LOCUS       NM_005591               6841 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens MRE11 homolog, double strand break repair nuclease
            (MRE11), transcript variant 1, mRNA.
ACCESSION   NM_005591
VERSION     NM_005591.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6841)
  AUTHORS   Khayat,F., Alshmery,M., Pal,M., Oliver,A.W. and Bianchi,A.
  TITLE     Binding of the TRF2 iDDR motif to RAD50 highlights a convergent
            evolutionary strategy to inactivate MRN at telomeres
  JOURNAL   Nucleic Acids Res 52 (13), 7704-7719 (2024)
   PUBMED   38884214
  REMARK    GeneRIF: Binding of the TRF2 iDDR motif to RAD50 highlights a
            convergent evolutionary strategy to inactivate MRN at telomeres.
REFERENCE   2  (bases 1 to 6841)
  AUTHORS   Chen,H., Li,Y., Li,H., Chen,X., Fu,H., Mao,D., Chen,W., Lan,L.,
            Wang,C., Hu,K., Li,J., Zhu,C., Evans,I., Cheung,E., Lu,D., He,Y.,
            Behrens,A., Yin,D. and Zhang,C.
  TITLE     NBS1 lactylation is required for efficient DNA repair and
            chemotherapy resistance
  JOURNAL   Nature 631 (8021), 663-669 (2024)
   PUBMED   38961290
REFERENCE   3  (bases 1 to 6841)
  AUTHORS   Techer,H., Gopaul,D., Heuze,J., Bouzalmad,N., Leray,B., Vernet,A.,
            Mettling,C., Moreaux,J., Pasero,P. and Lin,Y.L.
  TITLE     MRE11 and TREX1 control senescence by coordinating replication
            stress and interferon signaling
  JOURNAL   Nat Commun 15 (1), 5423 (2024)
   PUBMED   38926338
  REMARK    GeneRIF: MRE11 and TREX1 control senescence by coordinating
            replication stress and interferon signaling.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6841)
  AUTHORS   Du,D., Yang,Y., Zhang,Y., Wang,G., Chen,L., Guan,X., Rasmussen,L.J.
            and Liu,D.
  TITLE     MRE11A: a novel negative regulator of human DNA mismatch repair
  JOURNAL   Cell Mol Biol Lett 29 (1), 37 (2024)
   PUBMED   38486171
  REMARK    GeneRIF: MRE11A: a novel negative regulator of human DNA mismatch
            repair.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6841)
  AUTHORS   Cho,M.G., Kumar,R.J., Lin,C.C., Boyer,J.A., Shahir,J.A.,
            Fagan-Solis,K., Simpson,D.A., Fan,C., Foster,C.E., Goddard,A.M.,
            Lerner,L.M., Ellington,S.W., Wang,Q., Wang,Y., Ho,A.Y., Liu,P.,
            Perou,C.M., Zhang,Q., McGinty,R.K., Purvis,J.E. and Gupta,G.P.
  TITLE     MRE11 liberates cGAS from nucleosome sequestration during
            tumorigenesis
  JOURNAL   Nature 625 (7995), 585-592 (2024)
   PUBMED   38200309
  REMARK    GeneRIF: MRE11 liberates cGAS from nucleosome sequestration during
            tumorigenesis.
REFERENCE   6  (bases 1 to 6841)
  AUTHORS   Trujillo,K.M., Yuan,S.S., Lee,E.Y. and Sung,P.
  TITLE     Nuclease activities in a complex of human recombination and DNA
            repair factors Rad50, Mre11, and p95
  JOURNAL   J Biol Chem 273 (34), 21447-21450 (1998)
   PUBMED   9705271
REFERENCE   7  (bases 1 to 6841)
  AUTHORS   Paull,T.T. and Gellert,M.
  TITLE     The 3' to 5' exonuclease activity of Mre 11 facilitates repair of
            DNA double-strand breaks
  JOURNAL   Mol Cell 1 (7), 969-979 (1998)
   PUBMED   9651580
REFERENCE   8  (bases 1 to 6841)
  AUTHORS   Carney,J.P., Maser,R.S., Olivares,H., Davis,E.M., Le Beau,M.,
            Yates,J.R. 3rd, Hays,L., Morgan,W.F. and Petrini,J.H.
  TITLE     The hMre11/hRad50 protein complex and Nijmegen breakage syndrome:
            linkage of double-strand break repair to the cellular DNA damage
            response
  JOURNAL   Cell 93 (3), 477-486 (1998)
   PUBMED   9590181
REFERENCE   9  (bases 1 to 6841)
  AUTHORS   Dolganov,G.M., Maser,R.S., Novikov,A., Tosto,L., Chong,S.,
            Bressan,D.A. and Petrini,J.H.
  TITLE     Human Rad50 is physically associated with human Mre11:
            identification of a conserved multiprotein complex implicated in
            recombinational DNA repair
  JOURNAL   Mol Cell Biol 16 (9), 4832-4841 (1996)
   PUBMED   8756642
REFERENCE   10 (bases 1 to 6841)
  AUTHORS   Petrini,J.H., Walsh,M.E., DiMare,C., Chen,X.N., Korenberg,J.R. and
            Weaver,D.T.
  TITLE     Isolation and characterization of the human MRE11 homologue
  JOURNAL   Genomics 29 (1), 80-86 (1995)
   PUBMED   8530104
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF022778.1 and AP000765.5.
            
            On Nov 21, 2019 this sequence version replaced NM_005591.3.
            
            Summary: This gene encodes a nuclear protein involved in homologous
            recombination, telomere length maintenance, and DNA double-strand
            break repair. By itself, the protein has 3' to 5' exonuclease
            activity and endonuclease activity. The protein forms a complex
            with the RAD50 homolog; this complex is required for nonhomologous
            joining of DNA ends and possesses increased single-stranded DNA
            endonuclease and 3' to 5' exonuclease activities. In conjunction
            with a DNA ligase, this protein promotes the joining of
            noncomplementary ends in vitro using short homologies near the ends
            of the DNA fragments. This gene has a pseudogene on chromosome 3.
            Alternative splicing of this gene results in two transcript
            variants encoding different isoforms. [provided by RefSeq, Jul
            2008].
            
            Sequence Note: The RefSeq transcript was derived from the reference
            genome assembly. The genomic coordinates were determined from
            alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF022778.1, SRR14038191.3495987.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000323929.8/ ENSP00000325863.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2526              AF022778.1         12-2537
            2527-6841           AP000765.5         64177-68491         c
FEATURES             Location/Qualifiers
     source          1..6841
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q21"
     gene            1..6841
                     /gene="MRE11"
                     /gene_synonym="ATLD; HNGS1; MRE11A; MRE11B"
                     /note="MRE11 homolog, double strand break repair nuclease"
                     /db_xref="GeneID:4361"
                     /db_xref="HGNC:HGNC:7230"
                     /db_xref="MIM:600814"
     exon            1..54
                     /gene="MRE11"
                     /gene_synonym="ATLD; HNGS1; MRE11A; MRE11B"
                     /inference="alignment:Splign:2.1.0"
     exon            55..179
                     /gene="MRE11"
                     /gene_synonym="ATLD; HNGS1; MRE11A; MRE11B"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..2286
                     /gene="MRE11"
                     /gene_synonym="ATLD; HNGS1; MRE11A; MRE11B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     meiotic recombination 11 homolog A; AT-like disease;
                     double-strand break repair protein MRE11A; DNA
                     recombination and repair protein; endo/exonuclease Mre11;
                     MRE11 homolog 1; MRE11 homolog A, double strand break
                     repair nuclease; meiotic recombination 11 homolog 1; MRE11
                     meiotic recombination 11 homolog A; MRE11 double strand
                     break repair nuclease A; MRE11 homolog, double strand
                     break repair nuclease A; MRE11 meiotic recombination
                     11-like protein A"
                     /codon_start=1
                     /product="double-strand break repair protein MRE11 isoform
                     1"
                     /protein_id="NP_005582.1"
                     /db_xref="CCDS:CCDS8299.1"
                     /db_xref="GeneID:4361"
                     /db_xref="HGNC:HGNC:7230"
                     /db_xref="MIM:600814"
                     /translation="MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEIL
                     RLAQENEVDFILLGGDLFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFG
                     FSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVE
                     KIDISPVLLQKGSTKIALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQ
                     NRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSP
                     GEAVKKHVGLLRIKGRKMNMHKIPLHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQS
                     FCLEKIEEMLENAERERLGNSHQPEKPLVRLRVDYSGGFEPFSVLRFSQKFVDRVANP
                     KDIIHFFRHREQKEKTGEEINFGKLITKPSEGTTLRVEDLVKQYFQTAEKNVQLSLLT
                     ERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRETR
                     QKNTNEEDDEVREAMTRARALRSQSEESASAFSADDLMSIDLAEQMANDSDDSISAAT
                     NKGRGRGRGRRGGRGQNSASRGGSQRGRADTGLETSTRSRNSKTAVSASRNMSIIDAF
                     KSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTSKTDQRWSSTSSSKIMSQSQVSK
                     GVDFESSEDDDDDPFMNTSSLRRNRR"
     exon            180..312
                     /gene="MRE11"
                     /gene_synonym="ATLD; HNGS1; MRE11A; MRE11B"
                     /inference="alignment:Splign:2.1.0"
     exon            313..473
                     /gene="MRE11"
                     /gene_synonym="ATLD; HNGS1; MRE11A; MRE11B"
                     /inference="alignment:Splign:2.1.0"
     exon            474..561
                     /gene="MRE11"
                     /gene_synonym="ATLD; HNGS1; MRE11A; MRE11B"
                     /inference="alignment:Splign:2.1.0"
     exon            562..703
                     /gene="MRE11"
                     /gene_synonym="ATLD; HNGS1; MRE11A; MRE11B"
                     /inference="alignment:Splign:2.1.0"
     exon            704..818
                     /gene="MRE11"
                     /gene_synonym="ATLD; HNGS1; MRE11A; MRE11B"
                     /inference="alignment:Splign:2.1.0"
     exon            819..1004
                     /gene="MRE11"
                     /gene_synonym="ATLD; HNGS1; MRE11A; MRE11B"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1176
                     /gene="MRE11"
                     /gene_synonym="ATLD; HNGS1; MRE11A; MRE11B"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1257
                     /gene="MRE11"
                     /gene_synonym="ATLD; HNGS1; MRE11A; MRE11B"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1384
                     /gene="MRE11"
                     /gene_synonym="ATLD; HNGS1; MRE11A; MRE11B"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1485
                     /gene="MRE11"
                     /gene_synonym="ATLD; HNGS1; MRE11A; MRE11B"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1659
                     /gene="MRE11"
                     /gene_synonym="ATLD; HNGS1; MRE11A; MRE11B"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1722
                     /gene="MRE11"
                     /gene_synonym="ATLD; HNGS1; MRE11A; MRE11B"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1942
                     /gene="MRE11"
                     /gene_synonym="ATLD; HNGS1; MRE11A; MRE11B"
                     /inference="alignment:Splign:2.1.0"
     exon            1943..2026
                     /gene="MRE11"
                     /gene_synonym="ATLD; HNGS1; MRE11A; MRE11B"
                     /inference="alignment:Splign:2.1.0"
     exon            2027..2085
                     /gene="MRE11"
                     /gene_synonym="ATLD; HNGS1; MRE11A; MRE11B"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2153
                     /gene="MRE11"
                     /gene_synonym="ATLD; HNGS1; MRE11A; MRE11B"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..2229
                     /gene="MRE11"
                     /gene_synonym="ATLD; HNGS1; MRE11A; MRE11B"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..6841
                     /gene="MRE11"
                     /gene_synonym="ATLD; HNGS1; MRE11A; MRE11B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6802..6807
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRE11"
                     /gene_synonym="ATLD; HNGS1; MRE11A; MRE11B"
                     /note="hexamer: AATAAA"
     polyA_site      6841
                     /gene="MRE11"
                     /gene_synonym="ATLD; HNGS1; MRE11A; MRE11B"
                     /note="major polyA site"
ORIGIN      
        1 ggacgccgtt ctctcccgcg gaattcaggt ttacggccct gcgggttctc agagaatttc
       61 tagaatttgg aatcgagtgc attttctgac atttgagtac agtacccagg ggttcttgga
      121 gaagaacctg gtcccagagg agcttgactg accataaaaa tgagtactgc agatgcactt
      181 gatgatgaaa acacatttaa aatattagtt gcaacagata ttcatcttgg atttatggag
      241 aaagatgcag tcagaggaaa tgatacgttt gtaacactcg atgaaatttt aagacttgcc
      301 caggaaaatg aagtggattt tattttgtta ggtggtgatc tttttcatga aaataagccc
      361 tcaaggaaaa cattacatac ctgcctcgag ttattaagaa aatattgtat gggtgatcgg
      421 cctgtccagt ttgaaattct cagtgatcag tcagtcaact ttggttttag taagtttcca
      481 tgggtgaact atcaagatgg caacctcaac atttcaattc cagtgtttag tattcatggc
      541 aatcatgacg atcccacagg ggcagatgca ctttgtgcct tggacatttt aagttgtgct
      601 ggatttgtaa atcactttgg acgttcaatg tctgtggaga agatagacat tagtccggtt
      661 ttgcttcaaa aaggaagcac aaagattgcg ctatatggtt taggatccat tccagatgaa
      721 aggctctatc gaatgtttgt caataaaaaa gtaacaatgt tgagaccaaa ggaagatgag
      781 aactcttggt ttaacttatt tgtgattcat cagaacagga gtaaacatgg aagtactaac
      841 ttcattccag aacaattttt ggatgacttc attgatcttg ttatctgggg ccatgaacat
      901 gagtgtaaaa tagctccaac caaaaatgaa caacagctgt tttatatctc acaacctgga
      961 agctcagtgg ttacttctct ttccccagga gaagctgtaa agaaacatgt tggtttgctg
     1021 cgtattaaag ggaggaagat gaatatgcat aaaattcctc ttcacacagt gcggcagttt
     1081 ttcatggagg atattgttct agctaatcat ccagacattt ttaacccaga taatcctaaa
     1141 gtaacccaag ccatacaaag cttctgtttg gagaagattg aagaaatgct tgaaaatgct
     1201 gaacgggaac gtctgggtaa ttctcaccag ccagagaagc ctcttgtacg actgcgagtg
     1261 gactatagtg gaggttttga acctttcagt gttcttcgct ttagccagaa atttgtggat
     1321 cgggtagcta atccaaaaga cattatccat tttttcaggc atagagaaca aaaggaaaaa
     1381 acaggagaag agatcaactt tgggaaactt atcacaaagc cttcagaagg aacaacttta
     1441 agggtagaag atcttgtaaa acagtacttt caaaccgcag agaagaatgt gcagctctca
     1501 ctgctaacag aaagagggat gggtgaagca gtacaagaat ttgtggacaa ggaggagaaa
     1561 gatgccattg aggaattagt gaaataccag ttggaaaaaa cacagcgatt tcttaaagaa
     1621 cgtcatattg atgccctcga agacaaaatc gatgaggagg tacgtcgttt cagagaaacc
     1681 agacaaaaaa atactaatga agaagatgat gaagtccgtg aggctatgac cagggccaga
     1741 gcactcagat ctcagtcaga ggagtctgct tctgccttta gtgctgatga ccttatgagt
     1801 atagatttag cagaacagat ggctaatgac tctgatgata gcatctcagc agcaaccaac
     1861 aaaggaagag gccgaggaag aggtcgaaga ggtggaagag ggcagaattc agcatcgaga
     1921 ggagggtctc aaagaggaag agcagacact ggtctggaga cttctacccg tagcaggaac
     1981 tcaaagactg ctgtgtcagc atctagaaat atgtctatta tagatgcctt taaatctaca
     2041 agacagcagc cttcccgaaa tgtcactact aagaattatt cagaggtgat tgaggtagat
     2101 gaatcagatg tggaagaaga catttttcct accacttcaa agacagatca aaggtggtcc
     2161 agcacatcat ccagcaaaat catgtcccag agtcaagtat cgaaaggggt tgattttgaa
     2221 tcaagtgagg atgatgatga tgatcctttt atgaacacta gttctttaag aagaaataga
     2281 agataatata tttaatggca ctgagaaaca tgcaagatac aggaaaaatg aaaatgttac
     2341 aagctaagag tttacagttt aagattttaa gtattgtttc ctgagcataa ctccataagt
     2401 aagaaatttc tagttcacag acatacaata gcattgattc accttgtttt tttaacctgg
     2461 ttgttgtagt aagagctttg tttcaatatc actcttgagt aaagattaaa ataaagctac
     2521 cattttacat ttctatttca taatgaaaaa ctatgtcagt attttaatat ggttacattt
     2581 agccaaagtt gagggaaaga gcttataaaa tttaacttct tcataatttt agtaatttcc
     2641 tagaggttct gggttttctg aaagtaaaac aatttatgcg aacctatgtc taaattcact
     2701 gtttgttact atgtatgttt ttttccaatg cttcttataa gactaaatga ttagaagtac
     2761 ctaatagttt gaacagatat gtttttattt aaaagagtag aataaccttt cagaattact
     2821 gagtttttta ttccagttgt agcaaagatt tcaaaagatt gtgttcccat taagtggtag
     2881 taatttcctt tattattctg tatccttaat ggtgttctct ctctctctct ctctctctct
     2941 ctctccctct cccccccgtt ccccactctt cctttctcct ttgctttttc ttctctttca
     3001 tacatatatg cgtgcctagt tctaggagga aacgggttaa aaattgtttt aaactacatc
     3061 ttgaaaatat tgaagaattt gttttaggta gagtggtcag ttgaacctta cagtaaagta
     3121 tagaaatata tttaatgtgg aatgtcaatg ccaggatttc tcattaacaa tattttatct
     3181 caactttggt tcctgtgata catttctgaa tgggcaattc cagaaatctt agtagcccat
     3241 gttaagcttc tattttttac ttgttttcgg ggagaaataa gaattagaca tcttcagatt
     3301 taagttaaat aatcccattc tttataatcc tctgtaaaaa gatccctgag attattcctt
     3361 cttctagttt tatgcgacag ctttacttta aaattcaagt tatacatctt gggagtacaa
     3421 tggcccgaca tttcttcata ggtagaaaca aatacttgac tcagtgatac tcatgaccat
     3481 tagaatagtc atacctggaa tgtgtcaaat tataagagac agacacttgg ttagtggctg
     3541 cctcatatag cacttttgaa gaggcctaag tcaaaacttg caatataaca ttctattgac
     3601 tttcttaaaa atattttttc tgtacctaac ttgagcataa gggttatttg agcaagtaac
     3661 attaactcag tggaaggcat tgtcctgtga aatattctta ggcagatctg cccacatctt
     3721 tattgaactt gaaatctaat atttctagta tttgaacaaa gcagaaggtt aagtcaggga
     3781 agagcagtgc tgtccatgat gtaatggaag ctaccagggg aggcagtgtc tggatgatgc
     3841 tgtgctacct acccctgcac aagccatgct ggctcagtct gagctgtggg ccacatcagc
     3901 tagtggctct tctcatgcat cagttaggtg ggtctgggtg agagttatag tgagggaatg
     3961 gtcactaaag tatcctgaca agttcctagg aaaaaaggaa taaagttttt ttccttaaaa
     4021 aaaaaaaaat tgctcttggc tgtgaaaaga ggtactaaat gcgattcagt tcaccgctaa
     4081 ggaaagtgat gacatagcag ttacagaggg tgataaatct ctccagctaa ttcaggtcat
     4141 tttgtgaata ctatgtatca agccctgaaa atatggtaaa taaaacgtga cagggaaacc
     4201 tttttttgat tgaatattgt tacatagtta aatgtgctat atatccttaa tattttatat
     4261 tgatcctgca aaatctgttg gttttagggg agttttgttt tttgtttcta acaattttca
     4321 gacctgttgg tataggaatg tagaagtctt tcagatgatt tgaaagcagc tgcatttgct
     4381 cttggaggct ttgggagagc aggaatgaaa acattcagag gaagacatct gtagggaatt
     4441 cttctgttac ttaccaaaga ataagtgtct ttctggtgtt ttatttccta tcataaaaat
     4501 acaacagtgc atttacaagg ttaaagattc ctcgaagttc taggaaattc ttgaaaatat
     4561 aagtggtgct tagaaaattc aagcatttag gaatgtgacc tttaattcag gtatgtaaaa
     4621 gacttttttc ccaaactttt aaaagtagga aatacaataa atacagaaaa gtcatatggt
     4681 tgaataaata attataaatt gagcactgat ggaatccctc tacaggtcaa gaaatagcgc
     4741 agtgtcctgg atgcccatta tattgttttc tcctttctgg gtaacaagcc ctaacttctg
     4801 taatttaaaa gctcctactt ttgccacaag gtggtgcttc tgccattaga cgcagttagg
     4861 aggatgcaac tgcaaatcta aaattacgaa gttagtgtag ttgcaataaa cttagaacat
     4921 atgcattaat actaaaccta tgcagtaata ccataattag ccttctaatc atgtaatttg
     4981 ctttacttag gtatttcatt tggttcagcc tgttatggaa tttaccagct tgataaattt
     5041 gcctataaag ttttataaag aaaaggaata ttttgttttc ataaagagga aaatccattc
     5101 ttagaaaaaa actgagtaaa aaagtatctc aatgggctgg gtgcagtggc tcatgccttt
     5161 aatcccagca ctttgggagg ccgaggaggg ggttcacctg aggtcaggag tttgagacca
     5221 gcctggccaa catggtgaaa cctcgtctct actaaaaata caaaagatta gctgggcatg
     5281 gtggtgtgtg cctgtaatct tagctactca ggaggctgag gcaggagaat cgcttgaacc
     5341 caggaggcag aggttgcagt gagccgagat tgtgccattg cactgcagcc tgggcaacaa
     5401 gagtgaaact caatctcaaa aaaaaaaaaa gtatctaaat gtaaaatatc ttttttggaa
     5461 atatagaatt taaaagcgac tttcccccaa agaaatctga tgtccttttt gtatctgtca
     5521 taaatttaat tcatagtatt ttgggttttt tttgtttttt ttttttgaga cggagtctcg
     5581 cactcttgcc caggctggag ggcaggggca ccatttcggc tcactgcaag ctccacgcca
     5641 ttctcctgcc tcagcctccc aagtagctgg gactacaggc gcccaccacc acgcctggct
     5701 aatttttttt tttttttttt tgtattttta gtagagacag ggtttttctg tgttagccag
     5761 gatggtctcg atctcctgac cttgtgatcc acccacctca gcctcccaaa gtgctgggat
     5821 tacaggcctg agccaccacg cccagcctat tttgtgtttt tttaaagcta actaccatta
     5881 agatcattat agaagtttgg tataatgaag atttgggttt ttcagtccaa tgagtttcca
     5941 tattcttgaa tgaaaaagat ccacatttca tcatttgcct gtttcatttt cttttagtac
     6001 ttttgaactt agtttggtca gaaaatacta gaattttagt ttgatctaaa gaaccagctt
     6061 atataacttg ctgttgccat gtacatttgt atgtctttgc tgtgtcaaat aactggatct
     6121 gattttagct ctttttaagt ggtgaaagca atgcattttt attcttcaaa ttcagacatt
     6181 gaatgtgtat taaaatgtgt gtgcttacct ttaatcctct ccccaccgac aattaggaac
     6241 acgtttctcc aattactgtt ggcaagacta ccaagaaaaa ttgttgaatt agaatcccag
     6301 caccgggcac ggtggctcac gcctgtgatc ctagcacttt gggaggccaa agcaggcgga
     6361 tcacctgagg tcaggagttc gagaccagca gggccaacat ggcgaaaccc cgactctact
     6421 aaaaatacaa aaattagcca ggcatggtgg tgggcgcctg taatcccaac tactcaggag
     6481 gctgaggcag gagaattgct tgaacctggg agttggaggt cacggtgagc tgatatcacg
     6541 ccattgcact ccagcctggg caacagagca agactctgtc tcaatcaatc tatccatcaa
     6601 tcgataagaa ccccagattg tatagctaca tgttttagcc cccttttcaa agtatatgtt
     6661 ctccttggta cttattttga cattctgact tttctacata tgctttatca acctcttaat
     6721 taaaccatca ttgtctattt tgagagataa ctgcgctgct tcccgttgtg tgttttaaat
     6781 gttattgttc agtttgagtc aaataaaagg atatttaatc tgtggtgcct tgacattaaa
     6841 a
//
