LOCUS       NM_001085049            4098 bp    mRNA    linear   PRI 09-OCT-2024
DEFINITION  Homo sapiens muscle RAS oncogene homolog (MRAS), transcript variant
            2, mRNA.
ACCESSION   NM_001085049
VERSION     NM_001085049.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4098)
  AUTHORS   Bester,S.M., Abrahamsen,R., Rodrigues Samora,L., Wu,W.I. and
            Mou,T.C.
  TITLE     Crystal structure of the GDP-bound human M-RAS protein in two
            crystal forms
  JOURNAL   Acta Crystallogr F Struct Biol Commun 80 (Pt 9), 220-227 (2024)
   PUBMED   39196705
  REMARK    GeneRIF: Crystal structure of the GDP-bound human M-RAS protein in
            two crystal forms.
REFERENCE   2  (bases 1 to 4098)
  AUTHORS   Adachi,Y., Kimura,R., Hirade,K., Yanase,S., Nishioka,Y., Kasuga,N.,
            Yamaguchi,R. and Ebi,H.
  TITLE     Scribble mis-localization induces adaptive resistance to KRAS G12C
            inhibitors through feedback activation of MAPK signaling mediated
            by YAP-induced MRAS
  JOURNAL   Nat Cancer 4 (6), 829-843 (2023)
   PUBMED   37277529
  REMARK    GeneRIF: Scribble mis-localization induces adaptive resistance to
            KRAS G12C inhibitors through feedback activation of MAPK signaling
            mediated by YAP-induced MRAS.
REFERENCE   3  (bases 1 to 4098)
  AUTHORS   Bonsor,D.A., Alexander,P., Snead,K., Hartig,N., Drew,M.,
            Messing,S., Finci,L.I., Nissley,D.V., McCormick,F., Esposito,D.,
            Rodriguez-Viciana,P., Stephen,A.G. and Simanshu,D.K.
  TITLE     Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF
            activation and Noonan syndrome
  JOURNAL   Nat Struct Mol Biol 29 (10), 966-977 (2022)
   PUBMED   36175670
  REMARK    GeneRIF: Structure of the SHOC2-MRAS-PP1C complex provides insights
            into RAF activation and Noonan syndrome.
REFERENCE   4  (bases 1 to 4098)
  AUTHORS   Kwon,J.J., Hajian,B., Bian,Y., Young,L.C., Amor,A.J., Fuller,J.R.,
            Fraley,C.V., Sykes,A.M., So,J., Pan,J., Baker,L., Lee,S.J.,
            Wheeler,D.B., Mayhew,D.L., Persky,N.S., Yang,X., Root,D.E.,
            Barsotti,A.M., Stamford,A.W., Perry,C.K., Burgin,A., McCormick,F.,
            Lemke,C.T., Hahn,W.C. and Aguirre,A.J.
  TITLE     Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase
            complex
  JOURNAL   Nature 609 (7926), 408-415 (2022)
   PUBMED   35831509
  REMARK    GeneRIF: Structure-function analysis of the SHOC2-MRAS-PP1C
            holophosphatase complex.
REFERENCE   5  (bases 1 to 4098)
  AUTHORS   Kimmelman,A.C., Osada,M. and Chan,A.M.
  TITLE     R-Ras3, a brain-specific Ras-related protein, activates Akt and
            promotes cell survival in PC12 cells
  JOURNAL   Oncogene 19 (16), 2014-2022 (2000)
   PUBMED   10803462
REFERENCE   6  (bases 1 to 4098)
  AUTHORS   Ehrhardt,G.R., Leslie,K.B., Lee,F., Wieler,J.S. and Schrader,J.W.
  TITLE     M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of
            a constitutively active mutant results in factor-independent growth
            of an interleukin-3-dependent cell line
  JOURNAL   Blood 94 (7), 2433-2444 (1999)
   PUBMED   10498616
REFERENCE   7  (bases 1 to 4098)
  AUTHORS   Louahed,J., Grasso,L., De Smet,C., Van Roost,E., Wildmann,C.,
            Nicolaides,N.C., Levitt,R.C. and Renauld,J.C.
  TITLE     Interleukin-9-induced expression of M-Ras/R-Ras3 oncogene in
            T-helper clones
  JOURNAL   Blood 94 (5), 1701-1710 (1999)
   PUBMED   10477695
REFERENCE   8  (bases 1 to 4098)
  AUTHORS   Quilliam,L.A., Castro,A.F., Rogers-Graham,K.S., Martin,C.B.,
            Der,C.J. and Bi,C.
  TITLE     M-Ras/R-Ras3, a transforming ras protein regulated by Sos1, GRF1,
            and p120 Ras GTPase-activating protein, interacts with the putative
            Ras effector AF6
  JOURNAL   J Biol Chem 274 (34), 23850-23857 (1999)
   PUBMED   10446149
REFERENCE   9  (bases 1 to 4098)
  AUTHORS   Kimmelman,A., Tolkacheva,T., Lorenzi,M.V., Osada,M. and Chan,A.M.
  TITLE     Identification and characterization of R-ras3: a novel member of
            the RAS gene family with a non-ubiquitous pattern of tissue
            distribution
  JOURNAL   Oncogene 15 (22), 2675-2685 (1997)
   PUBMED   9400994
REFERENCE   10 (bases 1 to 4098)
  AUTHORS   Roberts,A.E.
  TITLE     Noonan Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301303
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022337.24, CN356600.1,
            BC047690.1, AF022080.1, AK316071.1, AK123833.1 and BC017733.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001085049.2.
            
            Summary: This gene encodes a member of the Ras family of small
            GTPases. These membrane-associated proteins function as signal
            transducers in multiple processes including cell growth and
            differentiation, and dysregulation of Ras signaling has been
            associated with many types of cancer. The encoded protein may play
            a role in the tumor necrosis factor-alpha and MAP kinase signaling
            pathways. Alternatively spliced transcript variants encoding
            multiple isoforms have been observed for this gene. [provided by
            RefSeq, Nov 2011].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.147716.1,
                                           SRR1660807.162634.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000423968.7/ ENSP00000389682.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AC022337.24        84640-84726
            88-94               CN356600.1         1-7
            95-417              BC047690.1         1-323
            418-834             AF022080.1         211-627
            835-1788            AK316071.1         479-1432
            1789-3576           AK123833.1         875-2662
            3577-4098           BC017733.1         204-725
FEATURES             Location/Qualifiers
     source          1..4098
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.3"
     gene            1..4098
                     /gene="MRAS"
                     /gene_synonym="M-RAs; NS11; R-RAS3; RRAS3"
                     /note="muscle RAS oncogene homolog"
                     /db_xref="GeneID:22808"
                     /db_xref="HGNC:HGNC:7227"
                     /db_xref="MIM:608435"
     exon            1..189
                     /gene="MRAS"
                     /gene_synonym="M-RAs; NS11; R-RAS3; RRAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            190..400
                     /gene="MRAS"
                     /gene_synonym="M-RAs; NS11; R-RAS3; RRAS3"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..834
                     /gene="MRAS"
                     /gene_synonym="M-RAs; NS11; R-RAS3; RRAS3"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; muscle and microspikes RAS; ras-related protein
                     M-Ras; ras-related protein R-Ras3"
                     /codon_start=1
                     /product="ras-related protein M-Ras isoform 1 precursor"
                     /protein_id="NP_001078518.1"
                     /db_xref="CCDS:CCDS3100.1"
                     /db_xref="GeneID:22808"
                     /db_xref="HGNC:HGNC:7227"
                     /db_xref="MIM:608435"
                     /translation="MATSAVPSDNLPTYKLVVVGDGGVGKSALTIQFFQKIFVPDYDP
                     TIEDSYLKHTEIDNQWAILDVLDTAGQEEFSAMREQYMRTGDGFLIVYSVTDKASFEH
                     VDRFHQLILRVKDRESFPMILVANKVDLMHLRKITREQGKEMATKHNIPYIETSAKDP
                     PLNVDKAFHDLVRVIRQQIPEKSQKKKKKTKWRGDRATGTHKLQCVIL"
     exon            401..554
                     /gene="MRAS"
                     /gene_synonym="M-RAs; NS11; R-RAS3; RRAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            555..654
                     /gene="MRAS"
                     /gene_synonym="M-RAs; NS11; R-RAS3; RRAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            655..734
                     /gene="MRAS"
                     /gene_synonym="M-RAs; NS11; R-RAS3; RRAS3"
                     /inference="alignment:Splign:2.1.0"
     exon            735..4098
                     /gene="MRAS"
                     /gene_synonym="M-RAs; NS11; R-RAS3; RRAS3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4080..4085
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MRAS"
                     /gene_synonym="M-RAs; NS11; R-RAS3; RRAS3"
                     /note="hexamer: AATAAA"
     polyA_site      4098
                     /gene="MRAS"
                     /gene_synonym="M-RAs; NS11; R-RAS3; RRAS3"
                     /note="major polyA site"
ORIGIN      
        1 ggggcgcacg ctggcggcgc ggtcgcttta aggaggcgcc ggggcgggga cggaccggag
       61 tggccggctg gcggggagcc gtcagtccgg cggccgcggg gcccggcggg cgcgacgctg
      121 cctcctcacc ggcgcaggct aggagggggc ggcctgagtg ccgtagccga gccggggctg
      181 gagcgcgcgg tctgacctac gagaaacatg gcaaccagcg ccgtccccag tgacaacctc
      241 cccacataca agctggtggt ggtgggggat gggggtgtgg gcaaaagtgc cctcaccatc
      301 cagtttttcc agaagatctt tgtgcctgac tatgacccca ccattgaaga ctcctacctg
      361 aaacatacgg agattgacaa tcaatgggcc atcttggacg ttctggacac agctgggcag
      421 gaggaattca gcgccatgcg ggagcaatac atgcgcacgg gggatggctt cctcatcgtc
      481 tactccgtca ctgacaaggc cagctttgag cacgtggacc gcttccacca gcttatcctg
      541 cgcgtcaaag acagggagtc attcccgatg atcctcgtgg ccaacaaggt cgatttgatg
      601 cacttgagga agatcaccag ggagcaagga aaagaaatgg cgaccaaaca caatattccg
      661 tacatagaaa ccagtgccaa ggacccacct ctcaatgtcg acaaagcctt ccatgacctc
      721 gttagagtaa ttaggcaaca gattccggaa aaaagccaga agaagaagaa gaaaaccaaa
      781 tggcggggag accgggccac aggcacccac aaactgcaat gtgtgatctt gtgacaggcc
      841 tgaggccctg ggcacagtga cggtggcctg gccagccctc gggacccctc cccacctaac
      901 tgcactgaaa ccatttctaa ccacaaccct tggcccaagg acttggtaca ggaagggaga
      961 agggcaggtg ggcagggagc agacagggtc tggctttgcc cagagggcac gggctttccc
     1021 acctctcaaa gagacaagga agccacctgt aagcagaagc agcatccaag tgcccctggc
     1081 ccccccatgt gttgattcaa cccggttcct ccccctctct cggtgggtgt gttgtttatt
     1141 gtaactacat agtgttggtt tgatgtggaa gtgtttatcc acatacaaag tacaaaacaa
     1201 gccatgaaca agcttctttc ccttaccccc catccacaat gtctgagctt ggatgtcttt
     1261 tatagatttt taaattattt tagtgattat tattttatta aaggggtctg ggctcactgc
     1321 ctggtgaagt ttcaagtgtt cagcagacct ctctggtaac atatctggaa tattgttgtt
     1381 gttttttaac cgagttttcc catcagtgcc aaaactcaac tcaatctgaa agtagagtgt
     1441 ctgagaggac agaaggtaat gggaactgta gctggaggcc tcaggccatg ggtcaaacct
     1501 gggagggaaa gagaccctac acatggccta gaaatgagag aagagagagg tatttaccca
     1561 gaggattttc ctatggttgg ggatgcaaat attagaaaac agattgtatt ttgctgaggg
     1621 gagtggctgt catgagcatg tcagttctaa aaggggtttt cattatcctg gaaatgtata
     1681 aactaaagta agctgattgg ctttgcaaac atgttcattt gtttttcaga cagtatgggt
     1741 taagttctct gccctcccca ggggtctgag gaggctctgg gtttctcaga tctgtctctt
     1801 gctgcgtttt cacatcagct gtgctgcttg gtgcctctct gatacgaata cactgacacg
     1861 tcaaagtaac ctaatgtgga caccatccag aaaactccag ttcatgctgg atcttaacca
     1921 aaaatgattc aatactgtta tcactaaaac agcaccaaga cctgaagcca tcttcccttg
     1981 gagtcaactg actaccacct ctataagcct agtcaatgag cagacccctt ccagtatttg
     2041 taaaagtagt actaggttgc ctttttggca atttttattg acctgttgaa tcttgactat
     2101 aaaatgatct gagaagtaag gaaggctggg ctgatgtgtg gctctcatat accttctgca
     2161 agggggcagt ctccccagct ccctgatgat gctcaccccc gcccccccac ctcaggtgct
     2221 gctggtgtga gccaaagact ggagtttttc cagctggggt gggagtggag agacaacagg
     2281 aacaacgctg caccaaagaa aaggtcagaa taaaaggcag cacagctggt gaccttattt
     2341 tctagatgtt acaaatcagg tcactatgca aactagaata tcctcagcag gtggcctggc
     2401 cactctggag aaagaaaccc aaggaaagtg agcacccaac tggatgccaa gacacccggg
     2461 ttctgaaaat gtgctgtgtt cctacctcgg caagatcacc agcactgagg ggcccagctg
     2521 gagaatgatt ctgctacaaa aggagacagt tgagactttt gcttgttgga aatcaaactt
     2581 cttatttgtc taaattgccc ctttttctgt tcctaaaagg aaggataaga gagaacattc
     2641 caggtgaggc acttcaaagt ttccttagac cctatagtgt taagaggtat tttaaacact
     2701 aaaaggacaa agctcttccc aatccttatg cttccctaag tggtatctgc agcagtttgt
     2761 tgtgtgcagt ttgatggcag ctgcaaactg gaggtgaggc ggaggaaagg caggtaggaa
     2821 ggagtaagga tggagatgct cagaatcaag agcatggcgg agtaggagaa gaagccctgc
     2881 acacagggca gtgtccacag ccagaaaact cctgctgggc accaaccact acgagcatac
     2941 cccatgccca ccgtggagct gcaactcctc gacagcactg agtttgatag tctcactgga
     3001 agcagatcag ctgatgtaga acagagacct cggccataaa ggtgagaaga catagggatt
     3061 tcaaccacac agttgggaca gaagggacag tgcatctgtt catccatcct gcacttggcc
     3121 cacgttgaac tccatggtgc ctgagagaga ctagttaagg gttggtcttc tgtatcctct
     3181 gctgttgagc ctctggtaag ctttcatctc ccatgaactc atttccccat aaatgaaatg
     3241 ggtaaataat gccccatttg tagaagtggg ccctcatgac tgaggtagct tccagatagg
     3301 ccagagtaga gtgtagagtg tgccccgtga catccctcca tcttctcctc cattatcatc
     3361 tagcagggtc agactgggaa acctggttgg ccacgccaca ccatgaccga ggagccaact
     3421 gggacttctg gctgtttgac atcctcatgt tcccgttggt cttccggaga atagtgctac
     3481 cctcacatcc cctggagcac agccttcctg aaatgccctc accccatgcc tttgccattg
     3541 tgtgctctca gatttcttcc actgtttgac accctcctta gagggctgct cttttttttc
     3601 cagagataat cctagccatc ctctccactc ccacggctgg ggacaatggc cacttactac
     3661 ctgtgcactt tgccactcgg gacacctgga tggtttctct taggactttg cccacctcct
     3721 tctcatggca cttgctgtgg aaaatgcctg gctggcctcg tggggcctgt ctcacttttc
     3781 caggagacat gacccactaa cgtggcaact ttaacccaaa ggcccctcag acatgttaca
     3841 gcaaatctgg agccacagac aggttccctc cattggcagc ccattgtgtt tgaaattcca
     3901 tgtcgggttt acttggaatg aaagatactt gaattattgt gcgcctgtga gcgcccagct
     3961 tctgtttcat agtcttaaca ggtggccatt gtcgtgaaac gagtgatgcc tgaagatctc
     4021 agtgatgttt gaaccttctg tgtaactttt tattaagtct ttgtatctct cgactgatta
     4081 ataaagaaga gaaacacg
//
