LOCUS       NM_198923                966 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens MAS related GPR family member D (MRGPRD), mRNA.
ACCESSION   NM_198923
VERSION     NM_198923.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 966)
  AUTHORS   Larrinaga,G., Valdivia,A., Arrieta-Aguirre,I., Solano-Iturri,J.D.,
            Ugalde-Olano,A., Loizaga-Iriarte,A., Santos-Martin,A.,
            Perez-Fernandez,A., Angulo,J.C. and Lopez,J.I.
  TITLE     The Expression of Alamandine Receptor MrgD in Clear Cell Renal Cell
            Carcinoma Is Associated with a Worse Prognosis and Unfavorable
            Response to Antiangiogenic Therapy
  JOURNAL   Int J Mol Sci 25 (3), 1499 (2024)
   PUBMED   38338778
  REMARK    GeneRIF: The Expression of Alamandine Receptor MrgD in Clear Cell
            Renal Cell Carcinoma Is Associated with a Worse Prognosis and
            Unfavorable Response to Antiangiogenic Therapy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 966)
  AUTHORS   Arora,R., Van Theemsche,K.M., Van Remoortel,S., Snyders,D.J.,
            Labro,A.J. and Timmermans,J.P.
  TITLE     Constitutive, Basal, and beta-Alanine-Mediated Activation of the
            Human Mas-Related G Protein-Coupled Receptor D Induces Release of
            the Inflammatory Cytokine IL-6 and Is Dependent on NF-kappaB
            Signaling
  JOURNAL   Int J Mol Sci 22 (24), 13254 (2021)
   PUBMED   34948051
  REMARK    GeneRIF: Constitutive, Basal, and beta-Alanine-Mediated Activation
            of the Human Mas-Related G Protein-Coupled Receptor D Induces
            Release of the Inflammatory Cytokine IL-6 and Is Dependent on
            NF-kappaB Signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 966)
  AUTHORS   Klein,A., Solinski,H.J., Malewicz,N.M., Ieong,H.F., Sypek,E.I.,
            Shimada,S.G., Hartke,T.V., Wooten,M., Wu,G., Dong,X., Hoon,M.A.,
            LaMotte,R.H. and Ringkamp,M.
  TITLE     Pruriception and neuronal coding in nociceptor subtypes in human
            and nonhuman primates
  JOURNAL   Elife 10, e64506 (2021)
   PUBMED   33891544
  REMARK    GeneRIF: Pruriception and neuronal coding in nociceptor subtypes in
            human and nonhuman primates.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 966)
  AUTHORS   Lautner,R.Q., Villela,D.C., Fraga-Silva,R.A., Silva,N.,
            Verano-Braga,T., Costa-Fraga,F., Jankowski,J., Jankowski,V.,
            Sousa,F., Alzamora,A., Soares,E., Barbosa,C., Kjeldsen,F.,
            Oliveira,A., Braga,J., Savergnini,S., Maia,G., Peluso,A.B.,
            Passos-Silva,D., Ferreira,A., Alves,F., Martins,A., Raizada,M.,
            Paula,R., Motta-Santos,D., Klempin,F., Pimenta,A., Alenina,N.,
            Sinisterra,R., Bader,M., Campagnole-Santos,M.J. and Santos,R.A.
  TITLE     Discovery and characterization of alamandine: a novel component of
            the renin-angiotensin system
  JOURNAL   Circ Res 112 (8), 1104-1111 (2013)
   PUBMED   23446738
  REMARK    GeneRIF: Heptapeptide alamandine acts through Mas-related
            G-protein-coupled receptor member D producing physiological actions
            that resemble those generated by angiotensin-1-7.
            Erratum:[Circ Res. 2013 May 24;112(11):e156. Kemplin, Friederike
            [corrected to Klempin, Friederike]]
REFERENCE   5  (bases 1 to 966)
  AUTHORS   Nishimura,S., Uno,M., Kaneta,Y., Fukuchi,K., Nishigohri,H.,
            Hasegawa,J., Komori,H., Takeda,S., Enomoto,K., Nara,F. and
            Agatsuma,T.
  TITLE     MRGD, a MAS-related G-protein coupled receptor, promotes
            tumorigenisis and is highly expressed in lung cancer
  JOURNAL   PLoS One 7 (6), e38618 (2012)
   PUBMED   22715397
  REMARK    GeneRIF: MRGD could be involved in tumorigenesis and could also be
            a novel anticancer drug target.
REFERENCE   6  (bases 1 to 966)
  AUTHORS   Gembardt,F., Grajewski,S., Vahl,M., Schultheiss,H.P. and Walther,T.
  TITLE     Angiotensin metabolites can stimulate receptors of the Mas-related
            genes family
  JOURNAL   Mol Cell Biochem 319 (1-2), 115-123 (2008)
   PUBMED   18636314
  REMARK    GeneRIF: Mas, MrgD, and MRG mediated Ang IV-stimulated AA release
            that was highest for Mas. While Ang III activated Mas and MrgX2,
            Ang II stimulated AA release via Mas and MRG.
REFERENCE   7  (bases 1 to 966)
  AUTHORS   Shinohara,T., Harada,M., Ogi,K., Maruyama,M., Fujii,R., Tanaka,H.,
            Fukusumi,S., Komatsu,H., Hosoya,M., Noguchi,Y., Watanabe,T.,
            Moriya,T., Itoh,Y. and Hinuma,S.
  TITLE     Identification of a G protein-coupled receptor specifically
            responsive to beta-alanine
  JOURNAL   J Biol Chem 279 (22), 23559-23564 (2004)
   PUBMED   15037633
REFERENCE   8  (bases 1 to 966)
  AUTHORS   Zylka,M.J., Dong,X., Southwell,A.L. and Anderson,D.J.
  TITLE     Atypical expansion in mice of the sensory neuron-specific Mrg G
            protein-coupled receptor family
  JOURNAL   Proc Natl Acad Sci U S A 100 (17), 10043-10048 (2003)
   PUBMED   12909716
REFERENCE   9  (bases 1 to 966)
  AUTHORS   Takeda,S., Kadowaki,S., Haga,T., Takaesu,H. and Mitaku,S.
  TITLE     Identification of G protein-coupled receptor genes from the human
            genome sequence
  JOURNAL   FEBS Lett 520 (1-3), 97-101 (2002)
   PUBMED   12044878
  REMARK    Erratum:[FEBS Lett 2002 Jul 17;523(1-3):257]
REFERENCE   10 (bases 1 to 966)
  AUTHORS   Dong,X., Han,S., Zylka,M.J., Simon,M.I. and Anderson,D.J.
  TITLE     A diverse family of GPCRs expressed in specific subsets of
            nociceptive sensory neurons
  JOURNAL   Cell 106 (5), 619-632 (2001)
   PUBMED   11551509
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY427820.1.
            
            On Feb 25, 2004 this sequence version replaced NM_198923.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AB154410.1, AY427820.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309106.3/ ENSP00000310631.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..966
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.3"
     gene            1..966
                     /gene="MRGPRD"
                     /gene_synonym="MRGD; TGR7"
                     /note="MAS related GPR family member D"
                     /db_xref="GeneID:116512"
                     /db_xref="HGNC:HGNC:29626"
                     /db_xref="MIM:607231"
     CDS             1..966
                     /gene="MRGPRD"
                     /gene_synonym="MRGD; TGR7"
                     /note="mas-related G protein-coupled MRGD; beta-alanine
                     receptor; G-protein coupled receptor TGR7; MAS-related
                     GPR, member D"
                     /codon_start=1
                     /product="mas-related G-protein coupled receptor member D"
                     /protein_id="NP_944605.2"
                     /db_xref="CCDS:CCDS31625.1"
                     /db_xref="GeneID:116512"
                     /db_xref="HGNC:HGNC:29626"
                     /db_xref="MIM:607231"
                     /translation="MNQTLNSSGTVESALNYSRGSTVHTAYLVLSSLAMFTCLCGMAG
                     NSMVIWLLGFRMHRNPFCIYILNLAAADLLFLFSMASTLSLETQPLVNTTDKVHELMK
                     RLMYFAYTVGLSLLTAISTQRCLSVLFPIWFKCHRPRHLSAWVCGLLWTLCLLMNGLT
                     SSFCSKFLKFNEDRCFRVDMVQAALIMGVLTPVMTLSSLTLFVWVRRSSQQWRRQPTR
                     LFVVVLASVLVFLICSLPLSIYWFVLYWLSLPPEMQVLCFSLSRLSSSVSSSANPVIY
                     FLVGSRRSHRLPTRSLGTVLQQALREEPELEGGETPTVGTNEMGA"
     exon            1..966
                     /gene="MRGPRD"
                     /gene_synonym="MRGD; TGR7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgaaccaga ctttgaatag cagtgggacc gtggagtcag ccctaaacta ttccagaggg
       61 agcacagtgc acacggccta cctggtgctg agctccctgg ccatgttcac ctgcctgtgc
      121 gggatggcag gcaacagcat ggtgatctgg ctgctgggct ttcgaatgca caggaacccc
      181 ttctgcatct atatcctcaa cctggcggca gccgacctcc tcttcctctt cagcatggct
      241 tccacgctca gcctggaaac ccagcccctg gtcaatacca ctgacaaggt ccacgagctg
      301 atgaagagac tgatgtactt tgcctacaca gtgggcctga gcctgctgac ggccatcagc
      361 acccagcgct gtctctctgt cctcttccct atctggttca agtgtcaccg gcccaggcac
      421 ctgtcagcct gggtgtgtgg cctgctgtgg acactctgtc tcctgatgaa cgggttgacc
      481 tcttccttct gcagcaagtt cttgaaattc aatgaagatc ggtgcttcag ggtggacatg
      541 gtccaggccg ccctcatcat gggggtctta accccagtga tgactctgtc cagcctgacc
      601 ctctttgtct gggtgcggag gagctcccag cagtggcggc ggcagcccac acggctgttc
      661 gtggtggtcc tggcctctgt cctggtgttc ctcatctgtt ccctgcctct gagcatctac
      721 tggtttgtgc tctactggtt gagcctgccg cccgagatgc aggtcctgtg cttcagcttg
      781 tcacgcctct cctcgtccgt aagcagcagc gccaaccccg tcatctactt cctggtgggc
      841 agccggagga gccacaggct gcccaccagg tccctgggga ctgtgctcca acaggcgctt
      901 cgcgaggagc ccgagctgga aggtggggag acgcccaccg tgggcaccaa tgagatgggg
      961 gcttga
//
