LOCUS       NM_203462               1578 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens Morf4 family associated protein 1 like 1 (MRFAP1L1),
            mRNA.
ACCESSION   NM_203462
VERSION     NM_203462.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1578)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1578)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1578)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1578)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1578)
  AUTHORS   Chen,S., Fragoza,R., Klei,L., Liu,Y., Wang,J., Roeder,K., Devlin,B.
            and Yu,H.
  TITLE     An interactome perturbation framework prioritizes damaging missense
            mutations for developmental disorders
  JOURNAL   Nat Genet 50 (7), 1032-1040 (2018)
   PUBMED   29892012
REFERENCE   6  (bases 1 to 1578)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1578)
  AUTHORS   Marcon,E., Ni,Z., Pu,S., Turinsky,A.L., Trimble,S.S., Olsen,J.B.,
            Silverman-Gavrila,R., Silverman-Gavrila,L., Phanse,S., Guo,H.,
            Zhong,G., Guo,X., Young,P., Bailey,S., Roudeva,D., Zhao,D.,
            Hewel,J., Li,J., Graslund,S., Paduch,M., Kossiakoff,A.A.,
            Lupien,M., Emili,A., Wodak,S.J. and Greenblatt,J.
  TITLE     Human-chromatin-related protein interactions identify a demethylase
            complex required for chromosome segregation
  JOURNAL   Cell Rep 8 (1), 297-310 (2014)
   PUBMED   24981860
REFERENCE   8  (bases 1 to 1578)
  AUTHORS   Suter,B., Fontaine,J.F., Yildirimman,R., Rasko,T., Schaefer,M.H.,
            Rasche,A., Porras,P., Vazquez-Alvarez,B.M., Russ,J., Rau,K.,
            Foulle,R., Zenkner,M., Saar,K., Herwig,R., Andrade-Navarro,M.A. and
            Wanker,E.E.
  TITLE     Development and application of a DNA microarray-based yeast
            two-hybrid system
  JOURNAL   Nucleic Acids Res 41 (3), 1496-1507 (2013)
   PUBMED   23275563
REFERENCE   9  (bases 1 to 1578)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   10 (bases 1 to 1578)
  AUTHORS   Bowman,B.R., Moure,C.M., Kirtane,B.M., Welschhans,R.L.,
            Tominaga,K., Pereira-Smith,O.M. and Quiocho,F.A.
  TITLE     Multipurpose MRG domain involved in cell senescence and
            proliferation exhibits structural homology to a DNA-interacting
            domain
  JOURNAL   Structure 14 (1), 151-158 (2006)
   PUBMED   16407074
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC066897.1, AC093323.3 and BC008087.1.
            
            On Nov 22, 2018 this sequence version replaced NM_203462.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.105831.1,
                                           SRR3476690.142915.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320848.7/ ENSP00000318154.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-332               BC066897.1         15-346
            333-635             AC093323.3         176154-176456       c
            636-1561            AC093323.3         174641-175566       c
            1562-1578           BC008087.1         1523-1539
FEATURES             Location/Qualifiers
     source          1..1578
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.1"
     gene            1..1578
                     /gene="MRFAP1L1"
                     /gene_synonym="PP784"
                     /note="Morf4 family associated protein 1 like 1"
                     /db_xref="GeneID:114932"
                     /db_xref="HGNC:HGNC:28796"
     exon            1..635
                     /gene="MRFAP1L1"
                     /gene_synonym="PP784"
                     /inference="alignment:Splign:2.1.0"
     CDS             237..620
                     /gene="MRFAP1L1"
                     /gene_synonym="PP784"
                     /codon_start=1
                     /product="MORF4 family-associated protein 1-like 1"
                     /protein_id="NP_982287.1"
                     /db_xref="CCDS:CCDS3392.1"
                     /db_xref="GeneID:114932"
                     /db_xref="HGNC:HGNC:28796"
                     /translation="MRPLDIDEVEAPEEVEVLEPEEDFEQFLLPVINEMREDIASLIR
                     EHGRAYLRTRSKLWEMDNMLIQIKTQVEASEESALNHVQHPSGEADERVSELCEKAEE
                     KAKEIAKMAEMLVELVWRIERSESS"
     exon            636..1578
                     /gene="MRFAP1L1"
                     /gene_synonym="PP784"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1513..1518
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRFAP1L1"
                     /gene_synonym="PP784"
                     /note="hexamer: AATAAA"
     polyA_site      1534
                     /gene="MRFAP1L1"
                     /gene_synonym="PP784"
     regulatory      1558..1563
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRFAP1L1"
                     /gene_synonym="PP784"
                     /note="hexamer: AATAAA"
     polyA_site      1578
                     /gene="MRFAP1L1"
                     /gene_synonym="PP784"
                     /note="major polyA site"
ORIGIN      
        1 gactccattt tgtaggccgc ttatttgtgt gcatccacgg cgattcttcc cgcagagttg
       61 tgaagcgaaa ggcttacaat taaaaggaag aaaaaaaaat aaagataatt cgggagtaca
      121 attgacaaag cgtgtgggtc gctcagcctc cagcagtaac tgctgatctc cagttcttgg
      181 agggttccgg tgagaagaac gcccctactg cggtactgag gaagcggcag gaggagatgc
      241 ggcccctgga catagacgag gtggaagcgc ctgaggaagt ggaggtgctg gagcccgagg
      301 aggatttcga gcagttcctg ctcccggtca tcaacgagat gcgcgaggac atcgcgtctc
      361 ttatacgcga gcacgggcgg gcgtacctgc ggaccaggag caagctgtgg gagatggaca
      421 atatgcttat ccagatcaaa acgcaggtgg aggcctcgga ggagagcgcc ctcaatcacg
      481 tgcagcaccc gagtggcgaa gccgacgaga gagtgtcgga gttgtgcgag aaggctgagg
      541 agaaagccaa ggagattgcg aagatggcag agatgctggt cgagctcgtc tggcgaatag
      601 agagaagcga gtcttcttga aggaggagat cggtggttca cagctgagga ctgtagtcaa
      661 ctggtaagga tgaactgaca ccttgaggaa actgaaacag cttgtcattt tctctgtttt
      721 gtttttgtat gttttttacc ccgatgtaac agtctccctt atggtcagtg attgatgacc
      781 tcgatatgga tttagattat caaatgtgtt tggttttgga aatataactt ttgtcaaaga
      841 aatactctca gaagagaaat ggggcttaat taagttgttt ttgtggtcac gtttattctt
      901 gttacttcgc tgtgtttttg aaatgttggg catggcctcg tattttgctg ttacctttgt
      961 gacctgattg ttttttggaa cacgtcaaga cgtgggatca gaatcttcca actttagagg
     1021 tgcaatggaa gacactacgc tacttggttg agcctggtga agaatgtatt aatgagactg
     1081 ctttgcataa aactgggaag aaagagaaga cagttggaga tggaagatgg ttttgtatat
     1141 attttggaac tttagttcct ctgtgagacg aaagaggaga gctatgtttt gtggcacatt
     1201 gtctgatata tattgtgtaa cctgtcaggt gagttgattt agacaacata gctgaccttt
     1261 tatgacaagg cagtttgaat agggactatt gtaataccct cacacattat aggggcatca
     1321 gagaatggca tggaagagac agtctacaga gagctttaag aggccggaga aaggaaaaga
     1381 cattatcagg gcctggaaag tctcttccag ttcatcaggg tagtagacct gtcagattgg
     1441 aggtcaaagt caaaagtata ataagtgtta atttgccttg aaaaacaaag acctaaaaag
     1501 ccttttttaa gaaataaatt ttttgttcac atgaccaaag cccctcctgt gtgtgttaat
     1561 aaaagaatca taaacaaa
//
