LOCUS       NM_006039               5719 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens mannose receptor C-type 2 (MRC2), mRNA.
ACCESSION   NM_006039
VERSION     NM_006039.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5719)
  AUTHORS   Cakilkaya,P., Sorensen,R.R., Jurgensen,H.J., Krigslund,O.,
            Gardsvoll,H., Nielsen,C.F., Santoni-Rugiu,E., Behrendt,N. and
            Engelholm,L.H.
  TITLE     The Collagen Receptor uPARAP in Malignant Mesothelioma: A Potential
            Diagnostic Marker and Therapeutic Target
  JOURNAL   Int J Mol Sci 22 (21), 11452 (2021)
   PUBMED   34768883
  REMARK    GeneRIF: The Collagen Receptor uPARAP in Malignant Mesothelioma: A
            Potential Diagnostic Marker and Therapeutic Target.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5719)
  AUTHORS   Li,L., Chen,X., Zhang,H., Wang,M. and Lu,W.
  TITLE     MRC2 Promotes Proliferation and Inhibits Apoptosis of Diabetic
            Nephropathy
  JOURNAL   Anal Cell Pathol (Amst) 2021, 6619870 (2021)
   PUBMED   34012764
  REMARK    GeneRIF: MRC2 Promotes Proliferation and Inhibits Apoptosis of
            Diabetic Nephropathy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5719)
  AUTHORS   Ji,B., Chen,J., Zhen,C., Yang,Q. and Yu,N.
  TITLE     Mathematical modelling of the role of Endo180 network in the
            development of metastatic bone disease in prostate cancer
  JOURNAL   Comput Biol Med 117, 103619 (2020)
   PUBMED   32072971
  REMARK    GeneRIF: Mathematical modelling of the role of Endo180 network in
            the development of metastatic bone disease in prostate cancer.
REFERENCE   4  (bases 1 to 5719)
  AUTHORS   Iwahashi,H., Kawashima,Y. and Masaki,H.
  TITLE     Interleukin-1 alpha derived from ultraviolet B-exposed
            keratinocytes is associated with a decrease of endocytic collagen
            receptor Endo180
  JOURNAL   Photodermatol Photoimmunol Photomed 36 (1), 34-41 (2020)
   PUBMED   31376337
  REMARK    GeneRIF: These results indicate that a substance secreted from
            UVB-exposed keratinocytes regulates Endo180 expression and that
            IL-1alpha may play an important role in the maintenance of Endo180.
REFERENCE   5  (bases 1 to 5719)
  AUTHORS   Caldwell,R.L., Egan,B.S. and Shepherd,V.L.
  TITLE     HIV-1 Tat represses transcription from the mannose receptor
            promoter
  JOURNAL   J Immunol 165 (12), 7035-7041 (2000)
   PUBMED   11120831
REFERENCE   6  (bases 1 to 5719)
  AUTHORS   Sheikh,H., Yarwood,H., Ashworth,A. and Isacke,C.M.
  TITLE     Endo180, an endocytic recycling glycoprotein related to the
            macrophage mannose receptor is expressed on fibroblasts,
            endothelial cells and macrophages and functions as a lectin
            receptor
  JOURNAL   J Cell Sci 113 (Pt 6), 1021-1032 (2000)
   PUBMED   10683150
REFERENCE   7  (bases 1 to 5719)
  AUTHORS   Behrendt,N., Jensen,O.N., Engelholm,L.H., Mortz,E., Mann,M. and
            Dano,K.
  TITLE     A urokinase receptor-associated protein with specific collagen
            binding properties
  JOURNAL   J Biol Chem 275 (3), 1993-2002 (2000)
   PUBMED   10636902
REFERENCE   8  (bases 1 to 5719)
  AUTHORS   Tajima,Y., Tashiro,K. and Camerini,D.
  TITLE     Cloning of human chromosome 17-specific cDNAs using
            representational difference analysis and human-mouse hybrid cells
  JOURNAL   Genomics 42 (2), 353-355 (1997)
   PUBMED   9192860
REFERENCE   9  (bases 1 to 5719)
  AUTHORS   Wu,K., Yuan,J. and Lasky,L.A.
  TITLE     Characterization of a novel member of the macrophage mannose
            receptor type C lectin family
  JOURNAL   J Biol Chem 271 (35), 21323-21330 (1996)
   PUBMED   8702911
REFERENCE   10 (bases 1 to 5719)
  AUTHORS   Behrendt,N., Ronne,E. and Dano,K.
  TITLE     A novel, specific pro-urokinase complex on monocyte-like cells,
            detected by transglutaminase-catalyzed cross-linking
  JOURNAL   FEBS Lett 336 (3), 394-396 (1993)
   PUBMED   7904248
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC153884.1, BC146647.1,
            BC032763.1 and AI458446.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006039.4.
            
            Summary: This gene encodes a member of the mannose receptor family
            of proteins that contain a fibronectin type II domain and multiple
            C-type lectin-like domains. The encoded protein plays a role in
            extracellular matrix remodeling by mediating the internalization
            and lysosomal degradation of collagen ligands. Expression of this
            gene may play a role in the tumorigenesis and metastasis of several
            malignancies including breast cancer, gliomas and metastatic bone
            disease. [provided by RefSeq, Feb 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC150212.1, BC146647.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303375.10/ ENSP00000307513.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BC153884.1         270-281
            13-2718             BC146647.1         1-2706
            2719-5667           BC032763.1         293-3241
            5668-5719           AI458446.1         17-68               c
FEATURES             Location/Qualifiers
     source          1..5719
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.2"
     gene            1..5719
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /note="mannose receptor C-type 2"
                     /db_xref="GeneID:9902"
                     /db_xref="HGNC:HGNC:16875"
                     /db_xref="MIM:612264"
     exon            1..251
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..4573
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /note="endocytic receptor (macrophage mannose receptor
                     family); endocytic receptor 180; UPAR-associated protein;
                     macrophage mannose receptor 2; C-type lectin domain family
                     13 member E; urokinase-type plasminogen activator
                     receptor-associated protein"
                     /codon_start=1
                     /product="C-type mannose receptor 2 precursor"
                     /protein_id="NP_006030.2"
                     /db_xref="CCDS:CCDS11634.1"
                     /db_xref="GeneID:9902"
                     /db_xref="HGNC:HGNC:16875"
                     /db_xref="MIM:612264"
                     /translation="MGPGRPAPAPWPRHLLRCVLLLGCLHLGRPGAPGDAALPEPNVF
                     LIFSHGLQGCLEAQGGQVRVTPACNTSLPAQRWKWVSRNRLFNLGTMQCLGTGWPGTN
                     TTASLGMYECDREALNLRWHCRTLGDQLSLLLGARTSNISKPGTLERGDQTRSGQWRI
                     YGSEEDLCALPYHEVYTIQGNSHGKPCTIPFKYDNQWFHGCTSTGREDGHLWCATTQD
                     YGKDERWGFCPIKSNDCETFWDKDQLTDSCYQFNFQSTLSWREAWASCEQQGADLLSI
                     TEIHEQTYINGLLTGYSSTLWIGLNDLDTSGGWQWSDNSPLKYLNWESDQPDNPSEEN
                     CGVIRTESSGGWQNRDCSIALPYVCKKKPNATAEPTPPDRWANVKVECEPSWQPFQGH
                     CYRLQAEKRSWQESKKACLRGGGDLVSIHSMAELEFITKQIKQEVEELWIGLNDLKLQ
                     MNFEWSDGSLVSFTHWHPFEPNNFRDSLEDCVTIWGPEGRWNDSPCNQSLPSICKKAG
                     QLSQGAAEEDHGCRKGWTWHSPSCYWLGEDQVTYSEARRLCTDHGSQLVTITNRFEQA
                     FVSSLIYNWEGEYFWTALQDLNSTGSFFWLSGDEVMYTHWNRDQPGYSRGGCVALATG
                     SAMGLWEVKNCTSFRARYICRQSLGTPVTPELPGPDPTPSLTGSCPQGWASDTKLRYC
                     YKVFSSERLQDKKSWVQAQGACQELGAQLLSLASYEEEHFVANMLNKIFGESEPEIHE
                     QHWFWIGLNRRDPRGGQSWRWSDGVGFSYHNFDRSRHDDDDIRGCAVLDLASLQWVAM
                     QCDTQLDWICKIPRGTDVREPDDSPQGRREWLRFQEAEYKFFEHHSTWAQAQRICTWF
                     QAELTSVHSQAELDFLSHNLQKFSRAQEQHWWIGLHTSESDGRFRWTDGSIINFISWA
                     PGKPRPVGKDKKCVYMTASREDWGDQRCLTALPYICKRSNVTKETQPPDLPTTALGGC
                     PSDWIQFLNKCFQVQGQEPQSRVKWSEAQFSCEQQEAQLVTITNPLEQAFITASLPNV
                     TFDLWIGLHASQRDFQWVEQEPLMYANWAPGEPSGPSPAPSGNKPTSCAVVLHSPSAH
                     FTGRWDDRSCTEETHGFICQKGTDPSLSPSPAALPPAPGTELSYLNGTFRLLQKPLRW
                     HDALLLCESRNASLAYVPDPYTQAFLTQAARGLRTPLWIGLAGEEGSRRYSWVSEEPL
                     NYVGWQDGEPQQPGGCTYVDVDGAWRTTSCDTKLQGAVCGVSSGPPPPRRISYHGSCP
                     QGLADSAWIPFREHCYSFHMELLLGHKEARQRCQRAGGAVLSILDEMENVFVWEHLQS
                     YEGQSRGAWLGMNFNPKGGTLVWQDNTAVNYSNWGPPGLGPSMLSHNSCYWIQSNSGL
                     WRPGACTNITMGVVCKLPRAEQSSFSPSALPENPAALVVVLMAVLLLLALLTAALILY
                     RRRQSIERGAFEGARYSRSSSSPTEATEKNILVSDMEMNEQQE"
     exon            252..653
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            654..827
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            828..992
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1106
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1250
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1251..1439
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1594
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1702
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1703..1818
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..1967
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2185
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2186..2328
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2431
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..2570
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2606
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2607..2767
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2768..2835
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2836..2936
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..3079
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3080..3194
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3195..3358
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3359..3467
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3468..3706
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3707..3875
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            3876..4025
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4026..4145
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4146..4325
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4326..4352
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     exon            4353..5719
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5688..5693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /note="hexamer: AATAAA"
     polyA_site      5719
                     /gene="MRC2"
                     /gene_synonym="CD280; CLEC13E; ENDO180; UPARAP"
                     /note="major polyA site"
ORIGIN      
        1 atcacttcgt cccgacccgg aggaggacgc gagccccttg cgggcggtca tcacagccca
       61 gcctcggggc tgccacagcg cgttgcgcct gtgcgccctc ggtccccgcg tccactgagc
      121 gccgcgctcg gggatggggc ccggccggcc ggcccccgcg ccctggcctc gtcacctgct
      181 gcgctgcgtc ctgctcctcg ggtgcctgca cctcggccgt cccggcgccc ctggggacgc
      241 cgccctcccg gaacccaacg tcttcctcat cttcagccat ggactgcagg gctgcctgga
      301 ggcccagggc gggcaggtca gagtcacccc ggcttgcaat accagcctcc ctgcccagcg
      361 ctggaagtgg gtctcccgaa accggctatt caacctgggt accatgcagt gcctgggcac
      421 aggctggcca ggcaccaaca ccacggcctc cctgggcatg tatgagtgtg accgggaagc
      481 actgaatctt cgctggcatt gtcgtacact gggtgaccag ctgtccttgc tcctgggggc
      541 ccgcaccagc aacatatcca agcctggcac ccttgagcgt ggtgaccaga cccgcagtgg
      601 ccagtggcgc atctacggca gcgaggagga cctatgtgct ctgccctacc acgaggtcta
      661 caccatccag ggaaactccc acggaaagcc gtgcaccatc cccttcaaat atgacaacca
      721 gtggttccac ggctgcacca gcacgggccg cgaggatggt cacctgtggt gtgccaccac
      781 ccaggactac ggcaaagacg agcgctgggg cttctgcccc atcaagagta acgactgcga
      841 gaccttctgg gacaaggacc agctgactga cagctgctac cagtttaact tccagtccac
      901 gctgtcgtgg agggaggcct gggccagctg cgagcagcag ggtgcggatc tgctgagcat
      961 cacggagatc cacgagcaga cctacatcaa cggcctcctc actgggtaca gctccaccct
     1021 gtggatcggc ttgaatgact tggacacgag cggaggctgg cagtggtcgg acaactcgcc
     1081 cctcaagtac ctcaactggg agagtgacca gccggacaac cccagtgagg agaactgtgg
     1141 agtgatccgc actgagtcct cgggcggctg gcagaaccgt gactgcagca tcgcgctgcc
     1201 ctatgtgtgc aagaagaagc ccaacgccac ggccgagccc acccctccag acaggtgggc
     1261 caatgtgaag gtggagtgcg agccgagctg gcagcccttc cagggccact gctaccgcct
     1321 gcaggccgag aagcgcagct ggcaggagtc caagaaggca tgtctacggg gcggtggcga
     1381 cctggtcagc atccacagca tggcggagct ggaattcatc accaagcaga tcaagcaaga
     1441 ggtggaggag ctgtggatcg gcctcaacga tttgaaactg cagatgaatt ttgagtggtc
     1501 tgacgggagc cttgtgagct tcacccactg gcaccccttt gagcccaaca acttccggga
     1561 cagtctggag gactgtgtca ccatctgggg cccggaaggc cgctggaacg acagtccctg
     1621 taaccagtcc ttgccatcca tctgcaagaa ggcaggccag ctgagccagg gggccgccga
     1681 ggaggaccat ggctgccgga agggttggac gtggcacagc ccatcctgct actggctggg
     1741 agaagaccaa gtgacctaca gtgaggcccg gcgcctgtgc actgaccatg gctctcagct
     1801 ggtcaccatc accaacaggt tcgagcaggc cttcgtcagc agcctcatct acaactggga
     1861 gggcgagtac ttctggacgg ccctgcagga cctcaacagc accggctcct tcttctggct
     1921 cagtggggat gaagtcatgt acacccactg gaaccgggac cagcccgggt acagccgtgg
     1981 gggctgcgtg gcgctggcca ctggcagcgc catggggctg tgggaggtga agaactgtac
     2041 ctcgttccgg gcccgctaca tctgccggca gagcctgggc actccagtga cgccggagct
     2101 gccggggcca gatcccacgc ccagcctcac tggctcctgt ccccagggct gggcctcgga
     2161 caccaaactc cggtattgct ataaggtgtt cagctcagag cggctgcagg acaagaagag
     2221 ctgggtccag gcccaggggg cctgccagga gctgggggcc cagctgctga gcctggccag
     2281 ctacgaggag gagcactttg tggccaacat gctcaacaag atcttcggtg aatcagaacc
     2341 cgagatccac gagcagcact ggttctggat cggcctgaac cgtcgggatc ccagaggggg
     2401 tcagagttgg cgctggagcg acggcgtagg gttctcttac cacaatttcg accggagccg
     2461 gcacgacgac gacgacatcc gaggctgtgc ggtgctggac ctggcctccc tgcagtgggt
     2521 ggccatgcag tgcgacacac agctggactg gatctgcaag atccccagag gtacggacgt
     2581 gcgggagccc gacgacagcc ctcaaggccg acgggaatgg ctgcgcttcc aggaggccga
     2641 gtacaagttc tttgagcacc actccacgtg ggcgcaggcg cagcgcatct gcacgtggtt
     2701 ccaggccgag ctgacctcgg tgcacagcca ggcggagcta gacttcctga gccacaactt
     2761 gcagaagttc tcccgggccc aggagcagca ctggtggatc ggcctgcaca cctctgagag
     2821 cgatgggcgc ttcagatgga cagatggttc cattataaac ttcatctcct gggcaccagg
     2881 caaacctcgg cctgtcggca aggacaagaa gtgcgtgtac atgacagcca gccgagagga
     2941 ctggggggac cagaggtgcc tgacagcctt gccctacatc tgcaagcgca gcaacgtcac
     3001 caaagaaacg cagcccccag acctgccaac tacagccctg gggggctgcc cctctgactg
     3061 gatccagttc ctcaacaagt gttttcaggt ccagggccag gaaccccaga gccgggtgaa
     3121 gtggtcagag gcacagttct cctgtgaaca gcaagaggcc cagctggtca ccatcacaaa
     3181 ccccttagag caagcattca tcacagccag cctgcccaat gtgacctttg acctttggat
     3241 tggcctccat gcctcgcaga gggacttcca gtgggtggag caggagcctt tgatgtatgc
     3301 caactgggca cctggggagc cctctggccc tagccctgct cccagtggca acaaaccgac
     3361 cagctgtgca gtggtcctgc acagcccctc agcccacttc actggccgct gggacgatcg
     3421 gagctgcacg gaggagaccc atggcttcat ctgccagaag ggcacggacc cctccctgag
     3481 cccgtcccca gcagcgctgc cccccgcccc gggcactgag ctctcctacc tcaacggcac
     3541 cttccggctg cttcagaagc cgctgcgctg gcacgatgcc ctcctgctgt gtgagagccg
     3601 caatgccagc ctggcctacg tgcccgaccc ctacacccag gccttcctca cgcaggctgc
     3661 ccgagggctg cgcacgccgc tctggattgg gctggctggc gaggagggct ctcggcggta
     3721 ctcctgggtc tcagaggagc cgctgaacta cgtgggctgg caggacgggg agccgcagca
     3781 gccggggggc tgtacctacg tagatgtgga cggggcctgg cgcaccacca gctgtgacac
     3841 caagctgcag ggggctgtgt gtggggttag cagtgggccc cctcctcccc gaagaataag
     3901 ctaccatggc agctgtcccc agggactggc agactccgcg tggattccct tccgggagca
     3961 ctgctattct ttccacatgg agctgctgct gggccacaag gaggcgcgac agcgctgcca
     4021 gagagcgggt ggggccgtcc tgtctatcct ggatgagatg gagaatgtgt ttgtctggga
     4081 gcacctgcag agctatgagg gccagagtcg gggcgcctgg ctgggcatga acttcaaccc
     4141 caaaggaggc actctggtct ggcaggacaa cacagctgtg aactactcca actgggggcc
     4201 cccgggcttg ggccccagca tgctgagcca caacagctgc tactggattc agagcaacag
     4261 cgggctatgg cgccccggcg cttgcaccaa catcaccatg ggtgtcgtct gcaagcttcc
     4321 tcgtgctgag cagagcagct tctccccatc agcgcttcca gagaacccag cggccctggt
     4381 ggtggtgctg atggcggtgc tgctgctcct ggccttgctg accgcagccc tcatccttta
     4441 ccggaggcgc cagagcatcg agcgcggggc ctttgagggt gcccgctaca gccgcagcag
     4501 ctccagcccc accgaggcca ctgagaagaa catcctggtg tcagacatgg aaatgaatga
     4561 gcaacaagaa tagagccagg cgcgtgggca gggccagggc gggaggagct ggggagctgg
     4621 ggccctgggt cagtctggcc ccccaccagc tgcctgtcca gttggcctat ggaagggtgc
     4681 ccttgggagt cgctgttggg agccggagct gggcagagcc tgggctggtg gggtgccacc
     4741 ctcccacaag ggctgggctg agacccagct gagtgcagcg tggcgtttcc ctttctgggg
     4801 gggcctgagg tcttgtcacc tggtcctgtg cccccacagg aaccagaggt aggatgggag
     4861 ggggaacgag agcctctttc tccccagagc ccccggccca ggcctgttga tccgcgcccc
     4921 aggaccccct tctttgcaga gcccgaggag cctcccctgt cccctcgggc agatctgttg
     4981 tgtctctctt cccacctggc agcctcagct ctgtgcccct caccctgctc cctctcgccc
     5041 cttctctccc accccttcct tctgagccgg gccctgggga ttggggagcc ctcttgttcc
     5101 tgatgagggt cagctgaggg ggctgagcat ccatcactcc tgtgcctgct ggggtggctg
     5161 tggggcgtgg caggaggggc ctaggtgggt tgggcctgag aaccagggca cgggtgtggt
     5221 gtctgctggg ctggagataa gactggggag agacacccca acctcccagg gtgggagctg
     5281 ggccgggctg ggatgtcatc tcctgccggg cgggggaggg ctctgcccct ggaagagtcc
     5341 cctgtgggga ccaaaataag ttccctaaca tctccagctc ctggctctgg tttggagcaa
     5401 ggggaagggt tgccagagtc ctgggggccc cagaggagca ggagtctggg agggcccaga
     5461 gttcaccctc tagtggatcc aggaggagca gcacccgagc cctggagtgg cccagtaccc
     5521 ttccaagagg ccacagtccc agccaggaca aagtatgcgg cccatcctgg tgcgacagcg
     5581 tgggacaatg tgaacatgga ctcgaagaca tggccctttc tctgtagttg attttttaaa
     5641 tgtgccatta ttgtttttaa aaaaaaagga aaaaagaaaa gcaaacaaat aaaacacctt
     5701 taagaggctt gaaagagaa
//
