LOCUS       NM_002438               5188 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens mannose receptor C-type 1 (MRC1), mRNA.
ACCESSION   NM_002438 XM_003959927 XM_003959928
VERSION     NM_002438.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5188)
  AUTHORS   Saadh,M.J., Pallathadka,H., Abed,H.S., Menon,S.V., Sivaprasad,G.V.,
            Hjazi,A., Rizaev,J., Suri,S., Jawad,M.A. and Husseen,B.
  TITLE     Detailed role of SR-A1 and SR-E3 in tumor biology, progression, and
            therapy
  JOURNAL   Cell Biochem Biophys 82 (3), 1735-1750 (2024)
   PUBMED   38884861
  REMARK    GeneRIF: Detailed role of SR-A1 and SR-E3 in tumor biology,
            progression, and therapy.
            Review article
REFERENCE   2  (bases 1 to 5188)
  AUTHORS   Mallorson,R., Miyagi,E., Kao,S., Sukegawa,S., Saito,H.,
            Fabryova,H., Morellatto Ruggieri,L., Mediouni,S., Valente,S.T. and
            Strebel,K.
  TITLE     Transcriptional regulation of the HIV-1 inhibitory factor human
            mannose receptor 1 by the myeloid-specific transcription factor
            PU.1
  JOURNAL   J Virol 98 (1), e0170223 (2024)
   PUBMED   38078733
  REMARK    GeneRIF: Transcriptional regulation of the HIV-1 inhibitory factor
            human mannose receptor 1 by the myeloid-specific transcription
            factor PU.1.
REFERENCE   3  (bases 1 to 5188)
  AUTHORS   Li,Y., Liu,X., Tian,M., Zou,R., Gao,Y., Huang,M., Zhou,K., Cao,M.
            and Cai,H.
  TITLE     Soluble CD206 levels correlate with disease deterioration and
            predict prognosis of anti-MDA5 antibody-positive dermatomyositis
            related interstitial lung disease
  JOURNAL   Clin Respir J 17 (6), 507-515 (2023)
   PUBMED   37041007
  REMARK    GeneRIF: Soluble CD206 levels correlate with disease deterioration
            and predict prognosis of anti-MDA5 antibody-positive
            dermatomyositis related interstitial lung disease.
REFERENCE   4  (bases 1 to 5188)
  AUTHORS   Aendekerk,J.P., Jiemy,W.F., Raveling-Eelsing,E., Bijnens,N.,
            Abdul-Hamid,M.A., Strating,I.M., Dekkema,G.J., Sanders,J.F.,
            Stegeman,C.A., Damoiseaux,J.G.M.C., Little,M.A., Heeringa,P. and
            van Paassen,P.
  TITLE     CD163 and CD206 expression define distinct macrophage subsets
            involved in active ANCA-associated glomerulonephritis
  JOURNAL   J Autoimmun 133, 102914 (2022)
   PUBMED   36183584
  REMARK    GeneRIF: CD163 and CD206 expression define distinct macrophage
            subsets involved in active ANCA-associated glomerulonephritis.
REFERENCE   5  (bases 1 to 5188)
  AUTHORS   An,X.N., Wei,Z.N., Xie,Y.Y., Xu,J., Shen,Y., Ni,L.Y., Shi,H.,
            Shen,P.Y., Zhang,W. and Chen,Y.X.
  TITLE     CD206+CD68+ mono-macrophages and serum soluble CD206 level are
            increased in antineutrophil cytoplasmic antibodies associated
            glomerulonephritis
  JOURNAL   BMC Immunol 23 (1), 55 (2022)
   PUBMED   36376784
  REMARK    GeneRIF: CD206[+]CD68[+] mono-macrophages and serum soluble CD206
            level are increased in antineutrophil cytoplasmic antibodies
            associated glomerulonephritis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5188)
  AUTHORS   Kim,S.J., Ruiz,N., Bezouska,K. and Drickamer,K.
  TITLE     Organization of the gene encoding the human macrophage mannose
            receptor (MRC1)
  JOURNAL   Genomics 14 (3), 721-727 (1992)
   PUBMED   1294118
REFERENCE   7  (bases 1 to 5188)
  AUTHORS   Taylor,M.E., Bezouska,K. and Drickamer,K.
  TITLE     Contribution to ligand binding by multiple carbohydrate-recognition
            domains in the macrophage mannose receptor
  JOURNAL   J Biol Chem 267 (3), 1719-1726 (1992)
   PUBMED   1730714
REFERENCE   8  (bases 1 to 5188)
  AUTHORS   Ezekowitz,R.A., Sastry,K., Bailly,P. and Warner,A.
  TITLE     Molecular characterization of the human macrophage mannose
            receptor: demonstration of multiple carbohydrate recognition-like
            domains and phagocytosis of yeasts in Cos-1 cells
  JOURNAL   J Exp Med 172 (6), 1785-1794 (1990)
   PUBMED   2258707
REFERENCE   9  (bases 1 to 5188)
  AUTHORS   Taylor,M.E., Conary,J.T., Lennartz,M.R., Stahl,P.D. and
            Drickamer,K.
  TITLE     Primary structure of the mannose receptor contains multiple motifs
            resembling carbohydrate-recognition domains
  JOURNAL   J Biol Chem 265 (21), 12156-12162 (1990)
   PUBMED   2373685
REFERENCE   10 (bases 1 to 5188)
  AUTHORS   Lennartz,M.R., Cole,F.S., Shepherd,V.L., Wileman,T.E. and
            Stahl,P.D.
  TITLE     Isolation and characterization of a mannose-specific endocytosis
            receptor from human placenta
  JOURNAL   J Biol Chem 262 (21), 9942-9944 (1987)
   PUBMED   3611070
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC296466.1, J05550.1,
            AL139238.13, AV659122.1 and AC069023.5.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_002438.3.
            
            Summary: The recognition of complex carbohydrate structures on
            glycoproteins is an important part of several biological processes,
            including cell-cell recognition, serum glycoprotein turnover, and
            neutralization of pathogens. The protein encoded by this gene is a
            type I membrane receptor that mediates the endocytosis of
            glycoproteins by macrophages. The protein has been shown to bind
            high-mannose structures on the surface of potentially pathogenic
            viruses, bacteria, and fungi so that they can be neutralized by
            phagocytic engulfment.[provided by RefSeq, Sep 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: J05550.1, X55635.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000569591.3/ ENSP00000455897.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                DC296466.1         6-20
            16-360              J05550.1           1-345
            361-530             DC296466.1         366-535
            531-843             J05550.1           516-828
            844-898             AL139238.13        100045-100099
            899-4161            J05550.1           884-4146
            4162-4315           AV659122.1         199-352
            4316-5186           J05550.1           4301-5171
            5187-5188           AC069023.5         52838-52839         c
FEATURES             Location/Qualifiers
     source          1..5188
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p12.33"
     gene            1..5188
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /note="mannose receptor C-type 1"
                     /db_xref="GeneID:4360"
                     /db_xref="HGNC:HGNC:7228"
                     /db_xref="MIM:153618"
     exon            1..179
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             119..4489
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /note="mannose receptor, C type 1-like 1; macrophage
                     mannose receptor 1-like protein 1; human mannose receptor;
                     C-type lectin domain family 13 member D"
                     /codon_start=1
                     /product="macrophage mannose receptor 1 precursor"
                     /protein_id="NP_002429.1"
                     /db_xref="CCDS:CCDS7123.2"
                     /db_xref="GeneID:4360"
                     /db_xref="HGNC:HGNC:7228"
                     /db_xref="MIM:153618"
                     /translation="MRLPLLLVFASVIPGAVLLLDTRQFLIYNEDHKRCVDAVSPSAV
                     QTAACNQDAESQKFRWVSESQIMSVAFKLCLGVPSKTDWVAITLYACDSKSEFQKWEC
                     KNDTLLGIKGEDLFFNYGNRQEKNIMLYKGSGLWSRWKIYGTTDNLCSRGYEAMYTLL
                     GNANGATCAFPFKFENKWYADCTSAGRSDGWLWCGTTTDYDTDKLFGYCPLKFEGSES
                     LWNKDPLTSVSYQINSKSALTWHQARKSCQQQNAELLSITEIHEQTYLTGLTSSLTSG
                     LWIGLNSLSFNSGWQWSDRSPFRYLNWLPGSPSAEPGKSCVSLNPGKNAKWENLECVQ
                     KLGYICKKGNTTLNSFVIPSESDVPTHCPSQWWPYAGHCYKIHRDEKKIQRDALTTCR
                     KEGGDLTSIHTIEELDFIISQLGYEPNDELWIGLNDIKIQMYFEWSDGTPVTFTKWLR
                     GEPSHENNRQEDCVVMKGKDGYWADRGCEWPLGYICKMKSRSQGPEIVEVEKGCRKGW
                     KKHHFYCYMIGHTLSTFAEANQTCNNENAYLTTIEDRYEQAFLTSFVGLRPEKYFWTG
                     LSDIQTKGTFQWTIEEEVRFTHWNSDMPGRKPGCVAMRTGIAGGLWDVLKCDEKAKFV
                     CKHWAEGVTHPPKPTTTPEPKCPEDWGASSRTSLCFKLYAKGKHEKKTWFESRDFCRA
                     LGGDLASINNKEEQQTIWRLITASGSYHKLFWLGLTYGSPSEGFTWSDGSPVSYENWA
                     YGEPNNYQNVEYCGELKGDPTMSWNDINCEHLNNWICQIQKGQTPKPEPTPAPQDNPP
                     VTEDGWVIYKDYQYYFSKEKETMDNARAFCKRNFGDLVSIQSESEKKFLWKYVNRNDA
                     QSAYFIGLLISLDKKFAWMDGSKVDYVSWATGEPNFANEDENCVTMYSNSGFWNDINC
                     GYPNAFICQRHNSSINATTVMPTMPSVPSGCKEGWNFYSNKCFKIFGFMEEERKNWQE
                     ARKACIGFGGNLVSIQNEKEQAFLTYHMKDSTFSAWTGLNDVNSEHTFLWTDGRGVHY
                     TNWGKGYPGGRRSSLSYEDADCVVIIGGASNEAGKWMDDTCDSKRGYICQTRSDPSLT
                     NPPATIQTDGFVKYGKSSYSLMRQKFQWHEAETYCKLHNSLIASILDPYSNAFAWLQM
                     ETSNERVWIALNSNLTDNQYTWTDKWRVRYTNWAADEPKLKSACVYLDLDGYWKTAHC
                     NESFYFLCKRSDEIPATEPPQLPGRCPESDHTAWIPFHGHCYYIESSYTRNWGQASLE
                     CLRMGSSLVSIESAAESSFLSYRVEPLKSKTNFWIGLFRNVEGTWLWINNSPVSFVNW
                     NTGDPSGERNDCVALHASSGFWSNIHCSSYKGYICKRPKIIDAKPTHELLTTKADTRK
                     MDPSKPSSNVAGVVIIVILLILTGAGLAAYFFYKKRRVHLPQEGAFENTLYFNSQSSP
                     GTSDMKDLVGNIEQNEHSVI"
     exon            180..581
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..755
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            756..920
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1034
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1181
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1367
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1368..1525
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1526..1636
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1752
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1901
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2101
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2229
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2230..2317
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2462
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2504
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2505..2668
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2669..2736
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..2837
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2838..2983
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2984..3098
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3099..3265
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3266..3368
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3369..3601
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3602..3767
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3768..3917
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3918..4031
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            4032..4196
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            4197..4238
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     exon            4239..5188
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5154..5159
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /note="hexamer: AATAAA"
     regulatory      5161..5166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /note="hexamer: ATTAAA"
     polyA_site      5171
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
                     /note="major polyA site"
     polyA_site      5188
                     /gene="MRC1"
                     /gene_synonym="bA541I19.1; CD206; CLEC13D; CLEC13DL; hMR;
                     MMR; MRC1L1"
ORIGIN      
        1 cagctgggca gctctgggaa cttggattag gtggagaggc agttgggggg cctcgttgtt
       61 ttgcgtctta gttccgccct cctgtccatc aggagaagga aaggataaac cctgggccat
      121 gaggctaccc ctgctcctgg tttttgcctc tgtcattccg ggtgctgttc tcctactgga
      181 caccaggcaa tttttaatct ataatgaaga tcacaagcgc tgcgtggatg cagtgagtcc
      241 cagtgccgtc caaaccgcag cttgcaacca ggatgccgaa tcacagaaat tccgatgggt
      301 gtccgaatct cagattatga gtgttgcatt taaattatgc ctgggagtgc catcaaaaac
      361 ggactgggtt gctatcactc tctatgcctg tgactcaaaa agtgaatttc agaaatggga
      421 gtgcaaaaat gacacacttt tggggatcaa aggagaagat ttatttttta actacggcaa
      481 cagacaagaa aagaatatta tgctctacaa gggatcgggt ttatggagca ggtggaagat
      541 ctatggaacc acagacaatc tgtgctccag aggttatgaa gccatgtata cgctactagg
      601 caatgccaat ggagcaacct gtgcattccc gttcaagttt gaaaacaagt ggtacgcaga
      661 ttgcacgagt gctgggcggt cggatggatg gctctggtgc ggaaccacta ctgactatga
      721 cacagacaag ctatttggat attgtccatt gaaatttgag ggcagtgaaa gcttatggaa
      781 taaagacccg ctgaccagcg tttcctacca gataaactcc aaatccgctt taacgtggca
      841 ccaggcgagg aaaagctgcc aacaacagaa cgctgagctc ctgagcatca cagagattca
      901 tgagcaaaca tacctgacag gattaaccag ttccttgacc tcaggactct ggattggact
      961 taacagtctg agcttcaaca gcggttggca gtggagtgac cgcagtcctt tccgatattt
     1021 gaactggtta ccaggaagtc catcagctga acctggaaaa agctgtgtgt cactaaatcc
     1081 tggaaaaaat gctaaatggg aaaatctgga atgtgttcag aaactgggct atatttgcaa
     1141 aaagggcaac accactttaa attcttttgt tattccctca gaaagtgatg tgcctactca
     1201 ctgtcctagt cagtggtggc cgtatgccgg tcactgttac aagattcaca gagatgagaa
     1261 aaaaatccag agggatgctc tgaccacctg caggaaggaa ggcggtgacc tcacaagtat
     1321 ccacaccatc gaggaattgg actttattat ctcccagcta ggatatgagc caaatgacga
     1381 attgtggatc ggcttaaatg acattaagat tcaaatgtac tttgagtgga gtgatgggac
     1441 ccctgtaacg tttaccaaat ggcttcgtgg agaaccaagc catgaaaaca acagacagga
     1501 ggattgtgtg gtgatgaaag gcaaggatgg gtactgggca gatcggggct gtgagtggcc
     1561 tcttggctac atctgcaaga tgaaatcacg aagccaaggt ccagaaatag tggaagtcga
     1621 aaaaggctgc aggaaaggct ggaaaaaaca tcacttttac tgctatatga ttggacatac
     1681 gctttcaaca tttgcagaag caaaccaaac ctgtaataat gagaatgctt atttaacaac
     1741 tattgaagac agatatgaac aagccttcct gactagtttc gttggcttaa ggcctgaaaa
     1801 atatttctgg acaggacttt cagatataca aaccaaaggg acttttcagt ggaccatcga
     1861 ggaagaggtt cggttcaccc actggaattc agatatgcca gggcgaaagc cagggtgtgt
     1921 tgccatgaga accgggattg cagggggctt atgggatgtt ttgaaatgtg atgaaaaggc
     1981 aaaatttgtg tgcaagcact gggcagaagg agtaacccac ccaccgaagc ccacgacgac
     2041 tcccgaaccc aaatgtccgg aggattgggg cgccagcagt agaacaagct tgtgtttcaa
     2101 gctgtatgca aaaggaaaac atgagaagaa aacgtggttt gaatctcgag atttttgtcg
     2161 agctctgggt ggagacttag ctagcatcaa taacaaagag gaacagcaaa caatatggcg
     2221 attaataaca gctagtggaa gctaccacaa actgttttgg ttgggattga catatggaag
     2281 cccttcagaa ggttttactt ggagtgatgg ttctcctgtt tcatatgaaa actgggctta
     2341 tggagaacct aataattatc aaaatgttga atactgtggt gagctgaaag gtgaccctac
     2401 tatgtcttgg aatgatatta attgtgaaca ccttaacaac tggatttgcc agatacaaaa
     2461 aggacaaaca ccaaaacctg agccaacacc agctcctcaa gacaatccac cagttactga
     2521 agatgggtgg gttatttaca aagactacca gtattatttc agcaaagaga aggaaaccat
     2581 ggacaatgcg cgagcgtttt gcaagaggaa ttttggtgat cttgtttcta ttcaaagtga
     2641 aagtgaaaag aagtttctat ggaaatatgt aaacagaaat gatgcacagt ctgcatattt
     2701 tattggttta ttgatcagct tggataaaaa gtttgcttgg atggatggaa gcaaagtgga
     2761 ttacgtgtct tgggccacag gtgaacccaa ttttgcaaat gaagatgaaa actgtgtgac
     2821 catgtattca aattcagggt tttggaatga cattaactgt ggctatccaa acgccttcat
     2881 ttgccagcga cataacagta gtatcaatgc taccacagtt atgcctacca tgccctcggt
     2941 cccatcaggg tgcaaggaag gttggaattt ctacagcaac aagtgtttca aaatctttgg
     3001 atttatggaa gaagaaagaa aaaattggca agaggcacga aaagcttgta taggctttgg
     3061 agggaatctg gtctccatac aaaatgaaaa agagcaagca tttcttacct atcacatgaa
     3121 ggactccact ttcagtgcct ggactgggct gaatgatgtc aattcagaac acacgttcct
     3181 ttggacggat ggacgaggag tccattacac aaactggggg aaaggttacc ctggtggaag
     3241 aagaagcagt ctttcttatg aagatgctga ctgtgttgtt attattggag gtgcatcaaa
     3301 tgaagcagga aaatggatgg atgatacctg cgacagtaaa cgaggctaca tatgccagac
     3361 acgatccgac ccttccttga ctaatcctcc agcaacgatt caaacagatg gctttgttaa
     3421 atatggcaaa agcagctatt cactcatgag acaaaaattt caatggcatg aagcggagac
     3481 atactgcaag cttcacaatt cccttatagc cagcattctg gatccctaca gtaatgcatt
     3541 tgcgtggctg cagatggaaa catctaatga acgtgtgtgg atcgccctga acagtaactt
     3601 gactgataat caatacactt ggactgataa gtggagggtg aggtacacta actgggctgc
     3661 tgatgagccc aaattgaaat cagcatgtgt ttatctggat cttgatggct actggaagac
     3721 agcacattgc aatgaaagtt tttactttct ctgtaaaaga tcagatgaaa tccctgctac
     3781 tgaaccccca caactgcctg gcagatgccc ggagtcagat cacacagcat ggattccttt
     3841 ccatggtcac tgttactata ttgagtcctc atatacaaga aactggggcc aagcttctct
     3901 ggaatgtctt cgaatgggtt cctctctggt ttccattgaa agtgctgcag aatccagttt
     3961 tctgtcatat cgggttgagc cacttaaaag taaaaccaat ttttggatag gattgttcag
     4021 aaatgttgaa gggacgtggc tgtggataaa taacagtccg gtctcctttg tcaactggaa
     4081 cacaggagat ccctctggtg aacggaatga ttgtgtagct ttacatgcgt cttctgggtt
     4141 ttggagtaat attcactgtt catcctacaa aggatatatt tgtaaaagac caaaaattat
     4201 tgatgctaaa cctactcatg aattacttac aacaaaagct gacacaagga agatggaccc
     4261 ttctaaaccg tcttccaacg tggccggagt agtcatcatt gtgatcctcc tgattttaac
     4321 gggtgctggc cttgccgcct atttctttta taagaaaaga cgtgtgcacc tacctcaaga
     4381 gggcgccttt gaaaacactc tgtattttaa cagtcagtca agcccaggaa ctagtgatat
     4441 gaaagatctc gtgggcaata ttgaacagaa tgaacactcg gtcatctagt acctcaatgc
     4501 gattctgaga tatttgaatt tcataaaatt gtaactgaaa tttaaaattt ttagttcaat
     4561 gtgattgttt tctttaaaat gagtactgaa ttgtactggt ctgtcctttt ttcctttgcc
     4621 taattgaaga aataattgct tgttttctag cctggcaaga tattttcata aaagagggat
     4681 aacaatgctg attactacct tttaaaatat tttagataaa tgcacagcac cacagcacca
     4741 catctaagca ttagtgatgg gtagctgatg tcagcttcat gtggatttta agcactctag
     4801 aaacaatgaa gcttcttggc atattttaag gagctcccaa aatgtgttac ctattaaatt
     4861 gtaactcagc aagtagaaga ccatttgaaa agtcaggtac aaatttcctc aagtggcata
     4921 aaaatgtagt cagttttctc ttttaccagt ttttatttcc actccaatta tttagaactt
     4981 tatttgtaca tgtgcagaag aataaggcag ctgagaatct tgtttccccc aagagagttt
     5041 tacaggctga gtgttgcaaa tgtgttcttt gtcctgttat atgtatatca ggaatacaag
     5101 gatgtgaaat aaaactgtaa atttgcataa ctggatgtac ttagataatg tgaaataaac
     5161 attaaagaca aggtctattt ttaataga
//
