mas-related G protein-coupled
                     receptor F; MAS-related GPR, member E"
                     /codon_start=1
                     /product="mas-related G-protein coupled receptor member E"
                     /protein_id="NP_001034254.2"
                     /db_xref="CCDS:CCDS41603.2"
                     /db_xref="GeneID:116534"
                     /db_xref="HGNC:HGNC:30694"
                     /db_xref="MIM:607232"
                     /translation="MMEPREAGQHVGAANGAQEDVAFNLIILSLTEGLGLGGLLGNGA
                     VLWLLSSNVYRNPFAIYLLDVACADLIFLGCHMVAIVPDLLQGRLDFPGFVQTSLATL
                     RFFCYIVGLSLLAAVSVEQCLAALFPAWYSCRRPRHLTTCVCALTWALCLLLHLLLSG
                     ACTQFFGEPSRHLCRTLWLVAAVLLALLCCTMCGASLMLLLRVERGPQRPPPRGFPGL
                     ILLTVLLFLFCGLPFGIYWLSRNLLWYIPHYFYHFSFLMAAVHCAAKPVVYFCLGSAQ
                     GRRLPLRLVLQRALGDEAELGAVRETSRRGLVDIAA"
     regulatory      4078..4083
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRGPRE"
                     /gene_synonym="GPR167; MGRF; MRGE"
                     /note="hexamer: AATAAA"
     polyA_site      4108
                     /gene="MRGPRE"
                     /gene_synonym="GPR167; MGRF; MRGE"
                     /note="major polyA site"
ORIGIN      
        1 gcctgccagg cctgcctgga aggctgcagg gaggttcagg gtttctcttg ctgtccacac
       61 ctgggcgaga gctgagcgga agagaagggg tcctcagaga gacaccttcc tgaccggccc
      121 cattccagct ggatgccatg tgactcggag gagctggtgg acactgaaca ggagccgccc
      181 agaggctctg gggactggag ccctcggccg cggccaggat agatccaagg cccagggtca
      241 gagcaggcag ggctcggcca gtcctctgcc ccaaacgggg catcaggaga gagagcgagc
      301 agaacacact cctgcagcat cccctggccc cccgccccat gatggagccc agagaagctg
      361 gacagcacgt gggggccgcc aacggcgccc aggaggatgt ggccttcaac ctcatcatcc
      421 tgtccctcac cgaggggctc ggcctcggtg ggctgctggg gaatggggca gtcctctggc
      481 tgctcagctc caatgtctac agaaacccct tcgccatcta cctcctggac gtggcctgcg
      541 cggatctcat cttccttggc tgccacatgg tggccatcgt ccccgacttg ctgcaaggcc
      601 ggctggactt cccgggcttc gtgcagacca gcctggcaac gctgcgcttc ttctgctaca
      661 tcgtgggcct gagtctcctg gcggccgtca gcgtggagca gtgcctggcc gccctcttcc
      721 cagcctggta ctcgtgccgc cgcccacgcc acctgaccac ctgtgtgtgc gccctcacct
      781 gggccctctg cctgctgctg cacctgctgc tcagcggcgc ctgcacccag ttcttcgggg
      841 agcccagccg ccacttgtgc cggacgctgt ggctggtggc agcggtgctg ctggctctgc
      901 tgtgttgcac catgtgtggg gccagcctta tgctgctgct gcgggtggag cgaggccccc
      961 agcggccccc accccggggc ttccctgggc tcatcctcct caccgtcctc ctcttcctct
     1021 tctgcggcct gcccttcggc atctactggc tgtcccggaa cctgctctgg tacatccccc
     1081 actacttcta ccacttcagc ttcctcatgg ccgccgtgca ctgcgcggcc aagcccgtcg
     1141 tctacttctg cctgggcagt gcccagggcc gcaggctgcc cctccggctg gtcctccagc
     1201 gagcgctggg agacgaggct gagctggggg ccgtcaggga gacctcccgc cggggcctgg
     1261 tggacatagc agcctgagcc ctggggcccc cgaccccagc tgcagccccc gtgaggcaag
     1321 agggtgactt ggggaaggtg gtggggtcag aggctggggc cagccggacc tggaggaggc
     1381 cttggtgggt gacccggtca tgtgctgtca aagttgtgac ccttggtctg gagcatgagg
     1441 ctcccctggg aggcagctgg aaaggcaagg tctctacatg cccaggcagg cgggccgggt
     1501 ctctggggag aaggccgagg aacgtgcatt tttgggaaac ctccccaacg gttcacgcac
     1561 tggcactcga gagctgctgc tgctacccat tccctgctca gctgcagtga ggagaccccg
     1621 gaaagcaagg aagcaaggcc agacgccagg tgaggggcag gtccaggcct ttccgcaggc
     1681 cacctcccct cccactccag cttcctcaat gctgcaggtg cacccacaga taacacaacc
     1741 atcccctcag ctcgccttgt gcccgctgtg gaagctaaat tgaccctaaa atggaagact
     1801 gcccaaaact tgaccccctc cccgtccttg atcatcagcc agttgctcaa ggccgtgcac
     1861 ctcagaccgg gacgatgcaa ccctcactcg gagcttcaga aaagccggcc ccatgggtgt
     1921 ccctggatat taggagggtg caccctgggt gggtggagag gcttcttaca gccccaccca
     1981 gcagcctgca gccctgtctc cccacaggac ccaggtcttc agcaaccaga aagcttcaca
     2041 ccggccccat ccaaggcagt tcacccgcct ctgtcctgag caagtcccgc tccagaggat
     2101 ccctctgagg aaggaaccca ggcttcaccc ctcaacaggt ttccgagctt ccgctgagtg
     2161 ccaggcctgg ctgccatcca ggagcatgtg ccaggggtgc tagagtgggg gctttggagc
     2221 ccacagcctg ggctgagccc cgctagccac cccactgtgc tgccaaggcc atctctgaac
     2281 atccctacgc ctctgtttgc tggtctgtaa aatatgagaa cccagtgctt tgaggcctgt
     2341 ccagcctctc gtgagcccaa gagaaatgtc tgtcgattct actgccacca acgccacaca
     2401 tccaagtcca cagtgcaatt cttagccaca gaccaaggca tctgagagtg ttttctttga
     2461 tttctgactc cggcctccat ggctggtgat ggaaggacat tccctctgga ccatgactga
     2521 accagcccct cttgagtctg ggtgtgagtc gcagatccct ggtcagcacc ctggaatccg
     2581 gctgcaccgg gcccctccca gcccacacag tgcgttcacc tcaggctccc gcacgtgccc
     2641 agcaggcctg ggtccaggta tcccttgaga ctgggagccc caggggctgg acccacctct
     2701 cctagagcac ctccagcccc cacttgggga cttacctcct cccaaattat ctccagccca
     2761 ggatctgcac agggccctct ctccccacct ccaggacgtg attagcaact tcagttcctc
     2821 agctggagaa acaagaacag aaagggaagt ggcctgtcca caaattccac tttcagcccc
     2881 aggacataaa cttcccccag aacaaggaag aaccaggagg aaaagcacag attcatctca
     2941 cggacatgac ctcaccgtgg acgtgttccc ggggaatcct cgtaataatg taggaaggtg
     3001 ctcccactct gcagatgagc caccaaggct ccgaggggct atgtggccgt tcaggaccac
     3061 aggaaagctg caaagccaga aggtgactcc cagcaccacc ctcccacgcc acacgctccg
     3121 cctcactgga ccagggctgg ctcaggtgtc ctcagcccca cactggctcc cccaaccctg
     3181 gccccatccc cacgcagacc cctttgctgc ataagggttc agagagattg cggaccctta
     3241 gaatgctcac ttcttcccag agagcctgct ctcagcatcc aggggattgg agtggctcta
     3301 gattcctcct tattagcccc ttctcgagga gtccgggaaa tgtggcctca tctgaggtct
     3361 ccatggaaac tgggcccagc tcgtccccac tctagtagct gctgtggcag caggtatatg
     3421 gcctgatggc ccaggatgct ggtggggtat ccccttggcc ccagatgtgc cagcttggcc
     3481 tccagttctg tggtccttga gccctcagga cattaggacc atgtgggctg gcctccaaac
     3541 tggaggctga gcttccgtcc aggctcccac ctgcccctgc ccagcctgcg cctcctctga
     3601 cctcccccgc tgcacctcct cttctgcccc cagagccaca aggccccacc agggacccct
     3661 ggctgcccta gaccccaccc tgcaggaccc tggggcctca ctgctcaaag gccacctcca
     3721 cctgggtcgc aggcaaagct cctcggtcag tgcccagccc accccatcca cccgcaaccc
     3781 cgggcccctg cggggctgcc gcggtcagca cagaattccc aagaacaggc ggctactcct
     3841 gggggcagcc aacattccag ggagcctgtg taacccgctc cgtcctcagg gcccagggag
     3901 gctgtgggtg aggactgtgt gtgtgaggac aggagcggag acaggcctgc ggccagcttc
     3961 cctatcccct ccccagcgcc cgggtacgag tctgtaaatc agcctgcgct gcatggcgtc
     4021 ttcacgggga gaggcaggct cactcctcag ctagttcatt agctcacacg ctggaaaaat
     4081 aaaaccaaac atcacactta aaacatga
//
