LOCUS       NM_018270               2752 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens MRG domain binding protein (MRGBP), mRNA.
ACCESSION   NM_018270
VERSION     NM_018270.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2752)
  AUTHORS   Long,X., Hu,Y., Duan,S., Liu,X., Huang,W., Liu,X., Xu,Q., Song,W.
            and Zhou,J.
  TITLE     MRGBP promotes colorectal cancer metastasis via
            DKK1/Wnt/beta-catenin and NF-kB/p65 pathways mediated EMT
  JOURNAL   Exp Cell Res 421 (1), 113375 (2022)
   PUBMED   36208716
  REMARK    GeneRIF: MRGBP promotes colorectal cancer metastasis via
            DKK1/Wnt/beta-catenin and NF-kB/p65 pathways mediated EMT.
REFERENCE   2  (bases 1 to 2752)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2752)
  AUTHORS   Huang,J., Chen,X. and Zhu,W.
  TITLE     MRGBP is a potential novel prognostic biomarker and is correlated
            with immune infiltrates in hepatocellular carcinoma
  JOURNAL   Medicine (Baltimore) 100 (12), e25234 (2021)
   PUBMED   33761715
  REMARK    GeneRIF: MRGBP is a potential novel prognostic biomarker and is
            correlated with immune infiltrates in hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 2752)
  AUTHORS   Rivero,S., Rodriguez-Real,G., Marin,I. and Huertas,P.
  TITLE     MRGBP, a member of the NuA4 complex, inhibits DNA double-strand
            break repair
  JOURNAL   FEBS Open Bio 11 (3), 622-632 (2021)
   PUBMED   33354938
  REMARK    GeneRIF: MRGBP, a member of the NuA4 complex, inhibits DNA
            double-strand break repair.
REFERENCE   5  (bases 1 to 2752)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2752)
  AUTHORS   Jin,J., Cai,Y., Yao,T., Gottschalk,A.J., Florens,L., Swanson,S.K.,
            Gutierrez,J.L., Coleman,M.K., Workman,J.L., Mushegian,A.,
            Washburn,M.P., Conaway,R.C. and Conaway,J.W.
  TITLE     A mammalian chromatin remodeling complex with similarities to the
            yeast INO80 complex
  JOURNAL   J Biol Chem 280 (50), 41207-41212 (2005)
   PUBMED   16230350
REFERENCE   7  (bases 1 to 2752)
  AUTHORS   Cai,Y., Jin,J., Florens,L., Swanson,S.K., Kusch,T., Li,B.,
            Workman,J.L., Washburn,M.P., Conaway,R.C. and Conaway,J.W.
  TITLE     The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60
            histone acetyltransferase and SRCAP complexes
  JOURNAL   J Biol Chem 280 (14), 13665-13670 (2005)
   PUBMED   15647280
REFERENCE   8  (bases 1 to 2752)
  AUTHORS   Doyon,Y., Selleck,W., Lane,W.S., Tan,S. and Cote,J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
REFERENCE   9  (bases 1 to 2752)
  AUTHORS   Cai,Y., Jin,J., Tomomori-Sato,C., Sato,S., Sorokina,I.,
            Parmely,T.J., Conaway,R.C. and Conaway,J.W.
  TITLE     Identification of new subunits of the multiprotein mammalian
            TRRAP/TIP60-containing histone acetyltransferase complex
  JOURNAL   J Biol Chem 278 (44), 42733-42736 (2003)
   PUBMED   12963728
  REMARK    GeneRIF: MRGBP is encoded by the FLJ10914 ORF and is a new
            component of the TRRAP/TIP60 HAT complex
REFERENCE   10 (bases 1 to 2752)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK001776.1, BC014235.2, AL035669.43 and BQ445915.1.
            
            On Nov 23, 2018 this sequence version replaced NM_018270.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.19920.1,
                                           SRR1660803.199607.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370487.5/ ENSP00000359518.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-864               AK001776.1         21-884
            865-1616            BC014235.2         856-1607
            1617-2338           AL035669.43        49771-50492
            2339-2752           BQ445915.1         26-439              c
FEATURES             Location/Qualifiers
     source          1..2752
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..2752
                     /gene="MRGBP"
                     /gene_synonym="C20orf20; Eaf7; MRG15BP; URCC4"
                     /note="MRG domain binding protein"
                     /db_xref="GeneID:55257"
                     /db_xref="HGNC:HGNC:15866"
                     /db_xref="MIM:611157"
     exon            1..199
                     /gene="MRGBP"
                     /gene_synonym="C20orf20; Eaf7; MRG15BP; URCC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             52..666
                     /gene="MRGBP"
                     /gene_synonym="C20orf20; Eaf7; MRG15BP; URCC4"
                     /note="MRG-binding protein; up-regulated in colon cancer
                     4; MRG/MORF4L binding protein"
                     /codon_start=1
                     /product="MRG/MORF4L-binding protein"
                     /protein_id="NP_060740.1"
                     /db_xref="CCDS:CCDS13503.1"
                     /db_xref="GeneID:55257"
                     /db_xref="HGNC:HGNC:15866"
                     /db_xref="MIM:611157"
                     /translation="MGEAEVGGGGAAGDKGPGEAATSPAEETVVWSPEVEVCLFHAML
                     GHKPVGVNRHFHMICIRDKFSQNIGRQVPSKVIWDHLSTMYDMQALHESEILPFPNPE
                     RNFVLPEEIIQEVREGKVMIEEEMKEEMKEDVDPHNGADDVFSSSGSLGKASEKSSKD
                     KEKNSSDLGCKEGADKRKRSRVTDKVLTANSNPSSPSAAKRRRT"
     exon            200..321
                     /gene="MRGBP"
                     /gene_synonym="C20orf20; Eaf7; MRG15BP; URCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            322..403
                     /gene="MRGBP"
                     /gene_synonym="C20orf20; Eaf7; MRG15BP; URCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            404..478
                     /gene="MRGBP"
                     /gene_synonym="C20orf20; Eaf7; MRG15BP; URCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            479..2752
                     /gene="MRGBP"
                     /gene_synonym="C20orf20; Eaf7; MRG15BP; URCC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1595..1600
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRGBP"
                     /gene_synonym="C20orf20; Eaf7; MRG15BP; URCC4"
                     /note="hexamer: ATTAAA"
     polyA_site      1616
                     /gene="MRGBP"
                     /gene_synonym="C20orf20; Eaf7; MRG15BP; URCC4"
                     /note="major polyA site"
     regulatory      2732..2737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRGBP"
                     /gene_synonym="C20orf20; Eaf7; MRG15BP; URCC4"
                     /note="hexamer: AATAAA"
     polyA_site      2752
                     /gene="MRGBP"
                     /gene_synonym="C20orf20; Eaf7; MRG15BP; URCC4"
ORIGIN      
        1 gtggccgcgc ctgctcccgc cgggggctcc ttgctcggcc gggccgcggc catgggagag
       61 gccgaggtgg gcggcggggg cgccgcaggc gacaagggcc cgggggaggc ggccaccagc
      121 ccggcggagg agacagtggt gtggagcccc gaggtggagg tgtgcctctt ccacgccatg
      181 ctgggccaca agcccgtcgg tgtgaaccga cacttccaca tgatttgtat tcgggacaag
      241 ttcagccaga acatcgggcg gcaggtccca tccaaggtca tctgggacca tctgagcacc
      301 atgtacgaca tgcaggcgct gcatgagtct gagattcttc cattcccgaa tccagagagg
      361 aacttcgtcc ttccagaaga gatcattcag gaggtccgag aaggaaaagt gatgatagaa
      421 gaggagatga aagaggagat gaaggaagac gtggaccccc acaatggggc tgacgatgtt
      481 ttttcatctt cagggagttt ggggaaagca tcagaaaaat ccagcaaaga caaagagaag
      541 aactcctcag acttggggtg caaagaaggc gcagacaagc ggaagcgcag ccgggtcacc
      601 gacaaagtcc tgaccgcaaa cagcaaccct tccagtccca gtgctgccaa gcggcgccgc
      661 acgtagaccc tcagccctgg tggcggcaga gaagcgggcg aggcactgtg gtcgctgagg
      721 gggttggctg ggtctgagtg ccacccccca ggccacagtg ataccatccc agtgccatga
      781 gcccacactg cccgccctca ggctctcagg tgaacgtggc cgtcagcggg gaaacgtgtg
      841 tgtcagttgg accatgtggg accctgatgg acctgaaaga ccaggatcgg tccagctcag
      901 atattgaggg ctctgaagcc tagttctgtc ttctctggag cagctgtggc ttccccgtgg
      961 ctgcttggtg acatggatta gcgctacgtg ggctgcagca tttgggatcc aggctaccta
     1021 gaggggcatc gggccaggga aaacctcgga ttagcaagca ataaaaacat gacctcactc
     1081 ttcctcaaag gagcccctgg tcttccctgt gtgactcagt tctttccatc tgtttgtccc
     1141 gctgcaagcc tctttctgcg ctgactgtga cattggaacg tggccttcct gtcaccccct
     1201 ccgtgccacg cactgaaggc cacccccacc cacctgggaa actaagaact ggatattttg
     1261 cctcattcac ttgtactgta acaatgtata taatttggtt ggtatttcac tatttaattt
     1321 ttaagaagcc tattttacta gtgttttata tgaacaaagt actgcagaag ttaaacctgt
     1381 gttgtatttt ttctgagatg ttttgcttta agagatactt tttgctcagt ttttatatgc
     1441 cagatacaga gaatttgtag cggttatttt tgtatgatct agtaacttgc aaacagacca
     1501 aatggatgag aggcggggac cgtgcagctg tcggctgatg aggaggcggc cgccccagtg
     1561 ctgatggaga tgccactttc gtgtgactgc gaacattaaa gcacaaaaaa atccaacctg
     1621 gagttgtgtg attttgatac caaagtaagt tcacttttcc tccaaaagga agtttttatt
     1681 tttccaagat ttataactaa agcatacact tagatgactt attaacattc acttgataca
     1741 acatataaac aaaatagtaa cagattctga gtggttattt tgtggactgt gacaagcact
     1801 tcaaatacaa aatgttagga gggcaaaacg gtgcgggccc tcgtaggtca ggcaggcacc
     1861 agtgggctcc ttcctgctga aagctgcggc tgtgagatga gaccgctggc tgggtcacag
     1921 agtgaaatcc agcgttccgt gtgcggacga ggagacaagc tgtcctggcc agccatcgca
     1981 ccccaatgtc ttcagcttga cgttgcttct ctgccagtgg agcctcctcc accacctggg
     2041 aacatccctg gccatctgtc cctgaagtcc tcctcaccat gacgcagatc acaaggcacc
     2101 cactaaaggg gcaaagccag gaatcccgtg ccatgtgatc gccccgtgtg gcacctgcca
     2161 ctcgtctgca ccaaacgcac tgccagttct ggggaagaac agcccaggga agctgctggt
     2221 ctacggcctg cctgagctgt attccaaggg tagagcagct gcctgggggg accctgtggg
     2281 tcccttttct atagagccgg gacaaatcca cagccctgca gtaacagcct gccacaaaga
     2341 gcaggcatct ggagggcccc acacacatag accaaaggac tgagcccgcc tggcattcct
     2401 ccactcacag cacaaatact cagccctgca gccagggaag ggtggggtct ccctttgctg
     2461 cccaagtgtg cccccttgcc cgtctgatct ctcctgttag gtcagcctca ttcagggctt
     2521 tgtgccaggt cctgtcctgg agtctcagtc cgggacagca gcctggctct taggcagtcc
     2581 agaagcagca gggcaaaggg gggcaaatac taacacgggg tgtcacggga tggccaggag
     2641 gagtcctgct cgccacccag gctcactgtc ctaaacctcc atctgaaacc gcatctcggg
     2701 tgacctcaga ttgtgctagg aaagcctagt taataaatct gcctcatctc ga
//
